IMP: Integrative Multi-species Prediction

Mus musculus

26 genes annotated in mouse

pigment biosynthetic process

The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouseInclude functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "pigment biosynthetic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "pigment biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
Tyr	tyrosinase	1.000
Mitf	microphthalmia-associated transcription factor	1.000
Tyrp1	tyrosinase-related protein 1	0.999	Mouse
Lyst	lysosomal trafficking regulator	0.998
Oca2	oculocutaneous albinism II	0.969
a	nonagouti	0.951
Pomc	pro-opiomelanocortin-alpha	0.828
Pax3	paired box gene 3	0.700
Isl1	ISL1 transcription factor, LIM/homeodomain	0.659
Exoc6	exocyst complex component 6	0.630
Pmel	premelanosome protein	0.579
Pgls	6-phosphogluconolactonase	0.541
Kit	kit oncogene	0.487
Tcfap2a	transcription factor AP-2, alpha	0.486
Pax6	paired box gene 6	0.482
Eda	ectodysplasin-A	0.420
Mlph	melanophilin	0.409
Hand1	heart and neural crest derivatives expressed transcript 1	0.346
Slc45a2	solute carrier family 45, member 2	0.336
Hps1	Hermansky-Pudlak syndrome 1 homolog (human)	0.317
Ap3b1	adaptor-related protein complex 3, beta 1 subunit	0.249
Pldn	pallidin	0.238
Gata4	GATA binding protein 4	0.223
Slc24a5	solute carrier family 24, member 5	0.203
Myo5a	myosin VA	0.191
Rab38	RAB38, member of RAS oncogene family	0.171
Hes1	hairy and enhancer of split 1 (Drosophila)	0.170
Shh	sonic hedgehog	0.156
Fgf8	fibroblast growth factor 8	0.153
Hps6	Hermansky-Pudlak syndrome 6	0.153
Ednrb	endothelin receptor type B	0.150
Alx4	aristaless-like homeobox 4	0.136
Mc1r	melanocortin 1 receptor	0.135
Hmbs	hydroxymethylbilane synthase	0.129
Rab27a	RAB27A, member RAS oncogene family	0.124
Nf1	neurofibromatosis 1	0.117
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.110
Hps4	Hermansky-Pudlak syndrome 4 homolog (human)	0.099
Fgfr3	fibroblast growth factor receptor 3	0.093
Hhex	hematopoietically expressed homeobox	0.083
Tfrc	transferrin receptor	0.081
Hbb-b2	hemoglobin, beta adult minor chain	0.079
Hba-a2	hemoglobin alpha, adult chain 2	0.074
Abcb7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	0.074
Fgf4	fibroblast growth factor 4	0.074
Rho	rhodopsin	0.074
Pdcd6	programmed cell death 6	0.070
Bmp7	bone morphogenetic protein 7	0.064
Dct	dopachrome tautomerase	0.062
Glrx5	glutaredoxin 5 homolog (S. cerevisiae)	0.059
Sall3	sal-like 3 (Drosophila)	0.058
Edar	ectodysplasin-A receptor	0.057
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.054
Bmp4	bone morphogenetic protein 4	0.052
She	src homology 2 domain-containing transforming protein E	0.051
Beta-s	hemoglobin subunit beta-1-like	0.046
Jag1	jagged 1	0.046
Pitx2	paired-like homeodomain transcription factor 2	0.046
Sox17	SRY-box containing gene 17	0.045	Mouse
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.045
Atad3a	ATPase family, AAA domain containing 3A	0.043
H2-M9	histocompatibility 2, M region locus 9	0.043
Vegfa	vascular endothelial growth factor A	0.042
Pgam1	phosphoglycerate mutase 1	0.041
Gpx1	glutathione peroxidase 1	0.040
Taldo1	transaldolase 1	0.040
Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.040
Fgf3	fibroblast growth factor 3	0.039
Pnpo	pyridoxine 5'-phosphate oxidase	0.038
Tead4	TEA domain family member 4	0.037
Cdsn	corneodesmosin	0.037
Crebbp	CREB binding protein	0.035
Tcfap2c	transcription factor AP-2, gamma	0.034
Snca	synuclein, alpha	0.034
Pou5f1	POU domain, class 5, transcription factor 1	0.034
Dlx4	distal-less homeobox 4	0.034
Nptx2	neuronal pentraxin 2	0.033
Cldn5	claudin 5	0.033
Gata6	GATA binding protein 6	0.033
Sall4	sal-like 4 (Drosophila)	0.032
Ren1	renin 1 structural	0.032
Blvrb	biliverdin reductase B (flavin reductase (NADPH))	0.032
C1qtnf5	C1q and tumor necrosis factor related protein 5	0.032
Tbrg4	transforming growth factor beta regulated gene 4	0.031
Esam	endothelial cell-specific adhesion molecule	0.031
2810422J05Rik	RIKEN cDNA 2810422J05 gene	0.031
Nadk	NAD kinase	0.030
Muted	muted	0.030
Hesx1	homeobox gene expressed in ES cells	0.029
Zic3	zinc finger protein of the cerebellum 3	0.028
Chrm5	cholinergic receptor, muscarinic 5	0.028
Lrat	lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)	0.028
Cno	cappuccino	0.027
Rxra	retinoid X receptor alpha	0.027
Slc26a4	solute carrier family 26, member 4	0.026
Plac1	placental specific protein 1	0.026
Cux1	cut-like homeobox 1	0.025
Tcfap2b	transcription factor AP-2 beta	0.025
Gpnmb	glycoprotein (transmembrane) nmb	0.025	Mouse
Rasip1	Ras interacting protein 1	0.025
Flt1	FMS-like tyrosine kinase 1	0.024
Ak2	adenylate kinase 2	0.024
Ihh	Indian hedgehog	0.024
Dhrs4	dehydrogenase/reductase (SDR family) member 4	0.024
Lef1	lymphoid enhancer binding factor 1	0.024
Sox3	SRY-box containing gene 3	0.024	Mouse
Magt1	magnesium transporter 1	0.024
Hoxd13	homeobox D13	0.024
Slc25a15	solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15	0.024
Star	steroidogenic acute regulatory protein	0.023
Meox2	mesenchyme homeobox 2	0.023
Epb4.1	erythrocyte protein band 4.1	0.022
Trpm1	transient receptor potential cation channel, subfamily M, member 1	0.022
Uros	uroporphyrinogen III synthase	0.022
Thrb	thyroid hormone receptor beta	0.022
Bicc1	bicaudal C homolog 1 (Drosophila)	0.022
Uqcrfs1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.022
Eng	endoglin	0.022
Zic2	zinc finger protein of the cerebellum 2	0.022
Fam46c	family with sequence similarity 46, member C	0.022
Impa1	inositol (myo)-1(or 4)-monophosphatase 1	0.022
Pi4kb	phosphatidylinositol 4-kinase, catalytic, beta polypeptide	0.021
Dusp9	dual specificity phosphatase 9	0.021
Pou3f3	POU domain, class 3, transcription factor 3	0.021
Gnat2	guanine nucleotide binding protein, alpha transducing 2	0.021
Azin1	antizyme inhibitor 1	0.021
Ntf3	neurotrophin 3	0.020
Cdh5	cadherin 5	0.020
Shmt2	serine hydroxymethyltransferase 2 (mitochondrial)	0.020
Gjb5	gap junction protein, beta 5	0.020
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.020
Cs	citrate synthase	0.020
Gzmg	granzyme G	0.020
Pycrl	pyrroline-5-carboxylate reductase-like	0.020
Galr1	galanin receptor 1	0.020
1300001I01Rik	RIKEN cDNA 1300001I01 gene	0.020
Krt34	keratin 34	0.020
Mtx2	metaxin 2	0.020
Slc25a39	solute carrier family 25, member 39	0.019
Smad6	MAD homolog 6 (Drosophila)	0.019
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.019
Dnm1l	dynamin 1-like	0.019
Ins2	insulin II	0.019
Pgd	phosphogluconate dehydrogenase	0.019
Atp5g3	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)	0.019
Rb1	retinoblastoma 1	0.019
Alx1	ALX homeobox 1	0.019
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.019
Mas1	MAS1 oncogene	0.019
C1qbp	complement component 1, q subcomponent binding protein	0.019
Tkt	transketolase	0.019
Kdr	kinase insert domain protein receptor	0.019
Xpo4	exportin 4	0.018
Adamts20	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20	0.018
Lhx5	LIM homeobox protein 5	0.018
Ctnnb1	catenin (cadherin associated protein), beta 1	0.018
Sdhd	succinate dehydrogenase complex, subunit D, integral membrane protein	0.018
Cldn14	claudin 14	0.018
Phlda2	pleckstrin homology-like domain, family A, member 2	0.018
Tgfa	transforming growth factor alpha	0.018
Robo4	roundabout homolog 4 (Drosophila)	0.018
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.018
Lrp2	low density lipoprotein receptor-related protein 2	0.018
En2	engrailed 2	0.018
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.018
Tspan10	tetraspanin 10	0.017
Krt33b	keratin 33B	0.017
Edaradd	EDAR (ectodysplasin-A receptor)-associated death domain	0.017
S100a3	S100 calcium binding protein A3	0.017
Abcb4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	0.017
Mpzl2	myelin protein zero-like 2	0.017
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.017
BC048355	cDNA sequence BC048355	0.017
Blvra	biliverdin reductase A	0.016
Csf3	colony stimulating factor 3 (granulocyte)	0.016
Foxi3	forkhead box I3	0.016
Ebp	phenylalkylamine Ca2+ antagonist (emopamil) binding protein	0.016
Grhpr	glyoxylate reductase/hydroxypyruvate reductase	0.016
Fgf10	fibroblast growth factor 10	0.016
Comtd1	catechol-O-methyltransferase domain containing 1	0.016
Cat	catalase	0.016
Ssr3	signal sequence receptor, gamma	0.016
Foxo4	forkhead box O4	0.016
Plekha7	pleckstrin homology domain containing, family A member 7	0.016
Fam195a	family with sequence similarity 195, member A	0.016
Gja4	gap junction protein, alpha 4	0.016
Lgi1	leucine-rich repeat LGI family, member 1	0.016
Chd7	chromodomain helicase DNA binding protein 7	0.016
Gldc	glycine decarboxylase	0.016
Dhh	desert hedgehog	0.015
Epas1	endothelial PAS domain protein 1	0.015
Alad	aminolevulinate, delta-, dehydratase	0.015
Adam3	a disintegrin and metallopeptidase domain 3 (cyritestin)	0.015
Tm9sf2	transmembrane 9 superfamily member 2	0.015
Psmb7	proteasome (prosome, macropain) subunit, beta type 7	0.015
Ptprb	protein tyrosine phosphatase, receptor type, B	0.015
Gpr172b	G protein-coupled receptor 172B	0.015
Acpp	acid phosphatase, prostate	0.015
Tmem55a	transmembrane protein 55A	0.015
Cmpk1	cytidine monophosphate (UMP-CMP) kinase 1	0.015
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.015
Vmn2r26	vomeronasal 2, receptor 26	0.015
Slc2a5	solute carrier family 2 (facilitated glucose transporter), member 5	0.015
Hsd17b12	hydroxysteroid (17-beta) dehydrogenase 12	0.015
Otp	orthopedia homolog (Drosophila)	0.015
Tulp2	tubby-like protein 2	0.015
Tcf15	transcription factor 15	0.015
Sfn	stratifin	0.014
Ifna5	interferon alpha 5	0.014
Igfbpl1	insulin-like growth factor binding protein-like 1	0.014
Dpf3	D4, zinc and double PHD fingers, family 3	0.014
Lmo1	LIM domain only 1	0.014
Lypla1	lysophospholipase 1	0.014
Trap1a	tumor rejection antigen P1A	0.014
Ceacam11	carcinoembryonic antigen-related cell adhesion molecule 11	0.014
Htr5b	5-hydroxytryptamine (serotonin) receptor 5B	0.014
Cycs	cytochrome c, somatic	0.014
Sct	secretin	0.014
Rapsn	receptor-associated protein of the synapse	0.014
Cbx2	chromobox homolog 2 (Drosophila Pc class)	0.014
Rarb	retinoic acid receptor, beta	0.014
Trappc10	trafficking protein particle complex 10	0.014
Ptafr	platelet-activating factor receptor	0.014
Zp1	zona pellucida glycoprotein 1	0.014
Fgfr2	fibroblast growth factor receptor 2	0.014
Wt1	Wilms tumor 1 homolog	0.014
Tectb	tectorin beta	0.013
Hand2	heart and neural crest derivatives expressed transcript 2	0.013
Car6	carbonic anhydrase 6	0.013
Mavs	mitochondrial antiviral signaling protein	0.013
Sfxn1	sideroflexin 1	0.013
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.013
Prrx2	paired related homeobox 2	0.013
Sox7	SRY-box containing gene 7	0.013	Mouse
Cubn	cubilin (intrinsic factor-cobalamin receptor)	0.013
Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	0.013
Nkx6-1	NK6 homeobox 1	0.013
Nudt1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	0.013
Tcte2	t-complex-associated testis expressed 2	0.013
Uts2r	urotensin 2 receptor	0.013
Epha6	Eph receptor A6	0.013
Cyc1	cytochrome c-1	0.013
Muc13	mucin 13, epithelial transmembrane	0.013
Aldh9a1	aldehyde dehydrogenase 9, subfamily A1	0.013
Gh	growth hormone	0.013
Atp5b	ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit	0.013
Nrk	Nik related kinase	0.013
Grm8	glutamate receptor, metabotropic 8	0.013
Cd68	CD68 antigen	0.013
Cryaa	crystallin, alpha A	0.012
Urod	uroporphyrinogen decarboxylase	0.012
Ramp2	receptor (calcitonin) activity modifying protein 2	0.012
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.012
Tmem106a	transmembrane protein 106A	0.012
Gata3	GATA binding protein 3	0.012
Eif5a	eukaryotic translation initiation factor 5A	0.012
Mapk13	mitogen-activated protein kinase 13	0.012
Lhx2	LIM homeobox protein 2	0.012
Afp	alpha fetoprotein	0.012
Hspd1	heat shock protein 1 (chaperonin)	0.012
Krt84	keratin 84	0.012
Lap3	leucine aminopeptidase 3	0.012
Hist1h3f	histone cluster 1, H3f	0.012
Ptrh1	peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)	0.012
Acsl1	acyl-CoA synthetase long-chain family member 1	0.012
Ushbp1	Usher syndrome 1C binding protein 1	0.012
Mab21l2	mab-21-like 2 (C. elegans)	0.012
Dhrs11	dehydrogenase/reductase (SDR family) member 11	0.012
Mtx1	metaxin 1	0.012
Msx2	homeobox, msh-like 2	0.012
Sox18	SRY-box containing gene 18	0.012	Mouse
Folr1	folate receptor 1 (adult)	0.012
E330034G19Rik	RIKEN cDNA E330034G19 gene	0.012
Etfb	electron transferring flavoprotein, beta polypeptide	0.012
Sdsl	serine dehydratase-like	0.012
Txnrd2	thioredoxin reductase 2	0.011
Acy1	aminoacylase 1	0.011
Entpd7	ectonucleoside triphosphate diphosphohydrolase 7	0.011
Odz4	odd Oz/ten-m homolog 4 (Drosophila)	0.011
Pacsin2	protein kinase C and casein kinase substrate in neurons 2	0.011
Scarb1	scavenger receptor class B, member 1	0.011
Hnf1b	HNF1 homeobox B	0.011	Mouse
Nanog	Nanog homeobox	0.011
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.011
Pigq	phosphatidylinositol glycan anchor biosynthesis, class Q	0.011
Hmox1	heme oxygenase (decycling) 1	0.011
Elovl1	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1	0.011
Pemt	phosphatidylethanolamine N-methyltransferase	0.011
Fh1	fumarate hydratase 1	0.011
Ppa1	pyrophosphatase (inorganic) 1	0.011
Sntb1	syntrophin, basic 1	0.011
Xpot	exportin, tRNA (nuclear export receptor for tRNAs)	0.011
Icam2	intercellular adhesion molecule 2	0.011
Fhl3	four and a half LIM domains 3	0.011
Mesp1	mesoderm posterior 1	0.011
Grpel2	GrpE-like 2, mitochondrial	0.011
Alk	anaplastic lymphoma kinase	0.011
Hsd3b5	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	0.011
Hapln3	hyaluronan and proteoglycan link protein 3	0.011
Magel2	melanoma antigen, family L, 2	0.011
Apeh	acylpeptide hydrolase	0.011
Pdxk	pyridoxal (pyridoxine, vitamin B6) kinase	0.011
Atox1	ATX1 (antioxidant protein 1) homolog 1 (yeast)	0.011
Mc2r	melanocortin 2 receptor	0.011	Mouse
Tsc1	tuberous sclerosis 1	0.011
Cox15	COX15 homolog, cytochrome c oxidase assembly protein (yeast)	0.011
Pitx1	paired-like homeodomain transcription factor 1	0.011
Ahcy	S-adenosylhomocysteine hydrolase	0.011
Mthfd1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	0.011
Rpe	ribulose-5-phosphate-3-epimerase	0.011
Fam49b	family with sequence similarity 49, member B	0.011
Zbtb46	zinc finger and BTB domain containing 46	0.011
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.011
Ncoa1	nuclear receptor coactivator 1	0.011
Mecr	mitochondrial trans-2-enoyl-CoA reductase	0.011
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.011
Foxd1	forkhead box D1	0.011
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.011
Cul4b	cullin 4B	0.011
Tmx1	thioredoxin-related transmembrane protein 1	0.011
Mrps2	mitochondrial ribosomal protein S2	0.011
Cndp2	CNDP dipeptidase 2 (metallopeptidase M20 family)	0.011
Cd70	CD70 antigen	0.011
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.011
Sox4	SRY-box containing gene 4	0.011	Mouse
Atp5a1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1	0.010
Slc19a1	solute carrier family 19 (sodium/hydrogen exchanger), member 1	0.010
Pnp	purine-nucleoside phosphorylase	0.010
Lass2	LAG1 homolog, ceramide synthase 2	0.010
Lrrk2	leucine-rich repeat kinase 2	0.010
Trim10	tripartite motif-containing 10	0.010
Muc15	mucin 15	0.010
Slc12a1	solute carrier family 12, member 1	0.010
Shroom3	shroom family member 3	0.010
Fpgs	folylpolyglutamyl synthetase	0.010
Lgals2	lectin, galactose-binding, soluble 2	0.010
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.010
Kitl	kit ligand	0.010
Mybl2	myeloblastosis oncogene-like 2	0.010
Ppbp	pro-platelet basic protein	0.010
Pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.010
Arhgap21	Rho GTPase activating protein 21	0.010
Sepx1	selenoprotein X 1	0.010
Krt36	keratin 36	0.010
Gnat1	guanine nucleotide binding protein, alpha transducing 1	0.010