IMP: Integrative Multi-species Prediction

Mus musculus

21 genes annotated in mouse

response to unfolded protein

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouseInclude functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to unfolded protein"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "response to unfolded protein" (in gray)

Name	Description	Probability	Func Analog Organism
Hspa5	heat shock protein 5	0.996
Hsp90b1	heat shock protein 90, beta (Grp94), member 1	0.994
Dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.867
Manf	mesencephalic astrocyte-derived neurotrophic factor	0.784
Pdia3	protein disulfide isomerase associated 3	0.770
Cdk4	cyclin-dependent kinase 4	0.759
Cdk6	cyclin-dependent kinase 6	0.665
Dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.663	Worm
Creld2	cysteine-rich with EGF-like domains 2	0.541
Sdf2l1	stromal cell-derived factor 2-like 1	0.507
Uso1	USO1 homolog, vesicle docking protein (yeast)	0.469
Canx	calnexin	0.454	Worm
Xbp1	X-box binding protein 1	0.378
Sel1l	sel-1 suppressor of lin-12-like (C. elegans)	0.332
Spcs2	signal peptidase complex subunit 2 homolog (S. cerevisiae)	0.331
Edem1	ER degradation enhancer, mannosidase alpha-like 1	0.286
Dnajb9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.281
Pdia6	protein disulfide isomerase associated 6	0.252
Tram1	translocating chain-associating membrane protein 1	0.212
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.203
Magt1	magnesium transporter 1	0.200
H47	histocompatibility 47	0.199
Surf4	surfeit gene 4	0.184
Ngly1	N-glycanase 1	0.184
Slc39a7	solute carrier family 39 (zinc transporter), member 7	0.182
Mgat2	mannoside acetylglucosaminyltransferase 2	0.177
Serp1	stress-associated endoplasmic reticulum protein 1	0.165
Slc33a1	solute carrier family 33 (acetyl-CoA transporter), member 1	0.156
Tmed7	transmembrane emp24 protein transport domain containing 7	0.156
Spcs3	signal peptidase complex subunit 3 homolog (S. cerevisiae)	0.152
Stt3a	STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)	0.151
Sec61a1	Sec61 alpha 1 subunit (S. cerevisiae)	0.144
Slc30a5	solute carrier family 30 (zinc transporter), member 5	0.144
Lman1	lectin, mannose-binding, 1	0.126
Ssr1	signal sequence receptor, alpha	0.118
Vcp	valosin containing protein	0.097	Worm
Atf6	activating transcription factor 6	0.093
Ccnd1	cyclin D1	0.086
Prkcsh	protein kinase C substrate 80K-H	0.083
Il18	interleukin 18	0.077
Erp44	endoplasmic reticulum protein 44	0.075	Human
Atf4	activating transcription factor 4	0.068
Hspd1	heat shock protein 1 (chaperonin)	0.068	Human Worm
Slc35b1	solute carrier family 35, member B1	0.068
Slc3a2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.066
Gbp5	guanylate binding protein 5	0.066
Tlr4	toll-like receptor 4	0.063
Tm9sf3	transmembrane 9 superfamily member 3	0.061
Rpn2	ribophorin II	0.061
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.059
Calr	calreticulin	0.058	Worm
Chordc1	cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1	0.057
Sars	seryl-aminoacyl-tRNA synthetase	0.057
Fndc3a	fibronectin type III domain containing 3A	0.055
Rpn1	ribophorin I	0.055
Pdia4	protein disulfide isomerase associated 4	0.052	Worm
Tmem33	transmembrane protein 33	0.050
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.048
Rrbp1	ribosome binding protein 1	0.047
Dnajb2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.046
Slc31a1	solute carrier family 31, member 1	0.043
Il1b	interleukin 1 beta	0.043
Mcfd2	multiple coagulation factor deficiency 2	0.042
Hspa9	heat shock protein 9	0.041
Bak1	BCL2-antagonist/killer 1	0.039
Rnf103	ring finger protein 103	0.039
Sec23b	SEC23B (S. cerevisiae)	0.037
Hsph1	heat shock 105kDa/110kDa protein 1	0.036
P4hb	prolyl 4-hydroxylase, beta polypeptide	0.035	Worm
Gbp7	guanylate binding protein 7	0.035
Txndc5	thioredoxin domain containing 5	0.035
Ssr3	signal sequence receptor, gamma	0.034
Hif1a	hypoxia inducible factor 1, alpha subunit	0.034
Tmed2	transmembrane emp24 domain trafficking protein 2	0.034
Hspa8	heat shock protein 8	0.033
Tm9sf2	transmembrane 9 superfamily member 2	0.032
Uba5	ubiquitin-like modifier activating enzyme 5	0.032
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.031
Arhgap31	Rho GTPase activating protein 31	0.030
Lass2	LAG1 homolog, ceramide synthase 2	0.029
Psmd3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.026
Rpe	ribulose-5-phosphate-3-epimerase	0.026
Syvn1	synovial apoptosis inhibitor 1, synoviolin	0.026	Fly
Nat2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.025
Mafk	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	0.025
Kdelr2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	0.025
Nars	asparaginyl-tRNA synthetase	0.025
Hspa13	heat shock protein 70 family, member 13	0.024
Tars	threonyl-tRNA synthetase	0.023
Hyou1	hypoxia up-regulated 1	0.023
Nmi	N-myc (and STAT) interactor	0.023
Derl2	Der1-like domain family, member 2	0.023	Human
Lonp1	lon peptidase 1, mitochondrial	0.022
Yars	tyrosyl-tRNA synthetase	0.022
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.021
Hsd17b12	hydroxysteroid (17-beta) dehydrogenase 12	0.021
Map3k2	mitogen-activated protein kinase kinase kinase 2	0.021
Gmppb	GDP-mannose pyrophosphorylase B	0.021
Cdk2	cyclin-dependent kinase 2	0.021
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.021
Sqstm1	sequestosome 1	0.020
Irgm1	immunity-related GTPase family M member 1	0.020
Gbp3	guanylate binding protein 3	0.020
Ifngr1	interferon gamma receptor 1	0.020
Dpagt1	dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)	0.019
Arcn1	archain 1	0.019
Trib3	tribbles homolog 3 (Drosophila)	0.019
Sec63	SEC63-like (S. cerevisiae)	0.019	Zebrafish
Bid	BH3 interacting domain death agonist	0.019
Ficd	FIC domain containing	0.018
Rbm42	RNA binding motif protein 42	0.018
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.018
Atf5	activating transcription factor 5	0.018
Jak2	Janus kinase 2	0.018
Sec22b	SEC22 vesicle trafficking protein homolog B (S. cerevisiae)	0.018
Lman2	lectin, mannose-binding 2	0.018
Itch	itchy, E3 ubiquitin protein ligase	0.017
Derl1	Der1-like domain family, member 1	0.017
Ubxn1	UBX domain protein 1	0.017
2310036O22Rik	RIKEN cDNA 2310036O22 gene	0.017
Fadd	Fas (TNFRSF6)-associated via death domain	0.017
A630007B06Rik	RIKEN cDNA A630007B06 gene	0.017
Txndc11	thioredoxin domain containing 11	0.017
Hmbs	hydroxymethylbilane synthase	0.016
Eif3b	eukaryotic translation initiation factor 3, subunit B	0.016
Irgm2	immunity-related GTPase family M member 2	0.016
Casp8	caspase 8	0.016	Mouse
Actn4	actinin alpha 4	0.016
Galk1	galactokinase 1	0.016
Slc30a7	solute carrier family 30 (zinc transporter), member 7	0.016
Emid2	EMI domain containing 2	0.016
Bhlha15	basic helix-loop-helix family, member a15	0.015
Asns	asparagine synthetase	0.015
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.015
Dohh	deoxyhypusine hydroxylase/monooxygenase	0.015
Osbp	oxysterol binding protein	0.015
Ostc	oligosaccharyltransferase complex subunit	0.015
Cflar	CASP8 and FADD-like apoptosis regulator	0.015
Erp29	endoplasmic reticulum protein 29	0.015
Ubxn4	UBX domain protein 4	0.015
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.015
Nsfl1c	NSFL1 (p97) cofactor (p47)	0.015
Mt1	metallothionein 1	0.015
Bcl2	B-cell leukemia/lymphoma 2	0.014
Tmed9	transmembrane emp24 protein transport domain containing 9	0.014
Nus1	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)	0.014
Clcnka	chloride channel Ka	0.014
Prf1	perforin 1 (pore forming protein)	0.014
Mt2	metallothionein 2	0.014
Golga4	golgi autoantigen, golgin subfamily a, 4	0.014
Stat1	signal transducer and activator of transcription 1	0.014
Foxo3	forkhead box O3	0.014
Rb1	retinoblastoma 1	0.014
Stt3b	STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)	0.014	Human
Ifih1	interferon induced with helicase C domain 1	0.014
Hspe1	heat shock protein 1 (chaperonin 10)	0.014
Gbp2	guanylate binding protein 2	0.014
Ak2	adenylate kinase 2	0.014
Dlk1	delta-like 1 homolog (Drosophila)	0.013
Dnajc1	DnaJ (Hsp40) homolog, subfamily C, member 1	0.013
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.013
Apaf1	apoptotic peptidase activating factor 1	0.013
Spcs1	signal peptidase complex subunit 1 homolog (S. cerevisiae)	0.013
Ubr4	ubiquitin protein ligase E3 component n-recognin 4	0.013
Tbc1d23	TBC1 domain family, member 23	0.013
Rab1	RAB1, member RAS oncogene family	0.013
Bsdc1	BSD domain containing 1	0.013
Cyld	cylindromatosis (turban tumor syndrome)	0.013
Hmgn5	high-mobility group nucleosome binding domain 5	0.013
Ctsc	cathepsin C	0.013
Brd2	bromodomain containing 2	0.013
Bag3	BCL2-associated athanogene 3	0.013
Adam9	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	0.013
Foxo1	forkhead box O1	0.013
Ddx50	DEAD (Asp-Glu-Ala-Asp) box polypeptide 50	0.012
Slc25a5	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5	0.012
Ly96	lymphocyte antigen 96	0.012
Mafg	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)	0.012
Copb2	coatomer protein complex, subunit beta 2 (beta prime)	0.012
Herpud1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.012
Ier2	immediate early response 2	0.012
Dnm1	dynamin 1	0.012
Cd2ap	CD2-associated protein	0.012
Ppm1g	protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform	0.012
Casp7	caspase 7	0.012	Mouse
Ssr2	signal sequence receptor, beta	0.012
Oxt	oxytocin	0.012
Tkt	transketolase	0.012
Cebpg	CCAAT/enhancer binding protein (C/EBP), gamma	0.012
Prnp	prion protein	0.012
Ero1lb	ERO1-like beta (S. cerevisiae)	0.012	Mouse
Sft2d1	SFT2 domain containing 1	0.012
Mlec	malectin	0.012
Copb1	coatomer protein complex, subunit beta 1	0.012
P4ha1	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide	0.012
Lyst	lysosomal trafficking regulator	0.012
Foxp1	forkhead box P1	0.012
Flcn	folliculin	0.012
Cltc	clathrin, heavy polypeptide (Hc)	0.012
Rfwd2	ring finger and WD repeat domain 2	0.012
Adam17	a disintegrin and metallopeptidase domain 17	0.012
Elf4	E74-like factor 4 (ets domain transcription factor)	0.012
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.012
Piga	phosphatidylinositol glycan anchor biosynthesis, class A	0.011
Vamp4	vesicle-associated membrane protein 4	0.011
Il15	interleukin 15	0.011
Ccnd3	cyclin D3	0.011	Mouse
Eif2ak3	eukaryotic translation initiation factor 2 alpha kinase 3	0.011
Adora2a	adenosine A2a receptor	0.011
Aup1	ancient ubiquitous protein 1	0.011
Hoxc9	homeobox C9	0.011
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.011
Znrf2	zinc and ring finger 2	0.011
Sstr3	somatostatin receptor 3	0.011
Stk40	serine/threonine kinase 40	0.011
Ube2l6	ubiquitin-conjugating enzyme E2L 6	0.011
Tomm40	translocase of outer mitochondrial membrane 40 homolog (yeast)	0.011
Mogs	mannosyl-oligosaccharide glucosidase	0.011
Edem3	ER degradation enhancer, mannosidase alpha-like 3	0.011	Fly
Ndel1	nuclear distribution gene E-like homolog 1 (A. nidulans)	0.011
Mylip	myosin regulatory light chain interacting protein	0.010
C1qbp	complement component 1, q subcomponent binding protein	0.010
Sec24d	Sec24 related gene family, member D (S. cerevisiae)	0.010
Smad1	MAD homolog 1 (Drosophila)	0.010
Irf9	interferon regulatory factor 9	0.010
H2afy	H2A histone family, member Y	0.010
Cyb5r4	cytochrome b5 reductase 4	0.010
Plscr1	phospholipid scramblase 1	0.010
Myc	myelocytomatosis oncogene	0.010
Ikbkg	inhibitor of kappaB kinase gamma	0.010
Man2a1	mannosidase 2, alpha 1	0.010
Ccdc117	coiled-coil domain containing 117	0.010
Ahi1	Abelson helper integration site 1	0.010
Zfp36	zinc finger protein 36	0.010