IMP
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mitotic g2 dna damage checkpoint
A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.
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Click on a gene's description to view its network relationships with genes known to be involved in "mitotic g2 dna damage checkpoint"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Brca1 | breast cancer 1 | 0.964 | ||
| Trp53 | transformation related protein 53 | 0.878 | ||
| Brca2 | breast cancer 2 | 0.764 | ||
| Nbn | nibrin | 0.653 | ||
| Gps1 | G protein pathway suppressor 1 | 0.564 | Fly | |
| Cdk4 | cyclin-dependent kinase 4 | 0.438 | ||
| Atm | ataxia telangiectasia mutated homolog (human) | 0.346 | Human Fly | |
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.304 | ||
| E2f1 | E2F transcription factor 1 | 0.276 | ||
| Rb1 | retinoblastoma 1 | 0.229 | ||
| Hells | helicase, lymphoid specific | 0.154 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.144 | ||
| Cops6 | COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) | 0.140 | ||
| Ezh2 | enhancer of zeste homolog 2 (Drosophila) | 0.137 | ||
| Stag1 | stromal antigen 1 | 0.119 | ||
| Smad4 | MAD homolog 4 (Drosophila) | 0.119 | ||
| Rbl1 | retinoblastoma-like 1 (p107) | 0.112 | Fly | |
| Mcm2 | minichromosome maintenance deficient 2 mitotin (S. cerevisiae) | 0.109 | ||
| Eif2c2 | eukaryotic translation initiation factor 2C, 2 | 0.085 | ||
| Cdca7 | cell division cycle associated 7 | 0.080 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.076 | ||
| Pten | phosphatase and tensin homolog | 0.063 | ||
| Syncrip | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.061 | ||
| Egr2 | early growth response 2 | 0.058 | ||
| Ncoa3 | nuclear receptor coactivator 3 | 0.055 | ||
| Cops2 | COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana) | 0.053 | ||
| Smc2 | structural maintenance of chromosomes 2 | 0.053 | ||
| Pola1 | polymerase (DNA directed), alpha 1 | 0.049 | ||
| Msh2 | mutS homolog 2 (E. coli) | 0.048 | ||
| Sufu | suppressor of fused homolog (Drosophila) | 0.042 | ||
| Suz12 | suppressor of zeste 12 homolog (Drosophila) | 0.040 | ||
| Apc | adenomatosis polyposis coli | 0.040 | ||
| Nasp | nuclear autoantigenic sperm protein (histone-binding) | 0.038 | ||
| Cdk2 | cyclin-dependent kinase 2 | 0.038 | Mouse | |
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.036 | ||
| Dtl | denticleless homolog (Drosophila) | 0.036 | Zebrafish | |
| Mcm4 | minichromosome maintenance deficient 4 homolog (S. cerevisiae) | 0.035 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.032 | ||
| Ccna2 | cyclin A2 | 0.031 | ||
| Ppp1cc | protein phosphatase 1, catalytic subunit, gamma isoform | 0.030 | ||
| Setdb1 | SET domain, bifurcated 1 | 0.030 | ||
| Haus6 | HAUS augmin-like complex, subunit 6 | 0.030 | ||
| Cct7 | chaperonin containing Tcp1, subunit 7 (eta) | 0.030 | ||
| Cops4 | COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) | 0.029 | ||
| Parp1 | poly (ADP-ribose) polymerase family, member 1 | 0.028 | ||
| Men1 | multiple endocrine neoplasia 1 | 0.027 | ||
| Akap9 | A kinase (PRKA) anchor protein (yotiao) 9 | 0.027 | ||
| Ash2l | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.025 | ||
| Topbp1 | topoisomerase (DNA) II binding protein 1 | 0.025 | Fly | |
| Rpa2 | replication protein A2 | 0.024 | ||
| Ruvbl2 | RuvB-like protein 2 | 0.023 | ||
| Mcm5 | minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 0.023 | ||
| Cdc6 | cell division cycle 6 homolog (S. cerevisiae) | 0.022 | ||
| Mms22l | MMS22-like, DNA repair protein | 0.022 | ||
| Cdc7 | cell division cycle 7 (S. cerevisiae) | 0.022 | ||
| Pkm2 | pyruvate kinase, muscle | 0.021 | ||
| Tial1 | Tia1 cytotoxic granule-associated RNA binding protein-like 1 | 0.021 | ||
| Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 0.021 | ||
| Pcna | proliferating cell nuclear antigen | 0.021 | ||
| Plk4 | polo-like kinase 4 (Drosophila) | 0.021 | ||
| Cdt1 | chromatin licensing and DNA replication factor 1 | 0.021 | ||
| Casp8ap2 | caspase 8 associated protein 2 | 0.021 | ||
| Ccnd1 | cyclin D1 | 0.020 | ||
| Pdpk1 | 3-phosphoinositide dependent protein kinase 1 | 0.020 | ||
| Cops3 | COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana) | 0.020 | Fly | |
| Ccne1 | cyclin E1 | 0.020 | ||
| H2afx | H2A histone family, member X | 0.020 | ||
| E2f8 | E2F transcription factor 8 | 0.020 | ||
| Bub1 | budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) | 0.019 | ||
| Zmym2 | zinc finger, MYM-type 2 | 0.018 | ||
| Foxo3 | forkhead box O3 | 0.018 | Mouse | |
| Rbbp5 | retinoblastoma binding protein 5 | 0.018 | ||
| Ube3a | ubiquitin protein ligase E3A | 0.017 | ||
| Trim28 | tripartite motif-containing 28 | 0.017 | ||
| Scaf11 | SR-related CTD-associated factor 11 | 0.017 | ||
| Elavl1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | 0.017 | ||
| Lsm2 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.017 | ||
| Mll3 | myeloid/lymphoid or mixed-lineage leukemia 3 | 0.016 | ||
| Kif23 | kinesin family member 23 | 0.016 | ||
| Rfc2 | replication factor C (activator 1) 2 | 0.016 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.016 | ||
| Gspt1 | G1 to S phase transition 1 | 0.016 | ||
| Chd2 | chromodomain helicase DNA binding protein 2 | 0.015 | ||
| Orc1 | origin recognition complex, subunit 1 | 0.015 | ||
| Ptch1 | patched homolog 1 | 0.015 | ||
| Tomm70a | translocase of outer mitochondrial membrane 70 homolog A (yeast) | 0.014 | ||
| Atr | ataxia telangiectasia and Rad3 related | 0.014 | Fly | |
| Zmym5 | zinc finger, MYM-type 5 | 0.014 | ||
| Ankhd1 | ankyrin repeat and KH domain containing 1 | 0.014 | ||
| Prc1 | protein regulator of cytokinesis 1 | 0.014 | ||
| Timeless | timeless homolog (Drosophila) | 0.014 | ||
| Wdhd1 | WD repeat and HMG-box DNA binding protein 1 | 0.014 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.013 | ||
| Rcc2 | regulator of chromosome condensation 2 | 0.013 | ||
| Ttk | Ttk protein kinase | 0.013 | ||
| Plk1 | polo-like kinase 1 (Drosophila) | 0.012 | ||
| Pole2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | 0.012 | ||
| Rps28 | ribosomal protein S28 | 0.012 | ||
| Kat2a | K(lysine) acetyltransferase 2A | 0.012 | ||
| Pou5f1 | POU domain, class 5, transcription factor 1 | 0.012 | ||
| Tia1 | cytotoxic granule-associated RNA binding protein 1 | 0.012 | ||
| Mll1 | myeloid/lymphoid or mixed-lineage leukemia 1 | 0.012 | ||
| Mre11a | meiotic recombination 11 homolog A (S. cerevisiae) | 0.012 | ||
| Tceb3 | transcription elongation factor B (SIII), polypeptide 3 | 0.012 | ||
| Rdx | radixin | 0.012 | ||
| Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.012 | ||
| Nup88 | nucleoporin 88 | 0.012 | ||
| Hnrpll | heterogeneous nuclear ribonucleoprotein L-like | 0.011 | ||
| Cops5 | COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) | 0.011 | Fly | |
| Top2a | topoisomerase (DNA) II alpha | 0.011 | ||
| Plagl2 | pleiomorphic adenoma gene-like 2 | 0.010 | ||
| Hnrnpm | heterogeneous nuclear ribonucleoprotein M | 0.010 | ||
| Npc1 | Niemann Pick type C1 | 0.010 | ||
| Brd8 | bromodomain containing 8 | 0.010 | ||
| Tada2a | transcriptional adaptor 2A | 0.010 |