IMP: Integrative Multi-species Prediction

Mus musculus

23 genes annotated in mouse

Multi-species View

negative regulation of protein localization to nucleus

GO:1900181

Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein localization to nucleus"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of protein localization to nucleus" (in gray)

Name	Description	Probability	Func Analog Organism
Yap1	yes-associated protein 1	0.808
Ctnnb1	catenin (cadherin associated protein), beta 1	0.771
Trp53	transformation related protein 53	0.602	Fly
Apc	adenomatosis polyposis coli	0.598
Rarg	retinoic acid receptor, gamma	0.584	Mouse
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.452
Casp1	caspase 1	0.372
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.295
Grb10	growth factor receptor bound protein 10	0.287
Gli3	GLI-Kruppel family member GLI3	0.281
Thra	thyroid hormone receptor alpha	0.256
Trp63	transformation related protein 63	0.240	Fly
Ncoa3	nuclear receptor coactivator 3	0.237
Axin1	axin 1	0.226
Rara	retinoic acid receptor, alpha	0.211	Mouse
Pycard	PYD and CARD domain containing	0.186
Rxra	retinoid X receptor alpha	0.171
Gopc	golgi associated PDZ and coiled-coil motif containing	0.134
Iigp1	interferon inducible GTPase 1	0.116
Aim2	absent in melanoma 2	0.109
Fgfr1	fibroblast growth factor receptor 1	0.100
Gbp2	guanylate binding protein 2	0.094	Mouse
Rnf115	ring finger protein 115	0.088
Smad3	MAD homolog 3 (Drosophila)	0.087
Kitl	kit ligand	0.072
Fzd8	frizzled homolog 8 (Drosophila)	0.072	Mouse
Dlg2	discs, large homolog 2 (Drosophila)	0.067
Bcl2	B-cell leukemia/lymphoma 2	0.065
Ikbkg	inhibitor of kappaB kinase gamma	0.064
Bicc1	bicaudal C homolog 1 (Drosophila)	0.060
Il6st	interleukin 6 signal transducer	0.058
Smad6	MAD homolog 6 (Drosophila)	0.057
Slc12a6	solute carrier family 12, member 6	0.057
Rras	Harvey rat sarcoma oncogene, subgroup R	0.054
Smo	smoothened homolog (Drosophila)	0.054
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.053
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.052
Notch2	Notch gene homolog 2 (Drosophila)	0.051
Htt	huntingtin	0.050
Casp12	caspase 12	0.049
Mapkap1	mitogen-activated protein kinase associated protein 1	0.047
Pax8	paired box gene 8	0.046
Pax2	paired box gene 2	0.045
Mdm2	transformed mouse 3T3 cell double minute 2	0.044
Pten	phosphatase and tensin homolog	0.043	Worm
Dlg1	discs, large homolog 1 (Drosophila)	0.042
Nmi	N-myc (and STAT) interactor	0.040
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.039
Bcl3	B-cell leukemia/lymphoma 3	0.039
Sox4	SRY-box containing gene 4	0.039
Pbx1	pre B-cell leukemia transcription factor 1	0.039
Wnt9b	wingless-type MMTV integration site 9B	0.038
Hes1	hairy and enhancer of split 1 (Drosophila)	0.037
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.037
Meox2	mesenchyme homeobox 2	0.035
Twist2	twist homolog 2 (Drosophila)	0.035
Fzd1	frizzled homolog 1 (Drosophila)	0.034
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.032
Fzd2	frizzled homolog 2 (Drosophila)	0.032	Mouse
Flot1	flotillin 1	0.030
Lef1	lymphoid enhancer binding factor 1	0.030
Sap18	Sin3-associated polypeptide 18	0.029
Tbx3	T-box 3	0.028
Duox2	dual oxidase 2	0.028
Arhgef25	Rho guanine nucleotide exchange factor (GEF) 25	0.028
Rptor	regulatory associated protein of MTOR, complex 1	0.028
Efnb1	ephrin B1	0.028
Dlg4	discs, large homolog 4 (Drosophila)	0.028
Marveld1	MARVEL (membrane-associating) domain containing 1	0.028
Sorbs3	sorbin and SH3 domain containing 3	0.027
Fgfr2	fibroblast growth factor receptor 2	0.027
Rhbdf1	rhomboid family 1 (Drosophila)	0.026
Megf8	multiple EGF-like-domains 8	0.026
Ncor1	nuclear receptor co-repressor 1	0.026
Cuedc1	CUE domain containing 1	0.026
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.026
Wnt5a	wingless-related MMTV integration site 5A	0.026
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.026
Rab34	RAB34, member of RAS oncogene family	0.026
Gli2	GLI-Kruppel family member GLI2	0.025
Cstb	cystatin B	0.025
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.025
Smtn	smoothelin	0.025
Emx2	empty spiracles homolog 2 (Drosophila)	0.025
Osr1	odd-skipped related 1 (Drosophila)	0.024
Srgn	serglycin	0.024
Ikbkb	inhibitor of kappaB kinase beta	0.024
Lrp5	low density lipoprotein receptor-related protein 5	0.024
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.024
Mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae)	0.024
Zfp358	zinc finger protein 358	0.024
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.023
Pdgfb	platelet derived growth factor, B polypeptide	0.023
Rnh1	ribonuclease/angiogenin inhibitor 1	0.023
Thrb	thyroid hormone receptor beta	0.023	Mouse
F2r	coagulation factor II (thrombin) receptor	0.023
Vegfa	vascular endothelial growth factor A	0.022
Ptpn21	protein tyrosine phosphatase, non-receptor type 21	0.022
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.022
Rictor	RPTOR independent companion of MTOR, complex 2	0.022
Tet1	tet oncogene 1	0.022
Igbp1	immunoglobulin (CD79A) binding protein 1	0.022
Gbp3	guanylate binding protein 3	0.021	Mouse
Vhl	von Hippel-Lindau tumor suppressor	0.021
Zfp651	zinc finger protein 651	0.021
Atp6v0e	ATPase, H+ transporting, lysosomal V0 subunit E	0.021
Lamb2	laminin, beta 2	0.021
Flot2	flotillin 2	0.021
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.020
Fgfrl1	fibroblast growth factor receptor-like 1	0.020
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.020
Plcd1	phospholipase C, delta 1	0.020
Lrp6	low density lipoprotein receptor-related protein 6	0.020
Mdk	midkine	0.020
Ptk7	PTK7 protein tyrosine kinase 7	0.020
Tef	thyrotroph embryonic factor	0.020
Acvr2b	activin receptor IIB	0.019
Mdm4	transformed mouse 3T3 cell double minute 4	0.019
Mndal	myeloid nuclear differentiation antigen like	0.019
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.019
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.019
Bmp5	bone morphogenetic protein 5	0.019
Hoxa9	homeobox A9	0.019
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.019
Lemd2	LEM domain containing 2	0.019
Acvr1	activin A receptor, type 1	0.018
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.018
Ifi203	interferon activated gene 203	0.018
Ece1	endothelin converting enzyme 1	0.018
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.018
Llgl1	lethal giant larvae homolog 1 (Drosophila)	0.018
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.018
Dbp	D site albumin promoter binding protein	0.018
Mfap2	microfibrillar-associated protein 2	0.018
Igf2r	insulin-like growth factor 2 receptor	0.018
Mcl1	myeloid cell leukemia sequence 1	0.018
Nek8	NIMA (never in mitosis gene a)-related expressed kinase 8	0.018
Apoe	apolipoprotein E	0.017
Rbms2	RNA binding motif, single stranded interacting protein 2	0.017
Eapp	E2F-associated phosphoprotein	0.017
Dach1	dachshund 1 (Drosophila)	0.017
Mapk12	mitogen-activated protein kinase 12	0.017
Lhx1	LIM homeobox protein 1	0.017
Csnk1e	casein kinase 1, epsilon	0.017
Fgf10	fibroblast growth factor 10	0.017
Ep300	E1A binding protein p300	0.017
Hr	hairless	0.017
Lgals3	lectin, galactose binding, soluble 3	0.017
Igf1r	insulin-like growth factor I receptor	0.017	Worm
Bcl6	B-cell leukemia/lymphoma 6	0.016
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.016
Anapc2	anaphase promoting complex subunit 2	0.016
Pias1	protein inhibitor of activated STAT 1	0.016
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.016
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.016
Socs3	suppressor of cytokine signaling 3	0.016
Siah2	seven in absentia 2	0.016
Mapk3	mitogen-activated protein kinase 3	0.016
Ar	androgen receptor	0.015
Ddr1	discoidin domain receptor family, member 1	0.015
Telo2	TEL2, telomere maintenance 2, homolog (S. cerevisiae)	0.015
Amotl2	angiomotin-like 2	0.015
Tead2	TEA domain family member 2	0.015
Gba	glucosidase, beta, acid	0.015
Dio3	deiodinase, iodothyronine type III	0.015
Ddr2	discoidin domain receptor family, member 2	0.015
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.015
Ifih1	interferon induced with helicase C domain 1	0.015
Sfrp1	secreted frizzled-related protein 1	0.015
Setdb1	SET domain, bifurcated 1	0.015
Smad7	MAD homolog 7 (Drosophila)	0.015
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.015
Col18a1	collagen, type XVIII, alpha 1	0.015
Igh	immunoglobulin heavy chain complex	0.015
Skil	SKI-like	0.015
H2afx	H2A histone family, member X	0.014
Spna2	spectrin alpha 2	0.014
Vangl2	vang-like 2 (van gogh, Drosophila)	0.014
Gbp7	guanylate binding protein 7	0.014	Mouse
Itch	itchy, E3 ubiquitin protein ligase	0.014
Itgb5	integrin beta 5	0.014
Nf2	neurofibromatosis 2	0.014
Smad4	MAD homolog 4 (Drosophila)	0.014
Gabarap	gamma-aminobutyric acid receptor associated protein	0.014
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.014
Wwc2	WW, C2 and coiled-coil domain containing 2	0.014
Prdm16	PR domain containing 16	0.014
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.014
Igf2	insulin-like growth factor 2	0.014
Fas	Fas (TNF receptor superfamily member 6)	0.014
Gbp9	guanylate-binding protein 9	0.014	Mouse
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.013
Smad2	MAD homolog 2 (Drosophila)	0.013
Nfic	nuclear factor I/C	0.013
Mecp2	methyl CpG binding protein 2	0.013
Plin2	perilipin 2	0.013
Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	0.013	Human
Lphn1	latrophilin 1	0.013
Lzts2	leucine zipper, putative tumor suppressor 2	0.013
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.013
Irf2bp1	interferon regulatory factor 2 binding protein 1	0.013
Snapc2	small nuclear RNA activating complex, polypeptide 2	0.013
Zbed3	zinc finger, BED domain containing 3	0.013
Cenpj	centromere protein J	0.013
Fabp4	fatty acid binding protein 4, adipocyte	0.013
Ccnd1	cyclin D1	0.013
Adam17	a disintegrin and metallopeptidase domain 17	0.013
Tax1bp3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.013
Hdac6	histone deacetylase 6	0.013
Ltbp4	latent transforming growth factor beta binding protein 4	0.013
Rmnd5a	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	0.013
Notch3	Notch gene homolog 3 (Drosophila)	0.013
Ppm1a	protein phosphatase 1A, magnesium dependent, alpha isoform	0.013	Human
Gbp8	guanylate-binding protein 8	0.013	Mouse
Cd44	CD44 antigen	0.013
Card11	caspase recruitment domain family, member 11	0.013
Arhgap29	Rho GTPase activating protein 29	0.013
Anxa4	annexin A4	0.013
Id3	inhibitor of DNA binding 3	0.013
Anxa7	annexin A7	0.013
Nfib	nuclear factor I/B	0.013
Ift140	intraflagellar transport 140 homolog (Chlamydomonas)	0.013
Hoxa7	homeobox A7	0.013
Tnf	tumor necrosis factor	0.013
Coro1b	coronin, actin binding protein 1B	0.012
Cd274	CD274 antigen	0.012
Mrc2	mannose receptor, C type 2	0.012
Gna11	guanine nucleotide binding protein, alpha 11	0.012
Capn1	calpain 1	0.012
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.012
Kif22	kinesin family member 22	0.012
Vwa5a	von Willebrand factor A domain containing 5A	0.012
Mvp	major vault protein	0.012
Dazap2	DAZ associated protein 2	0.012
Pdlim4	PDZ and LIM domain 4	0.012
Necap2	NECAP endocytosis associated 2	0.012
Slc4a2	solute carrier family 4 (anion exchanger), member 2	0.012
Ctsd	cathepsin D	0.012
Sqstm1	sequestosome 1	0.012
Igtp	interferon gamma induced GTPase	0.012
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.012
Twist1	twist homolog 1 (Drosophila)	0.012
Sox9	SRY-box containing gene 9	0.012
Prkar2a	protein kinase, cAMP dependent regulatory, type II alpha	0.012
Ptpn13	protein tyrosine phosphatase, non-receptor type 13	0.012
Becn1	beclin 1, autophagy related	0.012
Fzd4	frizzled homolog 4 (Drosophila)	0.012	Mouse
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.012
Fbxo32	F-box protein 32	0.012
Lilrb4	leukocyte immunoglobulin-like receptor, subfamily B, member 4	0.012
Trim30a	tripartite motif-containing 30A	0.012
Tcf4	transcription factor 4	0.012
Erap1	endoplasmic reticulum aminopeptidase 1	0.012
Hdac7	histone deacetylase 7	0.012
Hdac1	histone deacetylase 1	0.012
Phldb1	pleckstrin homology-like domain, family B, member 1	0.012
Wnt3a	wingless-related MMTV integration site 3A	0.012
Chmp2a	chromatin modifying protein 2A	0.012
Ptpn23	protein tyrosine phosphatase, non-receptor type 23	0.012
Bcl7a	B-cell CLL/lymphoma 7A	0.012
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.011
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.011
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.011
Cd81	CD81 antigen	0.011
Pkd1	polycystic kidney disease 1 homolog	0.011
Rnf111	ring finger 111	0.011
Arpc3	actin related protein 2/3 complex, subunit 3	0.011
Birc5	baculoviral IAP repeat-containing 5	0.011
Suds3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.011
Mmp11	matrix metallopeptidase 11	0.011
Asxl1	additional sex combs like 1 (Drosophila)	0.011
Pias3	protein inhibitor of activated STAT 3	0.011
Tspan9	tetraspanin 9	0.011
Col4a5	collagen, type IV, alpha 5	0.011
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.011
Pou2af1	POU domain, class 2, associating factor 1	0.011
Kdm5b	lysine (K)-specific demethylase 5B	0.011
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.011
Rhoq	ras homolog gene family, member Q	0.011
Zfhx3	zinc finger homeobox 3	0.011
Ddah2	dimethylarginine dimethylaminohydrolase 2	0.011
Prkci	protein kinase C, iota	0.011
Ppap2b	phosphatidic acid phosphatase type 2B	0.011
Sema6c	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	0.011
Rheb	Ras homolog enriched in brain	0.011
Plcb3	phospholipase C, beta 3	0.011
Leprel2	leprecan-like 2	0.011
Wnt4	wingless-related MMTV integration site 4	0.011
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.011
Ms4a4d	membrane-spanning 4-domains, subfamily A, member 4D	0.011
Med10	mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae)	0.011
Sox13	SRY-box containing gene 13	0.011
Pcbp4	poly(rC) binding protein 4	0.011
Ppp2ca	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	0.011	Rat
Plk1	polo-like kinase 1 (Drosophila)	0.011
Cxcl10	chemokine (C-X-C motif) ligand 10	0.011
Tgfb2	transforming growth factor, beta 2	0.011
Tgfb3	transforming growth factor, beta 3	0.010
Zfp444	zinc finger protein 444	0.010
Ptrf	polymerase I and transcript release factor	0.010
Hipk3	homeodomain interacting protein kinase 3	0.010
Ctdsp2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	0.010
Anxa5	annexin A5	0.010
Scn7a	sodium channel, voltage-gated, type VII, alpha	0.010
Cdh23	cadherin 23 (otocadherin)	0.010
Islr	immunoglobulin superfamily containing leucine-rich repeat	0.010
Nfix	nuclear factor I/X	0.010
Cttn	cortactin	0.010
Apcdd1	adenomatosis polyposis coli down-regulated 1	0.010
Sox17	SRY-box containing gene 17	0.010
Cfl2	cofilin 2, muscle	0.010
Prkd1	protein kinase D1	0.010
Hoxa5	homeobox A5	0.010
Gbp4	guanylate binding protein 4	0.010
Irgm2	immunity-related GTPase family M member 2	0.010
Mfng	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.010
Sat1	spermidine/spermine N1-acetyl transferase 1	0.010