IMP: Integrative Multi-species Prediction

Mus musculus

14 genes annotated in mouse

Multi-species View

negative regulation of insulin receptor signaling pathway

GO:0046627

Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of insulin receptor signaling pathway"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of insulin receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Ldb3	LIM domain binding 3	0.998
Lepr	leptin receptor	0.998
Fyn	Fyn proto-oncogene	0.992
Jak2	Janus kinase 2	0.991
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.963
Insr	insulin receptor	0.895
Tsc1	tuberous sclerosis 1	0.845	Fly
Tsc2	tuberous sclerosis 2	0.819	Fly
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.794
Src	Rous sarcoma oncogene	0.705
Igf1r	insulin-like growth factor I receptor	0.659
Nf2	neurofibromatosis 2	0.645
Il1b	interleukin 1 beta	0.622
Apc	adenomatosis polyposis coli	0.608
Cish	cytokine inducible SH2-containing protein	0.601	Mouse
Tek	endothelial-specific receptor tyrosine kinase	0.569
Akt1	thymoma viral proto-oncogene 1	0.527	Mouse
Grb2	growth factor receptor bound protein 2	0.493
Bcl2	B-cell leukemia/lymphoma 2	0.463
Efnb2	ephrin B2	0.433
Irs2	insulin receptor substrate 2	0.433
Actn2	actinin alpha 2	0.382
Ptprc	protein tyrosine phosphatase, receptor type, C	0.379	Mouse
Dok2	docking protein 2	0.371
Dok1	docking protein 1	0.367
Prkcb	protein kinase C, beta	0.341	Mouse
Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	0.334	Fly
Kit	kit oncogene	0.332
Tnf	tumor necrosis factor	0.324
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.317
Socs2	suppressor of cytokine signaling 2	0.314	Mouse
Efnb1	ephrin B1	0.313
Nf1	neurofibromatosis 1	0.290
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.282
Lck	lymphocyte protein tyrosine kinase	0.274
Ctnnb1	catenin (cadherin associated protein), beta 1	0.274
Pim1	proviral integration site 1	0.266
Prkce	protein kinase C, epsilon	0.260	Mouse
Vhl	von Hippel-Lindau tumor suppressor	0.252
Inpp5d	inositol polyphosphate-5-phosphatase D	0.242
Jak1	Janus kinase 1	0.228
Gsk3b	glycogen synthase kinase 3 beta	0.213
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.213
Ptk2	PTK2 protein tyrosine kinase 2	0.206
Plcg1	phospholipase C, gamma 1	0.198
Pparg	peroxisome proliferator activated receptor gamma	0.197
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.196
Fmr1	fragile X mental retardation syndrome 1 homolog	0.190	Fly
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.190
Fxr1	fragile X mental retardation gene 1, autosomal homolog	0.189	Fly
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.186
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.184
Xpa	xeroderma pigmentosum, complementation group A	0.178
Enah	enabled homolog (Drosophila)	0.176
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.168
Fbxw7	F-box and WD-40 domain protein 7	0.166
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.163
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.158
Il1a	interleukin 1 alpha	0.156	Mouse
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.156
Nsf	N-ethylmaleimide sensitive fusion protein	0.150
Stat5b	signal transducer and activator of transcription 5B	0.148
Pag1	phosphoprotein associated with glycosphingolipid microdomains 1	0.143
Cbl	Casitas B-lineage lymphoma	0.138
Stat5a	signal transducer and activator of transcription 5A	0.133
Cd28	CD28 antigen	0.122
Rora	RAR-related orphan receptor alpha	0.121
Tnip1	TNFAIP3 interacting protein 1	0.119
Tcra	T-cell receptor alpha chain	0.116
Il6st	interleukin 6 signal transducer	0.108
Rint1	RAD50 interactor 1	0.105
Irak4	interleukin-1 receptor-associated kinase 4	0.101
Agap3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	0.092
Htt	huntingtin	0.086
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.085
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.084
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.083
Ikzf1	IKAROS family zinc finger 1	0.080
Tbk1	TANK-binding kinase 1	0.079
Ar	androgen receptor	0.077
Clock	circadian locomotor output cycles kaput	0.075
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.073
Crb2	crumbs homolog 2 (Drosophila)	0.070
Stat3	signal transducer and activator of transcription 3	0.070
Csnk1g2	casein kinase 1, gamma 2	0.069
Prkci	protein kinase C, iota	0.068	Mouse
Irs1	insulin receptor substrate 1	0.066	Rat
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.066
Cenpc1	centromere protein C1	0.066
Cand1	cullin associated and neddylation disassociated 1	0.062
Cul5	cullin 5	0.061
Akt2	thymoma viral proto-oncogene 2	0.059	Mouse
Fbxl20	F-box and leucine-rich repeat protein 20	0.059
Braf	Braf transforming gene	0.058
Prkca	protein kinase C, alpha	0.058
Notch1	Notch gene homolog 1 (Drosophila)	0.057
Prkcd	protein kinase C, delta	0.056
Wipf1	WAS/WASL interacting protein family, member 1	0.055
Spin1	spindlin 1	0.054
Mefv	Mediterranean fever	0.053
Per2	period homolog 2 (Drosophila)	0.052
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.051
Lipe	lipase, hormone sensitive	0.049
Skp1a	S-phase kinase-associated protein 1A	0.049
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.049
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.048
Shc1	src homology 2 domain-containing transforming protein C1	0.047
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.046
Npc1	Niemann Pick type C1	0.045
Casp1	caspase 1	0.044
Smad3	MAD homolog 3 (Drosophila)	0.044
Wdfy2	WD repeat and FYVE domain containing 2	0.044
Gab1	growth factor receptor bound protein 2-associated protein 1	0.044
Cxcl1	chemokine (C-X-C motif) ligand 1	0.043
Ptpn2	protein tyrosine phosphatase, non-receptor type 2	0.042
Igf2	insulin-like growth factor 2	0.042
Add1	adducin 1 (alpha)	0.042
Mark2	MAP/microtubule affinity-regulating kinase 2	0.041
Lyz2	lysozyme 2	0.041
Ptch1	patched homolog 1	0.040
Hif1a	hypoxia inducible factor 1, alpha subunit	0.040
Vasp	vasodilator-stimulated phosphoprotein	0.039
Khdrbs1	KH domain containing, RNA binding, signal transduction associated 1	0.039
Cd44	CD44 antigen	0.039
Plxna1	plexin A1	0.038
Prkaca	protein kinase, cAMP dependent, catalytic, alpha	0.038
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.038
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.038
Foxo1	forkhead box O1	0.037	Fly
Npy1r	neuropeptide Y receptor Y1	0.037
Fzd8	frizzled homolog 8 (Drosophila)	0.036
Vav3	vav 3 oncogene	0.035
Man1a2	mannosidase, alpha, class 1A, member 2	0.035
Ccr1	chemokine (C-C motif) receptor 1	0.035
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.034
Il4ra	interleukin 4 receptor, alpha	0.034
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.033
Mapkap1	mitogen-activated protein kinase associated protein 1	0.033
Smad5	MAD homolog 5 (Drosophila)	0.032
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.032
Bcar1	breast cancer anti-estrogen resistance 1	0.032
Slfn2	schlafen 2	0.031
Fas	Fas (TNF receptor superfamily member 6)	0.031
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.031
Phlpp1	PH domain and leucine rich repeat protein phosphatase 1	0.030
Igbp1	immunoglobulin (CD79A) binding protein 1	0.030
Homer1	homer homolog 1 (Drosophila)	0.030
Vav1	vav 1 oncogene	0.029
Igh	immunoglobulin heavy chain complex	0.028
Myh10	myosin, heavy polypeptide 10, non-muscle	0.028
Ptpre	protein tyrosine phosphatase, receptor type, E	0.028
Ptprs	protein tyrosine phosphatase, receptor type, S	0.028
Igf2r	insulin-like growth factor 2 receptor	0.027
Dock2	dedicator of cyto-kinesis 2	0.027
Asprv1	aspartic peptidase, retroviral-like 1	0.027
Cxcl2	chemokine (C-X-C motif) ligand 2	0.026
Nod2	nucleotide-binding oligomerization domain containing 2	0.026
Ptger4	prostaglandin E receptor 4 (subtype EP4)	0.026
Ncoa3	nuclear receptor coactivator 3	0.026
Rnf167	ring finger protein 167	0.026
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.026
Rcan1	regulator of calcineurin 1	0.026
Sim1	single-minded homolog 1 (Drosophila)	0.025
Ulk1	Unc-51 like kinase 1 (C. elegans)	0.024
Skil	SKI-like	0.024
Arf3	ADP-ribosylation factor 3	0.023
Ggta1	glycoprotein galactosyltransferase alpha 1, 3	0.023
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.023
Socs3	suppressor of cytokine signaling 3	0.023
Csnk1d	casein kinase 1, delta	0.023
Spnb3	spectrin beta 3	0.023
Creb1	cAMP responsive element binding protein 1	0.023
Dlg3	discs, large homolog 3 (Drosophila)	0.023
Phf1	PHD finger protein 1	0.022
Birc3	baculoviral IAP repeat-containing 3	0.022
Cops2	COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)	0.022
Usf2	upstream transcription factor 2	0.022
Ep300	E1A binding protein p300	0.022
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.022
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.022
Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	0.022
Sh3rf1	SH3 domain containing ring finger 1	0.022
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.021
Bcl3	B-cell leukemia/lymphoma 3	0.021
Neo1	neogenin	0.021
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.021
Itgb2	integrin beta 2	0.021
Lcp2	lymphocyte cytosolic protein 2	0.021
Zeb1	zinc finger E-box binding homeobox 1	0.021
Prkcz	protein kinase C, zeta	0.021	Human Mouse
Lat	linker for activation of T cells	0.021
Itga1	integrin alpha 1	0.021
C3	complement component 3	0.021
Arrb2	arrestin, beta 2	0.020
Il17ra	interleukin 17 receptor A	0.020
Cd53	CD53 antigen	0.020
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.020
Cd151	CD151 antigen	0.020
Cd4	CD4 antigen	0.020
Lrig1	leucine-rich repeats and immunoglobulin-like domains 1	0.020
Glipr2	GLI pathogenesis-related 2	0.020
Cd40	CD40 antigen	0.020
Tceb1	transcription elongation factor B (SIII), polypeptide 1	0.020
Rb1	retinoblastoma 1	0.020
Mdm2	transformed mouse 3T3 cell double minute 2	0.019
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.019
Tgfbr1	transforming growth factor, beta receptor I	0.019
Cd86	CD86 antigen	0.019
Brd2	bromodomain containing 2	0.019
Txnip	thioredoxin interacting protein	0.019
Cyld	cylindromatosis (turban tumor syndrome)	0.019
Alms1	Alstrom syndrome 1 homolog (human)	0.019
Fpr2	formyl peptide receptor 2	0.018
Foxa2	forkhead box A2	0.018
Ogdh	oxoglutarate dehydrogenase (lipoamide)	0.018
Rps6ka3	ribosomal protein S6 kinase polypeptide 3	0.018
Tgm3	transglutaminase 3, E polypeptide	0.018
Kiss1	KiSS-1 metastasis-suppressor	0.018
Sema4d	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.018
Ubc	ubiquitin C	0.018
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.018
Ehmt2	euchromatic histone lysine N-methyltransferase 2	0.018
Mapkapk2	MAP kinase-activated protein kinase 2	0.017
Inpp4a	inositol polyphosphate-4-phosphatase, type I	0.017
Irg1	immunoresponsive gene 1	0.017
Mapk8	mitogen-activated protein kinase 8	0.017
Sell	selectin, lymphocyte	0.017
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.016
Taz	tafazzin	0.016
Abcg1	ATP-binding cassette, sub-family G (WHITE), member 1	0.016
Ghr	growth hormone receptor	0.016
Il1r1	interleukin 1 receptor, type I	0.016
Rasa3	RAS p21 protein activator 3	0.016
Ephb3	Eph receptor B3	0.016
Lsm14a	LSM14 homolog A (SCD6, S. cerevisiae)	0.016
Ezh1	enhancer of zeste homolog 1 (Drosophila)	0.016
Pip4k2a	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	0.016
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.016
Hgs	HGF-regulated tyrosine kinase substrate	0.016
Nfe2l1	nuclear factor, erythroid derived 2,-like 1	0.016
Egr1	early growth response 1	0.016
Blnk	B-cell linker	0.015
Fgf21	fibroblast growth factor 21	0.015
Fto	fat mass and obesity associated	0.015
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.015
Nlrp3	NLR family, pyrin domain containing 3	0.015
Dpysl2	dihydropyrimidinase-like 2	0.015
Trp53bp2	transformation related protein 53 binding protein 2	0.015
Elf4	E74-like factor 4 (ets domain transcription factor)	0.015
Ccr7	chemokine (C-C motif) receptor 7	0.015
Rapgef3	Rap guanine nucleotide exchange factor (GEF) 3	0.015
Alkbh1	alkB, alkylation repair homolog 1 (E. coli)	0.014
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.014
Prkcc	protein kinase C, gamma	0.014	Mouse
Fli1	Friend leukemia integration 1	0.014
Mib1	mindbomb homolog 1 (Drosophila)	0.014
Gigyf2	GRB10 interacting GYF protein 2	0.014
Galnt2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2	0.014
Ccndbp1	cyclin D-type binding-protein 1	0.014
Plxnb2	plexin B2	0.014
Nr6a1	nuclear receptor subfamily 6, group A, member 1	0.014
Slamf1	signaling lymphocytic activation molecule family member 1	0.014
Chst8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	0.014
Mtch1	mitochondrial carrier homolog 1 (C. elegans)	0.014
Fzd7	frizzled homolog 7 (Drosophila)	0.014
Myh14	myosin, heavy polypeptide 14	0.014
Zfp131	zinc finger protein 131	0.014
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.013
Dll1	delta-like 1 (Drosophila)	0.013
Ptprn	protein tyrosine phosphatase, receptor type, N	0.013
Fam105a	family with sequence similarity 105, member A	0.013
Apln	apelin	0.013
Selplg	selectin, platelet (p-selectin) ligand	0.013
Socs1	suppressor of cytokine signaling 1	0.013
Mdm4	transformed mouse 3T3 cell double minute 4	0.013
Map3k5	mitogen-activated protein kinase kinase kinase 5	0.013
Cdk7	cyclin-dependent kinase 7	0.013
Stam	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.013
Gcgr	glucagon receptor	0.013
Hs2st1	heparan sulfate 2-O-sulfotransferase 1	0.013
Plscr1	phospholipid scramblase 1	0.013
Apoe	apolipoprotein E	0.013
Itgav	integrin alpha V	0.013
Arrdc3	arrestin domain containing 3	0.013
Arid5b	AT rich interactive domain 5B (MRF1-like)	0.013
Frs2	fibroblast growth factor receptor substrate 2	0.013
Helq	helicase, POLQ-like	0.013
Ifrd1	interferon-related developmental regulator 1	0.013
Klc2	kinesin light chain 2	0.012
C77080	expressed sequence C77080	0.012
Ins2	insulin II	0.012
Il2rg	interleukin 2 receptor, gamma chain	0.012
Hipk3	homeodomain interacting protein kinase 3	0.012
Traf3	TNF receptor-associated factor 3	0.012
Rasgrp1	RAS guanyl releasing protein 1	0.012
Msr1	macrophage scavenger receptor 1	0.012
Dusp1	dual specificity phosphatase 1	0.012
Rps6kb1	ribosomal protein S6 kinase, polypeptide 1	0.012	Human Rat
Nck1	non-catalytic region of tyrosine kinase adaptor protein 1	0.012	Fly
Hrh1	histamine receptor H1	0.012
Pak2	p21 protein (Cdc42/Rac)-activated kinase 2	0.012
Fam49b	family with sequence similarity 49, member B	0.012
Adora2a	adenosine A2a receptor	0.012
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.012
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.012
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.012
Rap2a	RAS related protein 2a	0.012
Ank	progressive ankylosis	0.012
Arpc2	actin related protein 2/3 complex, subunit 2	0.012
Slfn1	schlafen 1	0.012
Fam65b	family with sequence similarity 65, member B	0.012
Il1f9	interleukin 1 family, member 9	0.012
S100a8	S100 calcium binding protein A8 (calgranulin A)	0.012
Shank2	SH3/ankyrin domain gene 2	0.012
Pde4b	phosphodiesterase 4B, cAMP specific	0.012
Egfr	epidermal growth factor receptor	0.012
Wdr1	WD repeat domain 1	0.011
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.011
Pnpla2	patatin-like phospholipase domain containing 2	0.011
Il18	interleukin 18	0.011
Zfp398	zinc finger protein 398	0.011
Ubr1	ubiquitin protein ligase E3 component n-recognin 1	0.011
Dgcr2	DiGeorge syndrome critical region gene 2	0.011
Lrrc8c	leucine rich repeat containing 8 family, member C	0.011
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.011
Vav2	vav 2 oncogene	0.011
Marcksl1	MARCKS-like 1	0.011
Mapkbp1	mitogen-activated protein kinase binding protein 1	0.011
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.011
Plxna3	plexin A3	0.011
Wsb2	WD repeat and SOCS box-containing 2	0.011
Axin2	axin2	0.011
Sorbs3	sorbin and SH3 domain containing 3	0.011
Map4k4	mitogen-activated protein kinase kinase kinase kinase 4	0.011
Il1rn	interleukin 1 receptor antagonist	0.011	Mouse
Maf1	MAF1 homolog (S. cerevisiae)	0.011
Junb	Jun-B oncogene	0.011
Slc5a3	solute carrier family 5 (inositol transporters), member 3	0.011
Wbp4	WW domain binding protein 4	0.011
Gpsm1	G-protein signalling modulator 1 (AGS3-like, C. elegans)	0.011
Ctnnal1	catenin (cadherin associated protein), alpha-like 1	0.010
4933407C03Rik	RIKEN cDNA 4933407C03 gene	0.010
Sirpa	signal-regulatory protein alpha	0.010
Slc12a3	solute carrier family 12, member 3	0.010
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.010
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.010
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.010
Hcls1	hematopoietic cell specific Lyn substrate 1	0.010
Ldb1	LIM domain binding 1	0.010
Axin1	axin 1	0.010
Ctnnd1	catenin (cadherin associated protein), delta 1	0.010
Pdzk1ip1	PDZK1 interacting protein 1	0.010
Ddx10	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	0.010
Ccl7	chemokine (C-C motif) ligand 7	0.010