IMP: Integrative Multi-species Prediction

Mus musculus

2 genes annotated in mouse

Multi-species View

positive regulation of mitotic sister chromatid separation

GO:1901970

Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of mitotic sister chromatid separation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of mitotic sister chromatid separation" (in gray)

Name	Description	Probability	Func Analog Organism
Ctnnb1	catenin (cadherin associated protein), beta 1	1.000
Trp53	transformation related protein 53	1.000
Pten	phosphatase and tensin homolog	0.997
Apc	adenomatosis polyposis coli	0.989
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.968
Ccnb2	cyclin B2	0.946
Ccna2	cyclin A2	0.860
Cdk1	cyclin-dependent kinase 1	0.859
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.839
Plk1	polo-like kinase 1 (Drosophila)	0.813	Human
Ccnb1	cyclin B1	0.769
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.734
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.676
H2afx	H2A histone family, member X	0.561
Rb1	retinoblastoma 1	0.529	Human
Atf2	activating transcription factor 2	0.525
Kif22	kinesin family member 22	0.502
Birc5	baculoviral IAP repeat-containing 5	0.496
Cdca8	cell division cycle associated 8	0.480
Psen1	presenilin 1	0.469
Chd7	chromodomain helicase DNA binding protein 7	0.465
Aurkb	aurora kinase B	0.438
Mki67	antigen identified by monoclonal antibody Ki 67	0.406
Kit	kit oncogene	0.392
Prc1	protein regulator of cytokinesis 1	0.389
Smad4	MAD homolog 4 (Drosophila)	0.373
Kif20a	kinesin family member 20A	0.367
Ccnf	cyclin F	0.332
Axin1	axin 1	0.274
Mdm2	transformed mouse 3T3 cell double minute 2	0.271
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.271
Cdca5	cell division cycle associated 5	0.270
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.252	Yeast Fly
Cenpa	centromere protein A	0.225
Ckap2	cytoskeleton associated protein 2	0.222
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.203
Notch1	Notch gene homolog 1 (Drosophila)	0.177
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.167
Brca1	breast cancer 1	0.166
Kif4	kinesin family member 4	0.156
Spag5	sperm associated antigen 5	0.149
Racgap1	Rac GTPase-activating protein 1	0.137
Aurka	aurora kinase A	0.136
Ythdf3	YTH domain family 3	0.136
Lrp6	low density lipoprotein receptor-related protein 6	0.133
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.132
Braf	Braf transforming gene	0.128
D2Ertd750e	DNA segment, Chr 2, ERATO Doi 750, expressed	0.127
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.124
Stil	Scl/Tal1 interrupting locus	0.122
Lmnb1	lamin B1	0.120
Bmi1	Bmi1 polycomb ring finger oncogene	0.119
Kif2c	kinesin family member 2C	0.117
Dlg1	discs, large homolog 1 (Drosophila)	0.114
Ube2c	ubiquitin-conjugating enzyme E2C	0.113	Fly
Cdkn3	cyclin-dependent kinase inhibitor 3	0.110
Ptch1	patched homolog 1	0.110
Wdr26	WD repeat domain 26	0.109
Nf2	neurofibromatosis 2	0.107
E2f1	E2F transcription factor 1	0.105
Ash1l	ash1 (absent, small, or homeotic)-like (Drosophila)	0.103
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.100
Ncapg	non-SMC condensin I complex, subunit G	0.095
Hif1a	hypoxia inducible factor 1, alpha subunit	0.094
Kif23	kinesin family member 23	0.092
Rrm2	ribonucleotide reductase M2	0.091
Melk	maternal embryonic leucine zipper kinase	0.091
Bmp4	bone morphogenetic protein 4	0.086
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.085
Kif11	kinesin family member 11	0.082
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.078
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.078
Rbl2	retinoblastoma-like 2	0.076
Cenpn	centromere protein N	0.076
Ranbp9	RAN binding protein 9	0.075
Tcf3	transcription factor 3	0.069
Top2b	topoisomerase (DNA) II beta	0.069
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.065
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.062
Ncaph	non-SMC condensin I complex, subunit H	0.059
Mgea5	meningioma expressed antigen 5 (hyaluronidase)	0.057
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.056
Ckap2l	cytoskeleton associated protein 2-like	0.056
Capn7	calpain 7	0.055
Gtse1	G two S phase expressed protein 1	0.054
Arid1a	AT rich interactive domain 1A (SWI-like)	0.053
Kitl	kit ligand	0.053
Espl1	extra spindle poles-like 1 (S. cerevisiae)	0.052
Fam64a	family with sequence similarity 64, member A	0.051
Incenp	inner centromere protein	0.050
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.048
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.048
Zc3h14	zinc finger CCCH type containing 14	0.048
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.047
Fam108a	family with sequence similarity 108, member A	0.045
Dyrk1a	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	0.044
Cul3	cullin 3	0.043	Human
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.042
BC018507	cDNA sequence BC018507	0.040
Shcbp1	Shc SH2-domain binding protein 1	0.040
Larp4b	La ribonucleoprotein domain family, member 4B	0.039
Dazap1	DAZ associated protein 1	0.038
Slmap	sarcolemma associated protein	0.038
Apaf1	apoptotic peptidase activating factor 1	0.037
Ncor1	nuclear receptor co-repressor 1	0.037
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.036
Col1a1	collagen, type I, alpha 1	0.035
Spnb2	spectrin beta 2	0.034
Crebbp	CREB binding protein	0.034
Nuf2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.034
Ncapd2	non-SMC condensin I complex, subunit D2	0.033
Kntc1	kinetochore associated 1	0.033
Rad51ap1	RAD51 associated protein 1	0.033
Chuk	conserved helix-loop-helix ubiquitous kinase	0.032
Pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.031
Mef2a	myocyte enhancer factor 2A	0.031
Pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.031
Gsk3b	glycogen synthase kinase 3 beta	0.031	Fly
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.030
Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	0.030
Cdc25b	cell division cycle 25 homolog B (S. pombe)	0.029
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.029
Ppp1cb	protein phosphatase 1, catalytic subunit, beta isoform	0.028
Mxd3	Max dimerization protein 3	0.028
Tk1	thymidine kinase 1	0.028
Lin7c	lin-7 homolog C (C. elegans)	0.028
Strn3	striatin, calmodulin binding protein 3	0.028
Ccnd1	cyclin D1	0.027
Cenpf	centromere protein F	0.027
Foxo3	forkhead box O3	0.027
Mbd3	methyl-CpG binding domain protein 3	0.027
Ssbp4	single stranded DNA binding protein 4	0.026
Smad2	MAD homolog 2 (Drosophila)	0.026
Zeb1	zinc finger E-box binding homeobox 1	0.026
Rab18	RAB18, member RAS oncogene family	0.026
Prmt5	protein arginine N-methyltransferase 5	0.025
Ube3a	ubiquitin protein ligase E3A	0.025
Apoe	apolipoprotein E	0.025
Trappc10	trafficking protein particle complex 10	0.025
Fas	Fas (TNF receptor superfamily member 6)	0.025
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.025
Lig1	ligase I, DNA, ATP-dependent	0.024
Npc1	Niemann Pick type C1	0.023
Thra	thyroid hormone receptor alpha	0.023
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	0.023
Akt1	thymoma viral proto-oncogene 1	0.023
Mybl2	myeloblastosis oncogene-like 2	0.022
Rab10	RAB10, member RAS oncogene family	0.022
Zmym2	zinc finger, MYM-type 2	0.022
Dgcr2	DiGeorge syndrome critical region gene 2	0.022
Efnb2	ephrin B2	0.022
Kif2a	kinesin family member 2A	0.021
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.021
Asna1	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)	0.021
Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	0.021
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.021
Diap3	diaphanous homolog 3 (Drosophila)	0.021
Son	Son DNA binding protein	0.021
Oxr1	oxidation resistance 1	0.021
Men1	multiple endocrine neoplasia 1	0.020
Eea1	early endosome antigen 1	0.020
Pde7a	phosphodiesterase 7A	0.020
Mcm5	minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)	0.019
Pbk	PDZ binding kinase	0.019
Tacc3	transforming, acidic coiled-coil containing protein 3	0.019
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.019
Sp3	trans-acting transcription factor 3	0.019
Hcfc1	host cell factor C1	0.019
Cab39	calcium binding protein 39	0.019
Tsc2	tuberous sclerosis 2	0.018
Csde1	cold shock domain containing E1, RNA binding	0.018
Zbtb45	zinc finger and BTB domain containing 45	0.018
Ppp4c	protein phosphatase 4, catalytic subunit	0.018
Meox2	mesenchyme homeobox 2	0.018
Stk11	serine/threonine kinase 11	0.018
Kpna1	karyopherin (importin) alpha 1	0.018
Stag2	stromal antigen 2	0.017
Bag6	BCL2-associated athanogene 6	0.017
Mapk1	mitogen-activated protein kinase 1	0.017
Git1	G protein-coupled receptor kinase-interactor 1	0.017
Myo6	myosin VI	0.017
Top2a	topoisomerase (DNA) II alpha	0.017
Brca2	breast cancer 2	0.017
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.017
Rnf26	ring finger protein 26	0.017
Senp6	SUMO/sentrin specific peptidase 6	0.017
Fbxo5	F-box protein 5	0.017
Mta2	metastasis-associated gene family, member 2	0.017
Vegfa	vascular endothelial growth factor A	0.017
Psap	prosaposin	0.017
Serinc1	serine incorporator 1	0.017
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.017
Sgol1	shugoshin-like 1 (S. pombe)	0.016
Hist1h2ao	histone cluster 1, H2ao	0.016
Fgfr2	fibroblast growth factor receptor 2	0.016
Ddx3x	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked	0.016
Qk	quaking	0.016
Sgta	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	0.016
Dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36	0.016
Otud4	OTU domain containing 4	0.016
Sec61a2	Sec61, alpha subunit 2 (S. cerevisiae)	0.016
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.016
Ube2d3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.015
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.015
Zmiz2	zinc finger, MIZ-type containing 2	0.015
Gtf2a1	general transcription factor II A, 1	0.015
Cdca2	cell division cycle associated 2	0.015
Foxc1	forkhead box C1	0.015
Rasa1	RAS p21 protein activator 1	0.015
Arid1b	AT rich interactive domain 1B (SWI-like)	0.015
Epn1	epsin 1	0.015
Impad1	inositol monophosphatase domain containing 1	0.015
Smad3	MAD homolog 3 (Drosophila)	0.015
Tcf19	transcription factor 19	0.015
Rcc1	regulator of chromosome condensation 1	0.014
Fbxl3	F-box and leucine-rich repeat protein 3	0.014
Ubr3	ubiquitin protein ligase E3 component n-recognin 3	0.014
Mpp5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	0.014
Fgfr1	fibroblast growth factor receptor 1	0.014
Sos2	son of sevenless homolog 2 (Drosophila)	0.014
Senp2	SUMO/sentrin specific peptidase 2	0.014
Atp2c1	ATPase, Ca++-sequestering	0.014
Tab3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.014
Cep55	centrosomal protein 55	0.014
Spc24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.014
Arid2	AT rich interactive domain 2 (ARID, RFX-like)	0.014
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.014
Usp33	ubiquitin specific peptidase 33	0.014
2810417H13Rik	RIKEN cDNA 2810417H13 gene	0.014
AW549877	expressed sequence AW549877	0.014
Ppp3cb	protein phosphatase 3, catalytic subunit, beta isoform	0.014
Depdc1a	DEP domain containing 1a	0.014
Anapc1	anaphase promoting complex subunit 1	0.013
E2f8	E2F transcription factor 8	0.013
Mcrs1	microspherule protein 1	0.013
Prrc2b	proline-rich coiled-coil 2B	0.013
Gipc1	GIPC PDZ domain containing family, member 1	0.013
Gja1	gap junction protein, alpha 1	0.013
Mapk8	mitogen-activated protein kinase 8	0.013
Trim23	tripartite motif-containing 23	0.013
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.013	Yeast Fly
Ap2s1	adaptor-related protein complex 2, sigma 1 subunit	0.013
Hivep1	human immunodeficiency virus type I enhancer binding protein 1	0.013
Adam17	a disintegrin and metallopeptidase domain 17	0.013
Ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.013
Iqgap3	IQ motif containing GTPase activating protein 3	0.013
Dcaf15	DDB1 and CUL4 associated factor 15	0.013
Ncoa1	nuclear receptor coactivator 1	0.013
Ep300	E1A binding protein p300	0.013
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.012
Ccne1	cyclin E1	0.012
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.012
Ncoa6	nuclear receptor coactivator 6	0.012
Tsc1	tuberous sclerosis 1	0.012
Pja2	praja 2, RING-H2 motif containing	0.012
Hes1	hairy and enhancer of split 1 (Drosophila)	0.012
Atf6b	activating transcription factor 6 beta	0.012
Msl1	male-specific lethal 1 homolog (Drosophila)	0.012
Arhgap21	Rho GTPase activating protein 21	0.012
Lepr	leptin receptor	0.012
Stat3	signal transducer and activator of transcription 3	0.012
Ireb2	iron responsive element binding protein 2	0.012
Ahr	aryl-hydrocarbon receptor	0.012
Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.012
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.012
BC005537	cDNA sequence BC005537	0.012
Dnmt1	DNA methyltransferase (cytosine-5) 1	0.012
Gphn	gephyrin	0.012
Fgfr3	fibroblast growth factor receptor 3	0.012
Prr11	proline rich 11	0.012
Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.012
Vhl	von Hippel-Lindau tumor suppressor	0.012
Tubgcp2	tubulin, gamma complex associated protein 2	0.012
Arid4b	AT rich interactive domain 4B (RBP1-like)	0.012
Etnk1	ethanolamine kinase 1	0.012
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.012
Haus4	HAUS augmin-like complex, subunit 4	0.012
Pmf1	polyamine-modulated factor 1	0.012
Slc12a2	solute carrier family 12, member 2	0.011
Rfwd2	ring finger and WD repeat domain 2	0.011
Atxn7l3	ataxin 7-like 3	0.011
Ehmt2	euchromatic histone lysine N-methyltransferase 2	0.011
Vangl2	vang-like 2 (van gogh, Drosophila)	0.011
Rnf111	ring finger 111	0.011
Htt	huntingtin	0.011
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.011
Lypla2	lysophospholipase 2	0.011
E130306D19Rik	RIKEN cDNA E130306D19 gene	0.011
Ube2g1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)	0.011
Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)	0.011
Rfc5	replication factor C (activator 1) 5	0.011
Cpeb4	cytoplasmic polyadenylation element binding protein 4	0.010
Wls	wntless homolog (Drosophila)	0.010
Kpna3	karyopherin (importin) alpha 3	0.010
Depdc1b	DEP domain containing 1B	0.010
Traf7	TNF receptor-associated factor 7	0.010
Ndfip1	Nedd4 family interacting protein 1	0.010
Add1	adducin 1 (alpha)	0.010
Vps26b	vacuolar protein sorting 26 homolog B (yeast)	0.010
Bptf	bromodomain PHD finger transcription factor	0.010
Rac1	RAS-related C3 botulinum substrate 1	0.010