IMP: Integrative Multi-species Prediction

Mus musculus

1 genes annotated in mouse

exogenous drug catabolic process

The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "exogenous drug catabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "exogenous drug catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Lepr	leptin receptor	0.989
Vdr	vitamin D receptor	0.972
Otc	ornithine transcarbamylase	0.928
Nr1i2	nuclear receptor subfamily 1, group I, member 2	0.919	Human
Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	0.835	Human
Cyp2b10	cytochrome P450, family 2, subfamily b, polypeptide 10	0.833	Human
Vegfa	vascular endothelial growth factor A	0.828
Lep	leptin	0.798
Cyp2a12	cytochrome P450, family 2, subfamily a, polypeptide 12	0.623
Cyp4a14	cytochrome P450, family 4, subfamily a, polypeptide 14	0.555
Cyp2b9	cytochrome P450, family 2, subfamily b, polypeptide 9	0.520	Human
Ptgs2	prostaglandin-endoperoxide synthase 2	0.470
Cyp2c38	cytochrome P450, family 2, subfamily c, polypeptide 38	0.457
Cyp2c50	cytochrome P450, family 2, subfamily c, polypeptide 50	0.448
Apoe	apolipoprotein E	0.441
Il10	interleukin 10	0.430
Sult1d1	sulfotransferase family 1D, member 1	0.423
Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	0.359	Human
Sult1b1	sulfotransferase family 1B, member 1	0.349
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.326
G6pc	glucose-6-phosphatase, catalytic	0.326
Cyp2c29	cytochrome P450, family 2, subfamily c, polypeptide 29	0.295
Agtr1a	angiotensin II receptor, type 1a	0.294
Pparg	peroxisome proliferator activated receptor gamma	0.284
Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.284
Rdh7	retinol dehydrogenase 7	0.276
Cyp3a44	cytochrome P450, family 3, subfamily a, polypeptide 44	0.272	Human
Crp	C-reactive protein, pentraxin-related	0.242
Ugt2b34	UDP glucuronosyltransferase 2 family, polypeptide B34	0.229
Gnrh1	gonadotropin releasing hormone 1	0.221
Timp4	tissue inhibitor of metalloproteinase 4	0.211
Gsta2	glutathione S-transferase, alpha 2 (Yc2)	0.205
Ldlr	low density lipoprotein receptor	0.171
Ces1d	carboxylesterase 1D	0.169
Cyp3a13	cytochrome P450, family 3, subfamily a, polypeptide 13	0.161	Human
Bche	butyrylcholinesterase	0.151
Ren1	renin 1 structural	0.149
Cyp3a16	cytochrome P450, family 3, subfamily a, polypeptide 16	0.143	Human
Fmo5	flavin containing monooxygenase 5	0.142
Tdo2	tryptophan 2,3-dioxygenase	0.135
Nr1i3	nuclear receptor subfamily 1, group I, member 3	0.134
Ces1g	carboxylesterase 1G	0.131
Lif	leukemia inhibitory factor	0.130
Apoh	apolipoprotein H	0.125
Cav1	caveolin 1, caveolae protein	0.120
Defb1	defensin beta 1	0.119
Pik3c2g	phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide	0.117
Cyp2b13	cytochrome P450, family 2, subfamily b, polypeptide 13	0.114	Human
Baat	bile acid-Coenzyme A: amino acid N-acyltransferase	0.112
Sval1	seminal vesicle antigen-like 1	0.107
Cps1	carbamoyl-phosphate synthetase 1	0.102
Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	0.099
Npy2r	neuropeptide Y receptor Y2	0.095
Adipoq	adiponectin, C1Q and collagen domain containing	0.092
Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	0.090
Ugt2b5	UDP glucuronosyltransferase 2 family, polypeptide B5	0.086
Slc22a1	solute carrier family 22 (organic cation transporter), member 1	0.083
Ptk6	PTK6 protein tyrosine kinase 6	0.083
Vip	vasoactive intestinal polypeptide	0.080
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.080
Nos2	nitric oxide synthase 2, inducible	0.078	Mouse
Sult2a2	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2	0.075
Vmn1r45	vomeronasal 1 receptor 45	0.075
Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	0.067
Slc4a4	solute carrier family 4 (anion exchanger), member 4	0.066
Inmt	indolethylamine N-methyltransferase	0.064
Klk1b4	kallikrein 1-related pepidase b4	0.064
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.063
Npy1r	neuropeptide Y receptor Y1	0.063
Gstm3	glutathione S-transferase, mu 3	0.061
Tex12	testis expressed gene 12	0.061
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.060
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.059
Cyp2c65	cytochrome P450, family 2, subfamily c, polypeptide 65	0.059	Human
Tlr4	toll-like receptor 4	0.058
Gsta3	glutathione S-transferase, alpha 3	0.057
Plg	plasminogen	0.057
Cyp2c55	cytochrome P450, family 2, subfamily c, polypeptide 55	0.054	Human
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.054
Esr1	estrogen receptor 1 (alpha)	0.053
Slc22a18	solute carrier family 22 (organic cation transporter), member 18	0.050
Prkg1	protein kinase, cGMP-dependent, type I	0.049
Cyp2c37	cytochrome P450, family 2. subfamily c, polypeptide 37	0.048
Cyp2g1	cytochrome P450, family 2, subfamily g, polypeptide 1	0.046
Hnf4g	hepatocyte nuclear factor 4, gamma	0.045
Upp2	uridine phosphorylase 2	0.044
Ugt2a3	UDP glucuronosyltransferase 2 family, polypeptide A3	0.044
Cyp3a41b	cytochrome P450, family 3, subfamily a, polypeptide 41B	0.043	Human
Iyd	iodotyrosine deiodinase	0.043
Hsd17b13	hydroxysteroid (17-beta) dehydrogenase 13	0.041
Ugt2b36	UDP glucuronosyltransferase 2 family, polypeptide B36	0.041
Serpina3m	serine (or cysteine) peptidase inhibitor, clade A, member 3M	0.040
Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.040
Vmn1r51	vomeronasal 1 receptor 51	0.039
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.038
Krtap6-1	keratin associated protein 6-1	0.038
Soat2	sterol O-acyltransferase 2	0.038
Adh7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	0.038
Ppara	peroxisome proliferator activated receptor alpha	0.038
Dsc3	desmocollin 3	0.037
Olfr749	olfactory receptor 749	0.036
Serpinb3a	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A	0.036
Tgfb1	transforming growth factor, beta 1	0.035
Cyp2f2	cytochrome P450, family 2, subfamily f, polypeptide 2	0.034
Ugt2b1	UDP glucuronosyltransferase 2 family, polypeptide B1	0.034
Fabp2	fatty acid binding protein 2, intestinal	0.034
Fmo3	flavin containing monooxygenase 3	0.034
Ugt2b35	UDP glucuronosyltransferase 2 family, polypeptide B35	0.034
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.033
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.033
Cyp2d9	cytochrome P450, family 2, subfamily d, polypeptide 9	0.033
Tph2	tryptophan hydroxylase 2	0.032
Mmp9	matrix metallopeptidase 9	0.032
Tmprss15	transmembrane protease, serine 15	0.032
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.032
Akr1d1	aldo-keto reductase family 1, member D1	0.031
Mup5	major urinary protein 5	0.031
Ces3a	carboxylesterase 3A	0.030
Fabp1	fatty acid binding protein 1, liver	0.030
Ccbp2	chemokine binding protein 2	0.030
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.029
Akr1c6	aldo-keto reductase family 1, member C6	0.029
Ces2a	carboxylesterase 2A	0.029
Clec2h	C-type lectin domain family 2, member h	0.028
Art2b	ADP-ribosyltransferase 2b	0.028
Anxa13	annexin A13	0.027
Slc4a5	solute carrier family 4, sodium bicarbonate cotransporter, member 5	0.026
Slc15a1	solute carrier family 15 (oligopeptide transporter), member 1	0.026
Bbox1	butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)	0.026
Cfhr1	complement factor H-related 1	0.026
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.026
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.026
Ces1f	carboxylesterase 1F	0.026
Tas2r105	taste receptor, type 2, member 105	0.025
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.025
Muc3	mucin 3, intestinal	0.025
Abcg8	ATP-binding cassette, sub-family G (WHITE), member 8	0.025
Ereg	epiregulin	0.025
Lgals2	lectin, galactose-binding, soluble 2	0.025
Cyp2c39	cytochrome P450, family 2, subfamily c, polypeptide 39	0.025
Cyp3a41a	cytochrome P450, family 3, subfamily a, polypeptide 41A	0.024	Human
Nr1h4	nuclear receptor subfamily 1, group H, member 4	0.024
Cyp4a31	cytochrome P450, family 4, subfamily a, polypeptide 31	0.024
Vmn1r56	vomeronasal 1 receptor 56	0.024
Apob	apolipoprotein B	0.023
Abca6	ATP-binding cassette, sub-family A (ABC1), member 6	0.023
Vhl	von Hippel-Lindau tumor suppressor	0.022
Serpinb6c	serine (or cysteine) peptidase inhibitor, clade B, member 6c	0.022
D630002G06Rik	RIKEN cDNA D630002G06 gene	0.022
Cyp2c68	cytochrome P450, family 2, subfamily c, polypeptide 68	0.022
Tmem30b	transmembrane protein 30B	0.022
Aadac	arylacetamide deacetylase (esterase)	0.022
Slc10a1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.022
Pon1	paraoxonase 1	0.021
Magea5	melanoma antigen, family A, 5	0.021
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.021
Slco1b2	solute carrier organic anion transporter family, member 1b2	0.020
Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	0.020
Lce1l	late cornified envelope 1L	0.020
Oxsm	3-oxoacyl-ACP synthase, mitochondrial	0.020
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.020
Clca6	chloride channel calcium activated 6	0.020
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.020
Mmp7	matrix metallopeptidase 7	0.020
Dsg1a	desmoglein 1 alpha	0.019
Myh14	myosin, heavy polypeptide 14	0.019
Umod	uromodulin	0.019
Rdh16	retinol dehydrogenase 16	0.019
Aldob	aldolase B, fructose-bisphosphate	0.019
Omt2b	oocyte maturation, beta	0.019
Aldh1a7	aldehyde dehydrogenase family 1, subfamily A7	0.019
Mas1	MAS1 oncogene	0.018
1810030J14Rik	RIKEN cDNA 1810030J14 gene	0.018
Prl2c1	Prolactin family 2, subfamily c, member 1	0.018
Slc5a1	solute carrier family 5 (sodium/glucose cotransporter), member 1	0.018
Tuba8	tubulin, alpha 8	0.018
Ces2g	carboxylesterase 2G	0.018
AB056442	cDNA sequence AB056442	0.018
Klra12	killer cell lectin-like receptor subfamily A, member 12	0.018
Fmo1	flavin containing monooxygenase 1	0.018
Slc17a1	solute carrier family 17 (sodium phosphate), member 1	0.017
Sult3a1	sulfotransferase family 3A, member 1	0.017
Vmn1r58	vomeronasal 1 receptor 58	0.017
Sec14l4	SEC14-like 4 (S. cerevisiae)	0.017
Sult1e1	sulfotransferase family 1E, member 1	0.017
Tat	tyrosine aminotransferase	0.017
Tsku	tsukushin	0.017
Prpmp5	proline-rich protein MP5	0.016
B4galnt2	beta-1,4-N-acetyl-galactosaminyl transferase 2	0.016
Vmn2r26	vomeronasal 2, receptor 26	0.016
Nat1	N-acetyl transferase 1	0.016
Dnm1	dynamin 1	0.016
Gm10228	predicted gene 10228	0.016
Tmem59	transmembrane protein 59	0.016
Sult1a1	sulfotransferase family 1A, phenol-preferring, member 1	0.016
Akr1b7	aldo-keto reductase family 1, member B7	0.016
Slc10a6	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	0.015
Pah	phenylalanine hydroxylase	0.015
Reg1	regenerating islet-derived 1	0.015
Plau	plasminogen activator, urokinase	0.015
Reg3a	regenerating islet-derived 3 alpha	0.015
Ghr	growth hormone receptor	0.014
Vsig4	V-set and immunoglobulin domain containing 4	0.014
Hsd3b3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3	0.014
Mug1	murinoglobulin 1	0.014
Cdhr5	cadherin-related family member 5	0.014
Mrap	melanocortin 2 receptor accessory protein	0.014
Orm3	orosomucoid 3	0.014
Ces1e	carboxylesterase 1E	0.014
Ces2e	carboxylesterase 2E	0.014
Pdgfb	platelet derived growth factor, B polypeptide	0.014
Cyp3a59	cytochrome P450, subfamily 3A, polypeptide 59	0.014	Human
Mfn2	mitofusin 2	0.014
Cyp1a1	cytochrome P450, family 1, subfamily a, polypeptide 1	0.014
Defb10	defensin beta 10	0.014
Flt1	FMS-like tyrosine kinase 1	0.014
Apcs	serum amyloid P-component	0.014
Mug2	murinoglobulin 2	0.013
Slc12a1	solute carrier family 12, member 1	0.013
Fbxw14	F-box and WD-40 domain protein 14	0.013
Dnajb7	DnaJ (Hsp40) homolog, subfamily B, member 7	0.013
Slc13a1	solute carrier family 13 (sodium/sulfate symporters), member 1	0.013
Accn5	amiloride-sensitive cation channel 5, intestinal	0.013
Epas1	endothelial PAS domain protein 1	0.013
P2ry2	purinergic receptor P2Y, G-protein coupled 2	0.013
Defa15	defensin, alpha, 15	0.013
Gstm6	glutathione S-transferase, mu 6	0.013
Sec14l2	SEC14-like 2 (S. cerevisiae)	0.013
Vmn2r88	vomeronasal 2, receptor 88	0.013
Aass	aminoadipate-semialdehyde synthase	0.013
Serpind1	serine (or cysteine) peptidase inhibitor, clade D, member 1	0.013
Cfhr2	complement factor H-related 2	0.013
Vnn3	vanin 3	0.013
2810007J24Rik	RIKEN cDNA 2810007J24 gene	0.013
AA672641	expressed sequence AA672641	0.013
Cyp17a1	cytochrome P450, family 17, subfamily a, polypeptide 1	0.013
Lrat	lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)	0.013
Slc23a1	solute carrier family 23 (nucleobase transporters), member 1	0.012
Olfr1471	olfactory receptor 1471	0.012
Mia2	melanoma inhibitory activity 2	0.012
Angptl3	angiopoietin-like 3	0.012
Gm10334	predicted gene 10334	0.012
Krt34	keratin 34	0.012
Fpr3	formyl peptide receptor 3	0.012
Hbb-b2	hemoglobin, beta adult minor chain	0.012
Adh1	alcohol dehydrogenase 1 (class I)	0.012
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.012
Acox2	acyl-Coenzyme A oxidase 2, branched chain	0.012
Slc26a3	solute carrier family 26, member 3	0.012
Ugt3a1	UDP glycosyltransferases 3 family, polypeptide A1	0.012
Gm16381	predicted gene 16381	0.012
Tspan8	tetraspanin 8	0.012
Krtap31-1	keratin associated protein 31-1	0.011
Cml5	camello-like 5	0.011
Prl3c1	prolactin family 3, subfamily c, member 1	0.011
Sox17	SRY-box containing gene 17	0.011
Olfr792	olfactory receptor 792	0.011
Nqo1	NAD(P)H dehydrogenase, quinone 1	0.011
Rab17	RAB17, member RAS oncogene family	0.011
Mep1a	meprin 1 alpha	0.011
Pemt	phosphatidylethanolamine N-methyltransferase	0.011
Rorc	RAR-related orphan receptor gamma	0.011
Gucy2c	guanylate cyclase 2c	0.011
Ar	androgen receptor	0.011
Arl14	ADP-ribosylation factor-like 14	0.011
Ggt6	gamma-glutamyltransferase 6	0.011
Myh1	myosin, heavy polypeptide 1, skeletal muscle, adult	0.011
Ces1c	carboxylesterase 1C	0.011
Enam	enamelin	0.011
Nrg4	neuregulin 4	0.011
Pnpla2	patatin-like phospholipase domain containing 2	0.011
Lrp2bp	Lrp2 binding protein	0.011
Hsd3b2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.011
Nt5e	5' nucleotidase, ecto	0.011
Scgb1a1	secretoglobin, family 1A, member 1 (uteroglobin)	0.011
Tm4sf4	transmembrane 4 superfamily member 4	0.010
Hyal4	hyaluronoglucosaminidase 4	0.010
Cyp2c69	cytochrome P450, family 2, subfamily c, polypeptide 69	0.010
9130016M20Rik	RIKEN cDNA 9130016M20 gene	0.010
Sva	seminal vesicle antigen	0.010
Spp1	secreted phosphoprotein 1	0.010
Prl8a6	prolactin family 8, subfamily a, member 6	0.010
Notch2	Notch gene homolog 2 (Drosophila)	0.010
Prlr	prolactin receptor	0.010
Olfr452	olfactory receptor 452	0.010
Lect2	leukocyte cell-derived chemotaxin 2	0.010
Dpep1	dipeptidase 1 (renal)	0.010
Vmn2r79	vomeronasal 2, receptor 79	0.010
BC089597	cDNA sequence BC089597	0.010