IMP
Process View
negative regulation of proteasomal ubiquitin dependent protein catabolic process
Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of proteasomal ubiquitin dependent protein catabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Trp53 | transformation related protein 53 | 0.907 | ||
| Ccnb1 | cyclin B1 | 0.894 | ||
| Cdk1 | cyclin-dependent kinase 1 | 0.839 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.668 | ||
| Ccnb2 | cyclin B2 | 0.541 | ||
| Ccna2 | cyclin A2 | 0.523 | ||
| Bub1b | budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) | 0.506 | Fly | |
| Prc1 | protein regulator of cytokinesis 1 | 0.494 | ||
| Cdca8 | cell division cycle associated 8 | 0.489 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.414 | ||
| Hmmr | hyaluronan mediated motility receptor (RHAMM) | 0.383 | ||
| Kif22 | kinesin family member 22 | 0.317 | ||
| Kif20a | kinesin family member 20A | 0.281 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.236 | ||
| Cdk2 | cyclin-dependent kinase 2 | 0.186 | ||
| Smarca4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 0.184 | ||
| Spag5 | sperm associated antigen 5 | 0.180 | ||
| Ccnf | cyclin F | 0.175 | ||
| Birc5 | baculoviral IAP repeat-containing 5 | 0.155 | ||
| Sgol2 | shugoshin-like 2 (S. pombe) | 0.136 | ||
| Cenpe | centromere protein E | 0.136 | ||
| Sgol1 | shugoshin-like 1 (S. pombe) | 0.114 | ||
| Pthlh | parathyroid hormone-like peptide | 0.107 | ||
| Cdc20 | cell division cycle 20 homolog (S. cerevisiae) | 0.107 | Yeast | |
| Ckap2 | cytoskeleton associated protein 2 | 0.104 | ||
| Nek2 | NIMA (never in mitosis gene a)-related expressed kinase 2 | 0.101 | ||
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.094 | ||
| Glrx3 | glutaredoxin 3 | 0.094 | ||
| Kif11 | kinesin family member 11 | 0.093 | ||
| Stil | Scl/Tal1 interrupting locus | 0.091 | ||
| Aurka | aurora kinase A | 0.087 | ||
| Ooep | oocyte expressed protein homolog (dog) | 0.087 | ||
| Lin9 | lin-9 homolog (C. elegans) | 0.086 | ||
| Asf1b | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | 0.086 | ||
| Cenpn | centromere protein N | 0.084 | ||
| Psmc2 | proteasome (prosome, macropain) 26S subunit, ATPase 2 | 0.081 | ||
| Nuf2 | NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) | 0.079 | ||
| Aurkb | aurora kinase B | 0.077 | ||
| Ube2c | ubiquitin-conjugating enzyme E2C | 0.074 | ||
| Pou5f1 | POU domain, class 5, transcription factor 1 | 0.071 | ||
| Csnk1g2 | casein kinase 1, gamma 2 | 0.067 | ||
| Anln | anillin, actin binding protein | 0.067 | ||
| Cops4 | COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) | 0.067 | ||
| Depdc1a | DEP domain containing 1a | 0.067 | ||
| C330027C09Rik | RIKEN cDNA C330027C09 gene | 0.065 | ||
| Arid1a | AT rich interactive domain 1A (SWI-like) | 0.061 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.053 | ||
| Cops6 | COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) | 0.052 | ||
| Ccne2 | cyclin E2 | 0.051 | Fly | |
| Rrm2 | ribonucleotide reductase M2 | 0.050 | ||
| Ect2 | ect2 oncogene | 0.048 | ||
| Cbx1 | chromobox homolog 1 (Drosophila HP1 beta) | 0.048 | ||
| Plk4 | polo-like kinase 4 (Drosophila) | 0.047 | ||
| Sox9 | SRY-box containing gene 9 | 0.047 | ||
| Bub1 | budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) | 0.046 | Fly | |
| Cep55 | centrosomal protein 55 | 0.045 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.043 | ||
| Cdca5 | cell division cycle associated 5 | 0.042 | ||
| Ar | androgen receptor | 0.041 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.041 | ||
| Kif4 | kinesin family member 4 | 0.041 | ||
| Kif2c | kinesin family member 2C | 0.039 | ||
| Psmd4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.039 | ||
| Ncapg | non-SMC condensin I complex, subunit G | 0.037 | ||
| Pten | phosphatase and tensin homolog | 0.037 | ||
| Mrpl24 | mitochondrial ribosomal protein L24 | 0.036 | ||
| Melk | maternal embryonic leucine zipper kinase | 0.036 | ||
| Kif23 | kinesin family member 23 | 0.036 | ||
| Plk1 | polo-like kinase 1 (Drosophila) | 0.036 | Human | |
| Fgf9 | fibroblast growth factor 9 | 0.035 | ||
| Psmc3 | proteasome (prosome, macropain) 26S subunit, ATPase 3 | 0.035 | ||
| Arid1b | AT rich interactive domain 1B (SWI-like) | 0.034 | ||
| Kntc1 | kinetochore associated 1 | 0.033 | ||
| Smc4 | structural maintenance of chromosomes 4 | 0.033 | ||
| Gli2 | GLI-Kruppel family member GLI2 | 0.032 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.032 | ||
| Col2a1 | collagen, type II, alpha 1 | 0.031 | ||
| Rb1 | retinoblastoma 1 | 0.031 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.031 | ||
| Wdhd1 | WD repeat and HMG-box DNA binding protein 1 | 0.030 | ||
| Aspm | asp (abnormal spindle)-like, microcephaly associated (Drosophila) | 0.030 | ||
| Suv39h2 | suppressor of variegation 3-9 homolog 2 (Drosophila) | 0.030 | ||
| Drap1 | Dr1 associated protein 1 (negative cofactor 2 alpha) | 0.030 | ||
| Dctn1 | dynactin 1 | 0.029 | ||
| Ubxn1 | UBX domain protein 1 | 0.029 | Human | |
| Dlgap5 | discs, large (Drosophila) homolog-associated protein 5 | 0.028 | ||
| Smarcd1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 0.028 | ||
| Mbd3 | methyl-CpG binding domain protein 3 | 0.028 | ||
| Aimp1 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 | 0.027 | ||
| 4632434I11Rik | RIKEN cDNA 4632434I11 gene | 0.027 | ||
| Ccne1 | cyclin E1 | 0.027 | Fly | |
| Cenpf | centromere protein F | 0.027 | ||
| Ptch1 | patched homolog 1 | 0.026 | ||
| Dsn1 | DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) | 0.026 | ||
| Trp63 | transformation related protein 63 | 0.025 | ||
| Brca1 | breast cancer 1 | 0.025 | ||
| Cdc25c | cell division cycle 25 homolog C (S. pombe) | 0.025 | ||
| Pcna | proliferating cell nuclear antigen | 0.025 | ||
| Mki67 | antigen identified by monoclonal antibody Ki 67 | 0.025 | ||
| Brca2 | breast cancer 2 | 0.024 | ||
| Chek1 | checkpoint kinase 1 homolog (S. pombe) | 0.024 | ||
| Ech1 | enoyl coenzyme A hydratase 1, peroxisomal | 0.024 | ||
| Mastl | microtubule associated serine/threonine kinase-like | 0.024 | ||
| Racgap1 | Rac GTPase-activating protein 1 | 0.024 | ||
| D2Ertd750e | DNA segment, Chr 2, ERATO Doi 750, expressed | 0.023 | ||
| Sfn | stratifin | 0.023 | ||
| Ehmt2 | euchromatic histone lysine N-methyltransferase 2 | 0.023 | ||
| Sema4b | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.023 | ||
| Trim59 | tripartite motif-containing 59 | 0.022 | ||
| Rad51c | RAD51 homolog c (S. cerevisiae) | 0.022 | ||
| Smarcb1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 0.022 | ||
| Top2a | topoisomerase (DNA) II alpha | 0.022 | ||
| Psmb7 | proteasome (prosome, macropain) subunit, beta type 7 | 0.022 | ||
| Gsg2 | germ cell-specific gene 2 | 0.022 | ||
| Bmi1 | Bmi1 polycomb ring finger oncogene | 0.022 | ||
| Creb1 | cAMP responsive element binding protein 1 | 0.022 | ||
| Bmp7 | bone morphogenetic protein 7 | 0.022 | ||
| Gnb2 | guanine nucleotide binding protein (G protein), beta 2 | 0.021 | ||
| Arl6ip6 | ADP-ribosylation factor-like 6 interacting protein 6 | 0.021 | ||
| Shcbp1 | Shc SH2-domain binding protein 1 | 0.021 | ||
| Gtse1 | G two S phase expressed protein 1 | 0.021 | ||
| Smad4 | MAD homolog 4 (Drosophila) | 0.021 | ||
| 6720463M24Rik | RIKEN cDNA 6720463M24 gene | 0.020 | ||
| Fignl1 | fidgetin-like 1 | 0.020 | ||
| Psma6 | proteasome (prosome, macropain) subunit, alpha type 6 | 0.020 | ||
| Acd | adrenocortical dysplasia | 0.020 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.020 | ||
| Asf1a | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) | 0.020 | ||
| Gm13290 | predicted gene 13290 | 0.020 | ||
| Ttk | Ttk protein kinase | 0.020 | Yeast Fly | |
| Pot1a | protection of telomeres 1A | 0.020 | ||
| Lig4 | ligase IV, DNA, ATP-dependent | 0.020 | ||
| Cks2 | CDC28 protein kinase regulatory subunit 2 | 0.020 | ||
| Rnf2 | ring finger protein 2 | 0.019 | ||
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.019 | ||
| Mis18bp1 | MIS18 binding protein 1 | 0.019 | ||
| Cdkn3 | cyclin-dependent kinase inhibitor 3 | 0.018 | ||
| Hdac3 | histone deacetylase 3 | 0.018 | ||
| Fbxo5 | F-box protein 5 | 0.018 | Human Fly | |
| Suz12 | suppressor of zeste 12 homolog (Drosophila) | 0.017 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.017 | ||
| Cul4a | cullin 4A | 0.017 | ||
| Vdac3 | voltage-dependent anion channel 3 | 0.017 | ||
| Kiss1 | KiSS-1 metastasis-suppressor | 0.017 | ||
| Ccdc99 | coiled-coil domain containing 99 | 0.017 | ||
| Ckap2l | cytoskeleton associated protein 2-like | 0.017 | ||
| H2afx | H2A histone family, member X | 0.017 | ||
| Sox2 | SRY-box containing gene 2 | 0.017 | ||
| Trp73 | transformation related protein 73 | 0.017 | ||
| Trim23 | tripartite motif-containing 23 | 0.017 | ||
| Ercc6l | excision repair cross-complementing rodent repair deficiency complementation group 6 - like | 0.016 | ||
| Sirt1 | sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) | 0.016 | ||
| Skp1a | S-phase kinase-associated protein 1A | 0.016 | ||
| Cenpk | centromere protein K | 0.016 | ||
| Ddx6 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 | 0.016 | ||
| Ube2t | ubiquitin-conjugating enzyme E2T (putative) | 0.016 | ||
| Stub1 | STIP1 homology and U-Box containing protein 1 | 0.016 | ||
| Hist1h2bm | histone cluster 1, H2bm | 0.015 | ||
| Use1 | unconventional SNARE in the ER 1 homolog (S. cerevisiae) | 0.015 | ||
| Zmym2 | zinc finger, MYM-type 2 | 0.015 | ||
| Klhdc2 | kelch domain containing 2 | 0.015 | ||
| Pds5b | PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) | 0.015 | ||
| Rrp1 | ribosomal RNA processing 1 homolog (S. cerevisiae) | 0.015 | ||
| Nr0b1 | nuclear receptor subfamily 0, group B, member 1 | 0.015 | ||
| Ergic3 | ERGIC and golgi 3 | 0.015 | ||
| Ncaph | non-SMC condensin I complex, subunit H | 0.015 | ||
| Hoxa10 | homeobox A10 | 0.015 | ||
| Gdf1 | growth differentiation factor 1 | 0.014 | ||
| 4930547N16Rik | RIKEN cDNA 4930547N16 gene | 0.014 | ||
| Cenpq | centromere protein Q | 0.014 | ||
| Scaf4 | SR-related CTD-associated factor 4 | 0.014 | ||
| Tcf21 | transcription factor 21 | 0.014 | ||
| Vps72 | vacuolar protein sorting 72 (yeast) | 0.014 | ||
| Cops7b | COP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis thaliana) | 0.014 | ||
| Ncapd3 | non-SMC condensin II complex, subunit D3 | 0.014 | ||
| 2810417H13Rik | RIKEN cDNA 2810417H13 gene | 0.014 | ||
| Wnt5a | wingless-related MMTV integration site 5A | 0.014 | ||
| Hoxd13 | homeobox D13 | 0.013 | ||
| Rpgrip1l | Rpgrip1-like | 0.013 | ||
| Cyth2 | cytohesin 2 | 0.013 | ||
| Sgta | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha | 0.013 | ||
| Hoxa13 | homeobox A13 | 0.013 | ||
| Ncapg2 | non-SMC condensin II complex, subunit G2 | 0.013 | ||
| Spry2 | sprouty homolog 2 (Drosophila) | 0.013 | ||
| March7 | membrane-associated ring finger (C3HC4) 7 | 0.013 | ||
| Axin1 | axin 1 | 0.013 | ||
| Lrr1 | leucine rich repeat protein 1 | 0.013 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.013 | ||
| Aamp | angio-associated migratory protein | 0.013 | ||
| Mtch1 | mitochondrial carrier homolog 1 (C. elegans) | 0.012 | ||
| Sos2 | son of sevenless homolog 2 (Drosophila) | 0.012 | ||
| Sall4 | sal-like 4 (Drosophila) | 0.012 | ||
| Apoa1bp | apolipoprotein A-I binding protein | 0.012 | ||
| Rim4 | recombination induced mutation 4 | 0.012 | ||
| Cenpi | centromere protein I | 0.012 | ||
| Nlrp5 | NLR family, pyrin domain containing 5 | 0.012 | ||
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.012 | ||
| Tm2d2 | TM2 domain containing 2 | 0.011 | ||
| Map3k7 | mitogen-activated protein kinase kinase kinase 7 | 0.011 | ||
| Ptbp2 | polypyrimidine tract binding protein 2 | 0.011 | ||
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.011 | ||
| E2f7 | E2F transcription factor 7 | 0.011 | ||
| Pax2 | paired box gene 2 | 0.011 | ||
| Skil | SKI-like | 0.011 | ||
| Thoc7 | THO complex 7 homolog (Drosophila) | 0.011 | ||
| Nf1 | neurofibromatosis 1 | 0.011 | ||
| Lrp2 | low density lipoprotein receptor-related protein 2 | 0.011 | ||
| Foxc1 | forkhead box C1 | 0.011 | ||
| Mterfd1 | MTERF domain containing 1 | 0.011 | ||
| Mllt1 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 | 0.011 | ||
| Rad51ap1 | RAD51 associated protein 1 | 0.011 | ||
| Pknox1 | Pbx/knotted 1 homeobox | 0.011 | ||
| Ndc80 | NDC80 homolog, kinetochore complex component (S. cerevisiae) | 0.011 | ||
| Cyp11a1 | cytochrome P450, family 11, subfamily a, polypeptide 1 | 0.011 | ||
| Anapc2 | anaphase promoting complex subunit 2 | 0.011 | ||
| H1 | histocompatibility 1 | 0.011 | ||
| Ube3a | ubiquitin protein ligase E3A | 0.011 | ||
| Tsc2 | tuberous sclerosis 2 | 0.011 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.010 | ||
| Ppp1ca | protein phosphatase 1, catalytic subunit, alpha isoform | 0.010 | ||
| Hist2h4 | histone cluster 2, H4 | 0.010 | ||
| Ufc1 | ubiquitin-fold modifier conjugating enzyme 1 | 0.010 | ||
| Git1 | G protein-coupled receptor kinase-interactor 1 | 0.010 | ||
| Rbmxl2 | RNA binding motif protein, X-linked-like 2 | 0.010 | ||
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.010 | ||
| Rab24 | RAB24, member RAS oncogene family | 0.010 |