IMP: Integrative Multi-species Prediction

Mus musculus

26 genes annotated in mouse

Multi-species View

negative regulation of transforming growth factor beta receptor signaling pathway

GO:0030512

Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of transforming growth factor beta receptor signaling pathway"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of transforming growth factor beta receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Pten	phosphatase and tensin homolog	0.996
Bgn	biglycan	0.960	Mouse
Pax8	paired box gene 8	0.933
Smad7	MAD homolog 7 (Drosophila)	0.888	Human Fly
Smad6	MAD homolog 6 (Drosophila)	0.887	Human Fly
Lum	lumican	0.874	Mouse
Trp53	transformation related protein 53	0.771
Fmod	fibromodulin	0.687	Mouse
Fgf10	fibroblast growth factor 10	0.658
Trp73	transformation related protein 73	0.618	Mouse
Nodal	nodal	0.585
Smad3	MAD homolog 3 (Drosophila)	0.528
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.525
Lep	leptin	0.517
Tgfbr1	transforming growth factor, beta receptor I	0.503
Cdx2	caudal type homeobox 2	0.483
Wnt4	wingless-related MMTV integration site 4	0.467	Mouse
Nog	noggin	0.452
Ar	androgen receptor	0.451
Gli2	GLI-Kruppel family member GLI2	0.450
Wnt3a	wingless-related MMTV integration site 3A	0.419	Mouse
Tgfbr2	transforming growth factor, beta receptor II	0.396
T	brachyury	0.354
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.354
Pou3f3	POU domain, class 3, transcription factor 3	0.348
Ptrf	polymerase I and transcript release factor	0.341
Rarb	retinoic acid receptor, beta	0.315
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.279
Onecut1	one cut domain, family member 1	0.268
Fgfr2	fibroblast growth factor receptor 2	0.267
Wnt6	wingless-related MMTV integration site 6	0.246	Mouse
Dcn	decorin	0.225	Mouse
Pkd1	polycystic kidney disease 1 homolog	0.224
Ctnnb1	catenin (cadherin associated protein), beta 1	0.223
Chrd	chordin	0.222
Axin1	axin 1	0.219
Mmp2	matrix metallopeptidase 2	0.218
Lhx1	LIM homeobox protein 1	0.210
Il6st	interleukin 6 signal transducer	0.210
Foxa2	forkhead box A2	0.199
Plin1	perilipin 1	0.197
Dag1	dystroglycan 1	0.189
Twist2	twist homolog 2 (Drosophila)	0.189
Rara	retinoic acid receptor, alpha	0.186
Mdm2	transformed mouse 3T3 cell double minute 2	0.183
Gdnf	glial cell line derived neurotrophic factor	0.182
Axin2	axin2	0.178
Pdgfa	platelet derived growth factor, alpha	0.172
Hsp90b1	heat shock protein 90, beta (Grp94), member 1	0.167
Fzd1	frizzled homolog 1 (Drosophila)	0.161
Edar	ectodysplasin-A receptor	0.158
Manf	mesencephalic astrocyte-derived neurotrophic factor	0.153
Bnc1	basonuclin 1	0.153
Fgf15	fibroblast growth factor 15	0.152
Gata6	GATA binding protein 6	0.150
Rarg	retinoic acid receptor, gamma	0.143
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.143
Fgf18	fibroblast growth factor 18	0.140
Kl	klotho	0.136
Npc1	Niemann Pick type C1	0.135
Ogn	osteoglycin	0.124
Mgp	matrix Gla protein	0.120
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.119	Human
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.117
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.116
Wnt10b	wingless related MMTV integration site 10b	0.115	Mouse
Zfp651	zinc finger protein 651	0.115
Dpt	dermatopontin	0.115
Wnt3	wingless-related MMTV integration site 3	0.113	Mouse
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.112
Gdf1	growth differentiation factor 1	0.112
Gab2	growth factor receptor bound protein 2-associated protein 2	0.110
Pgr	progesterone receptor	0.110
Amhr2	anti-Mullerian hormone type 2 receptor	0.110
Sfn	stratifin	0.110
Nbl1	neuroblastoma, suppression of tumorigenicity 1	0.108	Mouse
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.108
Gsk3b	glycogen synthase kinase 3 beta	0.106
Tbx3	T-box 3	0.106
Neurog1	neurogenin 1	0.105
Tacr1	tachykinin receptor 1	0.104
Fgfr1	fibroblast growth factor receptor 1	0.104
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.102
Islr	immunoglobulin superfamily containing leucine-rich repeat	0.102
Timp2	tissue inhibitor of metalloproteinase 2	0.102
Eng	endoglin	0.099
Tcf21	transcription factor 21	0.098
Meox2	mesenchyme homeobox 2	0.095
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.092
Dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.091
Fzd8	frizzled homolog 8 (Drosophila)	0.090
Wnt11	wingless-related MMTV integration site 11	0.089	Mouse
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.088
Tbx2	T-box 2	0.088
Emp2	epithelial membrane protein 2	0.086
Mgat3	mannoside acetylglucosaminyltransferase 3	0.086
Apc	adenomatosis polyposis coli	0.084
Amh	anti-Mullerian hormone	0.084
Hoxd11	homeobox D11	0.083
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.082
C1qtnf1	C1q and tumor necrosis factor related protein 1	0.082
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.082
Cav1	caveolin 1, caveolae protein	0.081	Mouse
Ret	ret proto-oncogene	0.081
Gna11	guanine nucleotide binding protein, alpha 11	0.081
Fgf2	fibroblast growth factor 2	0.081
Arx	aristaless related homeobox	0.081
Fgf5	fibroblast growth factor 5	0.080
Eln	elastin	0.080
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.079
Ppl	periplakin	0.079
Foxf1a	forkhead box F1a	0.078
Plxna1	plexin A1	0.078
Msln	mesothelin	0.078
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.078
Gata4	GATA binding protein 4	0.078
Creld2	cysteine-rich with EGF-like domains 2	0.076
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.075
Mfap5	microfibrillar associated protein 5	0.075
Tgfa	transforming growth factor alpha	0.074
Sh3pxd2a	SH3 and PX domains 2A	0.074
Gata5	GATA binding protein 5	0.074
Foxo3	forkhead box O3	0.074
Map3k2	mitogen-activated protein kinase kinase kinase 2	0.073
Foxd2	forkhead box D2	0.072
Ski	ski sarcoma viral oncogene homolog (avian)	0.072
Bcl2	B-cell leukemia/lymphoma 2	0.072
Stk11	serine/threonine kinase 11	0.070
Gak	cyclin G associated kinase	0.070
Ltbp3	latent transforming growth factor beta binding protein 3	0.070
Nkx6-1	NK6 homeobox 1	0.068
Adra2c	adrenergic receptor, alpha 2c	0.068
Hoxd9	homeobox D9	0.068
Tcf15	transcription factor 15	0.067
Hoxa11	homeobox A11	0.066
Hoxb9	homeobox B9	0.066
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.066
Hoxb6	homeobox B6	0.066
Lepr	leptin receptor	0.065
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.065
Ddr2	discoidin domain receptor family, member 2	0.064
Meox1	mesenchyme homeobox 1	0.064
Cdh6	cadherin 6	0.064
Ghr	growth hormone receptor	0.064
Ep300	E1A binding protein p300	0.063
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.062
Acvr1	activin A receptor, type 1	0.062	Fly
Ptprb	protein tyrosine phosphatase, receptor type, B	0.062
Rbl2	retinoblastoma-like 2	0.061
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.060
Porcn	porcupine homolog (Drosophila)	0.059
Ptgfr	prostaglandin F receptor	0.059
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.059
Mapk14	mitogen-activated protein kinase 14	0.057
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.057
Fzd10	frizzled homolog 10 (Drosophila)	0.056
Scara3	scavenger receptor class A, member 3	0.056
Fzd4	frizzled homolog 4 (Drosophila)	0.055
Cacnb2	calcium channel, voltage-dependent, beta 2 subunit	0.055
Tgfb2	transforming growth factor, beta 2	0.055
Adra2a	adrenergic receptor, alpha 2a	0.054
Esr1	estrogen receptor 1 (alpha)	0.054
Wnt9a	wingless-type MMTV integration site 9A	0.054	Mouse
Nkx2-1	NK2 homeobox 1	0.054	Human
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.054
Zfp703	zinc finger protein 703	0.054
Adrb1	adrenergic receptor, beta 1	0.054
Srpx	sushi-repeat-containing protein	0.053
Ephb2	Eph receptor B2	0.053
Tnks1bp1	tankyrase 1 binding protein 1	0.053
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.053
Efna4	ephrin A4	0.052
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.052
Adra1a	adrenergic receptor, alpha 1a	0.052
Pou3f1	POU domain, class 3, transcription factor 1	0.052
Pdx1	pancreatic and duodenal homeobox 1	0.052
App	amyloid beta (A4) precursor protein	0.052
Igfbp6	insulin-like growth factor binding protein 6	0.051
Hic1	hypermethylated in cancer 1	0.051
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.051
Gpr50	G-protein-coupled receptor 50	0.051
BC024139	cDNA sequence BC024139	0.050
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.050
Tgfb3	transforming growth factor, beta 3	0.049	Rat
Angptl2	angiopoietin-like 2	0.048
Bicc1	bicaudal C homolog 1 (Drosophila)	0.048
Zic3	zinc finger protein of the cerebellum 3	0.048
Syt7	synaptotagmin VII	0.048
Pcdh12	protocadherin 12	0.048
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.047
Onecut2	one cut domain, family member 2	0.047
Emx1	empty spiracles homolog 1 (Drosophila)	0.047
Ptf1a	pancreas specific transcription factor, 1a	0.047
Rxra	retinoid X receptor alpha	0.047
Trp63	transformation related protein 63	0.047	Mouse
Dkk3	dickkopf homolog 3 (Xenopus laevis)	0.047
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.047
Atf2	activating transcription factor 2	0.047
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.046
Yap1	yes-associated protein 1	0.046
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.046
Vax1	ventral anterior homeobox containing gene 1	0.045
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.045
Drd2	dopamine receptor D2	0.045
Osr1	odd-skipped related 1 (Drosophila)	0.045
Pdia3	protein disulfide isomerase associated 3	0.044
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.044
Spock1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1	0.044
Nos3	nitric oxide synthase 3, endothelial cell	0.044
Met	met proto-oncogene	0.044
Nobox	NOBOX oogenesis homeobox	0.044
Bmp2	bone morphogenetic protein 2	0.044
Fgf17	fibroblast growth factor 17	0.043
Ltbp2	latent transforming growth factor beta binding protein 2	0.043
Hip1	huntingtin interacting protein 1	0.043
Gpc3	glypican 3	0.043
Foxo1	forkhead box O1	0.043
Fosl2	fos-like antigen 2	0.043
Rem1	rad and gem related GTP binding protein 1	0.043
Adamts2	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2	0.043
Grid1	glutamate receptor, ionotropic, delta 1	0.043
Pitx2	paired-like homeodomain transcription factor 2	0.043
Col6a1	collagen, type VI, alpha 1	0.042
Crlf1	cytokine receptor-like factor 1	0.042
Stra6	stimulated by retinoic acid gene 6	0.042
Sox7	SRY-box containing gene 7	0.042
Hoxc9	homeobox C9	0.041
Ikzf4	IKAROS family zinc finger 4	0.041
Alx4	aristaless-like homeobox 4	0.041
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.041
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.041
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.040
Bmp6	bone morphogenetic protein 6	0.040
Adra2b	adrenergic receptor, alpha 2b	0.040
Masp1	mannan-binding lectin serine peptidase 1	0.040
Col1a1	collagen, type I, alpha 1	0.040
Cyld	cylindromatosis (turban tumor syndrome)	0.040
Pparg	peroxisome proliferator activated receptor gamma	0.040
Kcnk3	potassium channel, subfamily K, member 3	0.040
Pdia6	protein disulfide isomerase associated 6	0.039
Fzd7	frizzled homolog 7 (Drosophila)	0.039
Cntfr	ciliary neurotrophic factor receptor	0.039
Foxf2	forkhead box F2	0.039
Zfp362	zinc finger protein 362	0.039
Plin4	perilipin 4	0.039
Adora2a	adenosine A2a receptor	0.038
Gata2	GATA binding protein 2	0.038
Smoc2	SPARC related modular calcium binding 2	0.038
Col1a2	collagen, type I, alpha 2	0.038
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.038
Gdf10	growth differentiation factor 10	0.038
Tgfbr3	transforming growth factor, beta receptor III	0.038	Rat
Evx1	even skipped homeotic gene 1 homolog	0.038
Sim2	single-minded homolog 2 (Drosophila)	0.038
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.038
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.038
Chrnd	cholinergic receptor, nicotinic, delta polypeptide	0.037
Gli3	GLI-Kruppel family member GLI3	0.037
Hdac2	histone deacetylase 2	0.037
Pam	peptidylglycine alpha-amidating monooxygenase	0.037
Psen1	presenilin 1	0.037
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.037
Entpd2	ectonucleoside triphosphate diphosphohydrolase 2	0.037
Sdf2l1	stromal cell-derived factor 2-like 1	0.036
Apoe	apolipoprotein E	0.036
Shh	sonic hedgehog	0.036
Rcn3	reticulocalbin 3, EF-hand calcium binding domain	0.036
Tead3	TEA domain family member 3	0.036
Mecp2	methyl CpG binding protein 2	0.036
4933407C03Rik	RIKEN cDNA 4933407C03 gene	0.036
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.036
Eda	ectodysplasin-A	0.036
Mmp24	matrix metallopeptidase 24	0.035
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.035
Galnt2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2	0.035
Bmp4	bone morphogenetic protein 4	0.035
Hes1	hairy and enhancer of split 1 (Drosophila)	0.035
Nos1	nitric oxide synthase 1, neuronal	0.035
Loxl1	lysyl oxidase-like 1	0.035
Grb10	growth factor receptor bound protein 10	0.035
Sod3	superoxide dismutase 3, extracellular	0.035
Nuak1	NUAK family, SNF1-like kinase, 1	0.035
Npr1	natriuretic peptide receptor 1	0.035
Tcf7	transcription factor 7, T-cell specific	0.035
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.035
Npas1	neuronal PAS domain protein 1	0.035
Foxb1	forkhead box B1	0.034
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.034
Btbd17	BTB (POZ) domain containing 17	0.034
Ncoa1	nuclear receptor coactivator 1	0.034
Tmem119	transmembrane protein 119	0.034
Thrb	thyroid hormone receptor beta	0.034
Xiap	X-linked inhibitor of apoptosis	0.034
Pou3f2	POU domain, class 3, transcription factor 2	0.034
Acan	aggrecan	0.034
Nptx1	neuronal pentraxin 1	0.034
Itgb5	integrin beta 5	0.034
Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	0.033	Zebrafish
Esr2	estrogen receptor 2 (beta)	0.033
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.033
Sox3	SRY-box containing gene 3	0.033
Gpr27	G protein-coupled receptor 27	0.033
Col6a2	collagen, type VI, alpha 2	0.033
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.033
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.033
Adra1b	adrenergic receptor, alpha 1b	0.032
Skil	SKI-like	0.032
Gja5	gap junction protein, alpha 5	0.032
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.032	Human
Hbegf	heparin-binding EGF-like growth factor	0.032
Rbbp7	retinoblastoma binding protein 7	0.032
Slc30a9	solute carrier family 30 (zinc transporter), member 9	0.032
Prdm6	PR domain containing 6	0.032
Insr	insulin receptor	0.032
Serping1	serine (or cysteine) peptidase inhibitor, clade G, member 1	0.032
Wls	wntless homolog (Drosophila)	0.032
Vps13a	vacuolar protein sorting 13A (yeast)	0.031
Spnb2	spectrin beta 2	0.031
Hnf4a	hepatic nuclear factor 4, alpha	0.031
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.031
Col13a1	collagen, type XIII, alpha 1	0.031
Grem1	gremlin 1	0.031	Mouse
Gja4	gap junction protein, alpha 4	0.031
Pcmt1	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	0.031
Pvrl1	poliovirus receptor-related 1	0.030
Epas1	endothelial PAS domain protein 1	0.030
Lama1	laminin, alpha 1	0.030
Myf5	myogenic factor 5	0.030
Emid2	EMI domain containing 2	0.030
Foxl2	forkhead box L2	0.030
Hoxd13	homeobox D13	0.030
Lif	leukemia inhibitory factor	0.030
Fgfr4	fibroblast growth factor receptor 4	0.030
Nes	nestin	0.030
Nmd3	NMD3 homolog (S. cerevisiae)	0.030
Ece1	endothelin converting enzyme 1	0.030
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.030
Stat3	signal transducer and activator of transcription 3	0.030
Hr	hairless	0.029
Ano1	anoctamin 1, calcium activated chloride channel	0.029
Egfr	epidermal growth factor receptor	0.029
Igf1	insulin-like growth factor 1	0.029
Neurog3	neurogenin 3	0.029
Wnt2b	wingless related MMTV integration site 2b	0.029	Mouse
Fgf8	fibroblast growth factor 8	0.029
Srcin1	SRC kinase signaling inhibitor 1	0.029
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.029
Gtf2ird1	general transcription factor II I repeat domain-containing 1	0.029
Efemp1	epidermal growth factor-containing fibulin-like extracellular matrix protein 1	0.029
Cd248	CD248 antigen, endosialin	0.029
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.029
Tert	telomerase reverse transcriptase	0.028
Bmp1	bone morphogenetic protein 1	0.028
Sema3b	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	0.028
Zyx	zyxin	0.028
Cdkn1c	cyclin-dependent kinase inhibitor 1C (P57)	0.028
Cnr1	cannabinoid receptor 1 (brain)	0.028
Fbln5	fibulin 5	0.028
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.028
Atp8a1	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	0.028
Foxp3	forkhead box P3	0.027
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.027
Ncs1	neuronal calcium sensor 1	0.027
Pml	promyelocytic leukemia	0.027
Sh3rf1	SH3 domain containing ring finger 1	0.027
Sox1	SRY-box containing gene 1	0.027
Terf1	telomeric repeat binding factor 1	0.027
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.027
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.027
Tm4sf1	transmembrane 4 superfamily member 1	0.027
Slc25a29	solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29	0.027
Pofut1	protein O-fucosyltransferase 1	0.027
Htra3	HtrA serine peptidase 3	0.027
Lef1	lymphoid enhancer binding factor 1	0.027
Thbd	thrombomodulin	0.027
Inhbb	inhibin beta-B	0.027
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.027
Tgfb1	transforming growth factor, beta 1	0.027
Pcolce	procollagen C-endopeptidase enhancer protein	0.027
Stk4	serine/threonine kinase 4	0.027
Cacna1g	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.027
Muc5ac	mucin 5, subtypes A and C, tracheobronchial/gastric	0.027
Ccnd1	cyclin D1	0.027
Socs1	suppressor of cytokine signaling 1	0.026
Npas2	neuronal PAS domain protein 2	0.026
Krt86	keratin 86	0.026
Sdc2	syndecan 2	0.026
Gas1	growth arrest specific 1	0.026
Abi3bp	ABI gene family, member 3 (NESH) binding protein	0.026
Matn4	matrilin 4	0.026
Wnt10a	wingless related MMTV integration site 10a	0.026
Efs	embryonal Fyn-associated substrate	0.026
Prkab1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.026
Cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.026
Il10	interleukin 10	0.026
Ptprt	protein tyrosine phosphatase, receptor type, T	0.025
Ahr	aryl-hydrocarbon receptor	0.025
Sult5a1	sulfotransferase family 5A, member 1	0.025
Cys1	cystin 1	0.025
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.025
Slurp1	secreted Ly6/Plaur domain containing 1	0.025
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.025
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.025
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.025
Hoxc8	homeobox C8	0.025
Cox8b	cytochrome c oxidase, subunit VIIIb	0.025
Zp1	zona pellucida glycoprotein 1	0.025
Braf	Braf transforming gene	0.025
Sox18	SRY-box containing gene 18	0.025
Spry4	sprouty homolog 4 (Drosophila)	0.025
Dsc3	desmocollin 3	0.025
Socs5	suppressor of cytokine signaling 5	0.025
Aplnr	apelin receptor	0.025
Wnt5b	wingless-related MMTV integration site 5B	0.025	Mouse
Hrc	histidine rich calcium binding protein	0.024
Nf1	neurofibromatosis 1	0.024
Wwc2	WW, C2 and coiled-coil domain containing 2	0.024
Lhb	luteinizing hormone beta	0.024
Rasl10a	RAS-like, family 10, member A	0.024
Zc3h14	zinc finger CCCH type containing 14	0.024
Sav1	salvador homolog 1 (Drosophila)	0.024
Cd44	CD44 antigen	0.024
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.024
Nae1	NEDD8 activating enzyme E1 subunit 1	0.024
Slit3	slit homolog 3 (Drosophila)	0.024
Lpar1	lysophosphatidic acid receptor 1	0.024
Emx2	empty spiracles homolog 2 (Drosophila)	0.024
2610109H07Rik	RIKEN cDNA 2610109H07 gene	0.024
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.024
Cdx1	caudal type homeobox 1	0.024
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.024
Slco3a1	solute carrier organic anion transporter family, member 3a1	0.024
Sstr1	somatostatin receptor 1	0.024
Extl3	exostoses (multiple)-like 3	0.024
Fjx1	four jointed box 1 (Drosophila)	0.024
Foxe1	forkhead box E1	0.024
Mfn1	mitofusin 1	0.024
Ift88	intraflagellar transport 88 homolog (Chlamydomonas)	0.023
Atl2	atlastin GTPase 2	0.023
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.023
F2r	coagulation factor II (thrombin) receptor	0.023
Ky	kyphoscoliosis peptidase	0.023
Huwe1	HECT, UBA and WWE domain containing 1	0.023
Mfge8	milk fat globule-EGF factor 8 protein	0.023
Pthlh	parathyroid hormone-like peptide	0.023
Pmp22	peripheral myelin protein 22	0.023
Scube1	signal peptide, CUB domain, EGF-like 1	0.023
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.023
Upk3b	uroplakin 3B	0.023
Fbln2	fibulin 2	0.023
Hoxd1	homeobox D1	0.023
Glra1	glycine receptor, alpha 1 subunit	0.023
Egln1	EGL nine homolog 1 (C. elegans)	0.023
Egr1	early growth response 1	0.022
Tbl1x	transducin (beta)-like 1 X-linked	0.022
Cabp7	calcium binding protein 7	0.022
Cacna1e	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.022	Worm
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.022
Angpt1	angiopoietin 1	0.022
Sim1	single-minded homolog 1 (Drosophila)	0.022
Nkd2	naked cuticle 2 homolog (Drosophila)	0.022
Zic4	zinc finger protein of the cerebellum 4	0.022
Snai1	snail homolog 1 (Drosophila)	0.022
Aebp1	AE binding protein 1	0.022
9930013L23Rik	RIKEN cDNA 9930013L23 gene	0.022
Csf1	colony stimulating factor 1 (macrophage)	0.022
Vstm2b	V-set and transmembrane domain containing 2B	0.022
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.022
Ccnd2	cyclin D2	0.022
Fshr	follicle stimulating hormone receptor	0.022
Naalad2	N-acetylated alpha-linked acidic dipeptidase 2	0.022
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.022
Scn5a	sodium channel, voltage-gated, type V, alpha	0.022
Rpn1	ribophorin I	0.022
Prlr	prolactin receptor	0.022
Crbn	cereblon	0.022
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.022
Fibin	fin bud initiation factor homolog (zebrafish)	0.022
Eya4	eyes absent 4 homolog (Drosophila)	0.021
Avp	arginine vasopressin	0.021
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.021
Zic1	zinc finger protein of the cerebellum 1	0.021
Mfap4	microfibrillar-associated protein 4	0.021
Hoxa13	homeobox A13	0.021
Irx1	Iroquois related homeobox 1 (Drosophila)	0.021
Pmepa1	prostate transmembrane protein, androgen induced 1	0.021
Ncan	neurocan	0.021
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.021
Itga8	integrin alpha 8	0.021
Creb3l1	cAMP responsive element binding protein 3-like 1	0.021
Pnoc	prepronociceptin	0.021
Cacng6	calcium channel, voltage-dependent, gamma subunit 6	0.021
Kremen1	kringle containing transmembrane protein 1	0.021
Sftpb	surfactant associated protein B	0.021
Bax	BCL2-associated X protein	0.021
Acvrl1	activin A receptor, type II-like 1	0.021	Fly
Kcnh3	potassium voltage-gated channel, subfamily H (eag-related), member 3	0.021
Fut7	fucosyltransferase 7	0.021
Plcg1	phospholipase C, gamma 1	0.021
Bmp15	bone morphogenetic protein 15	0.021
Stx1b	syntaxin 1B	0.021
Tomm70a	translocase of outer mitochondrial membrane 70 homolog A (yeast)	0.021
Adam10	a disintegrin and metallopeptidase domain 10	0.020
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.020
Scn8a	sodium channel, voltage-gated, type VIII, alpha	0.020
Clock	circadian locomotor output cycles kaput	0.020
Tlr4	toll-like receptor 4	0.020
Spdef	SAM pointed domain containing ets transcription factor	0.020
Xirp1	xin actin-binding repeat containing 1	0.020
Rspo1	R-spondin homolog (Xenopus laevis)	0.020
Lefty1	left right determination factor 1	0.020
Irs4	insulin receptor substrate 4	0.020
Cx3cr1	chemokine (C-X3-C) receptor 1	0.020
Timp3	tissue inhibitor of metalloproteinase 3	0.020
Aff2	AF4/FMR2 family, member 2	0.020
Aplp2	amyloid beta (A4) precursor-like protein 2	0.020
Trappc8	trafficking protein particle complex 8	0.020
Id3	inhibitor of DNA binding 3	0.020
Vhl	von Hippel-Lindau tumor suppressor	0.020
Fuz	fuzzy homolog (Drosophila)	0.020
Mical2	microtubule associated monoxygenase, calponin and LIM domain containing 2	0.020
Igfbp4	insulin-like growth factor binding protein 4	0.020
Pkd2	polycystic kidney disease 2	0.020
Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	0.020
Tbx15	T-box 15	0.020
Thbs2	thrombospondin 2	0.020
Olfml3	olfactomedin-like 3	0.020
Lamc1	laminin, gamma 1	0.020
Plxdc2	plexin domain containing 2	0.020
Lrp5	low density lipoprotein receptor-related protein 5	0.020
Col8a2	collagen, type VIII, alpha 2	0.020
Odz2	odd Oz/ten-m homolog 2 (Drosophila)	0.020
Epha1	Eph receptor A1	0.020
Mdm4	transformed mouse 3T3 cell double minute 4	0.020
Sstr4	somatostatin receptor 4	0.019
Tlx3	T-cell leukemia, homeobox 3	0.019
Rapsn	receptor-associated protein of the synapse	0.019
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.019
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.019
Hes2	hairy and enhancer of split 2 (Drosophila)	0.019
Trim8	tripartite motif-containing 8	0.019
Olfml2b	olfactomedin-like 2B	0.019
Igfbp5	insulin-like growth factor binding protein 5	0.019
Csnk1e	casein kinase 1, epsilon	0.019
Fndc7	fibronectin type III domain containing 7	0.019
Apbb2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.019
Col9a2	collagen, type IX, alpha 2	0.019
Col22a1	collagen, type XXII, alpha 1	0.019
Nmur1	neuromedin U receptor 1	0.019
Cacng4	calcium channel, voltage-dependent, gamma subunit 4	0.019
Hspb8	heat shock protein 8	0.019
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.019
Hoxb2	homeobox B2	0.019
Ntsr1	neurotensin receptor 1	0.019
Elk4	ELK4, member of ETS oncogene family	0.019
Lcor	ligand dependent nuclear receptor corepressor	0.019
Rtn4r	reticulon 4 receptor	0.019
Fbln1	fibulin 1	0.019
Apln	apelin	0.019
Mpped1	metallophosphoesterase domain containing 1	0.019
Robo3	roundabout homolog 3 (Drosophila)	0.019
Des	desmin	0.019
Nf2	neurofibromatosis 2	0.019
Mmp11	matrix metallopeptidase 11	0.019
Twist1	twist homolog 1 (Drosophila)	0.019
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.019
Omt2b	oocyte maturation, beta	0.019
Vcl	vinculin	0.019
Vasn	vasorin	0.019	Human
Omp	olfactory marker protein	0.019
Trim62	tripartite motif-containing 62	0.019
Akt3	thymoma viral proto-oncogene 3	0.019
Dpysl2	dihydropyrimidinase-like 2	0.019
Usp25	ubiquitin specific peptidase 25	0.018
Clic3	chloride intracellular channel 3	0.018
Gdf11	growth differentiation factor 11	0.018
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.018
Sp5	trans-acting transcription factor 5	0.018
Syt6	synaptotagmin VI	0.018
Dmd	dystrophin, muscular dystrophy	0.018
Slit1	slit homolog 1 (Drosophila)	0.018
Itgbl1	integrin, beta-like 1	0.018
Rhoj	ras homolog gene family, member J	0.018
Efna5	ephrin A5	0.018
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.018
Ncor2	nuclear receptor co-repressor 2	0.018
Lhfp	lipoma HMGIC fusion partner	0.018
Fstl1	follistatin-like 1	0.018
Cxcl14	chemokine (C-X-C motif) ligand 14	0.018
Casp12	caspase 12	0.018
Krtap3-3	keratin associated protein 3-3	0.018
Lama2	laminin, alpha 2	0.018
Lmna	lamin A	0.018
1190002N15Rik	RIKEN cDNA 1190002N15 gene	0.018
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.018
Rfwd2	ring finger and WD repeat domain 2	0.018
Irf2bp2	interferon regulatory factor 2 binding protein 2	0.018
Lhx5	LIM homeobox protein 5	0.018
Agtr2	angiotensin II receptor, type 2	0.018
Galk2	galactokinase 2	0.018
Mmp23	matrix metallopeptidase 23	0.018
Ikzf1	IKAROS family zinc finger 1	0.018
Angpt4	angiopoietin 4	0.018
Cbl	Casitas B-lineage lymphoma	0.018
Nrg3	neuregulin 3	0.018
Adora2b	adenosine A2b receptor	0.018
Wrn	Werner syndrome homolog (human)	0.018
Clip2	CAP-GLY domain containing linker protein 2	0.018
Phf2	PHD finger protein 2	0.018
Mpp5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	0.017
Wisp2	WNT1 inducible signaling pathway protein 2	0.017
Hoxb7	homeobox B7	0.017
Tctex1d4	Tctex1 domain containing 4	0.017
Vdr	vitamin D receptor	0.017
Pax3	paired box gene 3	0.017
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.017
Wnt5a	wingless-related MMTV integration site 5A	0.017	Mouse
Dennd5a	DENN/MADD domain containing 5A	0.017
Ndfip1	Nedd4 family interacting protein 1	0.017
Agxt	alanine-glyoxylate aminotransferase	0.017
Hoxa7	homeobox A7	0.017
Foxb2	forkhead box B2	0.017
Igf1r	insulin-like growth factor I receptor	0.017
Sall1	sal-like 1 (Drosophila)	0.017
Hif1a	hypoxia inducible factor 1, alpha subunit	0.017
Sulf2	sulfatase 2	0.017
Zdhhc21	zinc finger, DHHC domain containing 21	0.017
Hoxa1	homeobox A1	0.017
Tspyl1	testis-specific protein, Y-encoded-like 1	0.017
Fzd6	frizzled homolog 6 (Drosophila)	0.017
Hoxa4	homeobox A4	0.017
Tspan9	tetraspanin 9	0.017
Cul4b	cullin 4B	0.017
Kit	kit oncogene	0.017
Myod1	myogenic differentiation 1	0.017
Calca	calcitonin/calcitonin-related polypeptide, alpha	0.017
Hipk3	homeodomain interacting protein kinase 3	0.017
Colec12	collectin sub-family member 12	0.017
Pdia4	protein disulfide isomerase associated 4	0.017
Egr4	early growth response 4	0.017
Il4	interleukin 4	0.017
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.017
C1s	complement component 1, s subcomponent	0.017
Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	0.017
Sstr5	somatostatin receptor 5	0.017
Zfp36l2	zinc finger protein 36, C3H type-like 2	0.017
Barx1	BarH-like homeobox 1	0.017
Tbx19	T-box 19	0.017
Arl6	ADP-ribosylation factor-like 6	0.017
Pld2	phospholipase D2	0.017
Ank1	ankyrin 1, erythroid	0.017
Arl8b	ADP-ribosylation factor-like 8B	0.016
Foxn4	forkhead box N4	0.016
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.016
Srsf3	serine/arginine-rich splicing factor 3	0.016
Dlx4	distal-less homeobox 4	0.016
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.016
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.016
Txndc16	thioredoxin domain containing 16	0.016
Wnt2	wingless-related MMTV integration site 2	0.016	Mouse
Wnt7b	wingless-related MMTV integration site 7B	0.016	Mouse
Ppm1a	protein phosphatase 1A, magnesium dependent, alpha isoform	0.016	Human
Gpr153	G protein-coupled receptor 153	0.016
Mxd4	Max dimerization protein 4	0.016
Fst	follistatin	0.016
Sh2b3	SH2B adaptor protein 3	0.016
Rhoc	ras homolog gene family, member C	0.016
Lrp1	low density lipoprotein receptor-related protein 1	0.016
Gad2	glutamic acid decarboxylase 2	0.016
Gphn	gephyrin	0.016
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.016
Pofut2	protein O-fucosyltransferase 2	0.016
Prnp	prion protein	0.016
Gpr3	G-protein coupled receptor 3	0.016
Fut8	fucosyltransferase 8	0.016
Slc27a3	solute carrier family 27 (fatty acid transporter), member 3	0.016
Pgrmc1	progesterone receptor membrane component 1	0.016
Numb	numb gene homolog (Drosophila)	0.016
Alx3	aristaless-like homeobox 3	0.016
Rps6ka3	ribosomal protein S6 kinase polypeptide 3	0.016
Hspa4l	heat shock protein 4 like	0.016
Adamtsl5	ADAMTS-like 5	0.016
Zbtb16	zinc finger and BTB domain containing 16	0.016
Smn1	survival motor neuron 1	0.016
Sox17	SRY-box containing gene 17	0.016
Cry1	cryptochrome 1 (photolyase-like)	0.016
Daxx	Fas death domain-associated protein	0.016
Barx2	BarH-like homeobox 2	0.016
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.016
Tnfrsf25	tumor necrosis factor receptor superfamily, member 25	0.016
Irx3	Iroquois related homeobox 3 (Drosophila)	0.016
Myc	myelocytomatosis oncogene	0.016
Cbr2	carbonyl reductase 2	0.016
Epn3	epsin 3	0.016
Zfp518b	zinc finger protein 518B	0.016
Cse1l	chromosome segregation 1-like (S. cerevisiae)	0.016
Col25a1	collagen, type XXV, alpha 1	0.016
Ptprm	protein tyrosine phosphatase, receptor type, M	0.016
Lhx6	LIM homeobox protein 6	0.016
Abl2	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	0.016
Col4a4	collagen, type IV, alpha 4	0.016
Spast	spastin	0.016
Aoc3	amine oxidase, copper containing 3	0.016
Vps41	vacuolar protein sorting 41 (yeast)	0.015
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.015
Plekha5	pleckstrin homology domain containing, family A member 5	0.015
Fgf4	fibroblast growth factor 4	0.015
Polk	polymerase (DNA directed), kappa	0.015
Ppp2ca	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	0.015
Mycl1	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	0.015
Zbtb7c	zinc finger and BTB domain containing 7C	0.015
Shc3	src homology 2 domain-containing transforming protein C3	0.015
Fbxw7	F-box and WD-40 domain protein 7	0.015
AU021092	expressed sequence AU021092	0.015
Rasl12	RAS-like, family 12	0.015
Dmtf1	cyclin D binding myb-like transcription factor 1	0.015
Lgals7	lectin, galactose binding, soluble 7	0.015
Card11	caspase recruitment domain family, member 11	0.015
Nfe2l3	nuclear factor, erythroid derived 2, like 3	0.015
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.015
Neo1	neogenin	0.015
Pura	purine rich element binding protein A	0.015
Slc2a10	solute carrier family 2 (facilitated glucose transporter), member 10	0.015
Psap	prosaposin	0.015
Dlgap4	discs, large homolog-associated protein 4 (Drosophila)	0.015
Isl2	insulin related protein 2 (islet 2)	0.015
Stip1	stress-induced phosphoprotein 1	0.015
Aicda	activation-induced cytidine deaminase	0.015
Sumo1	SMT3 suppressor of mif two 3 homolog 1 (yeast)	0.015
Cidec	cell death-inducing DFFA-like effector c	0.015	Mouse
Slc4a8	solute carrier family 4 (anion exchanger), member 8	0.015
Fbn1	fibrillin 1	0.015
Id1	inhibitor of DNA binding 1	0.015
Dlx1	distal-less homeobox 1	0.015
Prelp	proline arginine-rich end leucine-rich repeat	0.015
Ldlr	low density lipoprotein receptor	0.015
Myl7	myosin, light polypeptide 7, regulatory	0.015
Glis2	GLIS family zinc finger 2	0.015
Rmnd5a	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	0.015
Hrk	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.015
P4ha1	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide	0.015
Nrk	Nik related kinase	0.015
Adam23	a disintegrin and metallopeptidase domain 23	0.015
Mustn1	musculoskeletal, embryonic nuclear protein 1	0.015
Gdf5	growth differentiation factor 5	0.015
Tmed8	transmembrane emp24 domain containing 8	0.015
Fndc3b	fibronectin type III domain containing 3B	0.015
Enc1	ectodermal-neural cortex 1	0.015
Phox2a	paired-like homeobox 2a	0.015
Zbtb7a	zinc finger and BTB domain containing 7a	0.015