IMP: Integrative Multi-species Prediction

Mus musculus

4 genes annotated in mouse

endocardium formation

Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endocardium formation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "endocardium formation" (in gray)

Name	Description	Probability	Func Analog Organism
Meox2	mesenchyme homeobox 2	0.970
Gli3	GLI-Kruppel family member GLI3	0.928
Isl1	ISL1 transcription factor, LIM/homeodomain	0.925
Fgfr2	fibroblast growth factor receptor 2	0.898
Pax3	paired box gene 3	0.879
Shh	sonic hedgehog	0.840
Pax6	paired box gene 6	0.577
Nf1	neurofibromatosis 1	0.559
Sox11	SRY-box containing gene 11	0.475	Mouse
Otx2	orthodenticle homolog 2 (Drosophila)	0.456
Bmp4	bone morphogenetic protein 4	0.440
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.380
Tcfap2a	transcription factor AP-2, alpha	0.372
Vangl2	vang-like 2 (van gogh, Drosophila)	0.325
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.308
Pitx2	paired-like homeodomain transcription factor 2	0.307
Fgf8	fibroblast growth factor 8	0.272
Chd7	chromodomain helicase DNA binding protein 7	0.254
She	src homology 2 domain-containing transforming protein E	0.242
Hand1	heart and neural crest derivatives expressed transcript 1	0.209
Prrx1	paired related homeobox 1	0.196
Pou5f1	POU domain, class 5, transcription factor 1	0.169
Gbx2	gastrulation brain homeobox 2	0.141
Eya1	eyes absent 1 homolog (Drosophila)	0.140
Cldn5	claudin 5	0.139
Ptprb	protein tyrosine phosphatase, receptor type, B	0.119
Fgf10	fibroblast growth factor 10	0.112
Tgfb2	transforming growth factor, beta 2	0.106
Neurod1	neurogenic differentiation 1	0.102
Emx1	empty spiracles homolog 1 (Drosophila)	0.102
Smo	smoothened homolog (Drosophila)	0.101
Gata4	GATA binding protein 4	0.100
Alx4	aristaless-like homeobox 4	0.089
Zeb1	zinc finger E-box binding homeobox 1	0.088
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.087
Kdr	kinase insert domain protein receptor	0.086
Gli2	GLI-Kruppel family member GLI2	0.085
Ednrb	endothelin receptor type B	0.083
Fgfr3	fibroblast growth factor receptor 3	0.081
Msx1	homeobox, msh-like 1	0.081
Pitx1	paired-like homeodomain transcription factor 1	0.080
Tbx3	T-box 3	0.079
Ret	ret proto-oncogene	0.078
Aplnr	apelin receptor	0.074
Efnb2	ephrin B2	0.074
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.074
Foxc1	forkhead box C1	0.073
Hes1	hairy and enhancer of split 1 (Drosophila)	0.069
Hand2	heart and neural crest derivatives expressed transcript 2	0.068
Emcn	endomucin	0.068
Fgfr1	fibroblast growth factor receptor 1	0.068
Sox7	SRY-box containing gene 7	0.067	Mouse
Gdnf	glial cell line derived neurotrophic factor	0.066
Sox4	SRY-box containing gene 4	0.064	Mouse
Rarb	retinoic acid receptor, beta	0.063
Rara	retinoic acid receptor, alpha	0.062
Edar	ectodysplasin-A receptor	0.057
Sox2	SRY-box containing gene 2	0.054	Mouse
Tcfap2c	transcription factor AP-2, gamma	0.054
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.053
Insm1	insulinoma-associated 1	0.052
Ebf3	early B-cell factor 3	0.051
Nkx6-1	NK6 homeobox 1	0.050
Cdh5	cadherin 5	0.050
Bcl6b	B-cell CLL/lymphoma 6, member B	0.050
Eda	ectodysplasin-A	0.050
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.049
Gata1	GATA binding protein 1	0.049
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.049
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.048
Pbx1	pre B-cell leukemia transcription factor 1	0.045
Ntf3	neurotrophin 3	0.044
Hoxa3	homeobox A3	0.044
Tek	endothelial-specific receptor tyrosine kinase	0.044
Esam	endothelial cell-specific adhesion molecule	0.043
Sall3	sal-like 3 (Drosophila)	0.043
Rasip1	Ras interacting protein 1	0.041
Xpo4	exportin 4	0.041
Foxc2	forkhead box C2	0.040
Nodal	nodal	0.040
Sox3	SRY-box containing gene 3	0.040	Mouse
Trp63	transformation related protein 63	0.039
Bmp7	bone morphogenetic protein 7	0.039
Ctnnb1	catenin (cadherin associated protein), beta 1	0.038
Lef1	lymphoid enhancer binding factor 1	0.038
Hhex	hematopoietically expressed homeobox	0.037
Jag1	jagged 1	0.036
Ednra	endothelin receptor type A	0.035
Hes5	hairy and enhancer of split 5 (Drosophila)	0.034
Flt1	FMS-like tyrosine kinase 1	0.034
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.034
Gja4	gap junction protein, alpha 4	0.034
Atoh7	atonal homolog 7 (Drosophila)	0.033
Neurog2	neurogenin 2	0.033
Sall4	sal-like 4 (Drosophila)	0.033
Vegfa	vascular endothelial growth factor A	0.033
Tbx1	T-box 1	0.033
Kit	kit oncogene	0.033
Nog	noggin	0.032
Dll4	delta-like 4 (Drosophila)	0.032
Pou3f3	POU domain, class 3, transcription factor 3	0.032
Cldn3	claudin 3	0.031
Alx3	aristaless-like homeobox 3	0.031
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.031
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.031
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.031
Ldb2	LIM domain binding 2	0.031
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.030
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.030
Fgf4	fibroblast growth factor 4	0.030
Hdac1	histone deacetylase 1	0.030
Kitl	kit ligand	0.029
Alx1	ALX homeobox 1	0.029
Sox18	SRY-box containing gene 18	0.028
Col2a1	collagen, type II, alpha 1	0.026
Krt17	keratin 17	0.025
Lmx1b	LIM homeobox transcription factor 1 beta	0.025
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.025
Mab21l2	mab-21-like 2 (C. elegans)	0.025
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.024
Meox1	mesenchyme homeobox 1	0.023
Otx1	orthodenticle homolog 1 (Drosophila)	0.023
Ptch1	patched homolog 1	0.022
Fhl3	four and a half LIM domains 3	0.022
Gata6	GATA binding protein 6	0.022
Tcf15	transcription factor 15	0.022
Ugt8a	UDP galactosyltransferase 8A	0.022
Runx2	runt related transcription factor 2	0.022
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.021
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.021
Kcnk2	potassium channel, subfamily K, member 2	0.021
Rb1	retinoblastoma 1	0.021
Tbx2	T-box 2	0.021
Mest	mesoderm specific transcript	0.021
Emx2	empty spiracles homolog 2 (Drosophila)	0.021
Foxh1	forkhead box H1	0.020
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.020
Prrx2	paired related homeobox 2	0.020
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.020
Trp53	transformation related protein 53	0.020
Hrc	histidine rich calcium binding protein	0.020
Lhx3	LIM homeobox protein 3	0.020
Zic2	zinc finger protein of the cerebellum 2	0.020
Pou4f2	POU domain, class 4, transcription factor 2	0.019
Hoxa5	homeobox A5	0.019
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.019
Vwf	Von Willebrand factor homolog	0.019
Rgs5	regulator of G-protein signaling 5	0.019
Zic1	zinc finger protein of the cerebellum 1	0.019
Bmp5	bone morphogenetic protein 5	0.018
Foxi3	forkhead box I3	0.018
Icam2	intercellular adhesion molecule 2	0.018
Pou3f1	POU domain, class 3, transcription factor 1	0.018
Hoxa2	homeobox A2	0.018
Fgf3	fibroblast growth factor 3	0.018
Btbd17	BTB (POZ) domain containing 17	0.018
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.018
Gata2	GATA binding protein 2	0.018
En2	engrailed 2	0.018
Lrp2	low density lipoprotein receptor-related protein 2	0.018
Hoxd13	homeobox D13	0.018
Nfib	nuclear factor I/B	0.018
Sox17	SRY-box containing gene 17	0.018
Smad6	MAD homolog 6 (Drosophila)	0.017
Mn1	meningioma 1	0.017
Mitf	microphthalmia-associated transcription factor	0.017
Hesx1	homeobox gene expressed in ES cells	0.017
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.017
Nanog	Nanog homeobox	0.017
Gsc	goosecoid homeobox	0.017
Dlx1	distal-less homeobox 1	0.017
Notch3	Notch gene homolog 3 (Drosophila)	0.017
Il6st	interleukin 6 signal transducer	0.017
Olig2	oligodendrocyte transcription factor 2	0.016
Bmper	BMP-binding endothelial regulator	0.016
Flt4	FMS-like tyrosine kinase 4	0.016
Dlx5	distal-less homeobox 5	0.016
Npr3	natriuretic peptide receptor 3	0.016
Vstm2l	V-set and transmembrane domain containing 2-like	0.016
Sox9	SRY-box containing gene 9	0.016	Mouse
Nos3	nitric oxide synthase 3, endothelial cell	0.016
Zic3	zinc finger protein of the cerebellum 3	0.016
Gas1	growth arrest specific 1	0.016
Mab21l1	mab-21-like 1 (C. elegans)	0.015
Tcf21	transcription factor 21	0.015
Pax9	paired box gene 9	0.015
Lmo2	LIM domain only 2	0.015
Robo4	roundabout homolog 4 (Drosophila)	0.015
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.015
Pebp4	phosphatidylethanolamine binding protein 4	0.015
Eng	endoglin	0.015
Bmp6	bone morphogenetic protein 6	0.015
Ephb2	Eph receptor B2	0.014
Sall1	sal-like 1 (Drosophila)	0.014
Crhr2	corticotropin releasing hormone receptor 2	0.014
Dmrt1	doublesex and mab-3 related transcription factor 1	0.014
Sfn	stratifin	0.014
Grb10	growth factor receptor bound protein 10	0.014
Foxa2	forkhead box A2	0.014
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.014
Epas1	endothelial PAS domain protein 1	0.013
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.013
Foxg1	forkhead box G1	0.013
Phox2b	paired-like homeobox 2b	0.013
Fuz	fuzzy homolog (Drosophila)	0.013
Hoxb13	homeobox B13	0.013
Apc	adenomatosis polyposis coli	0.013
Gata3	GATA binding protein 3	0.013
Ushbp1	Usher syndrome 1C binding protein 1	0.013
Tmeff2	transmembrane protein with EGF-like and two follistatin-like domains 2	0.013
Mmrn2	multimerin 2	0.013
Onecut1	one cut domain, family member 1	0.013
Ramp2	receptor (calcitonin) activity modifying protein 2	0.013
Irx2	Iroquois related homeobox 2 (Drosophila)	0.012
Abcc9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	0.012
Cdh8	cadherin 8	0.012
Lmx1a	LIM homeobox transcription factor 1 alpha	0.012
Wnt3a	wingless-related MMTV integration site 3A	0.012
Tead4	TEA domain family member 4	0.012
Epha1	Eph receptor A1	0.012
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.012
Skor1	SKI family transcriptional corepressor 1	0.012
Barx2	BarH-like homeobox 2	0.012
Foxf1a	forkhead box F1a	0.012
Epha4	Eph receptor A4	0.012
Cldn4	claudin 4	0.012
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.012
Dlx2	distal-less homeobox 2	0.012
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.012
Sox21	SRY-box containing gene 21	0.012
Hoxa13	homeobox A13	0.012
Mesp1	mesoderm posterior 1	0.012
Agbl4	ATP/GTP binding protein-like 4	0.012
Wnt6	wingless-related MMTV integration site 6	0.012
Cadps	Ca2+-dependent secretion activator	0.012
Acan	aggrecan	0.011
Hcrtr1	hypocretin (orexin) receptor 1	0.011
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.011
Cxcl12	chemokine (C-X-C motif) ligand 12	0.011
Tgfa	transforming growth factor alpha	0.011
Sstr2	somatostatin receptor 2	0.011
Bmp2	bone morphogenetic protein 2	0.011
Alas2	aminolevulinic acid synthase 2, erythroid	0.011
Cldn6	claudin 6	0.011
BC020535	cDNA sequence BC020535	0.011
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.011
Pou3f4	POU domain, class 3, transcription factor 4	0.011
Tbx15	T-box 15	0.011
Nr4a3	nuclear receptor subfamily 4, group A, member 3	0.011
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.011
Pax2	paired box gene 2	0.011
Irx5	Iroquois related homeobox 5 (Drosophila)	0.011
Hoxa4	homeobox A4	0.011
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.011
Tsc1	tuberous sclerosis 1	0.011
Ccna1	cyclin A1	0.011
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.011
D7Ertd443e	DNA segment, Chr 7, ERATO Doi 443, expressed	0.011
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.011
Atp2c2	ATPase, Ca++ transporting, type 2C, member 2	0.011
Fzd4	frizzled homolog 4 (Drosophila)	0.010
Spaca4	sperm acrosome associated 4	0.010
Adrb1	adrenergic receptor, beta 1	0.010
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.010
Cdh2	cadherin 2	0.010
Ivl	involucrin	0.010
Sfrp2	secreted frizzled-related protein 2	0.010
Fign	fidgetin	0.010
Grik4	glutamate receptor, ionotropic, kainate 4	0.010
Dlx6	distal-less homeobox 6	0.010
Myl7	myosin, light polypeptide 7, regulatory	0.010
Col1a1	collagen, type I, alpha 1	0.010
Trim29	tripartite motif-containing 29	0.010
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.010
Myct1	myc target 1	0.010
Ptprm	protein tyrosine phosphatase, receptor type, M	0.010
Pyy	peptide YY	0.010
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.010