IMP
Process View
er associated ubiquitin dependent protein catabolic process
The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "er associated ubiquitin dependent protein catabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Ncstn | nicastrin | 0.677 | ||
| Psen1 | presenilin 1 | 0.615 | ||
| Hsp90b1 | heat shock protein 90, beta (Grp94), member 1 | 0.297 | Human | |
| Uso1 | USO1 homolog, vesicle docking protein (yeast) | 0.203 | ||
| Ngly1 | N-glycanase 1 | 0.183 | ||
| Canx | calnexin | 0.125 | ||
| Tmed7 | transmembrane emp24 protein transport domain containing 7 | 0.092 | ||
| Creld2 | cysteine-rich with EGF-like domains 2 | 0.061 | ||
| Ufd1l | ubiquitin fusion degradation 1 like | 0.060 | ||
| Pdia3 | protein disulfide isomerase associated 3 | 0.045 | ||
| Psmd6 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 0.040 | ||
| Hspa5 | heat shock protein 5 | 0.038 | Yeast | |
| Xbp1 | X-box binding protein 1 | 0.036 | ||
| Psme4 | proteasome (prosome, macropain) activator subunit 4 | 0.035 | ||
| Dnajc3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.033 | ||
| Nsfl1c | NSFL1 (p97) cofactor (p47) | 0.033 | ||
| Calr | calreticulin | 0.029 | ||
| Psmd4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.028 | ||
| Psmd12 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 0.027 | ||
| Dnajb11 | DnaJ (Hsp40) homolog, subfamily B, member 11 | 0.026 | ||
| Atl2 | atlastin GTPase 2 | 0.022 | ||
| Manf | mesencephalic astrocyte-derived neurotrophic factor | 0.022 | ||
| Ube2g1 | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) | 0.022 | Mouse | |
| Iqcb1 | IQ calmodulin-binding motif containing 1 | 0.021 | ||
| Strap | serine/threonine kinase receptor associated protein | 0.018 | ||
| Nphp4 | nephronophthisis 4 (juvenile) homolog (human) | 0.016 | ||
| Tram1 | translocating chain-associating membrane protein 1 | 0.016 | ||
| Psen2 | presenilin 2 | 0.015 | ||
| P4hb | prolyl 4-hydroxylase, beta polypeptide | 0.015 | ||
| Vcp | valosin containing protein | 0.015 | Human Yeast Worm | |
| Nploc4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.015 | ||
| Pdia6 | protein disulfide isomerase associated 6 | 0.015 | ||
| Rad23b | RAD23b homolog (S. cerevisiae) | 0.015 | ||
| Nphp1 | nephronophthisis 1 (juvenile) homolog (human) | 0.015 | ||
| Aph1a | anterior pharynx defective 1a homolog (C. elegans) | 0.014 | ||
| Mmadhc | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria | 0.014 | ||
| Ube4b | ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) | 0.014 | ||
| Cops5 | COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) | 0.014 | ||
| Ogfod2 | 2-oxoglutarate and iron-dependent oxygenase domain containing 2 | 0.014 | ||
| Kpna3 | karyopherin (importin) alpha 3 | 0.013 | ||
| Sdf2l1 | stromal cell-derived factor 2-like 1 | 0.013 | ||
| Cops2 | COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana) | 0.013 | ||
| Syvn1 | synovial apoptosis inhibitor 1, synoviolin | 0.013 | Human | |
| Ranbp9 | RAN binding protein 9 | 0.013 | ||
| Ube2d3 | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 0.013 | ||
| Cul2 | cullin 2 | 0.013 | ||
| Ficd | FIC domain containing | 0.013 | ||
| H47 | histocompatibility 47 | 0.012 | ||
| Fam103a1 | family with sequence similarity 103, member A1 | 0.012 | ||
| Clptm1l | CLPTM1-like | 0.012 | ||
| Kctd9 | potassium channel tetramerisation domain containing 9 | 0.011 | ||
| Psmd14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.011 | ||
| Ssr3 | signal sequence receptor, gamma | 0.011 | ||
| Psma1 | proteasome (prosome, macropain) subunit, alpha type 1 | 0.011 | ||
| Pnpla8 | patatin-like phospholipase domain containing 8 | 0.011 | ||
| Psmc2 | proteasome (prosome, macropain) 26S subunit, ATPase 2 | 0.011 | ||
| Kpna1 | karyopherin (importin) alpha 1 | 0.011 | ||
| Psmb7 | proteasome (prosome, macropain) subunit, beta type 7 | 0.011 | ||
| Fndc3a | fibronectin type III domain containing 3A | 0.011 | ||
| Herpud1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.011 | ||
| Uap1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.010 | ||
| Spcs3 | signal peptidase complex subunit 3 homolog (S. cerevisiae) | 0.010 | ||
| Rnf167 | ring finger protein 167 | 0.010 |