IMP
Process View
dna catabolic process
The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "dna catabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Rb1 | retinoblastoma 1 | 0.773 | ||
| Brca1 | breast cancer 1 | 0.763 | ||
| Brca2 | breast cancer 2 | 0.534 | ||
| Dffb | DNA fragmentation factor, beta subunit | 0.499 | ||
| Cdk4 | cyclin-dependent kinase 4 | 0.385 | ||
| Trp53 | transformation related protein 53 | 0.360 | ||
| Ppp1cc | protein phosphatase 1, catalytic subunit, gamma isoform | 0.330 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.267 | ||
| Nbn | nibrin | 0.197 | ||
| Casp1 | caspase 1 | 0.166 | Mouse | |
| Ccne1 | cyclin E1 | 0.164 | ||
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.150 | Mouse | |
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.116 | ||
| Hells | helicase, lymphoid specific | 0.112 | ||
| Gbp5 | guanylate binding protein 5 | 0.104 | ||
| Hspd1 | heat shock protein 1 (chaperonin) | 0.083 | ||
| Ccnd1 | cyclin D1 | 0.076 | ||
| Hdac1 | histone deacetylase 1 | 0.075 | ||
| Il18 | interleukin 18 | 0.072 | ||
| Wdhd1 | WD repeat and HMG-box DNA binding protein 1 | 0.071 | ||
| Cdc6 | cell division cycle 6 homolog (S. cerevisiae) | 0.070 | ||
| Map3k7 | mitogen-activated protein kinase kinase kinase 7 | 0.069 | ||
| Atm | ataxia telangiectasia mutated homolog (human) | 0.066 | Fly | |
| Terf1 | telomeric repeat binding factor 1 | 0.064 | ||
| Pycard | PYD and CARD domain containing | 0.063 | ||
| Ppp1ca | protein phosphatase 1, catalytic subunit, alpha isoform | 0.063 | ||
| Rfc3 | replication factor C (activator 1) 3 | 0.062 | ||
| Orc1 | origin recognition complex, subunit 1 | 0.060 | ||
| Rbl1 | retinoblastoma-like 1 (p107) | 0.055 | ||
| Pms2 | postmeiotic segregation increased 2 (S. cerevisiae) | 0.053 | ||
| Atr | ataxia telangiectasia and Rad3 related | 0.053 | Fly | |
| Igh | immunoglobulin heavy chain complex | 0.048 | ||
| Mis18bp1 | MIS18 binding protein 1 | 0.046 | ||
| Ezh2 | enhancer of zeste homolog 2 (Drosophila) | 0.046 | ||
| Dtl | denticleless homolog (Drosophila) | 0.044 | ||
| Tlr4 | toll-like receptor 4 | 0.043 | ||
| Nphp4 | nephronophthisis 4 (juvenile) homolog (human) | 0.043 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.042 | ||
| Casp3 | caspase 3 | 0.040 | ||
| Kiss1 | KiSS-1 metastasis-suppressor | 0.039 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.039 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.039 | Worm | |
| Nasp | nuclear autoantigenic sperm protein (histone-binding) | 0.039 | ||
| Plk4 | polo-like kinase 4 (Drosophila) | 0.037 | ||
| Cdk2 | cyclin-dependent kinase 2 | 0.037 | Yeast | |
| Plin1 | perilipin 1 | 0.037 | ||
| Pole2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | 0.036 | ||
| Mcm4 | minichromosome maintenance deficient 4 homolog (S. cerevisiae) | 0.036 | ||
| Lrpprc | leucine-rich PPR-motif containing | 0.035 | ||
| Ndufab1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 | 0.035 | ||
| Bub1 | budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) | 0.035 | ||
| Apc | adenomatosis polyposis coli | 0.033 | ||
| Drosha | drosha, ribonuclease type III | 0.033 | ||
| Mlh1 | mutL homolog 1 (E. coli) | 0.032 | ||
| Chek2 | CHK2 checkpoint homolog (S. pombe) | 0.032 | ||
| Cdca7l | cell division cycle associated 7 like | 0.032 | ||
| Il1b | interleukin 1 beta | 0.032 | ||
| Parp2 | poly (ADP-ribose) polymerase family, member 2 | 0.031 | ||
| Lig4 | ligase IV, DNA, ATP-dependent | 0.030 | ||
| Bak1 | BCL2-antagonist/killer 1 | 0.029 | ||
| Stk11 | serine/threonine kinase 11 | 0.029 | ||
| Wrn | Werner syndrome homolog (human) | 0.029 | ||
| Xpa | xeroderma pigmentosum, complementation group A | 0.028 | ||
| Fadd | Fas (TNFRSF6)-associated via death domain | 0.027 | ||
| Pola1 | polymerase (DNA directed), alpha 1 | 0.027 | ||
| Suz12 | suppressor of zeste 12 homolog (Drosophila) | 0.027 | ||
| Tfam | transcription factor A, mitochondrial | 0.026 | ||
| Cycs | cytochrome c, somatic | 0.026 | Human | |
| Trip13 | thyroid hormone receptor interactor 13 | 0.026 | ||
| Mcm7 | minichromosome maintenance deficient 7 (S. cerevisiae) | 0.025 | ||
| Fen1 | flap structure specific endonuclease 1 | 0.025 | ||
| Kif11 | kinesin family member 11 | 0.024 | ||
| Cenpk | centromere protein K | 0.024 | ||
| Srsf9 | serine/arginine-rich splicing factor 9 | 0.024 | ||
| Ccna2 | cyclin A2 | 0.024 | ||
| Prkab1 | protein kinase, AMP-activated, beta 1 non-catalytic subunit | 0.023 | ||
| Ccnb1 | cyclin B1 | 0.023 | ||
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.023 | ||
| Timm8a1 | translocase of inner mitochondrial membrane 8 homolog a1 (yeast) | 0.023 | ||
| Dhfr | dihydrofolate reductase | 0.023 | ||
| Ranbp1 | RAN binding protein 1 | 0.022 | ||
| Smc2 | structural maintenance of chromosomes 2 | 0.022 | ||
| Ikbkb | inhibitor of kappaB kinase beta | 0.022 | ||
| E2f1 | E2F transcription factor 1 | 0.021 | ||
| Hist1h1a | histone cluster 1, H1a | 0.021 | ||
| Gmnn | geminin | 0.021 | ||
| Ndufaf4 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 | 0.021 | ||
| Ints9 | integrator complex subunit 9 | 0.020 | ||
| Rttn | rotatin | 0.020 | ||
| Chek1 | checkpoint kinase 1 homolog (S. pombe) | 0.020 | ||
| Dsn1 | DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) | 0.020 | ||
| Impdh2 | inosine 5'-phosphate dehydrogenase 2 | 0.020 | ||
| Cdc7 | cell division cycle 7 (S. cerevisiae) | 0.020 | ||
| Mybl2 | myeloblastosis oncogene-like 2 | 0.020 | ||
| Ikbkg | inhibitor of kappaB kinase gamma | 0.020 | ||
| Prim1 | DNA primase, p49 subunit | 0.019 | ||
| Cox5a | cytochrome c oxidase, subunit Va | 0.019 | ||
| Nlrp3 | NLR family, pyrin domain containing 3 | 0.019 | ||
| Mcm10 | minichromosome maintenance deficient 10 (S. cerevisiae) | 0.019 | ||
| Ccdc99 | coiled-coil domain containing 99 | 0.019 | ||
| Cidea | cell death-inducing DNA fragmentation factor, alpha subunit-like effector A | 0.019 | ||
| Sod2 | superoxide dismutase 2, mitochondrial | 0.018 | ||
| Trp73 | transformation related protein 73 | 0.018 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.018 | ||
| Apaf1 | apoptotic peptidase activating factor 1 | 0.018 | ||
| Xrcc6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.017 | ||
| Parp1 | poly (ADP-ribose) polymerase family, member 1 | 0.017 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.017 | ||
| Blm | Bloom syndrome, RecQ helicase-like | 0.017 | Human | |
| Huwe1 | HECT, UBA and WWE domain containing 1 | 0.017 | ||
| Alms1 | Alstrom syndrome 1 homolog (human) | 0.017 | ||
| Mms22l | MMS22-like, DNA repair protein | 0.017 | ||
| Cidec | cell death-inducing DFFA-like effector c | 0.016 | Mouse | |
| Mcm8 | minichromosome maintenance deficient 8 (S. cerevisiae) | 0.016 | ||
| Cfd | complement factor D (adipsin) | 0.016 | ||
| Vrk1 | vaccinia related kinase 1 | 0.016 | ||
| Atad5 | ATPase family, AAA domain containing 5 | 0.016 | ||
| Ccne2 | cyclin E2 | 0.016 | ||
| Elavl1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | 0.016 | ||
| Atrip | ATR interacting protein | 0.016 | ||
| Bid | BH3 interacting domain death agonist | 0.015 | ||
| Birc3 | baculoviral IAP repeat-containing 3 | 0.015 | ||
| Prim2 | DNA primase, p58 subunit | 0.015 | ||
| Efemp2 | epidermal growth factor-containing fibulin-like extracellular matrix protein 2 | 0.015 | ||
| Mphosph9 | M-phase phosphoprotein 9 | 0.015 | ||
| Smarcd1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 0.015 | ||
| Wwox | WW domain-containing oxidoreductase | 0.015 | ||
| Clic1 | chloride intracellular channel 1 | 0.014 | ||
| Myc | myelocytomatosis oncogene | 0.014 | ||
| Pold3 | polymerase (DNA-directed), delta 3, accessory subunit | 0.014 | ||
| Men1 | multiple endocrine neoplasia 1 | 0.014 | ||
| Stat1 | signal transducer and activator of transcription 1 | 0.014 | ||
| Mtbp | Mdm2, transformed 3T3 cell double minute p53 binding protein | 0.014 | ||
| Aqp7 | aquaporin 7 | 0.014 | ||
| Fancd2 | Fanconi anemia, complementation group D2 | 0.014 | ||
| Stil | Scl/Tal1 interrupting locus | 0.014 | ||
| Ndufs1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1 | 0.013 | ||
| Skp1a | S-phase kinase-associated protein 1A | 0.013 | ||
| Gcsh | glycine cleavage system protein H (aminomethyl carrier) | 0.013 | ||
| Rpf2 | ribosome production factor 2 homolog (S. cerevisiae) | 0.013 | ||
| Lyst | lysosomal trafficking regulator | 0.013 | ||
| Eif2ak2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.013 | ||
| Cdt1 | chromatin licensing and DNA replication factor 1 | 0.013 | ||
| Ints7 | integrator complex subunit 7 | 0.013 | ||
| Parn | poly(A)-specific ribonuclease (deadenylation nuclease) | 0.013 | ||
| Idua | iduronidase, alpha-L- | 0.013 | ||
| Hspe1 | heat shock protein 1 (chaperonin 10) | 0.013 | ||
| Gfm1 | G elongation factor, mitochondrial 1 | 0.013 | ||
| Padi1 | peptidyl arginine deiminase, type I | 0.013 | ||
| Cdca7 | cell division cycle associated 7 | 0.013 | ||
| Mcm3 | minichromosome maintenance deficient 3 (S. cerevisiae) | 0.013 | ||
| Top2a | topoisomerase (DNA) II alpha | 0.012 | ||
| Casp8 | caspase 8 | 0.012 | Mouse | |
| Ly96 | lymphocyte antigen 96 | 0.012 | ||
| Stk3 | serine/threonine kinase 3 (Ste20, yeast homolog) | 0.012 | ||
| Bax | BCL2-associated X protein | 0.012 | Human | |
| Pask | PAS domain containing serine/threonine kinase | 0.012 | ||
| Dnaja3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.012 | ||
| Bard1 | BRCA1 associated RING domain 1 | 0.012 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.012 | ||
| Msh2 | mutS homolog 2 (E. coli) | 0.012 | Yeast | |
| Smn1 | survival motor neuron 1 | 0.012 | ||
| Ccnf | cyclin F | 0.012 | ||
| Sin3a | transcriptional regulator, SIN3A (yeast) | 0.012 | ||
| Agrp | agouti related protein | 0.012 | ||
| Gbp3 | guanylate binding protein 3 | 0.011 | ||
| Aicda | activation-induced cytidine deaminase | 0.011 | ||
| Ripk3 | receptor-interacting serine-threonine kinase 3 | 0.011 | ||
| Ptch1 | patched homolog 1 | 0.011 | ||
| Aim2 | absent in melanoma 2 | 0.011 | ||
| Plin4 | perilipin 4 | 0.011 | ||
| Gins1 | GINS complex subunit 1 (Psf1 homolog) | 0.011 | ||
| Prkag1 | protein kinase, AMP-activated, gamma 1 non-catalytic subunit | 0.011 | ||
| Bub1b | budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) | 0.011 | ||
| Mad2l1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.011 | ||
| Lrr1 | leucine rich repeat protein 1 | 0.011 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.011 | ||
| Mbd4 | methyl-CpG binding domain protein 4 | 0.011 | ||
| Tcrb | T-cell receptor beta chain | 0.011 | ||
| H2afx | H2A histone family, member X | 0.011 | ||
| Taf3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor | 0.011 | ||
| Il1r1 | interleukin 1 receptor, type I | 0.011 | ||
| Dlgap5 | discs, large (Drosophila) homolog-associated protein 5 | 0.011 | ||
| Casp7 | caspase 7 | 0.011 | Mouse | |
| Tnfsf10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.011 | ||
| Flt3l | FMS-like tyrosine kinase 3 ligand | 0.011 | ||
| Nup93 | nucleoporin 93 | 0.011 | ||
| Lep | leptin | 0.010 | ||
| C330027C09Rik | RIKEN cDNA C330027C09 gene | 0.010 | ||
| Dkc1 | dyskeratosis congenita 1, dyskerin homolog (human) | 0.010 | ||
| Rfc1 | replication factor C (activator 1) 1 | 0.010 | ||
| Amhr2 | anti-Mullerian hormone type 2 receptor | 0.010 | ||
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.010 | ||
| Haus6 | HAUS augmin-like complex, subunit 6 | 0.010 | ||
| Acd | adrenocortical dysplasia | 0.010 | ||
| Dlat | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 0.010 | ||
| Fbn1 | fibrillin 1 | 0.010 | ||
| Dclre1a | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) | 0.010 | ||
| Utf1 | undifferentiated embryonic cell transcription factor 1 | 0.010 | ||
| Sf3b3 | splicing factor 3b, subunit 3 | 0.010 |