IMP: Integrative Multi-species Prediction

Mus musculus

25 genes annotated in mouse

protein stabilization

Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein stabilization"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "protein stabilization" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	0.960
Mdm2	transformed mouse 3T3 cell double minute 2	0.793
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.454
Shh	sonic hedgehog	0.368
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.327	Fly
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.195	Fly
Pbx1	pre B-cell leukemia transcription factor 1	0.193
Gli3	GLI-Kruppel family member GLI3	0.179
Tsc2	tuberous sclerosis 2	0.146
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.144	Fly
Msx1	homeobox, msh-like 1	0.128	Human
Lrrk2	leucine-rich repeat kinase 2	0.122
Bmp4	bone morphogenetic protein 4	0.111
Rpgrip1l	Rpgrip1-like	0.110
Hbb-b1	hemoglobin, beta adult major chain	0.105
Prnp	prion protein	0.100
Cops6	COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)	0.094
Prrx1	paired related homeobox 1	0.091
Spna1	spectrin alpha 1	0.087
Tcf4	transcription factor 4	0.081	Mouse
Fgfr1	fibroblast growth factor receptor 1	0.077
Hand2	heart and neural crest derivatives expressed transcript 2	0.075
Ctnnb1	catenin (cadherin associated protein), beta 1	0.061
Fgf8	fibroblast growth factor 8	0.061
Tcfap2a	transcription factor AP-2, alpha	0.060
Hbb-b2	hemoglobin, beta adult minor chain	0.060
Sox4	SRY-box containing gene 4	0.059
Isl1	ISL1 transcription factor, LIM/homeodomain	0.058
Pax3	paired box gene 3	0.057
Id3	inhibitor of DNA binding 3	0.056
Fgfr2	fibroblast growth factor receptor 2	0.056
Ank1	ankyrin 1, erythroid	0.055	Mouse
Nf1	neurofibromatosis 1	0.053
Otx2	orthodenticle homolog 2 (Drosophila)	0.050
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.048
Skil	SKI-like	0.047
Hand1	heart and neural crest derivatives expressed transcript 1	0.046
Psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.046
Pim1	proviral integration site 1	0.043
Smarca5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.042
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.041
Daxx	Fas death domain-associated protein	0.041
Id1	inhibitor of DNA binding 1	0.040
Gps1	G protein pathway suppressor 1	0.039	Fly
Hspa9	heat shock protein 9	0.038
Axin1	axin 1	0.038
Acvr1	activin A receptor, type 1	0.037
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.037
Smad6	MAD homolog 6 (Drosophila)	0.036
Rab11a	RAB11a, member RAS oncogene family	0.035
Sox9	SRY-box containing gene 9	0.035	Mouse
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.033
Pax6	paired box gene 6	0.033
Ptch1	patched homolog 1	0.032
Stat5a	signal transducer and activator of transcription 5A	0.032
Cops5	COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)	0.031	Fly
Epas1	endothelial PAS domain protein 1	0.030
Apc	adenomatosis polyposis coli	0.030
Creb1	cAMP responsive element binding protein 1	0.030
Ttc7	tetratricopeptide repeat domain 7	0.029
Cops3	COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)	0.029	Fly
Ednra	endothelin receptor type A	0.029
Spnb1	spectrin beta 1	0.029
Eed	embryonic ectoderm development	0.029
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.028
Jarid2	jumonji, AT rich interactive domain 2	0.028
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.028
Ctsb	cathepsin B	0.028
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.027
App	amyloid beta (A4) precursor protein	0.027
Gata4	GATA binding protein 4	0.027
Tal1	T-cell acute lymphocytic leukemia 1	0.027
P4hb	prolyl 4-hydroxylase, beta polypeptide	0.027
Lef1	lymphoid enhancer binding factor 1	0.026
Pou5f1	POU domain, class 5, transcription factor 1	0.026
Bmp7	bone morphogenetic protein 7	0.025
Per1	period homolog 1 (Drosophila)	0.025
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.025
Stk4	serine/threonine kinase 4	0.024
Pklr	pyruvate kinase liver and red blood cell	0.024
ND6	NADH dehydrogenase subunit 6	0.023
Rint1	RAD50 interactor 1	0.022
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.022
Hes1	hairy and enhancer of split 1 (Drosophila)	0.022
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.021
Alx1	ALX homeobox 1	0.021
Cct4	chaperonin containing Tcp1, subunit 4 (delta)	0.021
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.021
Dync1i2	dynein cytoplasmic 1 intermediate chain 2	0.020
Cops4	COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)	0.020
Tgfb2	transforming growth factor, beta 2	0.020
Smad4	MAD homolog 4 (Drosophila)	0.020
Eya1	eyes absent 1 homolog (Drosophila)	0.020
Actg1	actin, gamma, cytoplasmic 1	0.020
Trp63	transformation related protein 63	0.020
Hsp90b1	heat shock protein 90, beta (Grp94), member 1	0.020
Pim3	proviral integration site 3	0.019	Mouse
Zzz3	zinc finger, ZZ domain containing 3	0.019
Gli2	GLI-Kruppel family member GLI2	0.019
Cops8	COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)	0.019
Id2	inhibitor of DNA binding 2	0.019
Gata6	GATA binding protein 6	0.019
Disp1	dispatched homolog 1 (Drosophila)	0.018
Pbx3	pre B-cell leukemia transcription factor 3	0.018
Aplp2	amyloid beta (A4) precursor-like protein 2	0.018
Plod3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.018
Purb	purine rich element binding protein B	0.018
Cux1	cut-like homeobox 1	0.018
Rara	retinoic acid receptor, alpha	0.018
Etf1	eukaryotic translation termination factor 1	0.018
Nf2	neurofibromatosis 2	0.017
Pkd2	polycystic kidney disease 2	0.017
Prkce	protein kinase C, epsilon	0.017
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.017
Kit	kit oncogene	0.017
Eno1	enolase 1, alpha non-neuron	0.017
Klf1	Kruppel-like factor 1 (erythroid)	0.017
Ppp2ca	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	0.016
Bmp2	bone morphogenetic protein 2	0.016
Zeb1	zinc finger E-box binding homeobox 1	0.016
Glrx3	glutaredoxin 3	0.016
Ddx1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	0.016
Cul1	cullin 1	0.016
Kitl	kit ligand	0.016
Hspb8	heat shock protein 8	0.016
Psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.016
Tcf3	transcription factor 3	0.016
Sox2	SRY-box containing gene 2	0.016	Mouse
Hhex	hematopoietically expressed homeobox	0.016
Sox17	SRY-box containing gene 17	0.016	Human Mouse
Sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.016
Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.016
Akr1a4	aldo-keto reductase family 1, member A4 (aldehyde reductase)	0.015
Ccar1	cell division cycle and apoptosis regulator 1	0.015
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.015
Fkbp1a	FK506 binding protein 1a	0.015
Fgf10	fibroblast growth factor 10	0.015
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.015
Hoxa5	homeobox A5	0.015
Hoxa13	homeobox A13	0.015
9430031J16Rik	RIKEN cDNA 9430031J16 gene	0.015
Ubap2	ubiquitin-associated protein 2	0.015
Pitx2	paired-like homeodomain transcription factor 2	0.015
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.015
Cbl	Casitas B-lineage lymphoma	0.015
Snca	synuclein, alpha	0.015
Vegfa	vascular endothelial growth factor A	0.015
Irf2bp1	interferon regulatory factor 2 binding protein 1	0.015
Trim25	tripartite motif-containing 25	0.014
Nfib	nuclear factor I/B	0.014
Ptges3	prostaglandin E synthase 3 (cytosolic)	0.014
Dpysl2	dihydropyrimidinase-like 2	0.014
Sox7	SRY-box containing gene 7	0.014	Mouse
Tbx15	T-box 15	0.014
Meox2	mesenchyme homeobox 2	0.014
Fmnl3	formin-like 3	0.014
Alx4	aristaless-like homeobox 4	0.014
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.014
Nucb1	nucleobindin 1	0.014
Sall4	sal-like 4 (Drosophila)	0.014
Pros1	protein S (alpha)	0.013
Hoxa9	homeobox A9	0.013
Tyr	tyrosinase	0.013
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.013
Ctsl	cathepsin L	0.013
Plxna1	plexin A1	0.013
Eif2s1	eukaryotic translation initiation factor 2, subunit 1 alpha	0.013
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.013
Vim	vimentin	0.013
Dock7	dedicator of cytokinesis 7	0.013
Fbrs	fibrosin	0.013
She	src homology 2 domain-containing transforming protein E	0.013
Hist2h2ab	histone cluster 2, H2ab	0.012
Flt1	FMS-like tyrosine kinase 1	0.012
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.012
Per2	period homolog 2 (Drosophila)	0.012
Pou3f3	POU domain, class 3, transcription factor 3	0.012
Plbd2	phospholipase B domain containing 2	0.012
Pnpla6	patatin-like phospholipase domain containing 6	0.012
Sec31a	Sec31 homolog A (S. cerevisiae)	0.012
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.012
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.012
Mest	mesoderm specific transcript	0.012
Kdelr2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	0.012
Pgls	6-phosphogluconolactonase	0.012
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.012
Tuba8	tubulin, alpha 8	0.012
Irs1	insulin receptor substrate 1	0.012
Krtcap2	keratinocyte associated protein 2	0.012
Cpd	carboxypeptidase D	0.012
Ednrb	endothelin receptor type B	0.012
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.012
Fam136a	family with sequence similarity 136, member A	0.012
Myl3	myosin, light polypeptide 3	0.012
Pip5k1c	phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma	0.012
Dnajb4	DnaJ (Hsp40) homolog, subfamily B, member 4	0.011
Cry2	cryptochrome 2 (photolyase-like)	0.011
Sall3	sal-like 3 (Drosophila)	0.011
Ep300	E1A binding protein p300	0.011
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.011
Lama3	laminin, alpha 3	0.011
Mapt	microtubule-associated protein tau	0.011
Ldb1	LIM domain binding 1	0.011
Eprs	glutamyl-prolyl-tRNA synthetase	0.011
Gsc	goosecoid homeobox	0.011
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.011
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.011
Rp1	retinitis pigmentosa 1 (human)	0.011
Add2	adducin 2 (beta)	0.011
Psmg2	proteasome (prosome, macropain) assembly chaperone 2	0.011
Gatad2a	GATA zinc finger domain containing 2A	0.011
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.011
Itm2b	integral membrane protein 2B	0.011
2010106G01Rik	RIKEN cDNA 2010106G01 gene	0.011
Cp	ceruloplasmin	0.011
Arhgap21	Rho GTPase activating protein 21	0.011
Gast	gastrin	0.011
Sepn1	selenoprotein N, 1	0.011
Hoxd13	homeobox D13	0.011
Spry4	sprouty homolog 4 (Drosophila)	0.011
Sox11	SRY-box containing gene 11	0.011	Mouse
Kif1b	kinesin family member 1B	0.011
Adrb2	adrenergic receptor, beta 2	0.011
Myh3	myosin, heavy polypeptide 3, skeletal muscle, embryonic	0.011
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.011
Odz4	odd Oz/ten-m homolog 4 (Drosophila)	0.011
Pkd1	polycystic kidney disease 1 homolog	0.011
Pbrm1	polybromo 1	0.011
Rarb	retinoic acid receptor, beta	0.011
Usp25	ubiquitin specific peptidase 25	0.011
Espn	espin	0.010
Pknox1	Pbx/knotted 1 homeobox	0.010
Vkorc1	vitamin K epoxide reductase complex, subunit 1	0.010
Ythdc1	YTH domain containing 1	0.010
Ctbp2	C-terminal binding protein 2	0.010
Nup153	nucleoporin 153	0.010
Chrd	chordin	0.010
Olig2	oligodendrocyte transcription factor 2	0.010
Ckap4	cytoskeleton-associated protein 4	0.010
Prrx2	paired related homeobox 2	0.010
Bud31	BUD31 homolog (yeast)	0.010
Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide	0.010
Vdac3	voltage-dependent anion channel 3	0.010