IMP: Integrative Multi-species Prediction

Mus musculus

25 genes annotated in mouse

Multi-species View

positive regulation of intrinsic apoptotic signaling pathway

GO:2001244

Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of intrinsic apoptotic signaling pathway"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of intrinsic apoptotic signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.991	Human
Trp53	transformation related protein 53	0.990	Human Mouse
Pten	phosphatase and tensin homolog	0.980
Igh	immunoglobulin heavy chain complex	0.946
Bcl2	B-cell leukemia/lymphoma 2	0.906	Mouse
S100a9	S100 calcium binding protein A9 (calgranulin B)	0.765	Human
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.678
S100a8	S100 calcium binding protein A8 (calgranulin A)	0.645	Human
Mfn2	mitofusin 2	0.442
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.431
Mcl1	myeloid cell leukemia sequence 1	0.422
Fgfr2	fibroblast growth factor receptor 2	0.399
Ncoa3	nuclear receptor coactivator 3	0.336
Tnf	tumor necrosis factor	0.334
Ptgs2	prostaglandin-endoperoxide synthase 2	0.295
Vhl	von Hippel-Lindau tumor suppressor	0.257
Tlr4	toll-like receptor 4	0.239
Trp63	transformation related protein 63	0.235	Mouse
Mmp9	matrix metallopeptidase 9	0.231
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.227	Human
Rxra	retinoid X receptor alpha	0.219
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.208
Kit	kit oncogene	0.200
Sox9	SRY-box containing gene 9	0.196
Cd44	CD44 antigen	0.192
Il10	interleukin 10	0.150	Mouse
Fas	Fas (TNF receptor superfamily member 6)	0.149
Rara	retinoic acid receptor, alpha	0.146
Lepr	leptin receptor	0.146
Fgfr1	fibroblast growth factor receptor 1	0.143
Plagl2	pleiomorphic adenoma gene-like 2	0.141
Sfn	stratifin	0.139
Ikbkg	inhibitor of kappaB kinase gamma	0.128
Gli3	GLI-Kruppel family member GLI3	0.126
Ctnnb1	catenin (cadherin associated protein), beta 1	0.123
Prnp	prion protein	0.112
Lyz2	lysozyme 2	0.105
Prrx1	paired related homeobox 1	0.104
Bax	BCL2-associated X protein	0.103
Stat3	signal transducer and activator of transcription 3	0.100
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.092
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.090
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.089
Casp8	caspase 8	0.086
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.084
Trp73	transformation related protein 73	0.081
Dlx5	distal-less homeobox 5	0.081
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.080
Gli2	GLI-Kruppel family member GLI2	0.080
Mtor	mechanistic target of rapamycin (serine/threonine kinase)	0.079
Chi3l3	chitinase 3-like 3	0.073
Rarg	retinoic acid receptor, gamma	0.071
Egr2	early growth response 2	0.070
Smo	smoothened homolog (Drosophila)	0.062
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.061
Cd8a	CD8 antigen, alpha chain	0.059
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.059
Pparg	peroxisome proliferator activated receptor gamma	0.058
Apc	adenomatosis polyposis coli	0.058
Pml	promyelocytic leukemia	0.058
Gnb2l1	guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1	0.057	Human
Syncrip	synaptotagmin binding, cytoplasmic RNA interacting protein	0.055
Hbb-b1	hemoglobin, beta adult major chain	0.053
Ikzf1	IKAROS family zinc finger 1	0.052
Myd88	myeloid differentiation primary response gene 88	0.052
5430411K18Rik	RIKEN cDNA 5430411K18 gene	0.050
Tlr2	toll-like receptor 2	0.050
Ncor2	nuclear receptor co-repressor 2	0.047
Foxp3	forkhead box P3	0.047
Ednra	endothelin receptor type A	0.045
Nlrp3	NLR family, pyrin domain containing 3	0.044
Bcl2l1	BCL2-like 1	0.043	Mouse
Ar	androgen receptor	0.043
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.042
Tgfb1	transforming growth factor, beta 1	0.042
Slc39a4	solute carrier family 39 (zinc transporter), member 4	0.041
Vdr	vitamin D receptor	0.041
Cox5a	cytochrome c oxidase, subunit Va	0.038
Ptbp2	polypyrimidine tract binding protein 2	0.037
Mdh2	malate dehydrogenase 2, NAD (mitochondrial)	0.036
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.036
Rps3	ribosomal protein S3	0.035
Apoe	apolipoprotein E	0.035
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.035
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.034
Lef1	lymphoid enhancer binding factor 1	0.034
Ern1	endoplasmic reticulum (ER) to nucleus signalling 1	0.033	Worm
Esr1	estrogen receptor 1 (alpha)	0.032
Tgfb2	transforming growth factor, beta 2	0.032
Fadd	Fas (TNFRSF6)-associated via death domain	0.032
Vasp	vasodilator-stimulated phosphoprotein	0.032
Traf6	TNF receptor-associated factor 6	0.032
Stat6	signal transducer and activator of transcription 6	0.030
Phb	prohibitin	0.030
Ppp2r2a	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform	0.030
Tcrb	T-cell receptor beta chain	0.030
Lrrk2	leucine-rich repeat kinase 2	0.030
Pax2	paired box gene 2	0.030
Runx1	runt related transcription factor 1	0.030
Pkd1	polycystic kidney disease 1 homolog	0.029
Cnot7	CCR4-NOT transcription complex, subunit 7	0.028
Tcrd	T-cell receptor delta chain	0.028
Zeb1	zinc finger E-box binding homeobox 1	0.027
Smad3	MAD homolog 3 (Drosophila)	0.027
Dyrk1a	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	0.027
Ptrf	polymerase I and transcript release factor	0.027
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.027
Aff1	AF4/FMR2 family, member 1	0.026
Ahr	aryl-hydrocarbon receptor	0.026
Myc	myelocytomatosis oncogene	0.026
Il1r1	interleukin 1 receptor, type I	0.026
Fnip1	folliculin interacting protein 1	0.026
Acd	adrenocortical dysplasia	0.026
Esf1	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	0.025
Wt1	Wilms tumor 1 homolog	0.025
Cd14	CD14 antigen	0.025
Dbi	diazepam binding inhibitor	0.024
Tcra	T-cell receptor alpha chain	0.024
Aplp2	amyloid beta (A4) precursor-like protein 2	0.024
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.024
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.024
Il2	interleukin 2	0.023
Nos2	nitric oxide synthase 2, inducible	0.023
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.023
Wrn	Werner syndrome homolog (human)	0.023
Mapk14	mitogen-activated protein kinase 14	0.022
Skil	SKI-like	0.022
Lep	leptin	0.022
Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	0.022
Hoxa13	homeobox A13	0.022
Mapk8	mitogen-activated protein kinase 8	0.021
Otud4	OTU domain containing 4	0.021
Ndufab1	NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1	0.021
Rab18	RAB18, member RAS oncogene family	0.021
Pias4	protein inhibitor of activated STAT 4	0.021
Acvr1	activin A receptor, type 1	0.021
Pnn	pinin	0.021
Dag1	dystroglycan 1	0.021
Kpna1	karyopherin (importin) alpha 1	0.020
BC031181	cDNA sequence BC031181	0.020
Jarid2	jumonji, AT rich interactive domain 2	0.020
Ptch1	patched homolog 1	0.020
Cyld	cylindromatosis (turban tumor syndrome)	0.020
Ccng1	cyclin G1	0.020
Slmap	sarcolemma associated protein	0.020
Actn1	actinin, alpha 1	0.020
Sufu	suppressor of fused homolog (Drosophila)	0.019
Gpbp1	GC-rich promoter binding protein 1	0.019
Atf2	activating transcription factor 2	0.019
Brca1	breast cancer 1	0.019
Pdx1	pancreatic and duodenal homeobox 1	0.019
Bak1	BCL2-antagonist/killer 1	0.019	Mouse
Wwox	WW domain-containing oxidoreductase	0.019
Lyst	lysosomal trafficking regulator	0.019
Rb1	retinoblastoma 1	0.019
Il6	interleukin 6	0.019
Ctdsp1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	0.019
Slfn4	schlafen 4	0.019
Cdx2	caudal type homeobox 2	0.019
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.019
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.019
Rnf11	ring finger protein 11	0.018
Lcn2	lipocalin 2	0.018
Rbl2	retinoblastoma-like 2	0.018
Bcl2a1a	B-cell leukemia/lymphoma 2 related protein A1a	0.018	Mouse
Yap1	yes-associated protein 1	0.018
Icam1	intercellular adhesion molecule 1	0.018
Atad5	ATPase family, AAA domain containing 5	0.018
Pja2	praja 2, RING-H2 motif containing	0.018
Nod2	nucleotide-binding oligomerization domain containing 2	0.017
Il1b	interleukin 1 beta	0.017
Stx11	syntaxin 11	0.017
Cxcl2	chemokine (C-X-C motif) ligand 2	0.017
Hif1a	hypoxia inducible factor 1, alpha subunit	0.017
Trim32	tripartite motif-containing 32	0.017
Zfp362	zinc finger protein 362	0.017
Hccs	holocytochrome c synthetase	0.017
Itm2b	integral membrane protein 2B	0.017
Il2rg	interleukin 2 receptor, gamma chain	0.017
Slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.017
Pbx1	pre B-cell leukemia transcription factor 1	0.017
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.016
Ifngr1	interferon gamma receptor 1	0.016
Tcf7	transcription factor 7, T-cell specific	0.016
Dok1	docking protein 1	0.016
Nf1	neurofibromatosis 1	0.016
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.016
Tmx2	thioredoxin-related transmembrane protein 2	0.016
Dhx15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	0.016
Hip1	huntingtin interacting protein 1	0.016
Traf2	TNF receptor-associated factor 2	0.016
Pias2	protein inhibitor of activated STAT 2	0.016	Mouse
Terf1	telomeric repeat binding factor 1	0.016
Etv6	ets variant gene 6 (TEL oncogene)	0.016
Becn1	beclin 1, autophagy related	0.016
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.016
Thra	thyroid hormone receptor alpha	0.016
Phb2	prohibitin 2	0.016
Uqcrb	ubiquinol-cytochrome c reductase binding protein	0.016
Sod2	superoxide dismutase 2, mitochondrial	0.016
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.016
Ube2d3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.015
Braf	Braf transforming gene	0.015
Bmf	BCL2 modifying factor	0.015
Camp	cathelicidin antimicrobial peptide	0.015
Huwe1	HECT, UBA and WWE domain containing 1	0.015
Thbs1	thrombospondin 1	0.015
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.015
Gm10615	predicted gene 10615	0.015
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.015
Ddx46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	0.015
Notch2	Notch gene homolog 2 (Drosophila)	0.015
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.015
Phf12	PHD finger protein 12	0.015
Spp1	secreted phosphoprotein 1	0.015
Topors	topoisomerase I binding, arginine/serine-rich	0.015
Scoc	short coiled-coil protein	0.014
Dsg4	desmoglein 4	0.014
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.014
Irf1	interferon regulatory factor 1	0.014
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.014	Mouse
Bmp7	bone morphogenetic protein 7	0.014
Il6st	interleukin 6 signal transducer	0.014
Sh3rf1	SH3 domain containing ring finger 1	0.014
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.014
Rbl1	retinoblastoma-like 1 (p107)	0.014
Ccr2	chemokine (C-C motif) receptor 2	0.014
Stk4	serine/threonine kinase 4	0.014
Meox2	mesenchyme homeobox 2	0.014
Apaf1	apoptotic peptidase activating factor 1	0.014
Ccl2	chemokine (C-C motif) ligand 2	0.014
1100001G20Rik	RIKEN cDNA 1100001G20 gene	0.014
Bcl3	B-cell leukemia/lymphoma 3	0.014
Ngp	neutrophilic granule protein	0.014
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.014
Chst14	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14	0.013
Cdk2	cyclin-dependent kinase 2	0.013
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.013
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.013
Eif3a	eukaryotic translation initiation factor 3, subunit A	0.013
Fbxl3	F-box and leucine-rich repeat protein 3	0.013
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.013
Smn1	survival motor neuron 1	0.013
Stk11	serine/threonine kinase 11	0.013
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.013
Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9	0.013
Clec4d	C-type lectin domain family 4, member d	0.013
Hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.013
Vegfa	vascular endothelial growth factor A	0.012
Arf2	ADP-ribosylation factor 2	0.012
Tgif1	TGFB-induced factor homeobox 1	0.012
Atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.012
Nkx2-1	NK2 homeobox 1	0.012
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.012
Atp5a1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1	0.012
Ripk3	receptor-interacting serine-threonine kinase 3	0.012
Egr1	early growth response 1	0.012
Robo1	roundabout homolog 1 (Drosophila)	0.012
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.012
Rpl7a	ribosomal protein L7A	0.012
Csde1	cold shock domain containing E1, RNA binding	0.012
Dtl	denticleless homolog (Drosophila)	0.012
Rarb	retinoic acid receptor, beta	0.012
Tgfbr1	transforming growth factor, beta receptor I	0.012
Hist1h1b	histone cluster 1, H1b	0.012
Emx2	empty spiracles homolog 2 (Drosophila)	0.012
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.012
Prf1	perforin 1 (pore forming protein)	0.012
Il1rn	interleukin 1 receptor antagonist	0.012
Il15	interleukin 15	0.012
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.012
Ndfip1	Nedd4 family interacting protein 1	0.012
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.012
Arhgap1	Rho GTPase activating protein 1	0.012
Bbc3	BCL2 binding component 3	0.012
Ddx3x	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked	0.012
Fgf10	fibroblast growth factor 10	0.012
Rin2	Ras and Rab interactor 2	0.012
Ifitm1	interferon induced transmembrane protein 1	0.012
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.012
Alx1	ALX homeobox 1	0.012
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.012
Rpl8	ribosomal protein L8	0.012
Bid	BH3 interacting domain death agonist	0.012
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.012
Lcp2	lymphocyte cytosolic protein 2	0.012
Gna11	guanine nucleotide binding protein, alpha 11	0.011
Eef1a1	eukaryotic translation elongation factor 1 alpha 1	0.011
Col1a1	collagen, type I, alpha 1	0.011
Hnrnpu	heterogeneous nuclear ribonucleoprotein U	0.011
Msx2	homeobox, msh-like 2	0.011
Pgrmc1	progesterone receptor membrane component 1	0.011
Rag1	recombination activating gene 1	0.011
Lif	leukemia inhibitory factor	0.011
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.011
Psmb3	proteasome (prosome, macropain) subunit, beta type 3	0.011
Tbp	TATA box binding protein	0.011
Daxx	Fas death domain-associated protein	0.011
Clstn1	calsyntenin 1	0.011
Plau	plasminogen activator, urokinase	0.011
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.011
Ccnd1	cyclin D1	0.011
Mdm4	transformed mouse 3T3 cell double minute 4	0.011
Prkci	protein kinase C, iota	0.011
Ece1	endothelin converting enzyme 1	0.011
Fpr1	formyl peptide receptor 1	0.011
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.011
Trak2	trafficking protein, kinesin binding 2	0.011
Hs2st1	heparan sulfate 2-O-sulfotransferase 1	0.011
Prrx2	paired related homeobox 2	0.011
Mlkl	mixed lineage kinase domain-like	0.011
Taldo1	transaldolase 1	0.011
Lpin1	lipin 1	0.011
Hmg20b	high mobility group 20 B	0.011
Herc2	hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2	0.010
Clcn4-2	chloride channel 4-2	0.010
Rps3a	ribosomal protein S3A	0.010
Txndc16	thioredoxin domain containing 16	0.010
Cdh1	cadherin 1	0.010
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.010
Rps2	ribosomal protein S2	0.010
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.010
Ccr1	chemokine (C-C motif) receptor 1	0.010
Was	Wiskott-Aldrich syndrome homolog (human)	0.010
Skp1a	S-phase kinase-associated protein 1A	0.010
Rora	RAR-related orphan receptor alpha	0.010
Irf6	interferon regulatory factor 6	0.010
Plaur	plasminogen activator, urokinase receptor	0.010
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.010
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.010
Pax3	paired box gene 3	0.010
Vps26b	vacuolar protein sorting 26 homolog B (yeast)	0.010
Hnrpdl	heterogeneous nuclear ribonucleoprotein D-like	0.010
Disp1	dispatched homolog 1 (Drosophila)	0.010
Ttc7	tetratricopeptide repeat domain 7	0.010
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.010
Rplp0	ribosomal protein, large, P0	0.010
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.010
Fpr2	formyl peptide receptor 2	0.010