IMP: Integrative Multi-species Prediction

Mus musculus

15 genes annotated in mouse

Multi-species View

negative regulation of gene expression epigenetic

GO:0045814

Any epigenetic process that stops, prevents or reduces the rate of gene expression.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of gene expression epigenetic"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of gene expression epigenetic" (in gray)

Name	Description	Probability	Func Analog Organism
Rnf2	ring finger protein 2	0.999	Worm Fly
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.996
Pou5f1	POU domain, class 5, transcription factor 1	0.996	Human
Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.993
Rbbp4	retinoblastoma binding protein 4	0.970	Yeast Fly
Hdac1	histone deacetylase 1	0.960	Fly
Ezh2	enhancer of zeste homolog 2 (Drosophila)	0.896	Human
Arid1b	AT rich interactive domain 1B (SWI-like)	0.886	Mouse
Mcm2	minichromosome maintenance deficient 2 mitotin (S. cerevisiae)	0.813
Arid1a	AT rich interactive domain 1A (SWI-like)	0.801
Ctcf	CCCTC-binding factor	0.789
Rybp	RING1 and YY1 binding protein	0.670
Trp53	transformation related protein 53	0.655
Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	0.565
Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	0.559	Yeast
H3f3a	H3 histone, family 3A	0.542
Brca1	breast cancer 1	0.508
Chd4	chromodomain helicase DNA binding protein 4	0.502
Smc1a	structural maintenance of chromosomes 1A	0.489
Smc3	structural maintenace of chromosomes 3	0.467
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.434
Hdac2	histone deacetylase 2	0.410	Human Fly
Dnmt1	DNA methyltransferase (cytosine-5) 1	0.376
Wdr5	WD repeat domain 5	0.369
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.366
Cbx5	chromobox homolog 5 (Drosophila HP1a)	0.355	Fly
Igh	immunoglobulin heavy chain complex	0.348
Ep400	E1A binding protein p400	0.346
Ep300	E1A binding protein p300	0.316
Mecp2	methyl CpG binding protein 2	0.310
Mll3	myeloid/lymphoid or mixed-lineage leukemia 3	0.304
Stag1	stromal antigen 1	0.292
Tcf3	transcription factor 3	0.286
Ash2l	ash2 (absent, small, or homeotic)-like (Drosophila)	0.271
Nanog	Nanog homeobox	0.269
Sin3a	transcriptional regulator, SIN3A (yeast)	0.256	Human Yeast
Mcm5	minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)	0.240	Yeast
Kdm2b	lysine (K)-specific demethylase 2B	0.240
Mcm7	minichromosome maintenance deficient 7 (S. cerevisiae)	0.234	Yeast
Mta2	metastasis-associated gene family, member 2	0.229
Cdt1	chromatin licensing and DNA replication factor 1	0.170
Dnmt3b	DNA methyltransferase 3B	0.158
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.154
Sp1	trans-acting transcription factor 1	0.149
Arid2	AT rich interactive domain 2 (ARID, RFX-like)	0.136	Fly
Timeless	timeless homolog (Drosophila)	0.129
Trim28	tripartite motif-containing 28	0.127
Cdk1	cyclin-dependent kinase 1	0.121
Pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.119
Rcc2	regulator of chromosome condensation 2	0.117
Mta1	metastasis associated 1	0.106
Hells	helicase, lymphoid specific	0.106
Hist1h3g	histone cluster 1, H3g	0.105
Crebbp	CREB binding protein	0.105
Ccna2	cyclin A2	0.101
Bmi1	Bmi1 polycomb ring finger oncogene	0.101	Fly
E2f1	E2F transcription factor 1	0.101
Atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.097	Fly
Lig1	ligase I, DNA, ATP-dependent	0.094
Tcfcp2l1	transcription factor CP2-like 1	0.086
Mga	MAX gene associated	0.082
Cbx8	chromobox homolog 8 (Drosophila Pc class)	0.073
Dnmt3a	DNA methyltransferase 3A	0.071
Brd4	bromodomain containing 4	0.070
Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.069	Yeast Mouse
Brca2	breast cancer 2	0.065
Parp1	poly (ADP-ribose) polymerase family, member 1	0.063
Plk1	polo-like kinase 1 (Drosophila)	0.062
Lrwd1	leucine-rich repeats and WD repeat domain containing 1	0.062
Phc2	polyhomeotic-like 2 (Drosophila)	0.061
Matr3	matrin 3	0.061
Csnk1a1	casein kinase 1, alpha 1	0.060
Skp1a	S-phase kinase-associated protein 1A	0.059
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.059
Trim24	tripartite motif-containing 24	0.057
Safb	scaffold attachment factor B	0.054
Creb1	cAMP responsive element binding protein 1	0.054
Ccnb2	cyclin B2	0.053
Supt16h	suppressor of Ty 16 homolog (S. cerevisiae)	0.052
Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.052
Erg	avian erythroblastosis virus E-26 (v-ets) oncogene related	0.050
Hmgb1	high mobility group box 1	0.050
Tfdp1	transcription factor Dp 1	0.048
Krit1	KRIT1, ankyrin repeat containing	0.047
H2afz	H2A histone family, member Z	0.045	Yeast
Suds3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.044
Msh2	mutS homolog 2 (E. coli)	0.043	Yeast
Rrm1	ribonucleotide reductase M1	0.043
Rest	RE1-silencing transcription factor	0.042
Sae1	SUMO1 activating enzyme subunit 1	0.042
Pcgf2	polycomb group ring finger 2	0.041	Fly
Sp4	trans-acting transcription factor 4	0.041
Ilf3	interleukin enhancer binding factor 3	0.039
Eed	embryonic ectoderm development	0.039	Fly
Jarid2	jumonji, AT rich interactive domain 2	0.037
Scaf11	SR-related CTD-associated factor 11	0.037
Lmnb1	lamin B1	0.037	Fly
Pcgf6	polycomb group ring finger 6	0.037
Nucks1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.037
Cdk2	cyclin-dependent kinase 2	0.036
Orc6	origin recognition complex, subunit 6	0.036
Bptf	bromodomain PHD finger transcription factor	0.035
Ikzf1	IKAROS family zinc finger 1	0.035
Pms2	postmeiotic segregation increased 2 (S. cerevisiae)	0.035
Mbtd1	mbt domain containing 1	0.034	Fly
Ncapd2	non-SMC condensin I complex, subunit D2	0.033
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.033	Fly
Atm	ataxia telangiectasia mutated homolog (human)	0.032	Fly
Chd7	chromodomain helicase DNA binding protein 7	0.032
Hcfc1	host cell factor C1	0.032
Tcf12	transcription factor 12	0.032
L3mbtl2	l(3)mbt-like 2 (Drosophila)	0.031	Fly
Cdca8	cell division cycle associated 8	0.031
Rcc1	regulator of chromosome condensation 1	0.031
Baz1b	bromodomain adjacent to zinc finger domain, 1B	0.031
Usp7	ubiquitin specific peptidase 7	0.031	Fly
Runx1	runt related transcription factor 1	0.030
Cdca7	cell division cycle associated 7	0.030
Sos2	son of sevenless homolog 2 (Drosophila)	0.030
Ddx3y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked	0.030
Ptma	prothymosin alpha	0.030
Ncaph	non-SMC condensin I complex, subunit H	0.030
Rb1	retinoblastoma 1	0.029
Orc1	origin recognition complex, subunit 1	0.029
Ehmt1	euchromatic histone methyltransferase 1	0.028
Ncor1	nuclear receptor co-repressor 1	0.028
Anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.028
Hdac3	histone deacetylase 3	0.028
Sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.028
Whsc1	Wolf-Hirschhorn syndrome candidate 1 (human)	0.027
Fbxo5	F-box protein 5	0.026
Ring1	ring finger protein 1	0.026	Worm Fly
Smc2	structural maintenance of chromosomes 2	0.026
Nipbl	Nipped-B homolog (Drosophila)	0.026
Srrt	serrate RNA effector molecule homolog (Arabidopsis)	0.026
Rrm2	ribonucleotide reductase M2	0.026
Cdk4	cyclin-dependent kinase 4	0.025
Yy1	YY1 transcription factor	0.025	Fly
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.025
Hnrnpk	heterogeneous nuclear ribonucleoprotein K	0.025
Pou2f1	POU domain, class 2, transcription factor 1	0.025
Rfc5	replication factor C (activator 1) 5	0.025
Max	Max protein	0.025
Hnrnpu	heterogeneous nuclear ribonucleoprotein U	0.024
Kdm5b	lysine (K)-specific demethylase 5B	0.024
Cry1	cryptochrome 1 (photolyase-like)	0.024
Pcna	proliferating cell nuclear antigen	0.024
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.023
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.023
Smarcc2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.023
Csnk2a1	casein kinase 2, alpha 1 polypeptide	0.023
Hist1h2bc	histone cluster 1, H2bc	0.022
Ccne1	cyclin E1	0.022
Smarcb1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.022
Fen1	flap structure specific endonuclease 1	0.022
Chaf1a	chromatin assembly factor 1, subunit A (p150)	0.021
Nono	non-POU-domain-containing, octamer binding protein	0.021
Cbx7	chromobox homolog 7	0.021
Dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36	0.021
Wdhd1	WD repeat and HMG-box DNA binding protein 1	0.021
Bcor	BCL6 interacting corepressor	0.021
BC005537	cDNA sequence BC005537	0.021
Plcg2	phospholipase C, gamma 2	0.020
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.020
Mybbp1a	MYB binding protein (P160) 1a	0.020
Pold3	polymerase (DNA-directed), delta 3, accessory subunit	0.020
Fmr1	fragile X mental retardation syndrome 1 homolog	0.020
Pten	phosphatase and tensin homolog	0.020
Hnrnpr	heterogeneous nuclear ribonucleoprotein R	0.020
Mms22l	MMS22-like, DNA repair protein	0.019
Cdca5	cell division cycle associated 5	0.019
Ckap5	cytoskeleton associated protein 5	0.019
Xrn1	5'-3' exoribonuclease 1	0.019
Rpa2	replication protein A2	0.019
Eftud2	elongation factor Tu GTP binding domain containing 2	0.019
Pabpn1	poly(A) binding protein, nuclear 1	0.019
Mdm4	transformed mouse 3T3 cell double minute 4	0.019
H2afx	H2A histone family, member X	0.018	Yeast
Zc3h18	zinc finger CCCH-type containing 18	0.018
Rbm14	RNA binding motif protein 14	0.018
Smarce1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.018
Cbx2	chromobox homolog 2 (Drosophila Pc class)	0.018
Pabpc1	poly(A) binding protein, cytoplasmic 1	0.018
Ptges3	prostaglandin E synthase 3 (cytosolic)	0.018
Dek	DEK oncogene (DNA binding)	0.017
Nasp	nuclear autoantigenic sperm protein (histone-binding)	0.017
Jmjd1c	jumonji domain containing 1C	0.017	Fly
Ccnf	cyclin F	0.017
Arid4b	AT rich interactive domain 4B (RBP1-like)	0.016
Ppp2ca	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	0.016
Smc6	structural maintenance of chromosomes 6	0.016
Rnf220	ring finger protein 220	0.016
Acin1	apoptotic chromatin condensation inducer 1	0.016
Brd8	bromodomain containing 8	0.016
Sox2	SRY-box containing gene 2	0.016
Pcgf1	polycomb group ring finger 1	0.016
Atad2b	ATPase family, AAA domain containing 2B	0.016
Nup85	nucleoporin 85	0.016
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.015
Kdm6a	4lysine (K)-specific demethylase 6A	0.015	Mouse
Top2b	topoisomerase (DNA) II beta	0.015	Fly
Morf4l1	mortality factor 4 like 1	0.015
Suv39h1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.015	Human
Myf5	myogenic factor 5	0.015
Spast	spastin	0.015
Rev3l	REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)	0.014
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.014	Yeast
Ube2c	ubiquitin-conjugating enzyme E2C	0.014
Rbbp6	retinoblastoma binding protein 6	0.014
Trrap	transformation/transcription domain-associated protein	0.014
Akap9	A kinase (PRKA) anchor protein (yotiao) 9	0.014
Dnmt3l	DNA (cytosine-5-)-methyltransferase 3-like	0.014	Mouse
U2af2	U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2	0.014
Mael	maelstrom homolog (Drosophila)	0.014
Prim1	DNA primase, p49 subunit	0.014
Lbr	lamin B receptor	0.014
Blzf1	basic leucine zipper nuclear factor 1	0.014
Dnajc9	DnaJ (Hsp40) homolog, subfamily C, member 9	0.013
Asf1a	ASF1 anti-silencing function 1 homolog A (S. cerevisiae)	0.013
Sept7	septin 7	0.013
Phc1	polyhomeotic-like 1 (Drosophila)	0.013
Ctbp2	C-terminal binding protein 2	0.013
Cdc73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.013
Zfp292	zinc finger protein 292	0.013
Tcf19	transcription factor 19	0.013
Cse1l	chromosome segregation 1-like (S. cerevisiae)	0.013
Tnrc6b	trinucleotide repeat containing 6b	0.013
Zbtb33	zinc finger and BTB domain containing 33	0.013
Rqcd1	rcd1 (required for cell differentiation) homolog 1 (S. pombe)	0.013
Mcm6	minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)	0.013
Nup188	nucleoporin 188	0.013
Mphosph9	M-phase phosphoprotein 9	0.013
Cenpn	centromere protein N	0.013
Cabin1	calcineurin binding protein 1	0.013
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.013
Men1	multiple endocrine neoplasia 1	0.012
Chordc1	cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1	0.012
Trim32	tripartite motif-containing 32	0.012
Top2a	topoisomerase (DNA) II alpha	0.012
March7	membrane-associated ring finger (C3HC4) 7	0.012
Rpa1	replication protein A1	0.012
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.012
Cbfb	core binding factor beta	0.012
Nacc1	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	0.012
Hist2h3c1	histone cluster 2, H3c1	0.012
Prc1	protein regulator of cytokinesis 1	0.012
Rbl2	retinoblastoma-like 2	0.012
Tpr	translocated promoter region	0.012
Ppp1cb	protein phosphatase 1, catalytic subunit, beta isoform	0.012
Sall4	sal-like 4 (Drosophila)	0.012
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.012
C80913	expressed sequence C80913	0.012
Piwil2	piwi-like homolog 2 (Drosophila)	0.012	Fly
Gtf3c2	general transcription factor IIIC, polypeptide 2, beta	0.011
Hn1	hematological and neurological expressed sequence 1	0.011
Ewsr1	Ewing sarcoma breakpoint region 1	0.011
Cramp1l	Crm, cramped-like (Drosophila)	0.011
Yaf2	YY1 associated factor 2	0.011
Wnk1	WNK lysine deficient protein kinase 1	0.011
Ncapd3	non-SMC condensin II complex, subunit D3	0.011
Cad	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	0.011
Mdm2	transformed mouse 3T3 cell double minute 2	0.011
Phc3	polyhomeotic-like 3 (Drosophila)	0.011
Ints7	integrator complex subunit 7	0.011
Bclaf1	BCL2-associated transcription factor 1	0.011
Dtl	denticleless homolog (Drosophila)	0.011
Zscan4b	zinc finger and SCAN domain containing 4B	0.011
Kntc1	kinetochore associated 1	0.011
Casp2	caspase 2	0.011
Zfp148	zinc finger protein 148	0.011
Kif22	kinesin family member 22	0.011
Epc1	enhancer of polycomb homolog 1 (Drosophila)	0.010	Human
Kdm1a	lysine (K)-specific demethylase 1A	0.010
Bod1l	biorientation of chromosomes in cell division 1-like	0.010
Chtf18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.010
Eme1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.010
Hira	histone cell cycle regulation defective homolog A (S. cerevisiae)	0.010
Ankhd1	ankyrin repeat and KH domain containing 1	0.010
Rfc1	replication factor C (activator 1) 1	0.010