IMP: Integrative Multi-species Prediction

Mus musculus

13 genes annotated in mouse

plasma lipoprotein particle clearance

The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "plasma lipoprotein particle clearance"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "plasma lipoprotein particle clearance" (in gray)

Name	Description	Probability	Func Analog Organism
Apoe	apolipoprotein E	0.984	Human
Dab1	disabled homolog 1 (Drosophila)	0.968
Apoa1	apolipoprotein A-I	0.921
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.838
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.825
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.810
Lrp1	low density lipoprotein receptor-related protein 1	0.803	Mouse
Ldlr	low density lipoprotein receptor	0.683
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.656
Lpin1	lipin 1	0.563
Pparg	peroxisome proliferator activated receptor gamma	0.553
Cav1	caveolin 1, caveolae protein	0.498
Npc1	Niemann Pick type C1	0.442
Lcat	lecithin cholesterol acyltransferase	0.404
App	amyloid beta (A4) precursor protein	0.368
Scd1	stearoyl-Coenzyme A desaturase 1	0.347
Hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.341
Klf15	Kruppel-like factor 15	0.269
Cdh5	cadherin 5	0.216
Gsk3b	glycogen synthase kinase 3 beta	0.187
Nphs2	nephrosis 2 homolog, podocin (human)	0.184
Abhd5	abhydrolase domain containing 5	0.180
Fgfr2	fibroblast growth factor receptor 2	0.168
Bcl2	B-cell leukemia/lymphoma 2	0.153
Tbx3	T-box 3	0.153
Agtr1a	angiotensin II receptor, type 1a	0.152
Plin1	perilipin 1	0.143
Axin1	axin 1	0.137
Flt1	FMS-like tyrosine kinase 1	0.127
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.122
Morf4l2	mortality factor 4 like 2	0.114
Pltp	phospholipid transfer protein	0.112
Hsd11b1	hydroxysteroid 11-beta dehydrogenase 1	0.100
Cd44	CD44 antigen	0.095
Notch2	Notch gene homolog 2 (Drosophila)	0.083
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.080
Plvap	plasmalemma vesicle associated protein	0.077
F10	coagulation factor X	0.074
Nr1h3	nuclear receptor subfamily 1, group H, member 3	0.073
Fgb	fibrinogen beta chain	0.065
Tgfbr2	transforming growth factor, beta receptor II	0.064
Scarb1	scavenger receptor class B, member 1	0.064
Fabp4	fatty acid binding protein 4, adipocyte	0.061
Sertad2	SERTA domain containing 2	0.060
Lpl	lipoprotein lipase	0.059
Pick1	protein interacting with C kinase 1	0.057
Ahsg	alpha-2-HS-glycoprotein	0.054
Lrp2	low density lipoprotein receptor-related protein 2	0.053	Mouse
Psen1	presenilin 1	0.053
Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	0.053
Vegfa	vascular endothelial growth factor A	0.049
Vangl2	vang-like 2 (van gogh, Drosophila)	0.048
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.048
Nos3	nitric oxide synthase 3, endothelial cell	0.047
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.047
Ccl2	chemokine (C-C motif) ligand 2	0.046
Abcg1	ATP-binding cassette, sub-family G (WHITE), member 1	0.045
Crtc3	CREB regulated transcription coactivator 3	0.045
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.044
Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	0.044
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.044
Gjb2	gap junction protein, beta 2	0.040
Ehd4	EH-domain containing 4	0.040	Mouse
Reln	reelin	0.039
Lrp6	low density lipoprotein receptor-related protein 6	0.039
Pnpla2	patatin-like phospholipase domain containing 2	0.038
Ncoa3	nuclear receptor coactivator 3	0.038
Prnp	prion protein	0.036
Apoa2	apolipoprotein A-II	0.035
Cfi	complement component factor i	0.032
Mesdc2	mesoderm development candidate 2	0.032
Vkorc1	vitamin K epoxide reductase complex, subunit 1	0.032
Slc34a1	solute carrier family 34 (sodium phosphate), member 1	0.032
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.031
Ehd3	EH-domain containing 3	0.030	Mouse
Timp3	tissue inhibitor of metalloproteinase 3	0.030
Ltbr	lymphotoxin B receptor	0.029
Agtr2	angiotensin II receptor, type 2	0.028
Hal	histidine ammonia lyase	0.027
Apoc2	apolipoprotein C-II	0.027
Dok2	docking protein 2	0.027
Lrp5	low density lipoprotein receptor-related protein 5	0.026	Mouse
Mt1	metallothionein 1	0.026
Mertk	c-mer proto-oncogene tyrosine kinase	0.026
Qk	quaking	0.025
Myl12b	myosin, light chain 12B, regulatory	0.024
Apob	apolipoprotein B	0.024	Human
Rad21	RAD21 homolog (S. pombe)	0.023
Apof	apolipoprotein F	0.023
Fas	Fas (TNF receptor superfamily member 6)	0.022
Itih4	inter alpha-trypsin inhibitor, heavy chain 4	0.022
Angptl4	angiopoietin-like 4	0.022
Gne	glucosamine	0.021
Dok1	docking protein 1	0.021
Cbx3	chromobox homolog 3 (Drosophila HP1 gamma)	0.021
Pofut1	protein O-fucosyltransferase 1	0.020
Pecam1	platelet/endothelial cell adhesion molecule 1	0.020
Lepr	leptin receptor	0.019
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.019
Lyz2	lysozyme 2	0.019
Myo7a	myosin VIIA	0.019
Mpv17	MpV17 mitochondrial inner membrane protein	0.019
Nucb1	nucleobindin 1	0.018
Itm2c	integral membrane protein 2C	0.018
Cd36	CD36 antigen	0.018
Fbn1	fibrillin 1	0.018
Igfbp1	insulin-like growth factor binding protein 1	0.018
F7	coagulation factor VII	0.018
Pdzk1	PDZ domain containing 1	0.017
Trfr2	transferrin receptor 2	0.017
Gaa	glucosidase, alpha, acid	0.017
Plg	plasminogen	0.017
Slc12a6	solute carrier family 12, member 6	0.017
Sox11	SRY-box containing gene 11	0.017
Fn1	fibronectin 1	0.017
Timd2	T-cell immunoglobulin and mucin domain containing 2	0.017
Fcna	ficolin A	0.017
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.017
Gulo	gulonolactone (L-) oxidase	0.016
Dhcr7	7-dehydrocholesterol reductase	0.016
Nono	non-POU-domain-containing, octamer binding protein	0.016
Txnip	thioredoxin interacting protein	0.016
Ctnnb1	catenin (cadherin associated protein), beta 1	0.016
Myof	myoferlin	0.015
Ninj1	ninjurin 1	0.015
Rora	RAR-related orphan receptor alpha	0.015
Il1r1	interleukin 1 receptor, type I	0.015
Kng1	kininogen 1	0.015
Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.015
Proc	protein C	0.015
Itgb3	integrin beta 3	0.015
Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.015
Pros1	protein S (alpha)	0.015
Spink3	serine peptidase inhibitor, Kazal type 3	0.015
C3	complement component 3	0.015
Hnf4a	hepatic nuclear factor 4, alpha	0.014
Foxa3	forkhead box A3	0.014
T	brachyury	0.014
Rbm3	RNA binding motif protein 3	0.014
Apoa4	apolipoprotein A-IV	0.014
Ccr2	chemokine (C-C motif) receptor 2	0.014
Uba2	ubiquitin-like modifier activating enzyme 2	0.014
Igfbp4	insulin-like growth factor binding protein 4	0.014
Lss	lanosterol synthase	0.014
Hpx	hemopexin	0.014
Cd59a	CD59a antigen	0.014
Cfb	complement factor B	0.013
Dhcr24	24-dehydrocholesterol reductase	0.013
Lmna	lamin A	0.013
Foxa2	forkhead box A2	0.013
Asgr2	asialoglycoprotein receptor 2	0.013
Grb7	growth factor receptor bound protein 7	0.013
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.013
Marco	macrophage receptor with collagenous structure	0.013	Mouse
Aacs	acetoacetyl-CoA synthetase	0.013
Il6st	interleukin 6 signal transducer	0.013
Hnrnpa3	heterogeneous nuclear ribonucleoprotein A3	0.013
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.013
Clec4d	C-type lectin domain family 4, member d	0.013
Clec4e	C-type lectin domain family 4, member e	0.013
Pofut2	protein O-fucosyltransferase 2	0.013
Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	0.013
Itgb5	integrin beta 5	0.013
Pcbd2	pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	0.013
Tspan4	tetraspanin 4	0.013
Mgll	monoglyceride lipase	0.012
Stx2	syntaxin 2	0.012
Dusp9	dual specificity phosphatase 9	0.012
Mafb	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.012
Pkd1	polycystic kidney disease 1 homolog	0.012
Cubn	cubilin (intrinsic factor-cobalamin receptor)	0.012
Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.012
Vil1	villin 1	0.012
F2	coagulation factor II	0.012
Fuca1	fucosidase, alpha-L- 1, tissue	0.012
Tpp1	tripeptidyl peptidase I	0.012
Cd5l	CD5 antigen-like	0.012
Sil1	endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)	0.012
C5ar1	complement component 5a receptor 1	0.012
Mst1	macrophage stimulating 1 (hepatocyte growth factor-like)	0.012
Plod3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.012
Gba	glucosidase, beta, acid	0.012
Lrp4	low density lipoprotein receptor-related protein 4	0.012	Mouse
Soat2	sterol O-acyltransferase 2	0.012
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.012
Ambp	alpha 1 microglobulin/bikunin	0.012
Foxc2	forkhead box C2	0.012
Soat1	sterol O-acyltransferase 1	0.012
Sall1	sal-like 1 (Drosophila)	0.012
Cyp2d10	cytochrome P450, family 2, subfamily d, polypeptide 10	0.012
Tcta	T-cell leukemia translocation altered gene	0.011
Myo1c	myosin IC	0.011
Psap	prosaposin	0.011
Fgfr3	fibroblast growth factor receptor 3	0.011
Por	P450 (cytochrome) oxidoreductase	0.011
Sema4g	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	0.011
Pygl	liver glycogen phosphorylase	0.011
Lama5	laminin, alpha 5	0.011
Lmf1	lipase maturation factor 1	0.011
Comt	catechol-O-methyltransferase	0.011
H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	0.011
Sulf2	sulfatase 2	0.011
Osbpl8	oxysterol binding protein-like 8	0.011
Mcoln2	mucolipin 2	0.011
Rbbp7	retinoblastoma binding protein 7	0.011
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.011
Rps6ka1	ribosomal protein S6 kinase polypeptide 1	0.011
Cd151	CD151 antigen	0.011
1100001G20Rik	RIKEN cDNA 1100001G20 gene	0.011
Abca3	ATP-binding cassette, sub-family A (ABC1), member 3	0.010
Vnn3	vanin 3	0.010
Hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2	0.010
Neurod6	neurogenic differentiation 6	0.010
Slc18a1	solute carrier family 18 (vesicular monoamine), member 1	0.010
Aldob	aldolase B, fructose-bisphosphate	0.010
Slc22a2	solute carrier family 22 (organic cation transporter), member 2	0.010
Mmp2	matrix metallopeptidase 2	0.010
Gpx3	glutathione peroxidase 3	0.010
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.010
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.010
Sardh	sarcosine dehydrogenase	0.010