IMP
Process View
endoplasmic reticulum unfolded protein response
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "endoplasmic reticulum unfolded protein response"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Hspa5 | heat shock protein 5 | 0.999 | ||
| Hsp90b1 | heat shock protein 90, beta (Grp94), member 1 | 0.997 | ||
| Dnajb11 | DnaJ (Hsp40) homolog, subfamily B, member 11 | 0.949 | ||
| Dnajc3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.882 | Worm | |
| Manf | mesencephalic astrocyte-derived neurotrophic factor | 0.817 | ||
| Creld2 | cysteine-rich with EGF-like domains 2 | 0.717 | ||
| Pdia3 | protein disulfide isomerase associated 3 | 0.714 | ||
| Uso1 | USO1 homolog, vesicle docking protein (yeast) | 0.705 | ||
| Cdk4 | cyclin-dependent kinase 4 | 0.634 | ||
| Sdf2l1 | stromal cell-derived factor 2-like 1 | 0.596 | ||
| Vcp | valosin containing protein | 0.532 | Worm | |
| Cdk6 | cyclin-dependent kinase 6 | 0.389 | ||
| Hsp90ab1 | heat shock protein 90 alpha (cytosolic), class B member 1 | 0.365 | ||
| Pdia6 | protein disulfide isomerase associated 6 | 0.364 | ||
| Dnajb9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.318 | ||
| Xbp1 | X-box binding protein 1 | 0.294 | ||
| Sel1l | sel-1 suppressor of lin-12-like (C. elegans) | 0.286 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.247 | ||
| Pycard | PYD and CARD domain containing | 0.239 | ||
| Serp1 | stress-associated endoplasmic reticulum protein 1 | 0.236 | ||
| Hspa9 | heat shock protein 9 | 0.230 | ||
| Edem1 | ER degradation enhancer, mannosidase alpha-like 1 | 0.223 | ||
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.201 | Mouse | |
| Surf4 | surfeit gene 4 | 0.199 | ||
| Tlr4 | toll-like receptor 4 | 0.194 | ||
| Sec61a1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.181 | ||
| Ncstn | nicastrin | 0.174 | ||
| Spcs2 | signal peptidase complex subunit 2 homolog (S. cerevisiae) | 0.171 | ||
| H47 | histocompatibility 47 | 0.167 | ||
| Mgat2 | mannoside acetylglucosaminyltransferase 2 | 0.158 | ||
| Slc39a7 | solute carrier family 39 (zinc transporter), member 7 | 0.154 | ||
| Ssr2 | signal sequence receptor, beta | 0.150 | ||
| Rpn2 | ribophorin II | 0.144 | ||
| Calr | calreticulin | 0.144 | Worm | |
| Spcs3 | signal peptidase complex subunit 3 homolog (S. cerevisiae) | 0.139 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.137 | ||
| Prkcsh | protein kinase C substrate 80K-H | 0.126 | ||
| Ngly1 | N-glycanase 1 | 0.123 | ||
| P4hb | prolyl 4-hydroxylase, beta polypeptide | 0.111 | Worm | |
| Magt1 | magnesium transporter 1 | 0.104 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.101 | ||
| Slc30a5 | solute carrier family 30 (zinc transporter), member 5 | 0.099 | ||
| Trp53 | transformation related protein 53 | 0.087 | ||
| Slc35b1 | solute carrier family 35, member B1 | 0.086 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.083 | ||
| Casp1 | caspase 1 | 0.081 | Mouse | |
| Rpn1 | ribophorin I | 0.079 | ||
| Uba5 | ubiquitin-like modifier activating enzyme 5 | 0.076 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.075 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.073 | ||
| Atf6 | activating transcription factor 6 | 0.072 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.071 | ||
| Sec23b | SEC23B (S. cerevisiae) | 0.069 | ||
| Tm9sf3 | transmembrane 9 superfamily member 3 | 0.069 | ||
| Ssr1 | signal sequence receptor, alpha | 0.061 | ||
| Gbp5 | guanylate binding protein 5 | 0.060 | ||
| Il18 | interleukin 18 | 0.060 | ||
| Erp44 | endoplasmic reticulum protein 44 | 0.051 | ||
| Tram1 | translocating chain-associating membrane protein 1 | 0.050 | ||
| Rrbp1 | ribosome binding protein 1 | 0.050 | ||
| Gmppb | GDP-mannose pyrophosphorylase B | 0.048 | ||
| Fndc3a | fibronectin type III domain containing 3A | 0.046 | ||
| Canx | calnexin | 0.044 | Worm | |
| Ubxn1 | UBX domain protein 1 | 0.044 | ||
| Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | 0.043 | ||
| Txndc5 | thioredoxin domain containing 5 | 0.043 | ||
| Myd88 | myeloid differentiation primary response gene 88 | 0.043 | ||
| Lman1 | lectin, mannose-binding, 1 | 0.042 | ||
| Nus1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | 0.042 | ||
| Tmed7 | transmembrane emp24 protein transport domain containing 7 | 0.041 | ||
| Stt3a | STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) | 0.040 | ||
| Lyz2 | lysozyme 2 | 0.038 | ||
| Hspa8 | heat shock protein 8 | 0.037 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.035 | ||
| Ccnd1 | cyclin D1 | 0.034 | ||
| Atf4 | activating transcription factor 4 | 0.033 | ||
| Bak1 | BCL2-antagonist/killer 1 | 0.032 | ||
| Copb2 | coatomer protein complex, subunit beta 2 (beta prime) | 0.032 | ||
| Slc3a2 | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | 0.032 | ||
| Hsph1 | heat shock 105kDa/110kDa protein 1 | 0.032 | ||
| Rb1 | retinoblastoma 1 | 0.031 | ||
| Yars | tyrosyl-tRNA synthetase | 0.030 | ||
| Birc3 | baculoviral IAP repeat-containing 3 | 0.030 | ||
| Lrrc59 | leucine rich repeat containing 59 | 0.030 | ||
| Ppp2r1a | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform | 0.030 | ||
| Slc33a1 | solute carrier family 33 (acetyl-CoA transporter), member 1 | 0.030 | ||
| Ifngr1 | interferon gamma receptor 1 | 0.030 | ||
| Rag1 | recombination activating gene 1 | 0.030 | ||
| D4Wsu53e | DNA segment, Chr 4, Wayne State University 53, expressed | 0.029 | ||
| Dnm1 | dynamin 1 | 0.029 | ||
| Mafk | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) | 0.029 | ||
| Psmd3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 0.028 | ||
| Rnf103 | ring finger protein 103 | 0.028 | ||
| Arhgap31 | Rho GTPase activating protein 31 | 0.028 | ||
| Sars | seryl-aminoacyl-tRNA synthetase | 0.027 | ||
| Gars | glycyl-tRNA synthetase | 0.027 | ||
| Eif3b | eukaryotic translation initiation factor 3, subunit B | 0.027 | ||
| Mcfd2 | multiple coagulation factor deficiency 2 | 0.027 | ||
| Syvn1 | synovial apoptosis inhibitor 1, synoviolin | 0.025 | Fly | |
| Ssr3 | signal sequence receptor, gamma | 0.025 | ||
| Nphp4 | nephronophthisis 4 (juvenile) homolog (human) | 0.025 | ||
| Adam9 | a disintegrin and metallopeptidase domain 9 (meltrin gamma) | 0.025 | ||
| Copb1 | coatomer protein complex, subunit beta 1 | 0.025 | ||
| Nploc4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.024 | ||
| Amfr | autocrine motility factor receptor | 0.024 | Human | |
| Il1r1 | interleukin 1 receptor, type I | 0.024 | ||
| Ccnd2 | cyclin D2 | 0.023 | Mouse | |
| Hsp90aa1 | heat shock protein 90, alpha (cytosolic), class A member 1 | 0.023 | ||
| Aim2 | absent in melanoma 2 | 0.022 | ||
| Bhlha15 | basic helix-loop-helix family, member a15 | 0.022 | ||
| Gpr132 | G protein-coupled receptor 132 | 0.022 | ||
| 1300001I01Rik | RIKEN cDNA 1300001I01 gene | 0.022 | ||
| Mrpl2 | mitochondrial ribosomal protein L2 | 0.021 | ||
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.021 | ||
| Dpagt1 | dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) | 0.021 | ||
| Hspa13 | heat shock protein 70 family, member 13 | 0.021 | ||
| Sec63 | SEC63-like (S. cerevisiae) | 0.021 | Zebrafish | |
| Stat1 | signal transducer and activator of transcription 1 | 0.021 | ||
| Txndc11 | thioredoxin domain containing 11 | 0.021 | ||
| Herpud1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.021 | ||
| Pdia4 | protein disulfide isomerase associated 4 | 0.020 | Worm | |
| Kdelr2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.020 | ||
| Map3k2 | mitogen-activated protein kinase kinase kinase 2 | 0.020 | ||
| C1qbp | complement component 1, q subcomponent binding protein | 0.020 | ||
| Derl1 | Der1-like domain family, member 1 | 0.020 | ||
| Ripk1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.020 | ||
| Dnajb2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 0.020 | ||
| Lonp1 | lon peptidase 1, mitochondrial | 0.020 | ||
| Acsl4 | acyl-CoA synthetase long-chain family member 4 | 0.019 | ||
| Hyou1 | hypoxia up-regulated 1 | 0.019 | ||
| Il1b | interleukin 1 beta | 0.019 | ||
| Lman2 | lectin, mannose-binding 2 | 0.019 | ||
| Yipf5 | Yip1 domain family, member 5 | 0.019 | ||
| Atp5b | ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit | 0.019 | ||
| Samm50 | sorting and assembly machinery component 50 homolog (S. cerevisiae) | 0.019 | ||
| Ero1lb | ERO1-like beta (S. cerevisiae) | 0.019 | Mouse | |
| Fadd | Fas (TNFRSF6)-associated via death domain | 0.019 | ||
| Lyst | lysosomal trafficking regulator | 0.018 | ||
| Cdk2 | cyclin-dependent kinase 2 | 0.018 | ||
| Cyld | cylindromatosis (turban tumor syndrome) | 0.018 | ||
| Vmp1 | vacuole membrane protein 1 | 0.018 | ||
| Edem3 | ER degradation enhancer, mannosidase alpha-like 3 | 0.018 | Fly | |
| Tars | threonyl-tRNA synthetase | 0.018 | ||
| A630007B06Rik | RIKEN cDNA A630007B06 gene | 0.017 | ||
| Skil | SKI-like | 0.017 | ||
| Clptm1l | CLPTM1-like | 0.017 | ||
| Srsf9 | serine/arginine-rich splicing factor 9 | 0.017 | ||
| Gorasp2 | golgi reassembly stacking protein 2 | 0.017 | ||
| Mrpl12 | mitochondrial ribosomal protein L12 | 0.017 | ||
| Dusp1 | dual specificity phosphatase 1 | 0.016 | ||
| Foxp1 | forkhead box P1 | 0.016 | ||
| Tmed2 | transmembrane emp24 domain trafficking protein 2 | 0.016 | ||
| Elf4 | E74-like factor 4 (ets domain transcription factor) | 0.016 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.016 | ||
| Cftr | cystic fibrosis transmembrane conductance regulator homolog | 0.016 | ||
| P4ha1 | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide | 0.016 | ||
| Sec22b | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) | 0.016 | ||
| Sec24d | Sec24 related gene family, member D (S. cerevisiae) | 0.016 | ||
| Hsd17b12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.015 | ||
| Nsfl1c | NSFL1 (p97) cofactor (p47) | 0.015 | ||
| Mobkl1b | MOB1, Mps One Binder kinase activator-like 1B (yeast) | 0.015 | ||
| Itch | itchy, E3 ubiquitin protein ligase | 0.015 | ||
| Arcn1 | archain 1 | 0.015 | ||
| Eif2ak3 | eukaryotic translation initiation factor 2 alpha kinase 3 | 0.015 | ||
| Prf1 | perforin 1 (pore forming protein) | 0.015 | ||
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.015 | ||
| Tmed9 | transmembrane emp24 protein transport domain containing 9 | 0.015 | ||
| Wrn | Werner syndrome homolog (human) | 0.015 | ||
| Ikbkg | inhibitor of kappaB kinase gamma | 0.015 | ||
| Mmp9 | matrix metallopeptidase 9 | 0.014 | ||
| Ficd | FIC domain containing | 0.014 | ||
| Irgm1 | immunity-related GTPase family M member 1 | 0.014 | ||
| Lass2 | LAG1 homolog, ceramide synthase 2 | 0.014 | ||
| Ikbkb | inhibitor of kappaB kinase beta | 0.014 | ||
| Ostc | oligosaccharyltransferase complex subunit | 0.014 | ||
| Derl2 | Der1-like domain family, member 2 | 0.014 | Human | |
| Psen1 | presenilin 1 | 0.014 | ||
| C78339 | expressed sequence C78339 | 0.014 | ||
| Casp7 | caspase 7 | 0.014 | Mouse | |
| Cpeb2 | cytoplasmic polyadenylation element binding protein 2 | 0.013 | ||
| Lap3 | leucine aminopeptidase 3 | 0.013 | ||
| Ulk2 | Unc-51 like kinase 2 (C. elegans) | 0.013 | ||
| Rbl2 | retinoblastoma-like 2 | 0.013 | ||
| Osbp | oxysterol binding protein | 0.013 | ||
| Brd2 | bromodomain containing 2 | 0.013 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.013 | ||
| Dab1 | disabled homolog 1 (Drosophila) | 0.013 | ||
| Stat2 | signal transducer and activator of transcription 2 | 0.013 | ||
| Srprb | signal recognition particle receptor, B subunit | 0.013 | ||
| Sqstm1 | sequestosome 1 | 0.013 | ||
| Mfn2 | mitofusin 2 | 0.013 | ||
| Afg3l1 | AFG3(ATPase family gene 3)-like 1 (yeast) | 0.013 | ||
| Irf9 | interferon regulatory factor 9 | 0.013 | ||
| Trib3 | tribbles homolog 3 (Drosophila) | 0.013 | ||
| App | amyloid beta (A4) precursor protein | 0.012 | ||
| Nars | asparaginyl-tRNA synthetase | 0.012 | ||
| Cflar | CASP8 and FADD-like apoptosis regulator | 0.012 | ||
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.012 | ||
| 2310036O22Rik | RIKEN cDNA 2310036O22 gene | 0.012 | ||
| Gbp7 | guanylate binding protein 7 | 0.012 | ||
| Hmox1 | heme oxygenase (decycling) 1 | 0.012 | ||
| Dhh | desert hedgehog | 0.012 | ||
| Mt1 | metallothionein 1 | 0.012 | ||
| Gbp3 | guanylate binding protein 3 | 0.012 | ||
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.012 | ||
| Bid | BH3 interacting domain death agonist | 0.012 | ||
| Ifnar1 | interferon (alpha and beta) receptor 1 | 0.012 | ||
| Dnajc1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.012 | ||
| Foxn1 | forkhead box N1 | 0.012 | ||
| Eif2ak2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.011 | ||
| St3gal4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 | 0.011 | ||
| Htr7 | 5-hydroxytryptamine (serotonin) receptor 7 | 0.011 | ||
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.011 | ||
| Il10 | interleukin 10 | 0.011 | ||
| Nfya | nuclear transcription factor-Y alpha | 0.011 | ||
| Cd70 | CD70 antigen | 0.011 | ||
| Atf5 | activating transcription factor 5 | 0.011 | ||
| Golga2 | golgi autoantigen, golgin subfamily a, 2 | 0.011 | ||
| Ccpg1 | cell cycle progression 1 | 0.011 | ||
| Ccdc47 | coiled-coil domain containing 47 | 0.011 | ||
| Pdx1 | pancreatic and duodenal homeobox 1 | 0.011 | ||
| Flcn | folliculin | 0.011 | ||
| Trim21 | tripartite motif-containing 21 | 0.011 | ||
| Mt2 | metallothionein 2 | 0.011 | ||
| Hoxb4 | homeobox B4 | 0.011 | ||
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.010 | ||
| Vamp4 | vesicle-associated membrane protein 4 | 0.010 | ||
| Bsdc1 | BSD domain containing 1 | 0.010 | ||
| Tm9sf2 | transmembrane 9 superfamily member 2 | 0.010 | ||
| Timm13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | 0.010 | ||
| P2rx1 | purinergic receptor P2X, ligand-gated ion channel, 1 | 0.010 | ||
| Pml | promyelocytic leukemia | 0.010 | ||
| Golph3 | golgi phosphoprotein 3 | 0.010 | ||
| Stt3b | STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) | 0.010 | ||
| Ppm1g | protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform | 0.010 | ||
| Oxt | oxytocin | 0.010 |