IMP: Integrative Multi-species Prediction

Mus musculus

1 genes annotated in mouse

negative regulation of defense response to virus by host

Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of defense response to virus by host"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of defense response to virus by host" (in gray)

Name	Description	Probability	Func Analog Organism
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.905	Human
Usp18	ubiquitin specific peptidase 18	0.850
Ifi35	interferon-induced protein 35	0.825
Irgm2	immunity-related GTPase family M member 2	0.810
Igtp	interferon gamma induced GTPase	0.801
Irgm1	immunity-related GTPase family M member 1	0.677
Trim21	tripartite motif-containing 21	0.655
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.618
Stat1	signal transducer and activator of transcription 1	0.524
Isg15	ISG15 ubiquitin-like modifier	0.520
Tgtp2	T-cell specific GTPase 2	0.394
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.352
Gbp3	guanylate binding protein 3	0.315
Irf9	interferon regulatory factor 9	0.299	Mouse
Stat2	signal transducer and activator of transcription 2	0.295
Gbp7	guanylate binding protein 7	0.295
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.255
Ifi47	interferon gamma inducible protein 47	0.246
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.246
Gbp2	guanylate binding protein 2	0.240
Irf8	interferon regulatory factor 8	0.207	Mouse
Iigp1	interferon inducible GTPase 1	0.194
Ifih1	interferon induced with helicase C domain 1	0.153
Rsad2	radical S-adenosyl methionine domain containing 2	0.135
Sfpi1	SFFV proviral integration 1	0.134
Uba7	ubiquitin-like modifier activating enzyme 7	0.121
Tapbp	TAP binding protein	0.103
AW112010	expressed sequence AW112010	0.102
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.102
Irf7	interferon regulatory factor 7	0.100	Mouse
H2-K1	histocompatibility 2, K1, K region	0.094
Rtp4	receptor transporter protein 4	0.089
Lgals3bp	lectin, galactoside-binding, soluble, 3 binding protein	0.072
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.062
Parp12	poly (ADP-ribose) polymerase family, member 12	0.053
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.050
Sp100	nuclear antigen Sp100	0.047
Znfx1	zinc finger, NFX1-type containing 1	0.046
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.045
Cxcl10	chemokine (C-X-C motif) ligand 10	0.044
Parp14	poly (ADP-ribose) polymerase family, member 14	0.044
Parp9	poly (ADP-ribose) polymerase family, member 9	0.044
Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.042
H2-Q7	histocompatibility 2, Q region locus 7	0.038
Ifi44	interferon-induced protein 44	0.034
Ikzf1	IKAROS family zinc finger 1	0.034
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.033
Lgals9	lectin, galactose binding, soluble 9	0.032
Ifi27l2a	interferon, alpha-inducible protein 27 like 2A	0.031
Trim30a	tripartite motif-containing 30A	0.030
Bcl3	B-cell leukemia/lymphoma 3	0.030
Igh	immunoglobulin heavy chain complex	0.028
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.026
H2-D1	histocompatibility 2, D region locus 1	0.026
Bst2	bone marrow stromal cell antigen 2	0.025
C920025E04Rik	RIKEN cDNA C920025E04 gene	0.024
Ifitm3	interferon induced transmembrane protein 3	0.024
Trim25	tripartite motif-containing 25	0.024
Ltb	lymphotoxin B	0.023
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.023
Ifit2	interferon-induced protein with tetratricopeptide repeats 2	0.023
Irf4	interferon regulatory factor 4	0.021	Mouse
Oas1a	2'-5' oligoadenylate synthetase 1A	0.020
BC006779	cDNA sequence BC006779	0.020
Gbp6	guanylate binding protein 6	0.020
Parp10	poly (ADP-ribose) polymerase family, member 10	0.019
Zbp1	Z-DNA binding protein 1	0.019
H2-DMa	histocompatibility 2, class II, locus DMa	0.019
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.019
Tor3a	torsin family 3, member A	0.017
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.016
H2-Aa	histocompatibility 2, class II antigen A, alpha	0.016
Ube2l6	ubiquitin-conjugating enzyme E2L 6	0.015
Cd79b	CD79B antigen	0.015
Fas	Fas (TNF receptor superfamily member 6)	0.015
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.015
H2-Eb1	histocompatibility 2, class II antigen E beta	0.014
B2m	beta-2 microglobulin	0.014
Nmi	N-myc (and STAT) interactor	0.014
Ifnar2	interferon (alpha and beta) receptor 2	0.014
Sfn	stratifin	0.014
Oas2	2'-5' oligoadenylate synthetase 2	0.013
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.013
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.013
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.012
Gbp10	guanylate-binding protein 10	0.011
Dtx3l	deltex 3-like (Drosophila)	0.011
Pih1d1	PIH1 domain containing 1	0.011
Mx1	myxovirus (influenza virus) resistance 1	0.011
Cd19	CD19 antigen	0.011
Rnf31	ring finger protein 31	0.011
C1ra	complement component 1, r subcomponent A	0.011
Apol9a	apolipoprotein L 9a	0.010
Socs3	suppressor of cytokine signaling 3	0.010