IMP
Process View
double strand break repair via nonhomologous end joining
The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "double strand break repair via nonhomologous end joining"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Trp53 | transformation related protein 53 | 0.937 | ||
| Atm | ataxia telangiectasia mutated homolog (human) | 0.917 | ||
| Prim1 | DNA primase, p49 subunit | 0.866 | ||
| Brca2 | breast cancer 2 | 0.726 | ||
| Hdac1 | histone deacetylase 1 | 0.631 | ||
| Mcm3 | minichromosome maintenance deficient 3 (S. cerevisiae) | 0.568 | ||
| Rpa1 | replication protein A1 | 0.480 | ||
| Prim2 | DNA primase, p58 subunit | 0.431 | ||
| Suds3 | suppressor of defective silencing 3 homolog (S. cerevisiae) | 0.419 | ||
| Nbn | nibrin | 0.394 | ||
| Cdt1 | chromatin licensing and DNA replication factor 1 | 0.328 | ||
| Mlh1 | mutL homolog 1 (E. coli) | 0.312 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.295 | ||
| Cdc6 | cell division cycle 6 homolog (S. cerevisiae) | 0.277 | ||
| Mcm4 | minichromosome maintenance deficient 4 homolog (S. cerevisiae) | 0.275 | ||
| Msh2 | mutS homolog 2 (E. coli) | 0.273 | ||
| Mcm7 | minichromosome maintenance deficient 7 (S. cerevisiae) | 0.249 | ||
| Pold1 | polymerase (DNA directed), delta 1, catalytic subunit | 0.242 | ||
| Brca1 | breast cancer 1 | 0.232 | ||
| Ccne1 | cyclin E1 | 0.211 | ||
| Tipin | timeless interacting protein | 0.211 | ||
| Hprt | hypoxanthine guanine phosphoribosyl transferase | 0.196 | ||
| Pola2 | polymerase (DNA directed), alpha 2 | 0.194 | ||
| Hdac6 | histone deacetylase 6 | 0.192 | ||
| Ezh2 | enhancer of zeste homolog 2 (Drosophila) | 0.168 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.166 | ||
| Dnajc9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | 0.166 | ||
| Cdk4 | cyclin-dependent kinase 4 | 0.143 | ||
| Wdhd1 | WD repeat and HMG-box DNA binding protein 1 | 0.140 | ||
| Dnmt1 | DNA methyltransferase (cytosine-5) 1 | 0.135 | ||
| Ssrp1 | structure specific recognition protein 1 | 0.123 | ||
| Mcm2 | minichromosome maintenance deficient 2 mitotin (S. cerevisiae) | 0.121 | ||
| Parp2 | poly (ADP-ribose) polymerase family, member 2 | 0.114 | ||
| Hells | helicase, lymphoid specific | 0.109 | ||
| Timeless | timeless homolog (Drosophila) | 0.103 | ||
| 2700029M09Rik | RIKEN cDNA 2700029M09 gene | 0.097 | ||
| Igh | immunoglobulin heavy chain complex | 0.093 | ||
| Rad50 | RAD50 homolog (S. cerevisiae) | 0.081 | ||
| Nup85 | nucleoporin 85 | 0.073 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.068 | ||
| Pcna | proliferating cell nuclear antigen | 0.065 | ||
| Lmnb1 | lamin B1 | 0.062 | ||
| Hdac2 | histone deacetylase 2 | 0.058 | ||
| Pole2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | 0.057 | ||
| Rnaseh2b | ribonuclease H2, subunit B | 0.054 | ||
| Rfc2 | replication factor C (activator 1) 2 | 0.053 | ||
| Cpsf3 | cleavage and polyadenylation specificity factor 3 | 0.051 | ||
| Xrcc6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.051 | ||
| Haus1 | HAUS augmin-like complex, subunit 1 | 0.051 | ||
| Rfc1 | replication factor C (activator 1) 1 | 0.050 | ||
| Gins1 | GINS complex subunit 1 (Psf1 homolog) | 0.047 | ||
| Gmnn | geminin | 0.046 | ||
| Ccna2 | cyclin A2 | 0.045 | ||
| Lrrc40 | leucine rich repeat containing 40 | 0.045 | ||
| Pold3 | polymerase (DNA-directed), delta 3, accessory subunit | 0.043 | ||
| Hspa14 | heat shock protein 14 | 0.042 | ||
| Rfc5 | replication factor C (activator 1) 5 | 0.041 | ||
| Mcm5 | minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 0.040 | ||
| Hat1 | histone aminotransferase 1 | 0.040 | ||
| Blm | Bloom syndrome, RecQ helicase-like | 0.039 | Fly | |
| H2afx | H2A histone family, member X | 0.038 | ||
| Ccz1 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) | 0.036 | ||
| Vrk1 | vaccinia related kinase 1 | 0.036 | ||
| Atad5 | ATPase family, AAA domain containing 5 | 0.036 | ||
| Nup88 | nucleoporin 88 | 0.036 | ||
| Lig1 | ligase I, DNA, ATP-dependent | 0.035 | ||
| Mtbp | Mdm2, transformed 3T3 cell double minute p53 binding protein | 0.035 | ||
| Th1l | TH1-like homolog (Drosophila) | 0.033 | ||
| Ppp1cc | protein phosphatase 1, catalytic subunit, gamma isoform | 0.033 | ||
| Rfc4 | replication factor C (activator 1) 4 | 0.032 | ||
| Smarcc1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.031 | ||
| Tcfcp2l1 | transcription factor CP2-like 1 | 0.031 | ||
| Chd1l | chromodomain helicase DNA binding protein 1-like | 0.030 | ||
| Rpa2 | replication protein A2 | 0.030 | ||
| Polr2b | polymerase (RNA) II (DNA directed) polypeptide B | 0.029 | ||
| Orc6 | origin recognition complex, subunit 6 | 0.028 | ||
| Nup107 | nucleoporin 107 | 0.026 | ||
| Tcrb | T-cell receptor beta chain | 0.026 | ||
| Xrcc5 | X-ray repair complementing defective repair in Chinese hamster cells 5 | 0.026 | Human | |
| Pms2 | postmeiotic segregation increased 2 (S. cerevisiae) | 0.025 | ||
| Nup93 | nucleoporin 93 | 0.025 | ||
| Syce2 | synaptonemal complex central element protein 2 | 0.025 | ||
| Ncapd3 | non-SMC condensin II complex, subunit D3 | 0.025 | ||
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.025 | ||
| Parn | poly(A)-specific ribonuclease (deadenylation nuclease) | 0.025 | ||
| Tcrd | T-cell receptor delta chain | 0.024 | ||
| Nasp | nuclear autoantigenic sperm protein (histone-binding) | 0.023 | ||
| Ncaph | non-SMC condensin I complex, subunit H | 0.023 | ||
| Topbp1 | topoisomerase (DNA) II binding protein 1 | 0.023 | ||
| Tada2a | transcriptional adaptor 2A | 0.023 | ||
| Cenpn | centromere protein N | 0.023 | ||
| Asf1b | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | 0.022 | ||
| Lars | leucyl-tRNA synthetase | 0.022 | ||
| Rad51 | RAD51 homolog (S. cerevisiae) | 0.021 | ||
| Dclre1c | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) | 0.021 | ||
| Rrm1 | ribonucleotide reductase M1 | 0.021 | ||
| Ttc27 | tetratricopeptide repeat domain 27 | 0.021 | ||
| Mad2l1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.020 | ||
| Ckap5 | cytoskeleton associated protein 5 | 0.020 | ||
| Creb1 | cAMP responsive element binding protein 1 | 0.019 | ||
| Nap1l4 | nucleosome assembly protein 1-like 4 | 0.019 | ||
| Rars2 | arginyl-tRNA synthetase 2, mitochondrial | 0.019 | ||
| Cse1l | chromosome segregation 1-like (S. cerevisiae) | 0.019 | ||
| Mcm6 | minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 0.019 | ||
| Hist1h1a | histone cluster 1, H1a | 0.019 | ||
| Bax | BCL2-associated X protein | 0.019 | ||
| Pola1 | polymerase (DNA directed), alpha 1 | 0.018 | Human | |
| Nup155 | nucleoporin 155 | 0.018 | ||
| Apex1 | apurinic/apyrimidinic endonuclease 1 | 0.018 | ||
| Paxip1 | PAX interacting (with transcription-activation domain) protein 1 | 0.018 | ||
| Ppp1r7 | protein phosphatase 1, regulatory (inhibitor) subunit 7 | 0.018 | ||
| Ints9 | integrator complex subunit 9 | 0.017 | ||
| Kdm5b | lysine (K)-specific demethylase 5B | 0.017 | ||
| Bub1b | budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) | 0.017 | ||
| Sin3a | transcriptional regulator, SIN3A (yeast) | 0.017 | Yeast | |
| Fam192a | family with sequence similarity 192, member A | 0.017 | ||
| Mre11a | meiotic recombination 11 homolog A (S. cerevisiae) | 0.017 | Yeast | |
| Rnf220 | ring finger protein 220 | 0.017 | ||
| Gpn1 | GPN-loop GTPase 1 | 0.016 | ||
| Pole | polymerase (DNA directed), epsilon | 0.016 | Yeast | |
| Smc2 | structural maintenance of chromosomes 2 | 0.016 | ||
| Incenp | inner centromere protein | 0.016 | ||
| Rc3h1 | RING CCCH (C3H) domains 1 | 0.016 | ||
| Orc5 | origin recognition complex, subunit 5 | 0.015 | ||
| Psma2 | proteasome (prosome, macropain) subunit, alpha type 2 | 0.015 | ||
| Mta2 | metastasis-associated gene family, member 2 | 0.015 | ||
| Terf1 | telomeric repeat binding factor 1 | 0.015 | ||
| Haus6 | HAUS augmin-like complex, subunit 6 | 0.015 | ||
| Pikfyve | phosphoinositide kinase, FYVE finger containing | 0.015 | ||
| Tcf19 | transcription factor 19 | 0.014 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.014 | ||
| Rqcd1 | rcd1 (required for cell differentiation) homolog 1 (S. pombe) | 0.014 | ||
| Dhfr | dihydrofolate reductase | 0.014 | ||
| Cfdp1 | craniofacial development protein 1 | 0.014 | ||
| Psma1 | proteasome (prosome, macropain) subunit, alpha type 1 | 0.014 | ||
| Cenpj | centromere protein J | 0.014 | ||
| Haus4 | HAUS augmin-like complex, subunit 4 | 0.014 | ||
| Nxt1 | NTF2-related export protein 1 | 0.013 | ||
| 8430410A17Rik | RIKEN cDNA 8430410A17 gene | 0.013 | ||
| Nudt5 | nudix (nucleoside diphosphate linked moiety X)-type motif 5 | 0.013 | ||
| Hirip3 | HIRA interacting protein 3 | 0.013 | ||
| Tmem194 | transmembrane protein 194 | 0.013 | ||
| Hnrnpd | heterogeneous nuclear ribonucleoprotein D | 0.013 | ||
| Trip13 | thyroid hormone receptor interactor 13 | 0.013 | ||
| Thoc4 | THO complex 4 | 0.013 | ||
| Lyst | lysosomal trafficking regulator | 0.013 | ||
| Mms22l | MMS22-like, DNA repair protein | 0.012 | ||
| Chek2 | CHK2 checkpoint homolog (S. pombe) | 0.012 | ||
| Cbl | Casitas B-lineage lymphoma | 0.012 | ||
| Mcm8 | minichromosome maintenance deficient 8 (S. cerevisiae) | 0.012 | ||
| Hira | histone cell cycle regulation defective homolog A (S. cerevisiae) | 0.012 | ||
| Huwe1 | HECT, UBA and WWE domain containing 1 | 0.012 | ||
| Casp3 | caspase 3 | 0.012 | ||
| Psmd5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | 0.012 | ||
| Haus5 | HAUS augmin-like complex, subunit 5 | 0.012 | ||
| Srbd1 | S1 RNA binding domain 1 | 0.012 | ||
| Smc4 | structural maintenance of chromosomes 4 | 0.012 | ||
| Anapc5 | anaphase-promoting complex subunit 5 | 0.012 | ||
| Rfwd3 | ring finger and WD repeat domain 3 | 0.012 | ||
| Sap30 | sin3 associated polypeptide | 0.012 | ||
| Wrn | Werner syndrome homolog (human) | 0.012 | ||
| Srsf4 | serine/arginine-rich splicing factor 4 | 0.012 | ||
| Ints4 | integrator complex subunit 4 | 0.012 | ||
| H2afz | H2A histone family, member Z | 0.011 | ||
| Vta1 | Vps20-associated 1 homolog (S. cerevisiae) | 0.011 | ||
| Rtcd1 | RNA terminal phosphate cyclase domain 1 | 0.011 | ||
| Utp3 | UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) | 0.011 | ||
| Brd7 | bromodomain containing 7 | 0.011 | ||
| Tcra | T-cell receptor alpha chain | 0.011 | ||
| Cdc25a | cell division cycle 25 homolog A (S. pombe) | 0.011 | ||
| Cdk5rap2 | CDK5 regulatory subunit associated protein 2 | 0.011 | ||
| Ncapg2 | non-SMC condensin II complex, subunit G2 | 0.011 | ||
| Cdca8 | cell division cycle associated 8 | 0.011 | ||
| Fancm | Fanconi anemia, complementation group M | 0.011 | ||
| Cwf19l1 | CWF19-like 1, cell cycle control (S. pombe) | 0.011 | ||
| Smyd2 | SET and MYND domain containing 2 | 0.011 | ||
| Pms1 | postmeiotic segregation increased 1 (S. cerevisiae) | 0.011 | ||
| Hmgn5 | high-mobility group nucleosome binding domain 5 | 0.011 | ||
| Arhgap11a | Rho GTPase activating protein 11A | 0.010 | ||
| Nsmce4a | non-SMC element 4 homolog A (S. cerevisiae) | 0.010 | ||
| Asxl1 | additional sex combs like 1 (Drosophila) | 0.010 | ||
| Cks1b | CDC28 protein kinase 1b | 0.010 | ||
| Braf | Braf transforming gene | 0.010 | ||
| Pnpt1 | polyribonucleotide nucleotidyltransferase 1 | 0.010 | ||
| Blmh | bleomycin hydrolase | 0.010 |