IMP
Process View
intra s dna damage checkpoint
A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
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Click on a gene's description to view its network relationships with genes known to be involved in "intra s dna damage checkpoint"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Rb1 | retinoblastoma 1 | 0.991 | ||
| Pten | phosphatase and tensin homolog | 0.957 | ||
| Trp53 | transformation related protein 53 | 0.957 | ||
| Xpa | xeroderma pigmentosum, complementation group A | 0.928 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.918 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.885 | ||
| Mapk14 | mitogen-activated protein kinase 14 | 0.839 | ||
| Timeless | timeless homolog (Drosophila) | 0.829 | ||
| Brca2 | breast cancer 2 | 0.745 | ||
| Nbn | nibrin | 0.596 | ||
| Atm | ataxia telangiectasia mutated homolog (human) | 0.507 | ||
| Stk11 | serine/threonine kinase 11 | 0.473 | ||
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.464 | ||
| Prim1 | DNA primase, p49 subunit | 0.456 | ||
| Brca1 | breast cancer 1 | 0.428 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.409 | ||
| Pold1 | polymerase (DNA directed), delta 1, catalytic subunit | 0.361 | ||
| Msh2 | mutS homolog 2 (E. coli) | 0.334 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.319 | ||
| Mapk1 | mitogen-activated protein kinase 1 | 0.276 | ||
| E2f1 | E2F transcription factor 1 | 0.272 | ||
| Mlh1 | mutL homolog 1 (E. coli) | 0.268 | ||
| Mapk8 | mitogen-activated protein kinase 8 | 0.256 | ||
| Mcm2 | minichromosome maintenance deficient 2 mitotin (S. cerevisiae) | 0.256 | ||
| Rpa1 | replication protein A1 | 0.213 | ||
| Apc | adenomatosis polyposis coli | 0.204 | ||
| Rbl2 | retinoblastoma-like 2 | 0.190 | ||
| Hprt | hypoxanthine guanine phosphoribosyl transferase | 0.189 | ||
| Mms22l | MMS22-like, DNA repair protein | 0.188 | ||
| Men1 | multiple endocrine neoplasia 1 | 0.179 | ||
| Rfc3 | replication factor C (activator 1) 3 | 0.170 | ||
| Lig1 | ligase I, DNA, ATP-dependent | 0.168 | ||
| Tcf3 | transcription factor 3 | 0.154 | ||
| Rad50 | RAD50 homolog (S. cerevisiae) | 0.144 | ||
| Foxo3 | forkhead box O3 | 0.135 | ||
| Usp33 | ubiquitin specific peptidase 33 | 0.130 | ||
| Mcm3 | minichromosome maintenance deficient 3 (S. cerevisiae) | 0.126 | ||
| Cdt1 | chromatin licensing and DNA replication factor 1 | 0.126 | ||
| Mcm4 | minichromosome maintenance deficient 4 homolog (S. cerevisiae) | 0.122 | ||
| Prim2 | DNA primase, p58 subunit | 0.118 | ||
| Pms2 | postmeiotic segregation increased 2 (S. cerevisiae) | 0.112 | ||
| Ptch1 | patched homolog 1 | 0.110 | ||
| Pole2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | 0.103 | ||
| Rfc1 | replication factor C (activator 1) 1 | 0.090 | ||
| Pola1 | polymerase (DNA directed), alpha 1 | 0.083 | ||
| Tsc1 | tuberous sclerosis 1 | 0.083 | ||
| Rbl1 | retinoblastoma-like 1 (p107) | 0.080 | ||
| Wdhd1 | WD repeat and HMG-box DNA binding protein 1 | 0.070 | ||
| Braf | Braf transforming gene | 0.070 | ||
| Rfc4 | replication factor C (activator 1) 4 | 0.066 | ||
| Mcm5 | minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 0.064 | ||
| AW549877 | expressed sequence AW549877 | 0.060 | ||
| Parp2 | poly (ADP-ribose) polymerase family, member 2 | 0.059 | ||
| Pcna | proliferating cell nuclear antigen | 0.059 | ||
| Eef1a1 | eukaryotic translation elongation factor 1 alpha 1 | 0.058 | ||
| Kit | kit oncogene | 0.055 | ||
| Usp9x | ubiquitin specific peptidase 9, X chromosome | 0.055 | ||
| Rps6ka5 | ribosomal protein S6 kinase, polypeptide 5 | 0.052 | ||
| Lrrc40 | leucine rich repeat containing 40 | 0.051 | ||
| Mapk11 | mitogen-activated protein kinase 11 | 0.047 | ||
| Tle1 | transducin-like enhancer of split 1, homolog of Drosophila E(spl) | 0.043 | ||
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.039 | ||
| Syce2 | synaptonemal complex central element protein 2 | 0.039 | ||
| Myo6 | myosin VI | 0.039 | ||
| Vrk1 | vaccinia related kinase 1 | 0.039 | ||
| Igh | immunoglobulin heavy chain complex | 0.037 | ||
| Orc6 | origin recognition complex, subunit 6 | 0.037 | ||
| Gmnn | geminin | 0.037 | ||
| Hmmr | hyaluronan mediated motility receptor (RHAMM) | 0.036 | ||
| Bmi1 | Bmi1 polycomb ring finger oncogene | 0.036 | ||
| Cdkn2d | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 0.036 | ||
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.034 | ||
| Ahr | aryl-hydrocarbon receptor | 0.034 | ||
| Tcf19 | transcription factor 19 | 0.032 | ||
| Haus1 | HAUS augmin-like complex, subunit 1 | 0.031 | ||
| 4930427A07Rik | RIKEN cDNA 4930427A07 gene | 0.030 | ||
| Sirt1 | sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) | 0.029 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.029 | ||
| Cdca7l | cell division cycle associated 7 like | 0.028 | ||
| Xrcc6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.028 | ||
| Mcm7 | minichromosome maintenance deficient 7 (S. cerevisiae) | 0.027 | ||
| Kitl | kit ligand | 0.027 | ||
| Pou5f1 | POU domain, class 5, transcription factor 1 | 0.027 | ||
| Ints9 | integrator complex subunit 9 | 0.026 | ||
| Ep300 | E1A binding protein p300 | 0.026 | ||
| Rrm1 | ribonucleotide reductase M1 | 0.026 | ||
| Alms1 | Alstrom syndrome 1 homolog (human) | 0.026 | ||
| Rfc2 | replication factor C (activator 1) 2 | 0.025 | ||
| Ndfip1 | Nedd4 family interacting protein 1 | 0.025 | ||
| Tmpo | thymopoietin | 0.025 | ||
| Hells | helicase, lymphoid specific | 0.024 | ||
| Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | 0.023 | ||
| Mapk9 | mitogen-activated protein kinase 9 | 0.023 | ||
| Topbp1 | topoisomerase (DNA) II binding protein 1 | 0.023 | ||
| Dnajc9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | 0.023 | ||
| Haus5 | HAUS augmin-like complex, subunit 5 | 0.022 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.021 | ||
| Ppih | peptidyl prolyl isomerase H | 0.021 | ||
| Rmnd5a | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.021 | ||
| Wwox | WW domain-containing oxidoreductase | 0.021 | ||
| Smc3 | structural maintenace of chromosomes 3 | 0.021 | ||
| Pik3ca | phosphatidylinositol 3-kinase, catalytic, alpha polypeptide | 0.021 | ||
| Rplp0 | ribosomal protein, large, P0 | 0.020 | ||
| Blm | Bloom syndrome, RecQ helicase-like | 0.020 | ||
| Ncapd3 | non-SMC condensin II complex, subunit D3 | 0.020 | ||
| Fen1 | flap structure specific endonuclease 1 | 0.019 | ||
| Tdp2 | tyrosyl-DNA phosphodiesterase 2 | 0.019 | ||
| Rps28 | ribosomal protein S28 | 0.019 | ||
| Cpsf3 | cleavage and polyadenylation specificity factor 3 | 0.018 | ||
| Pcmtd2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.018 | ||
| Hp1bp3 | heterochromatin protein 1, binding protein 3 | 0.018 | ||
| Rad51ap1 | RAD51 associated protein 1 | 0.018 | ||
| Recql | RecQ protein-like | 0.018 | ||
| Eif2ak3 | eukaryotic translation initiation factor 2 alpha kinase 3 | 0.017 | ||
| Casp3 | caspase 3 | 0.017 | ||
| Elavl1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | 0.017 | ||
| Prpsap2 | phosphoribosyl pyrophosphate synthetase-associated protein 2 | 0.017 | ||
| Mtbp | Mdm2, transformed 3T3 cell double minute p53 binding protein | 0.017 | ||
| Kntc1 | kinetochore associated 1 | 0.017 | ||
| Caprin2 | caprin family member 2 | 0.016 | ||
| Mad2l1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.016 | ||
| Kif22 | kinesin family member 22 | 0.016 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.016 | ||
| Saal1 | serum amyloid A-like 1 | 0.016 | ||
| Lgr4 | leucine-rich repeat-containing G protein-coupled receptor 4 | 0.015 | ||
| Mybl2 | myeloblastosis oncogene-like 2 | 0.015 | ||
| Ncaph | non-SMC condensin I complex, subunit H | 0.015 | ||
| Nf2 | neurofibromatosis 2 | 0.015 | ||
| Ltb | lymphotoxin B | 0.015 | ||
| Ccnd1 | cyclin D1 | 0.015 | ||
| Haus6 | HAUS augmin-like complex, subunit 6 | 0.015 | ||
| 1190002N15Rik | RIKEN cDNA 1190002N15 gene | 0.014 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.014 | ||
| Wrn | Werner syndrome homolog (human) | 0.014 | ||
| Rttn | rotatin | 0.014 | ||
| Pinx1 | PIN2/TERF1 interacting, telomerase inhibitor 1 | 0.014 | ||
| Nup43 | nucleoporin 43 | 0.014 | ||
| Hirip3 | HIRA interacting protein 3 | 0.014 | ||
| Asf1b | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | 0.014 | ||
| Rnaseh2b | ribonuclease H2, subunit B | 0.014 | ||
| Abl1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.013 | ||
| Kif18a | kinesin family member 18A | 0.013 | ||
| Txndc16 | thioredoxin domain containing 16 | 0.013 | ||
| Mylk | myosin, light polypeptide kinase | 0.013 | ||
| Smc2 | structural maintenance of chromosomes 2 | 0.013 | ||
| Etnk1 | ethanolamine kinase 1 | 0.013 | ||
| Pola2 | polymerase (DNA directed), alpha 2 | 0.013 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.013 | ||
| Nvl | nuclear VCP-like | 0.013 | ||
| Rfwd2 | ring finger and WD repeat domain 2 | 0.013 | ||
| Arid4a | AT rich interactive domain 4A (RBP1-like) | 0.013 | ||
| Id3 | inhibitor of DNA binding 3 | 0.012 | ||
| Tk2 | thymidine kinase 2, mitochondrial | 0.012 | ||
| Lig4 | ligase IV, DNA, ATP-dependent | 0.012 | ||
| Cenpf | centromere protein F | 0.012 | ||
| Nup133 | nucleoporin 133 | 0.012 | ||
| Pole | polymerase (DNA directed), epsilon | 0.012 | Yeast | |
| Nup107 | nucleoporin 107 | 0.012 | ||
| Id1 | inhibitor of DNA binding 1 | 0.012 | ||
| Becn1 | beclin 1, autophagy related | 0.012 | ||
| Ezh2 | enhancer of zeste homolog 2 (Drosophila) | 0.012 | ||
| Ncoa1 | nuclear receptor coactivator 1 | 0.012 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.012 | ||
| Rad1 | RAD1 homolog (S. pombe) | 0.012 | ||
| Pcmtd1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.012 | ||
| Lyst | lysosomal trafficking regulator | 0.012 | ||
| Zmym2 | zinc finger, MYM-type 2 | 0.012 | ||
| Pik3c3 | phosphoinositide-3-kinase, class 3 | 0.012 | ||
| Ercc6l | excision repair cross-complementing rodent repair deficiency complementation group 6 - like | 0.012 | ||
| Papolg | poly(A) polymerase gamma | 0.012 | ||
| Fancm | Fanconi anemia, complementation group M | 0.012 | ||
| Tcfcp2l1 | transcription factor CP2-like 1 | 0.011 | ||
| Nsmce4a | non-SMC element 4 homolog A (S. cerevisiae) | 0.011 | ||
| Traf6 | TNF receptor-associated factor 6 | 0.011 | ||
| Etaa1 | Ewing's tumor-associated antigen 1 | 0.011 | ||
| Sav1 | salvador homolog 1 (Drosophila) | 0.011 | ||
| Ireb2 | iron responsive element binding protein 2 | 0.011 | ||
| Myo7a | myosin VIIA | 0.011 | ||
| Pds5b | PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) | 0.011 | ||
| Mecp2 | methyl CpG binding protein 2 | 0.011 | ||
| Nup188 | nucleoporin 188 | 0.011 | ||
| Parp1 | poly (ADP-ribose) polymerase family, member 1 | 0.011 | ||
| Cdc6 | cell division cycle 6 homolog (S. cerevisiae) | 0.011 | ||
| Cyld | cylindromatosis (turban tumor syndrome) | 0.011 | ||
| Racgap1 | Rac GTPase-activating protein 1 | 0.011 | ||
| Tmem194 | transmembrane protein 194 | 0.011 | ||
| Foxo1 | forkhead box O1 | 0.011 | ||
| Mcm8 | minichromosome maintenance deficient 8 (S. cerevisiae) | 0.011 | ||
| Oxr1 | oxidation resistance 1 | 0.011 | ||
| Dhx36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.011 | ||
| Rpa3 | replication protein A3 | 0.011 | ||
| Tgfbr1 | transforming growth factor, beta receptor I | 0.011 | ||
| Dennd4c | DENN/MADD domain containing 4C | 0.011 | ||
| Pofut1 | protein O-fucosyltransferase 1 | 0.011 | ||
| Nup85 | nucleoporin 85 | 0.011 | ||
| Htatip2 | HIV-1 tat interactive protein 2, homolog (human) | 0.011 | ||
| Pdpk1 | 3-phosphoinositide dependent protein kinase 1 | 0.011 | ||
| Atad5 | ATPase family, AAA domain containing 5 | 0.011 | ||
| Prpf6 | PRP6 pre-mRNA splicing factor 6 homolog (yeast) | 0.011 | ||
| Stag2 | stromal antigen 2 | 0.010 | ||
| Ccz1 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) | 0.010 | ||
| Fam126b | family with sequence similarity 126, member B | 0.010 | ||
| Klhl24 | kelch-like 24 (Drosophila) | 0.010 | ||
| Zbtb25 | zinc finger and BTB domain containing 25 | 0.010 | ||
| Parn | poly(A)-specific ribonuclease (deadenylation nuclease) | 0.010 | ||
| Hdac1 | histone deacetylase 1 | 0.010 | ||
| Trim37 | tripartite motif-containing 37 | 0.010 | ||
| Raf1 | v-raf-leukemia viral oncogene 1 | 0.010 | ||
| Dtymk | deoxythymidylate kinase | 0.010 | ||
| Ncapd2 | non-SMC condensin I complex, subunit D2 | 0.010 |