IMP: Integrative Multi-species Prediction

Mus musculus

71 genes annotated in mouse

transforming growth factor beta receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "transforming growth factor beta receptor signaling pathway"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "transforming growth factor beta receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Tgfbr2	transforming growth factor, beta receptor II	1.000
Nodal	nodal	0.995
Smad6	MAD homolog 6 (Drosophila)	0.984	Human Mouse Fly
Smad4	MAD homolog 4 (Drosophila)	0.980
Lox	lysyl oxidase	0.977
Smad3	MAD homolog 3 (Drosophila)	0.977
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.974
Smad7	MAD homolog 7 (Drosophila)	0.961
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.927
Tgfbr1	transforming growth factor, beta receptor I	0.898
Gpc3	glypican 3	0.862
Tgfb2	transforming growth factor, beta 2	0.855	Human Mouse Fly
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.851
Skil	SKI-like	0.841
Thbs1	thrombospondin 1	0.839
Bmp1	bone morphogenetic protein 1	0.828
Bgn	biglycan	0.805	Mouse
Mstn	myostatin	0.801
Apc	adenomatosis polyposis coli	0.783
Lum	lumican	0.778	Mouse
Acvr1	activin A receptor, type 1	0.774
Axin1	axin 1	0.767
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.764
Col1a1	collagen, type I, alpha 1	0.748
Tgfb1	transforming growth factor, beta 1	0.735
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.735
Csf1	colony stimulating factor 1 (macrophage)	0.733
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.726	Mouse Fly
Lep	leptin	0.711
Pkd2	polycystic kidney disease 2	0.698
Mmp2	matrix metallopeptidase 2	0.689
Trp53	transformation related protein 53	0.637
Bmp4	bone morphogenetic protein 4	0.607
Fgfr2	fibroblast growth factor receptor 2	0.561
Itgb3	integrin beta 3	0.553	Mouse
Jun	Jun oncogene	0.538	Human
Fgfr1	fibroblast growth factor receptor 1	0.529
Smo	smoothened homolog (Drosophila)	0.529
Fst	follistatin	0.527
Fgf8	fibroblast growth factor 8	0.504
Ctnnb1	catenin (cadherin associated protein), beta 1	0.481
Col5a1	collagen, type V, alpha 1	0.466
Pgr	progesterone receptor	0.466
Nf1	neurofibromatosis 1	0.433
Rarg	retinoic acid receptor, gamma	0.428
Wnt4	wingless-related MMTV integration site 4	0.423	Mouse
Emp2	epithelial membrane protein 2	0.422
Mdm2	transformed mouse 3T3 cell double minute 2	0.418
Zfp651	zinc finger protein 651	0.406
Mmp9	matrix metallopeptidase 9	0.397
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.396	Mouse
Bmp7	bone morphogenetic protein 7	0.392	Mouse
Gas1	growth arrest specific 1	0.383
Smad1	MAD homolog 1 (Drosophila)	0.381	Mouse Fly
Apoe	apolipoprotein E	0.379
Scara3	scavenger receptor class A, member 3	0.364
Ltbp1	latent transforming growth factor beta binding protein 1	0.364	Mouse
Atf2	activating transcription factor 2	0.360
Aebp1	AE binding protein 1	0.358
Tbx1	T-box 1	0.358
Trp63	transformation related protein 63	0.356	Mouse
Cyr61	cysteine rich protein 61	0.356
Sulf2	sulfatase 2	0.347	Fly
Fbln2	fibulin 2	0.347	Mouse
Timp2	tissue inhibitor of metalloproteinase 2	0.345
Col12a1	collagen, type XII, alpha 1	0.343
Dlg1	discs, large homolog 1 (Drosophila)	0.343
Foxc1	forkhead box C1	0.341
Cul3	cullin 3	0.338
Vcl	vinculin	0.334
Smad2	MAD homolog 2 (Drosophila)	0.325
Pten	phosphatase and tensin homolog	0.316
Col1a2	collagen, type I, alpha 2	0.314	Human
Foxf2	forkhead box F2	0.312
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.312	Mouse
Sox4	SRY-box containing gene 4	0.309
Vegfa	vascular endothelial growth factor A	0.308
Fgf5	fibroblast growth factor 5	0.300
Lhx1	LIM homeobox protein 1	0.298
Inhba	inhibin beta-A	0.296
Prrx2	paired related homeobox 2	0.289
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.287
Islr	immunoglobulin superfamily containing leucine-rich repeat	0.284
C1qtnf1	C1q and tumor necrosis factor related protein 1	0.282
Efna4	ephrin A4	0.280
Rarb	retinoic acid receptor, beta	0.280
Spnb2	spectrin beta 2	0.277
Fgf10	fibroblast growth factor 10	0.274
Gsk3b	glycogen synthase kinase 3 beta	0.273
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.270	Mouse
Fzd2	frizzled homolog 2 (Drosophila)	0.270
Pax2	paired box gene 2	0.270
Cx3cr1	chemokine (C-X3-C) receptor 1	0.268
Flna	filamin, alpha	0.267
Loxl1	lysyl oxidase-like 1	0.264
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.263
Plin1	perilipin 1	0.263
Fzd1	frizzled homolog 1 (Drosophila)	0.257
Ephb2	Eph receptor B2	0.255
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.249	Human
Pdlim4	PDZ and LIM domain 4	0.249
Ptk2	PTK2 protein tyrosine kinase 2	0.247	Human
Efs	embryonal Fyn-associated substrate	0.244
Sfrp2	secreted frizzled-related protein 2	0.240
Nog	noggin	0.239
Il6st	interleukin 6 signal transducer	0.236
Twist1	twist homolog 1 (Drosophila)	0.236
Ptrf	polymerase I and transcript release factor	0.235
Hoxb3	homeobox B3	0.235
Thbs2	thrombospondin 2	0.231	Mouse
Fbln5	fibulin 5	0.222	Mouse
Cd44	CD44 antigen	0.222
Gli1	GLI-Kruppel family member GLI1	0.220
Postn	periostin, osteoblast specific factor	0.216
Gdf10	growth differentiation factor 10	0.213	Mouse
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.213
Chrd	chordin	0.212
Fos	FBJ osteosarcoma oncogene	0.208	Human
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.207
Msh2	mutS homolog 2 (E. coli)	0.205
Dnahc5	dynein, axonemal, heavy chain 5	0.204
Angptl2	angiopoietin-like 2	0.200
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.199
Wnt3a	wingless-related MMTV integration site 3A	0.197	Mouse
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.196
Cnn1	calponin 1	0.194
Fbn1	fibrillin 1	0.192
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.192
Gata4	GATA binding protein 4	0.190
Msln	mesothelin	0.188
Braf	Braf transforming gene	0.187
Gdf5	growth differentiation factor 5	0.185	Mouse
Acvr2b	activin receptor IIB	0.185
Insr	insulin receptor	0.181
Ptk7	PTK7 protein tyrosine kinase 7	0.181
Mmp11	matrix metallopeptidase 11	0.180
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.177
Wnt6	wingless-related MMTV integration site 6	0.177	Mouse
Clock	circadian locomotor output cycles kaput	0.177
Ptf1a	pancreas specific transcription factor, 1a	0.176
Esr1	estrogen receptor 1 (alpha)	0.172
Fzd7	frizzled homolog 7 (Drosophila)	0.172
Col6a2	collagen, type VI, alpha 2	0.171
Sulf1	sulfatase 1	0.171	Fly
Col5a2	collagen, type V, alpha 2	0.171
Gdf1	growth differentiation factor 1	0.168
Zic3	zinc finger protein of the cerebellum 3	0.167
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.165
Tagln	transgelin	0.165
Gata6	GATA binding protein 6	0.164
Fmod	fibromodulin	0.162	Mouse
Rcn3	reticulocalbin 3, EF-hand calcium binding domain	0.161
Rara	retinoic acid receptor, alpha	0.160
Arrb1	arrestin, beta 1	0.160
Tln1	talin 1	0.159
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.158
Grb10	growth factor receptor bound protein 10	0.155
Kitl	kit ligand	0.152
Daxx	Fas death domain-associated protein	0.151
Adam12	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	0.150	Mouse
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.149
Ltbp2	latent transforming growth factor beta binding protein 2	0.148	Mouse
Fgf15	fibroblast growth factor 15	0.148
Dusp1	dual specificity phosphatase 1	0.148
Nid1	nidogen 1	0.147
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.145
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.143
Lama5	laminin, alpha 5	0.141
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.141
Ogn	osteoglycin	0.140
Zyx	zyxin	0.140
Gdnf	glial cell line derived neurotrophic factor	0.139
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.139
Ar	androgen receptor	0.137
Wls	wntless homolog (Drosophila)	0.135
Gdf11	growth differentiation factor 11	0.134	Mouse
Mef2a	myocyte enhancer factor 2A	0.133
Efnb2	ephrin B2	0.132
Amhr2	anti-Mullerian hormone type 2 receptor	0.132	Mouse Rat
Onecut1	one cut domain, family member 1	0.132
Itga3	integrin alpha 3	0.131	Human Mouse
Fgf2	fibroblast growth factor 2	0.131
Mgat3	mannoside acetylglucosaminyltransferase 3	0.130
Rhbdf1	rhomboid family 1 (Drosophila)	0.130
Pax8	paired box gene 8	0.130
Foxh1	forkhead box H1	0.130
Plec	plectin	0.128
Cpd	carboxypeptidase D	0.126
Eln	elastin	0.126
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.123
Fn1	fibronectin 1	0.122
Fut7	fucosyltransferase 7	0.122
Wt1	Wilms tumor 1 homolog	0.122
Thbd	thrombomodulin	0.122
Inhbb	inhibin beta-B	0.122
Nos2	nitric oxide synthase 2, inducible	0.122
Tcf21	transcription factor 21	0.121
Onecut2	one cut domain, family member 2	0.120
Cd248	CD248 antigen, endosialin	0.119
Igfbp5	insulin-like growth factor binding protein 5	0.118
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.118
Xiap	X-linked inhibitor of apoptosis	0.118
Crlf1	cytokine receptor-like factor 1	0.118
Cdh11	cadherin 11	0.117
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.117
Smad5	MAD homolog 5 (Drosophila)	0.116
Jag1	jagged 1	0.116
Wnt3	wingless-related MMTV integration site 3	0.115	Mouse
Pxn	paxillin	0.115
Ltbp3	latent transforming growth factor beta binding protein 3	0.115
Pdgfa	platelet derived growth factor, alpha	0.115
Dpt	dermatopontin	0.114
Col16a1	collagen, type XVI, alpha 1	0.113
Plcd1	phospholipase C, delta 1	0.113
Tspan9	tetraspanin 9	0.113
Jup	junction plakoglobin	0.113
Tm4sf1	transmembrane 4 superfamily member 1	0.111
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.110
Cul7	cullin 7	0.110
Dcn	decorin	0.110	Mouse
Ube2g1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)	0.109
Col4a5	collagen, type IV, alpha 5	0.108
Ciita	class II transactivator	0.108
Gja3	gap junction protein, alpha 3	0.108
Cald1	caldesmon 1	0.108
Foxa2	forkhead box A2	0.107
Wnt7a	wingless-related MMTV integration site 7A	0.107	Mouse
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.105
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.105
Hic1	hypermethylated in cancer 1	0.104
Itgb4	integrin beta 4	0.104	Mouse
Wfikkn1	WAP, FS, Ig, KU, and NTR-containing protein 1	0.103
Smtn	smoothelin	0.102
Stk11	serine/threonine kinase 11	0.102
Bmp5	bone morphogenetic protein 5	0.101	Mouse
Pld2	phospholipase D2	0.101
Tenc1	tensin like C1 domain-containing phosphatase	0.100
Clip2	CAP-GLY domain containing linker protein 2	0.100
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.100
Ptgs2	prostaglandin-endoperoxide synthase 2	0.099
Tnks1bp1	tankyrase 1 binding protein 1	0.098
Nos3	nitric oxide synthase 3, endothelial cell	0.098
Osr1	odd-skipped related 1 (Drosophila)	0.098
Klf4	Kruppel-like factor 4 (gut)	0.097
Hif1a	hypoxia inducible factor 1, alpha subunit	0.096
Foxf1a	forkhead box F1a	0.095
Fnip1	folliculin interacting protein 1	0.095
Yap1	yes-associated protein 1	0.095
Rac1	RAS-related C3 botulinum substrate 1	0.095
Hbegf	heparin-binding EGF-like growth factor	0.094
Smoc2	SPARC related modular calcium binding 2	0.094
Bmp2	bone morphogenetic protein 2	0.094
Fzd9	frizzled homolog 9 (Drosophila)	0.094
Tlr4	toll-like receptor 4	0.093
Cxcr7	chemokine (C-X-C motif) receptor 7	0.093
Adam9	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	0.092
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.092
Acvr1b	activin A receptor, type 1B	0.092	Mouse
Myl9	myosin, light polypeptide 9, regulatory	0.092
Ddah2	dimethylarginine dimethylaminohydrolase 2	0.092
Mapk8	mitogen-activated protein kinase 8	0.092
Shh	sonic hedgehog	0.092
Mapk14	mitogen-activated protein kinase 14	0.091	Fly
Cacna1h	calcium channel, voltage-dependent, T type, alpha 1H subunit	0.091
Nos1	nitric oxide synthase 1, neuronal	0.091
Selp	selectin, platelet	0.091
Lef1	lymphoid enhancer binding factor 1	0.091
Plekhg2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	0.090
Adam17	a disintegrin and metallopeptidase domain 17	0.090
Pml	promyelocytic leukemia	0.090
Pitx2	paired-like homeodomain transcription factor 2	0.089
Ptgs1	prostaglandin-endoperoxide synthase 1	0.089
Galnt6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6	0.089
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.089
Fosl2	fos-like antigen 2	0.088
Nbn	nibrin	0.088
Adamts2	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2	0.088
Nkd2	naked cuticle 2 homolog (Drosophila)	0.088
Gab2	growth factor receptor bound protein 2-associated protein 2	0.087
Phldb1	pleckstrin homology-like domain, family B, member 1	0.087
Foxe1	forkhead box E1	0.086
Npc1	Niemann Pick type C1	0.086
Cntfr	ciliary neurotrophic factor receptor	0.085
Myf5	myogenic factor 5	0.085
Fzd8	frizzled homolog 8 (Drosophila)	0.084
Pou3f3	POU domain, class 3, transcription factor 3	0.084
Irs1	insulin receptor substrate 1	0.084
E2f1	E2F transcription factor 1	0.084
Ece1	endothelin converting enzyme 1	0.084
Pax3	paired box gene 3	0.083
Flnc	filamin C, gamma	0.082
Hoxb6	homeobox B6	0.082
Abi3bp	ABI gene family, member 3 (NESH) binding protein	0.082
Lamb2	laminin, beta 2	0.081
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.080
Pcdh12	protocadherin 12	0.080
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.080
Met	met proto-oncogene	0.079
Barx1	BarH-like homeobox 1	0.079
Foxo3	forkhead box O3	0.078
Pkd1	polycystic kidney disease 1 homolog	0.078
Ano1	anoctamin 1, calcium activated chloride channel	0.078
Fmn1	formin 1	0.078
Crebbp	CREB binding protein	0.077
Rasgrp1	RAS guanyl releasing protein 1	0.077
Ephb3	Eph receptor B3	0.077
Krt19	keratin 19	0.077
Sema4b	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B	0.077
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.077
Zfp703	zinc finger protein 703	0.077
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.077
Rb1	retinoblastoma 1	0.076
Igfbp7	insulin-like growth factor binding protein 7	0.076
Tgfbr3	transforming growth factor, beta receptor III	0.076
Fermt2	fermitin family homolog 2 (Drosophila)	0.076	Human
Acvr2a	activin receptor IIA	0.075
Ctdsp2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	0.075
Olfml3	olfactomedin-like 3	0.075
Kpna1	karyopherin (importin) alpha 1	0.075
Mgp	matrix Gla protein	0.074
Pdgfb	platelet derived growth factor, B polypeptide	0.074
Zmym2	zinc finger, MYM-type 2	0.074
Bmp6	bone morphogenetic protein 6	0.074	Mouse
Gpc4	glypican 4	0.074
Rhoj	ras homolog gene family, member J	0.073
Lrp1	low density lipoprotein receptor-related protein 1	0.073
Mknk1	MAP kinase-interacting serine/threonine kinase 1	0.073
Gli3	GLI-Kruppel family member GLI3	0.073
Frmd6	FERM domain containing 6	0.073
Runx1	runt related transcription factor 1	0.073
Fbln1	fibulin 1	0.072	Mouse
Lama4	laminin, alpha 4	0.072
Pmepa1	prostate transmembrane protein, androgen induced 1	0.072
Lcor	ligand dependent nuclear receptor corepressor	0.072
Epn3	epsin 3	0.072
Bcar1	breast cancer anti-estrogen resistance 1	0.071
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.071
Adam15	a disintegrin and metallopeptidase domain 15 (metargidin)	0.071	Mouse
Ghr	growth hormone receptor	0.070
Cdh3	cadherin 3	0.070
Gdf9	growth differentiation factor 9	0.070
Fzd6	frizzled homolog 6 (Drosophila)	0.070
Wnt9a	wingless-type MMTV integration site 9A	0.069	Mouse
Tmem119	transmembrane protein 119	0.069
Wfikkn2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.069
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.069
Nbl1	neuroblastoma, suppression of tumorigenicity 1	0.069	Mouse
Creb3l1	cAMP responsive element binding protein 3-like 1	0.069
Pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.068
Mrc2	mannose receptor, C type 2	0.068
Rasa1	RAS p21 protein activator 1	0.068
Cdx1	caudal type homeobox 1	0.068
Phldb2	pleckstrin homology-like domain, family B, member 2	0.068
Itga6	integrin alpha 6	0.067	Mouse
Apaf1	apoptotic peptidase activating factor 1	0.067
Gak	cyclin G associated kinase	0.067
Fuz	fuzzy homolog (Drosophila)	0.067
Ntf3	neurotrophin 3	0.067
Tpbg	trophoblast glycoprotein	0.066
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.066
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.066
Apcdd1	adenomatosis polyposis coli down-regulated 1	0.066
Gdf6	growth differentiation factor 6	0.065	Mouse
Adra1b	adrenergic receptor, alpha 1b	0.065
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.065
Scarf2	scavenger receptor class F, member 2	0.065
Masp1	mannan-binding lectin serine peptidase 1	0.065
Rbms1	RNA binding motif, single stranded interacting protein 1	0.064
Hip1	huntingtin interacting protein 1	0.064
Itgav	integrin alpha V	0.064	Mouse
Mfap4	microfibrillar-associated protein 4	0.064
Ptgfr	prostaglandin F receptor	0.064
Emx2	empty spiracles homolog 2 (Drosophila)	0.064
Igfbp6	insulin-like growth factor binding protein 6	0.063
Rbl2	retinoblastoma-like 2	0.063
Rel	reticuloendotheliosis oncogene	0.063
Ccr2	chemokine (C-C motif) receptor 2	0.063
Samd4	sterile alpha motif domain containing 4	0.063
Tnc	tenascin C	0.063
Ate1	arginyltransferase 1	0.063
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.063
Ahr	aryl-hydrocarbon receptor	0.063
9930013L23Rik	RIKEN cDNA 9930013L23 gene	0.063
Pcolce	procollagen C-endopeptidase enhancer protein	0.063
Usp25	ubiquitin specific peptidase 25	0.063
Adam10	a disintegrin and metallopeptidase domain 10	0.062
Sema3b	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	0.062
Smarcd3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.062
Slc27a3	solute carrier family 27 (fatty acid transporter), member 3	0.062
Traf6	TNF receptor-associated factor 6	0.062
Lhfp	lipoma HMGIC fusion partner	0.062
Gtf2ird1	general transcription factor II I repeat domain-containing 1	0.062
Lzts2	leucine zipper, putative tumor suppressor 2	0.062
Zbtb7b	zinc finger and BTB domain containing 7B	0.061
Tpm2	tropomyosin 2, beta	0.061
Kdm5a	lysine (K)-specific demethylase 5A	0.061
Fjx1	four jointed box 1 (Drosophila)	0.061
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.060	Fly
Cxcl12	chemokine (C-X-C motif) ligand 12	0.060
Sirpa	signal-regulatory protein alpha	0.060
Prkg1	protein kinase, cGMP-dependent, type I	0.060
Bptf	bromodomain PHD finger transcription factor	0.060
C230081A13Rik	RIKEN cDNA C230081A13 gene	0.060
Ilk	integrin linked kinase	0.060
Fgf17	fibroblast growth factor 17	0.059
Ccr9	chemokine (C-C motif) receptor 9	0.059
Trip12	thyroid hormone receptor interactor 12	0.059
Cyld	cylindromatosis (turban tumor syndrome)	0.059
Abcc9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	0.059
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.058
Lmna	lamin A	0.058
Barx2	BarH-like homeobox 2	0.058
Atf3	activating transcription factor 3	0.058
Mapkapk2	MAP kinase-activated protein kinase 2	0.058
Mfap5	microfibrillar associated protein 5	0.058
Ccr1	chemokine (C-C motif) receptor 1	0.058
F2r	coagulation factor II (thrombin) receptor	0.057
Mcam	melanoma cell adhesion molecule	0.057
Hoxc9	homeobox C9	0.057
Lpar1	lysophosphatidic acid receptor 1	0.057
Hoxd11	homeobox D11	0.056
Slco3a1	solute carrier organic anion transporter family, member 3a1	0.056
Mitf	microphthalmia-associated transcription factor	0.056
Plat	plasminogen activator, tissue	0.056
Dock2	dedicator of cyto-kinesis 2	0.055
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.055	Mouse Fly
Dmd	dystrophin, muscular dystrophy	0.055
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.055
Slc30a9	solute carrier family 30 (zinc transporter), member 9	0.055
Bmx	BMX non-receptor tyrosine kinase	0.055
Lyst	lysosomal trafficking regulator	0.055
Polm	polymerase (DNA directed), mu	0.055
Ret	ret proto-oncogene	0.055
Arl4c	ADP-ribosylation factor-like 4C	0.054
Crabp2	cellular retinoic acid binding protein II	0.054
Mapk7	mitogen-activated protein kinase 7	0.054
Rbl1	retinoblastoma-like 1 (p107)	0.054
Sdc2	syndecan 2	0.054
Foxb2	forkhead box B2	0.054
Trappc8	trafficking protein particle complex 8	0.054
Fndc3b	fibronectin type III domain containing 3B	0.054
Leprel2	leprecan-like 2	0.054
Htra1	HtrA serine peptidase 1	0.053
Dag1	dystroglycan 1	0.053
Alox15	arachidonate 15-lipoxygenase	0.053
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.053
Col6a1	collagen, type VI, alpha 1	0.053
Wisp1	WNT1 inducible signaling pathway protein 1	0.053
Aff1	AF4/FMR2 family, member 1	0.053
Csk	c-src tyrosine kinase	0.053
Has2	hyaluronan synthase 2	0.052
Itga8	integrin alpha 8	0.052
Rab34	RAB34, member of RAS oncogene family	0.052
Foxc2	forkhead box C2	0.052
Actn1	actinin, alpha 1	0.052
Itgbl1	integrin, beta-like 1	0.052
Slc4a8	solute carrier family 4 (anion exchanger), member 8	0.051
Pcdh18	protocadherin 18	0.051
Per3	period homolog 3 (Drosophila)	0.051
Adcy7	adenylate cyclase 7	0.051
Dnahc11	dynein, axonemal, heavy chain 11	0.051
Tek	endothelial-specific receptor tyrosine kinase	0.051
Mmp23	matrix metallopeptidase 23	0.051
Btbd17	BTB (POZ) domain containing 17	0.050
Ptgis	prostaglandin I2 (prostacyclin) synthase	0.050
Dkk3	dickkopf homolog 3 (Xenopus laevis)	0.050
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.050
Wnt5a	wingless-related MMTV integration site 5A	0.050	Mouse
Mapk12	mitogen-activated protein kinase 12	0.050	Fly
Actg2	actin, gamma 2, smooth muscle, enteric	0.050
Snai1	snail homolog 1 (Drosophila)	0.050
Rxra	retinoid X receptor alpha	0.050
Fyn	Fyn proto-oncogene	0.050
Porcn	porcupine homolog (Drosophila)	0.050
Sdc3	syndecan 3	0.050
Ucp2	uncoupling protein 2 (mitochondrial, proton carrier)	0.050
Lrrk1	leucine-rich repeat kinase 1	0.049
Col8a1	collagen, type VIII, alpha 1	0.049
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.049
Cbl	Casitas B-lineage lymphoma	0.049
Fzd10	frizzled homolog 10 (Drosophila)	0.049
Tbx2	T-box 2	0.049
Mxra8	matrix-remodelling associated 8	0.049
Stk4	serine/threonine kinase 4	0.049
Rdh10	retinol dehydrogenase 10 (all-trans)	0.049
Hhex	hematopoietically expressed homeobox	0.049
Nov	nephroblastoma overexpressed gene	0.049
Junb	Jun-B oncogene	0.049
Gab1	growth factor receptor bound protein 2-associated protein 1	0.048
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.048
Rem1	rad and gem related GTP binding protein 1	0.048
Klf6	Kruppel-like factor 6	0.048
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.048
Pou3f1	POU domain, class 3, transcription factor 1	0.048
Ep300	E1A binding protein p300	0.048
Bnc1	basonuclin 1	0.048
Plcg1	phospholipase C, gamma 1	0.048
Cpxm1	carboxypeptidase X 1 (M14 family)	0.048
Neo1	neogenin	0.048
Plaur	plasminogen activator, urokinase receptor	0.048
Parva	parvin, alpha	0.048
Mybph	myosin binding protein H	0.048
Tcf15	transcription factor 15	0.048
Nckap1l	NCK associated protein 1 like	0.047
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.047
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.047
Cachd1	cache domain containing 1	0.047
Enc1	ectodermal-neural cortex 1	0.047
Sh2b3	SH2B adaptor protein 3	0.047
Epb4.1l2	erythrocyte protein band 4.1-like 2	0.047
Arnt	aryl hydrocarbon receptor nuclear translocator	0.047
Nt5e	5' nucleotidase, ecto	0.047
Ager	advanced glycosylation end product-specific receptor	0.047
Prelp	proline arginine-rich end leucine-rich repeat	0.046
Megf8	multiple EGF-like-domains 8	0.046
Tbx3	T-box 3	0.046
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.046
Galnt2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2	0.046
Tgfb3	transforming growth factor, beta 3	0.046	Human Rat
Rspo1	R-spondin homolog (Xenopus laevis)	0.046
Wisp2	WNT1 inducible signaling pathway protein 2	0.046
Muc5ac	mucin 5, subtypes A and C, tracheobronchial/gastric	0.046
Sfrp4	secreted frizzled-related protein 4	0.045
Egr1	early growth response 1	0.045
Npas2	neuronal PAS domain protein 2	0.045
Epha3	Eph receptor A3	0.045
Pax6	paired box gene 6	0.045
Plxna1	plexin A1	0.045
Fhl1	four and a half LIM domains 1	0.045
Lrp5	low density lipoprotein receptor-related protein 5	0.045
Boll	bol, boule-like (Drosophila)	0.045
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.045
Tcl1	T-cell lymphoma breakpoint 1	0.045
Crhr2	corticotropin releasing hormone receptor 2	0.045
Shc3	src homology 2 domain-containing transforming protein C3	0.045
Slfn4	schlafen 4	0.045
Sav1	salvador homolog 1 (Drosophila)	0.044
Gdf3	growth differentiation factor 3	0.044
Ntsr1	neurotensin receptor 1	0.044
Fkbp10	FK506 binding protein 10	0.044
Osbpl11	oxysterol binding protein-like 11	0.044
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.044
T	brachyury	0.044
Map3k2	mitogen-activated protein kinase kinase kinase 2	0.044
Plagl1	pleiomorphic adenoma gene-like 1	0.044
Gabrq	gamma-aminobutyric acid (GABA) A receptor, subunit theta	0.044
Prlr	prolactin receptor	0.044
Sfn	stratifin	0.044
Aspn	asporin	0.044
Aoc3	amine oxidase, copper containing 3	0.043
Myh11	myosin, heavy polypeptide 11, smooth muscle	0.043
Hrh1	histamine receptor H1	0.043
Efemp1	epidermal growth factor-containing fibulin-like extracellular matrix protein 1	0.043	Mouse
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.043
Tcfap2a	transcription factor AP-2, alpha	0.043
Cd97	CD97 antigen	0.043
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.043
Slc12a4	solute carrier family 12, member 4	0.043
Cdh6	cadherin 6	0.043
Hoxa1	homeobox A1	0.043
1500015O10Rik	RIKEN cDNA 1500015O10 gene	0.043
Clec3b	C-type lectin domain family 3, member b	0.043
Ptpn13	protein tyrosine phosphatase, non-receptor type 13	0.043
Esyt2	extended synaptotagmin-like protein 2	0.043
Padi3	peptidyl arginine deiminase, type III	0.043
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.043
Plod3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.042
Rnf111	ring finger 111	0.042
Elk4	ELK4, member of ETS oncogene family	0.042
Amotl2	angiomotin-like 2	0.042
Atoh7	atonal homolog 7 (Drosophila)	0.042
Prg2	proteoglycan 2, bone marrow	0.042
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.042
Efna2	ephrin A2	0.042
Cd22	CD22 antigen	0.042
Map3k11	mitogen-activated protein kinase kinase kinase 11	0.042
Ikbkb	inhibitor of kappaB kinase beta	0.042
Wnt1	wingless-related MMTV integration site 1	0.042
Vps13c	vacuolar protein sorting 13C (yeast)	0.042
Serpine2	serine (or cysteine) peptidase inhibitor, clade E, member 2	0.042
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.042	Human Fly
Bicc1	bicaudal C homolog 1 (Drosophila)	0.042
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.042
Tm9sf3	transmembrane 9 superfamily member 3	0.041
F3	coagulation factor III	0.041
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.041
Iqgap1	IQ motif containing GTPase activating protein 1	0.041
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.041
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.041	Human Mouse
Hdac2	histone deacetylase 2	0.041
Pllp	plasma membrane proteolipid	0.041
Ddr2	discoidin domain receptor family, member 2	0.040
Sntb2	syntrophin, basic 2	0.040
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.040
Spast	spastin	0.040
Wrn	Werner syndrome homolog (human)	0.040
Ptprj	protein tyrosine phosphatase, receptor type, J	0.040
Prkab1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.040
Pdzrn3	PDZ domain containing RING finger 3	0.040
Axin2	axin2	0.040	Mouse
Iffo2	intermediate filament family orphan 2	0.040
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.040
Matn4	matrilin 4	0.040
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.040
Fstl1	follistatin-like 1	0.040
Leprel4	leprecan-like 4	0.039
Dsg4	desmoglein 4	0.039
Wnt7b	wingless-related MMTV integration site 7B	0.039	Mouse
Igfbp3	insulin-like growth factor binding protein 3	0.039
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.039
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.039
Hmga2	high mobility group AT-hook 2	0.039
Ptpra	protein tyrosine phosphatase, receptor type, A	0.039
Rfwd2	ring finger and WD repeat domain 2	0.039
Ptgir	prostaglandin I receptor (IP)	0.039
Phlda3	pleckstrin homology-like domain, family A, member 3	0.039
Timp3	tissue inhibitor of metalloproteinase 3	0.039
Fam129b	family with sequence similarity 129, member B	0.039
Msx2	homeobox, msh-like 2	0.038
Csf1r	colony stimulating factor 1 receptor	0.038
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.038
Gipc3	GIPC PDZ domain containing family, member 3	0.038	Mouse
Il17d	interleukin 17D	0.038
Pknox1	Pbx/knotted 1 homeobox	0.038
Gja1	gap junction protein, alpha 1	0.038
Adora2a	adenosine A2a receptor	0.038
Htra3	HtrA serine peptidase 3	0.038
Lefty1	left right determination factor 1	0.037
Epha1	Eph receptor A1	0.037
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.037
Mrgprf	MAS-related GPR, member F	0.037
Krt86	keratin 86	0.037
Col6a3	collagen, type VI, alpha 3	0.037
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.037
Pou3f2	POU domain, class 3, transcription factor 2	0.037
Adra1a	adrenergic receptor, alpha 1a	0.037
Rhob	ras homolog gene family, member B	0.037
Pkdcc	protein kinase domain containing, cytoplasmic	0.037
Pth1r	parathyroid hormone 1 receptor	0.037
Twist2	twist homolog 2 (Drosophila)	0.037
Fcer1a	Fc receptor, IgE, high affinity I, alpha polypeptide	0.037
Sphk1	sphingosine kinase 1	0.037
Ptpre	protein tyrosine phosphatase, receptor type, E	0.037
Sox7	SRY-box containing gene 7	0.037
Arid3a	AT rich interactive domain 3A (BRIGHT-like)	0.036
6330512M04Rik	RIKEN cDNA 6330512M04 gene	0.036
Rtkn	rhotekin	0.036
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.036
Pdlim3	PDZ and LIM domain 3	0.036
Tbx6	T-box 6	0.036
Prkce	protein kinase C, epsilon	0.036
L1cam	L1 cell adhesion molecule	0.036
Spag4	sperm associated antigen 4	0.036
Fkbp9	FK506 binding protein 9	0.036
Fads3	fatty acid desaturase 3	0.036
Lyzl4	lysozyme-like 4	0.036
Sgms1	sphingomyelin synthase 1	0.036
Foxd4	forkhead box D4	0.036
Il17ra	interleukin 17 receptor A	0.036
Myh10	myosin, heavy polypeptide 10, non-muscle	0.036
Il12b	interleukin 12b	0.036
Src	Rous sarcoma oncogene	0.036	Human
Fndc7	fibronectin type III domain containing 7	0.035
Mapk9	mitogen-activated protein kinase 9	0.035
Sypl	synaptophysin-like protein	0.035
Soat1	sterol O-acyltransferase 1	0.035
Zfp503	zinc finger protein 503	0.035
Rbpms	RNA binding protein gene with multiple splicing	0.035
Btbd3	BTB (POZ) domain containing 3	0.035
Socs1	suppressor of cytokine signaling 1	0.035
Efna1	ephrin A1	0.035
Cldn15	claudin 15	0.035
Rbp1	retinol binding protein 1, cellular	0.035
Lamc2	laminin, gamma 2	0.035
Hipk3	homeodomain interacting protein kinase 3	0.035	Mouse
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.035
Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.035
Mmp15	matrix metallopeptidase 15	0.035
Serping1	serine (or cysteine) peptidase inhibitor, clade G, member 1	0.035
C3ar1	complement component 3a receptor 1	0.035
Irf2bp2	interferon regulatory factor 2 binding protein 2	0.035
Prl3a1	prolactin family 3, subfamily a, member 1	0.035
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.035
Svep1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.035
Ggt5	gamma-glutamyltransferase 5	0.035
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.035
Nkain1	Na+/K+ transporting ATPase interacting 1	0.035
Atxn1	ataxin 1	0.034
Jub	ajuba	0.034	Mouse
Ptx3	pentraxin related gene	0.034
Lama1	laminin, alpha 1	0.034
Treml1	triggering receptor expressed on myeloid cells-like 1	0.034
Il10	interleukin 10	0.034
Cidec	cell death-inducing DFFA-like effector c	0.034	Mouse
Sox18	SRY-box containing gene 18	0.034
Nuak1	NUAK family, SNF1-like kinase, 1	0.034
5031439G07Rik	RIKEN cDNA 5031439G07 gene	0.034
Gata5	GATA binding protein 5	0.034
Mdk	midkine	0.034
4931408A02Rik	RIKEN cDNA 4931408A02 gene	0.034
Zc3h14	zinc finger CCCH type containing 14	0.034
Atp2c1	ATPase, Ca++-sequestering	0.034
Ndst4	N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4	0.034
Tgif2	TGFB-induced factor homeobox 2	0.034
Tmem132c	transmembrane protein 132C	0.034
Nfia	nuclear factor I/A	0.034
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.034
Pax7	paired box gene 7	0.034
Sipa1	signal-induced proliferation associated gene 1	0.034
Tcf3	transcription factor 3	0.034
Rps6ka1	ribosomal protein S6 kinase polypeptide 1	0.034
Bmp8a	bone morphogenetic protein 8a	0.034	Mouse
Aff4	AF4/FMR2 family, member 4	0.034
Shisa9	shisa homolog 9 (Xenopus laevis)	0.034
Btg2	B-cell translocation gene 2, anti-proliferative	0.034
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.033
Tssk6	testis-specific serine kinase 6	0.033
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.033
Sh3bp1	SH3-domain binding protein 1	0.033
Shroom1	shroom family member 1	0.033
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.033
Pkn2	protein kinase N2	0.033
P2ry2	purinergic receptor P2Y, G-protein coupled 2	0.033
Adra2b	adrenergic receptor, alpha 2b	0.033
Lefty2	left-right determination factor 2	0.033
Pofut1	protein O-fucosyltransferase 1	0.033
Cacna1e	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.033	Worm
Prss23	protease, serine, 23	0.033
Tmod3	tropomodulin 3	0.033
Cd38	CD38 antigen	0.033
Tnni1	troponin I, skeletal, slow 1	0.033
Edar	ectodysplasin-A receptor	0.033
Diap1	diaphanous homolog 1 (Drosophila)	0.033
Chpf	chondroitin polymerizing factor	0.033
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.033
Usp43	ubiquitin specific peptidase 43	0.033
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.033
Map2k4	mitogen-activated protein kinase kinase 4	0.032
Ctnna1	catenin (cadherin associated protein), alpha 1	0.032
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.032
Vax1	ventral anterior homeobox containing gene 1	0.032
Nlrp3	NLR family, pyrin domain containing 3	0.032
Cd180	CD180 antigen	0.032
Oprd1	opioid receptor, delta 1	0.032
Trim47	tripartite motif-containing 47	0.032
Cspg4	chondroitin sulfate proteoglycan 4	0.032
Sox15	SRY-box containing gene 15	0.032
4921536K21Rik	RIKEN cDNA 4921536K21 gene	0.032
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.032
Zfp36	zinc finger protein 36	0.032