IMP
Process View
translesion synthesis
The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "translesion synthesis"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Timeless | timeless homolog (Drosophila) | 0.764 | ||
| Mcm3 | minichromosome maintenance deficient 3 (S. cerevisiae) | 0.727 | ||
| Cdc6 | cell division cycle 6 homolog (S. cerevisiae) | 0.693 | ||
| Brca1 | breast cancer 1 | 0.549 | ||
| Nsfl1c | NSFL1 (p97) cofactor (p47) | 0.444 | ||
| Cdt1 | chromatin licensing and DNA replication factor 1 | 0.428 | ||
| Ccna2 | cyclin A2 | 0.413 | ||
| Mcm5 | minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 0.399 | ||
| Polh | polymerase (DNA directed), eta (RAD 30 related) | 0.370 | ||
| Brca2 | breast cancer 2 | 0.354 | ||
| Ppp1cc | protein phosphatase 1, catalytic subunit, gamma isoform | 0.354 | ||
| Cdk1 | cyclin-dependent kinase 1 | 0.345 | ||
| Wdhd1 | WD repeat and HMG-box DNA binding protein 1 | 0.305 | ||
| Lig1 | ligase I, DNA, ATP-dependent | 0.293 | ||
| Ncaph | non-SMC condensin I complex, subunit H | 0.287 | ||
| Poli | polymerase (DNA directed), iota | 0.286 | Fly | |
| Mcm2 | minichromosome maintenance deficient 2 mitotin (S. cerevisiae) | 0.265 | ||
| Cdca5 | cell division cycle associated 5 | 0.253 | ||
| Hsp90ab1 | heat shock protein 90 alpha (cytosolic), class B member 1 | 0.244 | ||
| Ttk | Ttk protein kinase | 0.218 | ||
| Ppp1ca | protein phosphatase 1, catalytic subunit, alpha isoform | 0.218 | ||
| Chek1 | checkpoint kinase 1 homolog (S. pombe) | 0.212 | ||
| Ccnb1 | cyclin B1 | 0.199 | ||
| Mki67 | antigen identified by monoclonal antibody Ki 67 | 0.178 | ||
| Ube4b | ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) | 0.178 | ||
| Polk | polymerase (DNA directed), kappa | 0.174 | ||
| Rad51 | RAD51 homolog (S. cerevisiae) | 0.162 | ||
| Eif4a2 | eukaryotic translation initiation factor 4A2 | 0.146 | ||
| Kif11 | kinesin family member 11 | 0.132 | ||
| Mad2l1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.124 | ||
| Bub1 | budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) | 0.124 | ||
| Rad51ap1 | RAD51 associated protein 1 | 0.121 | ||
| Clk4 | CDC like kinase 4 | 0.118 | ||
| Ufd1l | ubiquitin fusion degradation 1 like | 0.116 | ||
| Uhrf1 | ubiquitin-like, containing PHD and RING finger domains, 1 | 0.109 | ||
| Aurkb | aurora kinase B | 0.108 | ||
| Asf1b | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | 0.106 | ||
| Paip2 | polyadenylate-binding protein-interacting protein 2 | 0.105 | ||
| Trip13 | thyroid hormone receptor interactor 13 | 0.104 | ||
| Prim1 | DNA primase, p49 subunit | 0.102 | ||
| Hdac6 | histone deacetylase 6 | 0.098 | ||
| Prc1 | protein regulator of cytokinesis 1 | 0.097 | ||
| Birc5 | baculoviral IAP repeat-containing 5 | 0.097 | ||
| Pold1 | polymerase (DNA directed), delta 1, catalytic subunit | 0.095 | ||
| Tk1 | thymidine kinase 1 | 0.095 | ||
| Dna2 | DNA replication helicase 2 homolog (yeast) | 0.093 | ||
| Rrm2 | ribonucleotide reductase M2 | 0.092 | ||
| Smc2 | structural maintenance of chromosomes 2 | 0.087 | ||
| Ptma | prothymosin alpha | 0.084 | ||
| Hprt | hypoxanthine guanine phosphoribosyl transferase | 0.083 | ||
| Tacc3 | transforming, acidic coiled-coil containing protein 3 | 0.083 | ||
| Ranbp1 | RAN binding protein 1 | 0.077 | ||
| Ckap2 | cytoskeleton associated protein 2 | 0.073 | ||
| Top2a | topoisomerase (DNA) II alpha | 0.070 | ||
| Pole2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | 0.068 | ||
| Cdc7 | cell division cycle 7 (S. cerevisiae) | 0.068 | ||
| Ect2 | ect2 oncogene | 0.067 | ||
| Kif4 | kinesin family member 4 | 0.066 | ||
| Ercc6l | excision repair cross-complementing rodent repair deficiency complementation group 6 - like | 0.065 | ||
| Parp2 | poly (ADP-ribose) polymerase family, member 2 | 0.064 | ||
| Hells | helicase, lymphoid specific | 0.064 | ||
| Rfc3 | replication factor C (activator 1) 3 | 0.064 | ||
| Cdca8 | cell division cycle associated 8 | 0.063 | ||
| E2f8 | E2F transcription factor 8 | 0.063 | ||
| Orc1 | origin recognition complex, subunit 1 | 0.063 | ||
| Cenpk | centromere protein K | 0.061 | ||
| Tia1 | cytotoxic granule-associated RNA binding protein 1 | 0.059 | ||
| Rev1 | REV1 homolog (S. cerevisiae) | 0.059 | ||
| Cdca7l | cell division cycle associated 7 like | 0.058 | ||
| Plk4 | polo-like kinase 4 (Drosophila) | 0.058 | ||
| Kif23 | kinesin family member 23 | 0.056 | ||
| Stil | Scl/Tal1 interrupting locus | 0.056 | ||
| Rrm1 | ribonucleotide reductase M1 | 0.054 | ||
| Ncapd2 | non-SMC condensin I complex, subunit D2 | 0.052 | ||
| Bub1b | budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) | 0.050 | ||
| Fam103a1 | family with sequence similarity 103, member A1 | 0.050 | ||
| Wee1 | WEE 1 homolog 1 (S. pombe) | 0.049 | ||
| Cenph | centromere protein H | 0.049 | ||
| Mms22l | MMS22-like, DNA repair protein | 0.048 | ||
| Plk1 | polo-like kinase 1 (Drosophila) | 0.048 | ||
| Racgap1 | Rac GTPase-activating protein 1 | 0.047 | ||
| Ube2t | ubiquitin-conjugating enzyme E2T (putative) | 0.047 | ||
| Nek2 | NIMA (never in mitosis gene a)-related expressed kinase 2 | 0.045 | ||
| Hmmr | hyaluronan mediated motility receptor (RHAMM) | 0.044 | ||
| Fbxo5 | F-box protein 5 | 0.044 | ||
| Melk | maternal embryonic leucine zipper kinase | 0.042 | ||
| Blm | Bloom syndrome, RecQ helicase-like | 0.042 | ||
| Cdk2 | cyclin-dependent kinase 2 | 0.041 | ||
| Psma4 | proteasome (prosome, macropain) subunit, alpha type 4 | 0.040 | ||
| Slbp | stem-loop binding protein | 0.040 | ||
| Kntc1 | kinetochore associated 1 | 0.039 | ||
| Mgea5 | meningioma expressed antigen 5 (hyaluronidase) | 0.039 | ||
| Clk1 | CDC-like kinase 1 | 0.037 | ||
| Hat1 | histone aminotransferase 1 | 0.037 | ||
| H2afz | H2A histone family, member Z | 0.037 | ||
| Tipin | timeless interacting protein | 0.036 | ||
| Zfand6 | zinc finger, AN1-type domain 6 | 0.036 | ||
| Cdca7 | cell division cycle associated 7 | 0.034 | ||
| Mis18bp1 | MIS18 binding protein 1 | 0.034 | ||
| Ccnb2 | cyclin B2 | 0.034 | ||
| Pola1 | polymerase (DNA directed), alpha 1 | 0.034 | ||
| Lmnb1 | lamin B1 | 0.032 | ||
| Ccdc99 | coiled-coil domain containing 99 | 0.032 | ||
| Hnrnpf | heterogeneous nuclear ribonucleoprotein F | 0.032 | ||
| Atp5b | ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit | 0.032 | ||
| Naa38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | 0.029 | ||
| Zfp639 | zinc finger protein 639 | 0.029 | ||
| Ube2d3 | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 0.029 | ||
| H3f3a | H3 histone, family 3A | 0.028 | ||
| Pde7a | phosphodiesterase 7A | 0.028 | ||
| Neil3 | nei like 3 (E. coli) | 0.028 | ||
| E2f1 | E2F transcription factor 1 | 0.027 | ||
| Mcm7 | minichromosome maintenance deficient 7 (S. cerevisiae) | 0.027 | ||
| Gsg2 | germ cell-specific gene 2 | 0.026 | ||
| Mbd4 | methyl-CpG binding domain protein 4 | 0.026 | ||
| Nploc4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.026 | ||
| Zfml | zinc finger, matrin-like | 0.025 | ||
| Sgol1 | shugoshin-like 1 (S. pombe) | 0.025 | ||
| Plrg1 | pleiotropic regulator 1, PRL1 homolog (Arabidopsis) | 0.024 | ||
| Syce2 | synaptonemal complex central element protein 2 | 0.024 | ||
| Rfc5 | replication factor C (activator 1) 5 | 0.023 | ||
| Kif22 | kinesin family member 22 | 0.023 | ||
| Sumo2 | SMT3 suppressor of mif two 3 homolog 2 (yeast) | 0.023 | ||
| Dnajc9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | 0.023 | ||
| Immp1l | IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.023 | ||
| Ppia | peptidylprolyl isomerase A | 0.023 | ||
| A530054K11Rik | RIKEN cDNA A530054K11 gene | 0.023 | ||
| Polb | polymerase (DNA directed), beta | 0.022 | ||
| Fen1 | flap structure specific endonuclease 1 | 0.022 | ||
| Kars | lysyl-tRNA synthetase | 0.022 | ||
| Fbxl3 | F-box and leucine-rich repeat protein 3 | 0.022 | ||
| Amfr | autocrine motility factor receptor | 0.022 | ||
| Ngly1 | N-glycanase 1 | 0.021 | ||
| Dlgap5 | discs, large (Drosophila) homolog-associated protein 5 | 0.021 | ||
| Lrr1 | leucine rich repeat protein 1 | 0.021 | ||
| Cenpa | centromere protein A | 0.021 | ||
| Clspn | claspin homolog (Xenopus laevis) | 0.021 | ||
| Cyb5r4 | cytochrome b5 reductase 4 | 0.021 | ||
| Mat2b | methionine adenosyltransferase II, beta | 0.020 | ||
| 2810417H13Rik | RIKEN cDNA 2810417H13 gene | 0.020 | Human | |
| Yipf4 | Yip1 domain family, member 4 | 0.020 | ||
| Ncapg | non-SMC condensin I complex, subunit G | 0.020 | ||
| Nbn | nibrin | 0.020 | ||
| Tsg101 | tumor susceptibility gene 101 | 0.019 | ||
| Cse1l | chromosome segregation 1-like (S. cerevisiae) | 0.019 | ||
| Zwilch | Zwilch, kinetochore associated, homolog (Drosophila) | 0.019 | ||
| Mcm6 | minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 0.019 | ||
| Psmd4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.019 | ||
| Gmnn | geminin | 0.019 | ||
| Atl2 | atlastin GTPase 2 | 0.019 | ||
| Ube2c | ubiquitin-conjugating enzyme E2C | 0.019 | ||
| Psmc5 | protease (prosome, macropain) 26S subunit, ATPase 5 | 0.019 | ||
| Tcf19 | transcription factor 19 | 0.019 | ||
| Shcbp1 | Shc SH2-domain binding protein 1 | 0.019 | ||
| Ogt | O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) | 0.018 | ||
| Pkm2 | pyruvate kinase, muscle | 0.018 | ||
| Aspm | asp (abnormal spindle)-like, microcephaly associated (Drosophila) | 0.018 | ||
| Rpa2 | replication protein A2 | 0.018 | ||
| Bod1l | biorientation of chromosomes in cell division 1-like | 0.018 | ||
| Rnaseh2b | ribonuclease H2, subunit B | 0.018 | ||
| Spag5 | sperm associated antigen 5 | 0.017 | ||
| Zmym5 | zinc finger, MYM-type 5 | 0.017 | ||
| Diap3 | diaphanous homolog 3 (Drosophila) | 0.017 | ||
| Isca1 | iron-sulfur cluster assembly 1 homolog (S. cerevisiae) | 0.017 | ||
| Pbk | PDZ binding kinase | 0.017 | ||
| Pole4 | polymerase (DNA-directed), epsilon 4 (p12 subunit) | 0.017 | ||
| Rad18 | RAD18 homolog (S. cerevisiae) | 0.017 | ||
| Zfand5 | zinc finger, AN1-type domain 5 | 0.016 | ||
| Ywhah | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 0.016 | ||
| Vdac2 | voltage-dependent anion channel 2 | 0.016 | ||
| Atad2 | ATPase family, AAA domain containing 2 | 0.016 | ||
| Srek1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.015 | ||
| Ranbp9 | RAN binding protein 9 | 0.015 | ||
| Cript | cysteine-rich PDZ-binding protein | 0.015 | ||
| Zfp40 | zinc finger protein 40 | 0.015 | ||
| Anln | anillin, actin binding protein | 0.015 | ||
| Hist1h2ao | histone cluster 1, H2ao | 0.015 | ||
| Cdadc1 | cytidine and dCMP deaminase domain containing 1 | 0.015 | ||
| Erh | enhancer of rudimentary homolog (Drosophila) | 0.015 | ||
| 1110004F10Rik | RIKEN cDNA 1110004F10 gene | 0.014 | ||
| Gins1 | GINS complex subunit 1 (Psf1 homolog) | 0.014 | ||
| Cdc20 | cell division cycle 20 homolog (S. cerevisiae) | 0.014 | ||
| Kif2c | kinesin family member 2C | 0.014 | ||
| Zfp868 | zinc finger protein 868 | 0.014 | ||
| Kif20a | kinesin family member 20A | 0.014 | ||
| Stmn1 | stathmin 1 | 0.014 | ||
| Cwc15 | CWC15 homolog (S. cerevisiae) | 0.014 | ||
| Nusap1 | nucleolar and spindle associated protein 1 | 0.014 | ||
| Ttc14 | tetratricopeptide repeat domain 14 | 0.014 | ||
| Pcmtd2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.014 | ||
| Mastl | microtubule associated serine/threonine kinase-like | 0.014 | ||
| Ezh2 | enhancer of zeste homolog 2 (Drosophila) | 0.014 | ||
| Cenpi | centromere protein I | 0.013 | ||
| Krit1 | KRIT1, ankyrin repeat containing | 0.013 | ||
| Pcbp1 | poly(rC) binding protein 1 | 0.013 | ||
| Atm | ataxia telangiectasia mutated homolog (human) | 0.013 | ||
| Zfp101 | zinc finger protein 101 | 0.013 | ||
| Exo1 | exonuclease 1 | 0.013 | ||
| Nuf2 | NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) | 0.013 | ||
| Ccnf | cyclin F | 0.013 | ||
| Atr | ataxia telangiectasia and Rad3 related | 0.013 | ||
| Prim2 | DNA primase, p58 subunit | 0.013 | ||
| Cenpn | centromere protein N | 0.013 | ||
| Hspa8 | heat shock protein 8 | 0.013 | ||
| Spice1 | spindle and centriole associated protein 1 | 0.013 | ||
| Rpa1 | replication protein A1 | 0.013 | ||
| Hnrnph3 | heterogeneous nuclear ribonucleoprotein H3 | 0.012 | ||
| Skp1a | S-phase kinase-associated protein 1A | 0.012 | ||
| Nde1 | nuclear distribution gene E homolog 1 (A nidulans) | 0.012 | ||
| Prpsap2 | phosphoribosyl pyrophosphate synthetase-associated protein 2 | 0.012 | ||
| Nup35 | nucleoporin 35 | 0.012 | ||
| Mapkapk5 | MAP kinase-activated protein kinase 5 | 0.012 | ||
| Wdr90 | WD repeat domain 90 | 0.012 | ||
| Klhl24 | kelch-like 24 (Drosophila) | 0.012 | ||
| Crebzf | CREB/ATF bZIP transcription factor | 0.012 | ||
| Nasp | nuclear autoantigenic sperm protein (histone-binding) | 0.012 | ||
| Cenpe | centromere protein E | 0.012 | ||
| Eif1b | eukaryotic translation initiation factor 1B | 0.012 | ||
| Atg5 | autophagy-related 5 (yeast) | 0.012 | ||
| Mns1 | meiosis-specific nuclear structural protein 1 | 0.012 | ||
| Vrk1 | vaccinia related kinase 1 | 0.012 | ||
| Gpbp1 | GC-rich promoter binding protein 1 | 0.012 | ||
| Phip | pleckstrin homology domain interacting protein | 0.012 | ||
| Rpl4 | ribosomal protein L4 | 0.012 | ||
| Shprh | SNF2 histone linker PHD RING helicase | 0.012 | ||
| Mcm10 | minichromosome maintenance deficient 10 (S. cerevisiae) | 0.011 | ||
| Dtl | denticleless homolog (Drosophila) | 0.011 | Human | |
| Rab18 | RAB18, member RAS oncogene family | 0.011 | ||
| Vps26a | vacuolar protein sorting 26 homolog A (yeast) | 0.011 | ||
| Cenpf | centromere protein F | 0.011 | ||
| Cdc25c | cell division cycle 25 homolog C (S. pombe) | 0.011 | ||
| Cep55 | centrosomal protein 55 | 0.011 | ||
| Asnsd1 | asparagine synthetase domain containing 1 | 0.011 | ||
| AW549877 | expressed sequence AW549877 | 0.011 | ||
| 2700029M09Rik | RIKEN cDNA 2700029M09 gene | 0.011 | ||
| Prpf39 | PRP39 pre-mRNA processing factor 39 homolog (yeast) | 0.010 | ||
| P4hb | prolyl 4-hydroxylase, beta polypeptide | 0.010 | ||
| Eapp | E2F-associated phosphoprotein | 0.010 | ||
| Tuba1b | tubulin, alpha 1B | 0.010 | ||
| Rsrc2 | arginine/serine-rich coiled-coil 2 | 0.010 | ||
| D4Wsu53e | DNA segment, Chr 4, Wayne State University 53, expressed | 0.010 | ||
| Fam111a | family with sequence similarity 111, member A | 0.010 | ||
| Phax | phosphorylated adaptor for RNA export | 0.010 | ||
| Espl1 | extra spindle poles-like 1 (S. cerevisiae) | 0.010 | ||
| Tonsl | tonsoku-like, DNA repair protein | 0.010 | ||
| Caprin2 | caprin family member 2 | 0.010 | ||
| Arid4b | AT rich interactive domain 4B (RBP1-like) | 0.010 | ||
| Pcmtd1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.010 | ||
| Chek2 | CHK2 checkpoint homolog (S. pombe) | 0.010 |