IMP: Integrative Multi-species Prediction

Mus musculus

17 genes annotated in mouse

Multi-species View

negative regulation of interleukin 6 production

GO:0032715

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of interleukin 6 production"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of interleukin 6 production" (in gray)

Name	Description	Probability	Func Analog Organism
Myd88	myeloid differentiation primary response gene 88	0.999
Irak4	interleukin-1 receptor-associated kinase 4	0.951
Tlr4	toll-like receptor 4	0.865
Traf6	TNF receptor-associated factor 6	0.790
Arrb2	arrestin, beta 2	0.789
Tnf	tumor necrosis factor	0.771
Stat3	signal transducer and activator of transcription 3	0.766
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.596
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.593	Rat
Trim30d	tripartite motif-containing 30D	0.504	Mouse
Il1r1	interleukin 1 receptor, type I	0.413
Arrb1	arrestin, beta 1	0.403	Human Mouse
Ikbkg	inhibitor of kappaB kinase gamma	0.356
Chrna3	cholinergic receptor, nicotinic, alpha polypeptide 3	0.310	Mouse
Nlrp3	NLR family, pyrin domain containing 3	0.286
Casp1	caspase 1	0.265
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.258	Mouse
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.210	Mouse
Tlr2	toll-like receptor 2	0.209	Mouse
Trim30a	tripartite motif-containing 30A	0.200
Spp1	secreted phosphoprotein 1	0.187
Ticam1	toll-like receptor adaptor molecule 1	0.158
Ccl2	chemokine (C-C motif) ligand 2	0.156
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.132
Rtp4	receptor transporter protein 4	0.129
9430031J16Rik	RIKEN cDNA 9430031J16 gene	0.124
Cd44	CD44 antigen	0.118
Stat5b	signal transducer and activator of transcription 5B	0.108
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.106
Lyz2	lysozyme 2	0.103
Ttc7	tetratricopeptide repeat domain 7	0.098
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.095
Trim12a	tripartite motif-containing 12A	0.089	Mouse
Stat1	signal transducer and activator of transcription 1	0.088
Igh	immunoglobulin heavy chain complex	0.087
Ikbkb	inhibitor of kappaB kinase beta	0.086
Chrnb4	cholinergic receptor, nicotinic, beta polypeptide 4	0.081	Mouse
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.077
Mmp9	matrix metallopeptidase 9	0.076
Stat5a	signal transducer and activator of transcription 5A	0.073
Il10	interleukin 10	0.070
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.062
Lepr	leptin receptor	0.061
Irak1	interleukin-1 receptor-associated kinase 1	0.058	Mouse
Dok1	docking protein 1	0.055
Il6	interleukin 6	0.055
Stat6	signal transducer and activator of transcription 6	0.055
Prf1	perforin 1 (pore forming protein)	0.052
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.050	Mouse
Cdh5	cadherin 5	0.049
Cblb	Casitas B-lineage lymphoma b	0.047
Il1f9	interleukin 1 family, member 9	0.047
Plcg2	phospholipase C, gamma 2	0.047
Herc6	hect domain and RLD 6	0.046
Inpp5d	inositol polyphosphate-5-phosphatase D	0.045
Il10ra	interleukin 10 receptor, alpha	0.043
Il1a	interleukin 1 alpha	0.041	Mouse
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.041
Sykb	spleen tyrosine kinase	0.037
Tifa	TRAF-interacting protein with forkhead-associated domain	0.037
Dok2	docking protein 2	0.036
Cd300ld	CD300 molecule-like family member d	0.034
Ddx60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.032
Shc1	src homology 2 domain-containing transforming protein C1	0.032
Msr1	macrophage scavenger receptor 1	0.032
Irak3	interleukin-1 receptor-associated kinase 3	0.031
Stat2	signal transducer and activator of transcription 2	0.031
Irg1	immunoresponsive gene 1	0.029
Ccl4	chemokine (C-C motif) ligand 4	0.029
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.029
Pyhin1	pyrin and HIN domain family, member 1	0.029
Tirap	toll-interleukin 1 receptor (TIR) domain-containing adaptor protein	0.028
Ncoa3	nuclear receptor coactivator 3	0.027
Birc3	baculoviral IAP repeat-containing 3	0.027
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.027
Irf5	interferon regulatory factor 5	0.027
Ifi44	interferon-induced protein 44	0.027
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.026
Prpmp5	proline-rich protein MP5	0.024
Grb2	growth factor receptor bound protein 2	0.024
Gli2	GLI-Kruppel family member GLI2	0.024
Parp14	poly (ADP-ribose) polymerase family, member 14	0.023
Isl2	insulin related protein 2 (islet 2)	0.023
Ccr2	chemokine (C-C motif) receptor 2	0.022
Clk2	CDC-like kinase 2	0.022
Irf7	interferon regulatory factor 7	0.022
Sharpin	SHANK-associated RH domain interacting protein	0.021
Oas2	2'-5' oligoadenylate synthetase 2	0.021
Kif19a	kinesin family member 19A	0.021
Gprin1	G protein-regulated inducer of neurite outgrowth 1	0.021
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.020
Lpar5	lysophosphatidic acid receptor 5	0.020
Dkk4	dickkopf homolog 4 (Xenopus laevis)	0.020
Yipf5	Yip1 domain family, member 5	0.020
Fas	Fas (TNF receptor superfamily member 6)	0.020
Trim21	tripartite motif-containing 21	0.019	Mouse
Sprr2k	small proline-rich protein 2K	0.019
Rpn1	ribophorin I	0.019
Tssk1	testis-specific serine kinase 1	0.019
Chrnb3	cholinergic receptor, nicotinic, beta polypeptide 3	0.019	Mouse
Noto	notochord homolog (Xenopus laevis)	0.018
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.018
Nos2	nitric oxide synthase 2, inducible	0.018
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.018
Lcp2	lymphocyte cytosolic protein 2	0.018
Traf2	TNF receptor-associated factor 2	0.017
Dnahc11	dynein, axonemal, heavy chain 11	0.017
Stx11	syntaxin 11	0.017
Csprs	component of Sp100-rs	0.017
Samhd1	SAM domain and HD domain, 1	0.017
Cacna1d	calcium channel, voltage-dependent, L type, alpha 1D subunit	0.017
Tlr6	toll-like receptor 6	0.017	Mouse
Irf9	interferon regulatory factor 9	0.016
Hhex	hematopoietically expressed homeobox	0.016
Il4ra	interleukin 4 receptor, alpha	0.016
Slamf1	signaling lymphocytic activation molecule family member 1	0.016
Drd4	dopamine receptor D4	0.016
Prkcd	protein kinase C, delta	0.016
Ccl3	chemokine (C-C motif) ligand 3	0.016
Fpr3	formyl peptide receptor 3	0.016
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.016
Gpr132	G protein-coupled receptor 132	0.016
Lair1	leukocyte-associated Ig-like receptor 1	0.016
Btk	Bruton agammaglobulinemia tyrosine kinase	0.016
Myog	myogenin	0.016
Unc93b1	unc-93 homolog B1 (C. elegans)	0.015
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.015
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.015
Ly96	lymphocyte antigen 96	0.015
Parvg	parvin, gamma	0.015
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.015
Krt6a	keratin 6A	0.014
Cd84	CD84 antigen	0.014
Plekho2	pleckstrin homology domain containing, family O member 2	0.014
Cacna1f	calcium channel, voltage-dependent, alpha 1F subunit	0.014
Gpr45	G protein-coupled receptor 45	0.014
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.014
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.014
Rel	reticuloendotheliosis oncogene	0.014
Runx1	runt related transcription factor 1	0.013
Gpr84	G protein-coupled receptor 84	0.013
C78513	EST C78513	0.013
Spna1	spectrin alpha 1	0.013
Dtx3l	deltex 3-like (Drosophila)	0.013
Zp1	zona pellucida glycoprotein 1	0.013
Emr4	EGF-like module containing, mucin-like, hormone receptor-like sequence 4	0.013
BC013712	cDNA sequence BC013712	0.013
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.013
Sfpi1	SFFV proviral integration 1	0.013
Zfp362	zinc finger protein 362	0.013
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.013
Tor3a	torsin family 3, member A	0.013
Siglece	sialic acid binding Ig-like lectin E	0.012
Chrna5	cholinergic receptor, nicotinic, alpha polypeptide 5	0.012	Mouse
Foxp1	forkhead box P1	0.012	Mouse
Ifi203	interferon activated gene 203	0.012
Sash3	SAM and SH3 domain containing 3	0.012
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.012
Kcnk4	potassium channel, subfamily K, member 4	0.012
Slfn2	schlafen 2	0.012
Dcx	doublecortin	0.012
Dyx1c1	dyslexia susceptibility 1 candidate 1 homolog (human)	0.012
Dsc1	desmocollin 1	0.012
Nxnl1	nucleoredoxin-like 1	0.012
Cd14	CD14 antigen	0.012
Shisa5	shisa homolog 5 (Xenopus laevis)	0.012
Ccr3	chemokine (C-C motif) receptor 3	0.012
Mx2	myxovirus (influenza virus) resistance 2	0.012
Ccr6	chemokine (C-C motif) receptor 6	0.011
Epsti1	epithelial stromal interaction 1 (breast)	0.011
Scamp2	secretory carrier membrane protein 2	0.011
Foxm1	forkhead box M1	0.011	Mouse
Sp110	Sp110 nuclear body protein	0.011
Oas1b	2'-5' oligoadenylate synthetase 1B	0.011
Vangl1	vang-like 1 (van gogh, Drosophila)	0.011
Trim34a	tripartite motif-containing 34A	0.011	Mouse
Abcg3	ATP-binding cassette, sub-family G (WHITE), member 3	0.011
Elf4	E74-like factor 4 (ets domain transcription factor)	0.011
Itgal	integrin alpha L	0.011
Vwa5a	von Willebrand factor A domain containing 5A	0.011
Musk	muscle, skeletal, receptor tyrosine kinase	0.011
Gbp7	guanylate binding protein 7	0.011
Ly9	lymphocyte antigen 9	0.011
Slamf8	SLAM family member 8	0.011
Sipa1	signal-induced proliferation associated gene 1	0.011
Ifng	interferon gamma	0.011
Cd86	CD86 antigen	0.011
Clec4e	C-type lectin domain family 4, member e	0.011
Naip6	NLR family, apoptosis inhibitory protein 6	0.011
Foxp2	forkhead box P2	0.011	Mouse
Ecel1	endothelin converting enzyme-like 1	0.011
Hcn3	hyperpolarization-activated, cyclic nucleotide-gated K+ 3	0.011
Slfn8	schlafen 8	0.011
Samd9l	sterile alpha motif domain containing 9-like	0.011
Il1b	interleukin 1 beta	0.011	Mouse
Cxcl2	chemokine (C-X-C motif) ligand 2	0.011
0610031J06Rik	RIKEN cDNA 0610031J06 gene	0.011
Lcn8	lipocalin 8	0.011
Nxnl2	nucleoredoxin-like 2	0.011
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.011
Il18	interleukin 18	0.011
Pilra	paired immunoglobin-like type 2 receptor alpha	0.011
Naip2	NLR family, apoptosis inhibitory protein 2	0.011
Mak	male germ cell-associated kinase	0.011
Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.011
Gm7609	predicted pseudogene 7609	0.010
Ptgs2	prostaglandin-endoperoxide synthase 2	0.010
Pde6c	phosphodiesterase 6C, cGMP specific, cone, alpha prime	0.010
Pou2f2	POU domain, class 2, transcription factor 2	0.010
Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.010
Trim12c	tripartite motif-containing 12C	0.010	Mouse
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.010
Cd33	CD33 antigen	0.010
Allc	allantoicase	0.010
Xpo6	exportin 6	0.010
Cd97	CD97 antigen	0.010
Hpgds	hematopoietic prostaglandin D synthase	0.010