IMP: Integrative Multi-species Prediction

Mus musculus

72 genes annotated in mouse

jnk cascade

An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "jnk cascade"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "jnk cascade" (in gray)

Name	Description	Probability	Func Analog Organism
Traf6	TNF receptor-associated factor 6	0.999	Human Mouse Rat
Mapk14	mitogen-activated protein kinase 14	0.997	Mouse
Mapk8ip3	mitogen-activated protein kinase 8 interacting protein 3	0.997
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.992
Rac1	RAS-related C3 botulinum substrate 1	0.991	Fly
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.990
Mapk8	mitogen-activated protein kinase 8	0.987
Vangl2	vang-like 2 (van gogh, Drosophila)	0.985
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.975	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.971
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.966
Myd88	myeloid differentiation primary response gene 88	0.949
Cd40	CD40 antigen	0.945
Wnt3a	wingless-related MMTV integration site 3A	0.943	Mouse
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.927
Axin1	axin 1	0.927
Efnb2	ephrin B2	0.919
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.915
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.906
Tnf	tumor necrosis factor	0.877
Jun	Jun oncogene	0.874	Fly
Il1b	interleukin 1 beta	0.851
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.843	Rat
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.823
Ccr1	chemokine (C-C motif) receptor 1	0.823
Wnt5a	wingless-related MMTV integration site 5A	0.821
Klc1	kinesin light chain 1	0.821
C3ar1	complement component 3a receptor 1	0.804
Fos	FBJ osteosarcoma oncogene	0.803
Smad6	MAD homolog 6 (Drosophila)	0.800
Casp1	caspase 1	0.786
Thbs1	thrombospondin 1	0.775
Mdm2	transformed mouse 3T3 cell double minute 2	0.752
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.745
Grb10	growth factor receptor bound protein 10	0.729
Atf2	activating transcription factor 2	0.716
Prkce	protein kinase C, epsilon	0.711
Cd44	CD44 antigen	0.695
Pten	phosphatase and tensin homolog	0.657
Cxcl13	chemokine (C-X-C motif) ligand 13	0.652
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.650	Human
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.642	Mouse
Dlg1	discs, large homolog 1 (Drosophila)	0.627
Gsk3b	glycogen synthase kinase 3 beta	0.624	Fly
Mapk1	mitogen-activated protein kinase 1	0.616	Fly
Pax2	paired box gene 2	0.573
Efnb1	ephrin B1	0.572
Sfrp2	secreted frizzled-related protein 2	0.571
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.563
Msr1	macrophage scavenger receptor 1	0.557
Ephb2	Eph receptor B2	0.550	Mouse
Casp8	caspase 8	0.540
Gli2	GLI-Kruppel family member GLI2	0.529
Apc	adenomatosis polyposis coli	0.524
Ptk7	PTK7 protein tyrosine kinase 7	0.522
Sfrp1	secreted frizzled-related protein 1	0.503
Ltb	lymphotoxin B	0.499
Traf2	TNF receptor-associated factor 2	0.498
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.472	Human Mouse
Cd14	CD14 antigen	0.468
Tlr4	toll-like receptor 4	0.445
Zfp36	zinc finger protein 36	0.433
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.429
Smad7	MAD homolog 7 (Drosophila)	0.414
Met	met proto-oncogene	0.406
Sox9	SRY-box containing gene 9	0.404
Clec4d	C-type lectin domain family 4, member d	0.403
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.403
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.398
Cxcr5	chemokine (C-X-C motif) receptor 5	0.397
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.396
Cyld	cylindromatosis (turban tumor syndrome)	0.392
Smad3	MAD homolog 3 (Drosophila)	0.378
Ccl3	chemokine (C-C motif) ligand 3	0.375	Mouse
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.364
Cdx2	caudal type homeobox 2	0.353
Parva	parvin, alpha	0.353
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.348
Grap2	GRB2-related adaptor protein 2	0.332
Ube2g1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)	0.320
Ikbkg	inhibitor of kappaB kinase gamma	0.319
Ndel1	nuclear distribution gene E-like homolog 1 (A. nidulans)	0.318
Ptk2	PTK2 protein tyrosine kinase 2	0.317	Rat
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.315
Dusp1	dual specificity phosphatase 1	0.314	Mouse
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.314
Emx1	empty spiracles homolog 1 (Drosophila)	0.313
Vangl1	vang-like 1 (van gogh, Drosophila)	0.311	Mouse
Epha4	Eph receptor A4	0.311
Fgfr1	fibroblast growth factor receptor 1	0.308
Csnk1e	casein kinase 1, epsilon	0.307
Fzd8	frizzled homolog 8 (Drosophila)	0.305
Rarg	retinoic acid receptor, gamma	0.304
Cd4	CD4 antigen	0.302
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.297
Clec4n	C-type lectin domain family 4, member n	0.290
Tcf7	transcription factor 7, T-cell specific	0.290
Bcl10	B-cell leukemia/lymphoma 10	0.286
Cxcl2	chemokine (C-X-C motif) ligand 2	0.279
Gli3	GLI-Kruppel family member GLI3	0.279
Fgf18	fibroblast growth factor 18	0.278
Phc2	polyhomeotic-like 2 (Drosophila)	0.274
Lyz2	lysozyme 2	0.272
Atf3	activating transcription factor 3	0.270
Nf1	neurofibromatosis 1	0.270
Smc1a	structural maintenance of chromosomes 1A	0.267
Ch25h	cholesterol 25-hydroxylase	0.266
Plcg1	phospholipase C, gamma 1	0.262
Ccl4	chemokine (C-C motif) ligand 4	0.261	Mouse
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.258	Mouse Fly
Src	Rous sarcoma oncogene	0.257
T	brachyury	0.257
Ccl2	chemokine (C-C motif) ligand 2	0.254
Ctsw	cathepsin W	0.252
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.250
Grb2	growth factor receptor bound protein 2	0.249
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.246
Cd86	CD86 antigen	0.246
Gopc	golgi associated PDZ and coiled-coil motif containing	0.243
Ccl7	chemokine (C-C motif) ligand 7	0.241	Mouse
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.234
Mapk11	mitogen-activated protein kinase 11	0.231	Mouse
Birc3	baculoviral IAP repeat-containing 3	0.229
Spnb2	spectrin beta 2	0.228
Fgf10	fibroblast growth factor 10	0.227
Kif27	kinesin family member 27	0.226
Trp53	transformation related protein 53	0.221	Mouse
Selp	selectin, platelet	0.220
Il7	interleukin 7	0.218
Ntf3	neurotrophin 3	0.216
Irak4	interleukin-1 receptor-associated kinase 4	0.216
Lrp5	low density lipoprotein receptor-related protein 5	0.216
Ier2	immediate early response 2	0.215
Cbl	Casitas B-lineage lymphoma	0.211
Lrp6	low density lipoprotein receptor-related protein 6	0.210
Cd19	CD19 antigen	0.207
Egr2	early growth response 2	0.207
Ephb3	Eph receptor B3	0.206	Mouse
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.206
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.203
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.203
Per2	period homolog 2 (Drosophila)	0.202
Il1a	interleukin 1 alpha	0.200	Mouse
Junb	Jun-B oncogene	0.200	Fly
Runx1	runt related transcription factor 1	0.199
Ccl22	chemokine (C-C motif) ligand 22	0.198
Fcgr1	Fc receptor, IgG, high affinity I	0.196	Mouse
Ccl8	chemokine (C-C motif) ligand 8	0.196
Slpi	secretory leukocyte peptidase inhibitor	0.196
Cd22	CD22 antigen	0.195
Fasl	Fas ligand (TNF superfamily, member 6)	0.194	Mouse Fly
Ccr2	chemokine (C-C motif) receptor 2	0.193
L1cam	L1 cell adhesion molecule	0.191
Dab2	disabled homolog 2 (Drosophila)	0.190
Rhoh	ras homolog gene family, member H	0.188
Sox5	SRY-box containing gene 5	0.186
Bdnf	brain derived neurotrophic factor	0.185
Acvr1	activin A receptor, type 1	0.185
Ccl12	chemokine (C-C motif) ligand 12	0.182	Mouse
Irak3	interleukin-1 receptor-associated kinase 3	0.181	Mouse
Hsph1	heat shock 105kDa/110kDa protein 1	0.181
Il1rn	interleukin 1 receptor antagonist	0.179	Mouse Rat
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.179
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.176
Cd28	CD28 antigen	0.174
Tbxas1	thromboxane A synthase 1, platelet	0.173
Smad1	MAD homolog 1 (Drosophila)	0.171
Ikzf1	IKAROS family zinc finger 1	0.169
Rab3il1	RAB3A interacting protein (rabin3)-like 1	0.169
Sfn	stratifin	0.168
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.167	Mouse
Lcp2	lymphocyte cytosolic protein 2	0.167
Map2k4	mitogen-activated protein kinase kinase 4	0.166	Zebrafish Mouse Rat Fly
Mecp2	methyl CpG binding protein 2	0.166
Il4	interleukin 4	0.162
Smad2	MAD homolog 2 (Drosophila)	0.161
Bcar1	breast cancer anti-estrogen resistance 1	0.160
Irg1	immunoresponsive gene 1	0.159
Ccnd1	cyclin D1	0.159
Fgfr3	fibroblast growth factor receptor 3	0.157
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.156
Sult5a1	sulfotransferase family 5A, member 1	0.155
Tnks1bp1	tankyrase 1 binding protein 1	0.155
Cyr61	cysteine rich protein 61	0.152
Lta	lymphotoxin A	0.152	Mouse Fly
Mmp12	matrix metallopeptidase 12	0.152
Rbms1	RNA binding motif, single stranded interacting protein 1	0.151
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.149
Nog	noggin	0.149
Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	0.148
Trp63	transformation related protein 63	0.147	Mouse
Rel	reticuloendotheliosis oncogene	0.146
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.146
Gbp5	guanylate binding protein 5	0.145
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.145
Klf4	Kruppel-like factor 4 (gut)	0.145
Pak1	p21 protein (Cdc42/Rac)-activated kinase 1	0.144	Human
Skil	SKI-like	0.141
Wnt4	wingless-related MMTV integration site 4	0.139	Mouse
Cd2	CD2 antigen	0.139
Btg2	B-cell translocation gene 2, anti-proliferative	0.139
Fzd1	frizzled homolog 1 (Drosophila)	0.137	Mouse
Lat	linker for activation of T cells	0.136
Shc1	src homology 2 domain-containing transforming protein C1	0.136
Ednrb	endothelin receptor type B	0.133
Clec4e	C-type lectin domain family 4, member e	0.131
Arhgap1	Rho GTPase activating protein 1	0.131
Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.130
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.130
Clock	circadian locomotor output cycles kaput	0.129
Sertad1	SERTA domain containing 1	0.127
Cpd	carboxypeptidase D	0.126
Lef1	lymphoid enhancer binding factor 1	0.126
Mapk9	mitogen-activated protein kinase 9	0.126	Human Mouse Rat Worm Fly
Tacr1	tachykinin receptor 1	0.124
Mef2a	myocyte enhancer factor 2A	0.123
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.122	Mouse
Tgfa	transforming growth factor alpha	0.122
Lhx1	LIM homeobox protein 1	0.121
Aim2	absent in melanoma 2	0.120
Trp73	transformation related protein 73	0.118
Npr3	natriuretic peptide receptor 3	0.118
Adra2b	adrenergic receptor, alpha 2b	0.117
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.117
Gzma	granzyme A	0.117
Yap1	yes-associated protein 1	0.116
Fosl2	fos-like antigen 2	0.115
Aoah	acyloxyacyl hydrolase	0.115
Epn1	epsin 1	0.115
Il2rb	interleukin 2 receptor, beta chain	0.114
Ret	ret proto-oncogene	0.114
Tlr6	toll-like receptor 6	0.114	Human Mouse
Fgfr4	fibroblast growth factor receptor 4	0.114
Aldh1a3	aldehyde dehydrogenase family 1, subfamily A3	0.112
Cd96	CD96 antigen	0.112
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.111
C5ar1	complement component 5a receptor 1	0.111
Il7r	interleukin 7 receptor	0.111
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.110
Klf6	Kruppel-like factor 6	0.109
Ccl6	chemokine (C-C motif) ligand 6	0.109	Mouse
Midn	midnolin	0.108
Mgat3	mannoside acetylglucosaminyltransferase 3	0.108
Hoxd13	homeobox D13	0.108
Slfn1	schlafen 1	0.107
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.105
Clec7a	C-type lectin domain family 7, member a	0.105
Xcl1	chemokine (C motif) ligand 1	0.104	Mouse
Folr2	folate receptor 2 (fetal)	0.104
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.104
Pyhin1	pyrin and HIN domain family, member 1	0.103
Socs3	suppressor of cytokine signaling 3	0.103
Foxp2	forkhead box P2	0.103
Cry2	cryptochrome 2 (photolyase-like)	0.103
Nfe2l3	nuclear factor, erythroid derived 2, like 3	0.103
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.102
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.102
Btk	Bruton agammaglobulinemia tyrosine kinase	0.102
Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide	0.102
Cd180	CD180 antigen	0.101	Mouse
Cd5	CD5 antigen	0.101
Zbtb7b	zinc finger and BTB domain containing 7B	0.101
Myo1c	myosin IC	0.100
Ubc	ubiquitin C	0.100
Gata5	GATA binding protein 5	0.099
Klf7	Kruppel-like factor 7 (ubiquitous)	0.099
Gli1	GLI-Kruppel family member GLI1	0.099
Fgf23	fibroblast growth factor 23	0.098
Sh3rf1	SH3 domain containing ring finger 1	0.098
Rnf111	ring finger 111	0.097
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.096
Rnf11	ring finger protein 11	0.096
Il10ra	interleukin 10 receptor, alpha	0.096
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.095
Gpr132	G protein-coupled receptor 132	0.095
Tspan12	tetraspanin 12	0.094
Efna3	ephrin A3	0.093
Pou2af1	POU domain, class 2, associating factor 1	0.093
Mmp16	matrix metallopeptidase 16	0.093
Vax1	ventral anterior homeobox containing gene 1	0.093
Wnt11	wingless-related MMTV integration site 11	0.093	Mouse
Zfp703	zinc finger protein 703	0.092
Fadd	Fas (TNFRSF6)-associated via death domain	0.091
Dact3	dapper homolog 3, antagonist of beta-catenin (xenopus)	0.091
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.090
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.090
Pou3f2	POU domain, class 3, transcription factor 2	0.089
Il18rap	interleukin 18 receptor accessory protein	0.089
Gadd45g	growth arrest and DNA-damage-inducible 45 gamma	0.089	Human Fly
Kif5b	kinesin family member 5B	0.089
Efna4	ephrin A4	0.088
Icos	inducible T-cell co-stimulator	0.088
Rhob	ras homolog gene family, member B	0.088
Gata6	GATA binding protein 6	0.088
Plxna1	plexin A1	0.087
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.087
Kif1b	kinesin family member 1B	0.087
Cul3	cullin 3	0.086
Lck	lymphocyte protein tyrosine kinase	0.086
Foxc2	forkhead box C2	0.086
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.086
Errfi1	ERBB receptor feedback inhibitor 1	0.086
Mdm4	transformed mouse 3T3 cell double minute 4	0.085
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.085
Lrrk2	leucine-rich repeat kinase 2	0.084
Ccl9	chemokine (C-C motif) ligand 9	0.084	Mouse
Smad5	MAD homolog 5 (Drosophila)	0.083
Itch	itchy, E3 ubiquitin protein ligase	0.083
Il2rg	interleukin 2 receptor, gamma chain	0.083
Agap3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	0.083
Fpr2	formyl peptide receptor 2	0.082
Mrc1	mannose receptor, C type 1	0.082
Vegfc	vascular endothelial growth factor C	0.082
Git1	G protein-coupled receptor kinase-interactor 1	0.081
Mavs	mitochondrial antiviral signaling protein	0.081
Msn	moesin	0.081
Dock1	dedicator of cytokinesis 1	0.080
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.080
Otud7b	OTU domain containing 7B	0.080
Kl	klotho	0.080
Gdnf	glial cell line derived neurotrophic factor	0.080
Il1r1	interleukin 1 receptor, type I	0.080
Ccr7	chemokine (C-C motif) receptor 7	0.080
Arf6	ADP-ribosylation factor 6	0.080
Plek	pleckstrin	0.079
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.079	Mouse
Ccr5	chemokine (C-C motif) receptor 5	0.079
Ubd	ubiquitin D	0.079
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.079
Pycard	PYD and CARD domain containing	0.079	Human
Onecut1	one cut domain, family member 1	0.079
Sntb1	syntrophin, basic 1	0.078
Hck	hemopoietic cell kinase	0.078
Aff1	AF4/FMR2 family, member 1	0.078
Nr2f6	nuclear receptor subfamily 2, group F, member 6	0.078
Notch1	Notch gene homolog 1 (Drosophila)	0.078
Myh10	myosin, heavy polypeptide 10, non-muscle	0.078
Fjx1	four jointed box 1 (Drosophila)	0.077
Becn1	beclin 1, autophagy related	0.077
Pou2f2	POU domain, class 2, transcription factor 2	0.076
Lag3	lymphocyte-activation gene 3	0.076
Dlg4	discs, large homolog 4 (Drosophila)	0.076
Hspa1b	heat shock protein 1B	0.075
Ticam1	toll-like receptor adaptor molecule 1	0.075
Prkcc	protein kinase C, gamma	0.075
Lats2	large tumor suppressor 2	0.075
Mll5	myeloid/lymphoid or mixed-lineage leukemia 5	0.075
Pcdh18	protocadherin 18	0.075
Cxadr	coxsackie virus and adenovirus receptor	0.075
Rab10	RAB10, member RAS oncogene family	0.074
Dusp6	dual specificity phosphatase 6	0.074	Mouse
Socs1	suppressor of cytokine signaling 1	0.074
Ptafr	platelet-activating factor receptor	0.074
Ngf	nerve growth factor	0.073
Cyp24a1	cytochrome P450, family 24, subfamily a, polypeptide 1	0.073
Klc2	kinesin light chain 2	0.073
Nkd2	naked cuticle 2 homolog (Drosophila)	0.073
Csde1	cold shock domain containing E1, RNA binding	0.072
Reln	reelin	0.072
Cd7	CD7 antigen	0.072
Smo	smoothened homolog (Drosophila)	0.072
Mapk10	mitogen-activated protein kinase 10	0.071
Fign	fidgetin	0.071
Nrg1	neuregulin 1	0.071
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.070
Klf13	Kruppel-like factor 13	0.070
Ptgir	prostaglandin I receptor (IP)	0.070
Tox	thymocyte selection-associated high mobility group box	0.070
Snn	stannin	0.070
Nfib	nuclear factor I/B	0.069
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.069
Pax1	paired box gene 1	0.069
Lrp8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	0.069
Mapkapk2	MAP kinase-activated protein kinase 2	0.069	Fly
Ptprk	protein tyrosine phosphatase, receptor type, K	0.068
Zfp36l2	zinc finger protein 36, C3H type-like 2	0.068
Acvr2a	activin receptor IIA	0.068
Pvrl2	poliovirus receptor-related 2	0.068
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.068
Gja5	gap junction protein, alpha 5	0.068
Lrp4	low density lipoprotein receptor-related protein 4	0.068
Ctnnd1	catenin (cadherin associated protein), delta 1	0.067
Wnt6	wingless-related MMTV integration site 6	0.067	Mouse
Sell	selectin, lymphocyte	0.067
Ccr9	chemokine (C-C motif) receptor 9	0.067
Sav1	salvador homolog 1 (Drosophila)	0.066
Prox1	prospero-related homeobox 1	0.066
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.066
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.066
Strn3	striatin, calmodulin binding protein 3	0.066	Fly
Cflar	CASP8 and FADD-like apoptosis regulator	0.066
Spag9	sperm associated antigen 9	0.066
Mmp8	matrix metallopeptidase 8	0.066
Emp2	epithelial membrane protein 2	0.066
Gna11	guanine nucleotide binding protein, alpha 11	0.066
Kdr	kinase insert domain protein receptor	0.065
Zeb1	zinc finger E-box binding homeobox 1	0.065	Mouse
Il27ra	interleukin 27 receptor, alpha	0.065
Sept1	septin 1	0.065
Emid2	EMI domain containing 2	0.065
Fgf2	fibroblast growth factor 2	0.064
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.064
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.063
Msh2	mutS homolog 2 (E. coli)	0.063
A230046K03Rik	RIKEN cDNA A230046K03 gene	0.063
Pcdh1	protocadherin 1	0.063
Cd3g	CD3 antigen, gamma polypeptide	0.063
Trem2	triggering receptor expressed on myeloid cells 2	0.062
Vdac3	voltage-dependent anion channel 3	0.062
Axin2	axin2	0.062	Mouse
Mycl1	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	0.062
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.062
Lilrb4	leukocyte immunoglobulin-like receptor, subfamily B, member 4	0.062
Dll1	delta-like 1 (Drosophila)	0.062
Irs1	insulin receptor substrate 1	0.062
H2-Oa	histocompatibility 2, O region alpha locus	0.062
Pkn2	protein kinase N2	0.062
Zfpm2	zinc finger protein, multitype 2	0.062
Itga6	integrin alpha 6	0.061
Amotl2	angiomotin-like 2	0.061
Agrn	agrin	0.061
Ms4a6c	membrane-spanning 4-domains, subfamily A, member 6C	0.061
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.061
Capn6	calpain 6	0.060
Wnt5b	wingless-related MMTV integration site 5B	0.060	Mouse
Hoxc9	homeobox C9	0.060
Emx2	empty spiracles homolog 2 (Drosophila)	0.060
Pvrl1	poliovirus receptor-related 1	0.060
Lmx1a	LIM homeobox transcription factor 1 alpha	0.060
Pthlh	parathyroid hormone-like peptide	0.059
Blk	B lymphoid kinase	0.059
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.059
Slfn4	schlafen 4	0.059
Map3k4	mitogen-activated protein kinase kinase kinase 4	0.058
Csf1	colony stimulating factor 1 (macrophage)	0.058
Chrng	cholinergic receptor, nicotinic, gamma polypeptide	0.058
Tmem64	transmembrane protein 64	0.058
Pde3a	phosphodiesterase 3A, cGMP inhibited	0.057
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.056
Ly9	lymphocyte antigen 9	0.056
Pdcd1	programmed cell death 1	0.056
Iffo2	intermediate filament family orphan 2	0.056
Dlg3	discs, large homolog 3 (Drosophila)	0.056
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.056
Epha1	Eph receptor A1	0.055	Mouse
Map2k3	mitogen-activated protein kinase kinase 3	0.055	Mouse
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.055
Hdac7	histone deacetylase 7	0.055
Erf	Ets2 repressor factor	0.055
C3	complement component 3	0.055
Nde1	nuclear distribution gene E homolog 1 (A nidulans)	0.055
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.055
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.054
Cab39	calcium binding protein 39	0.054
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.054
Fyttd1	forty-two-three domain containing 1	0.054
Zfhx3	zinc finger homeobox 3	0.054
Artn	artemin	0.054
Mmp13	matrix metallopeptidase 13	0.054
Wls	wntless homolog (Drosophila)	0.054
Vav1	vav 1 oncogene	0.054
Flt3	FMS-like tyrosine kinase 3	0.054
Add1	adducin 1 (alpha)	0.054
Eda	ectodysplasin-A	0.054
Cxcl1	chemokine (C-X-C motif) ligand 1	0.054
Galnt3	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3	0.054
Kif12	kinesin family member 12	0.053
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.053	Mouse
Porcn	porcupine homolog (Drosophila)	0.053
Gata3	GATA binding protein 3	0.053
Cd300ld	CD300 molecule-like family member d	0.053
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.053	Mouse
Gna12	guanine nucleotide binding protein, alpha 12	0.053
Lims1	LIM and senescent cell antigen-like domains 1	0.053	Fly
Vcam1	vascular cell adhesion molecule 1	0.053
Dach1	dachshund 1 (Drosophila)	0.053
Nrg3	neuregulin 3	0.053
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.053
Usp2	ubiquitin specific peptidase 2	0.052
Dnajb1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.052
Sh3pxd2a	SH3 and PX domains 2A	0.052
Neurog1	neurogenin 1	0.052
Traf3	TNF receptor-associated factor 3	0.052	Mouse
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.052
Chordc1	cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1	0.052
Slamf8	SLAM family member 8	0.052
Fam20c	family with sequence similarity 20, member C	0.052
Prdx6	peroxiredoxin 6	0.051
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.051
Baz2b	bromodomain adjacent to zinc finger domain, 2B	0.051
Ptp4a2	protein tyrosine phosphatase 4a2	0.051
Gata4	GATA binding protein 4	0.051
Tpm4	tropomyosin 4	0.051
Igf2	insulin-like growth factor 2	0.051
Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.050
Wnt1	wingless-related MMTV integration site 1	0.050	Mouse
Pxn	paxillin	0.050
Ube3a	ubiquitin protein ligase E3A	0.050
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.050
Tead2	TEA domain family member 2	0.050
Ly86	lymphocyte antigen 86	0.050
Ifnar1	interferon (alpha and beta) receptor 1	0.050
Klf2	Kruppel-like factor 2 (lung)	0.050
Ier3	immediate early response 3	0.050
Mmp24	matrix metallopeptidase 24	0.050
Il6st	interleukin 6 signal transducer	0.050
Qk	quaking	0.050
Col2a1	collagen, type II, alpha 1	0.050
Fgfrl1	fibroblast growth factor receptor-like 1	0.049
Rara	retinoic acid receptor, alpha	0.049
Tbx2	T-box 2	0.049
Notum	notum pectinacetylesterase homolog (Drosophila)	0.049
Arrdc3	arrestin domain containing 3	0.049
Wnt2b	wingless related MMTV integration site 2b	0.049	Mouse
Fhdc1	FH2 domain containing 1	0.049
Fyn	Fyn proto-oncogene	0.049
Zbtb7a	zinc finger and BTB domain containing 7a	0.049
Vldlr	very low density lipoprotein receptor	0.048
Jup	junction plakoglobin	0.048
Shank2	SH3/ankyrin domain gene 2	0.048
Csrnp1	cysteine-serine-rich nuclear protein 1	0.048
Cd27	CD27 antigen	0.048
Cdk14	cyclin-dependent kinase 14	0.048
Egr1	early growth response 1	0.048
Phlda1	pleckstrin homology-like domain, family A, member 1	0.047
Sim2	single-minded homolog 2 (Drosophila)	0.047
Gabpa	GA repeat binding protein, alpha	0.047
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.047
Wnt7a	wingless-related MMTV integration site 7A	0.047	Mouse
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.047
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.047
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.046
Ikbkb	inhibitor of kappaB kinase beta	0.046
Scube1	signal peptide, CUB domain, EGF-like 1	0.046
Rfwd2	ring finger and WD repeat domain 2	0.046
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.046
Fosl1	fos-like antigen 1	0.046
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.046
Mapk3	mitogen-activated protein kinase 3	0.046	Fly
Homer1	homer homolog 1 (Drosophila)	0.046
Postn	periostin, osteoblast specific factor	0.046
Hgf	hepatocyte growth factor	0.046
Cldn3	claudin 3	0.046
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.046
Ly6d	lymphocyte antigen 6 complex, locus D	0.046
S1pr4	sphingosine-1-phosphate receptor 4	0.045
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.045
Adam10	a disintegrin and metallopeptidase domain 10	0.045
Irx2	Iroquois related homeobox 2 (Drosophila)	0.045
Fzd10	frizzled homolog 10 (Drosophila)	0.045
Epx	eosinophil peroxidase	0.045
Krt17	keratin 17	0.045
Gripap1	GRIP1 associated protein 1	0.045
Dmtf1	cyclin D binding myb-like transcription factor 1	0.044
Acan	aggrecan	0.044
Id2	inhibitor of DNA binding 2	0.044
Ms4a7	membrane-spanning 4-domains, subfamily A, member 7	0.044
Lima1	LIM domain and actin binding 1	0.044
Adam12	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	0.044
Dll4	delta-like 4 (Drosophila)	0.044
Plk3	polo-like kinase 3 (Drosophila)	0.044
Myf5	myogenic factor 5	0.044
Vhl	von Hippel-Lindau tumor suppressor	0.044
Mcl1	myeloid cell leukemia sequence 1	0.044
Cxcr4	chemokine (C-X-C motif) receptor 4	0.044
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.044
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.044
Ahr	aryl-hydrocarbon receptor	0.043
Clip1	CAP-GLY domain containing linker protein 1	0.043
Il18	interleukin 18	0.043
Ptgs1	prostaglandin-endoperoxide synthase 1	0.043
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.043
Rnd3	Rho family GTPase 3	0.043
Ppp3cb	protein phosphatase 3, catalytic subunit, beta isoform	0.043
Lcp1	lymphocyte cytosolic protein 1	0.043
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.043
Lrp2	low density lipoprotein receptor-related protein 2	0.043
Gm11428	predicted gene 11428	0.043
Nf2	neurofibromatosis 2	0.043
Pld2	phospholipase D2	0.043
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.043
Gjc1	gap junction protein, gamma 1	0.043
Vipr2	vasoactive intestinal peptide receptor 2	0.043
Mafk	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	0.043
Pnpla6	patatin-like phospholipase domain containing 6	0.043
Efna5	ephrin A5	0.043
Nckap1l	NCK associated protein 1 like	0.043
Ifng	interferon gamma	0.043
Supv3l1	suppressor of var1, 3-like 1 (S. cerevisiae)	0.042
Sh3bp4	SH3-domain binding protein 4	0.042
Adam11	a disintegrin and metallopeptidase domain 11	0.042
Twist1	twist homolog 1 (Drosophila)	0.042
Neurog3	neurogenin 3	0.042
Bcl3	B-cell leukemia/lymphoma 3	0.042
Ppl	periplakin	0.042
Zbtb7c	zinc finger and BTB domain containing 7C	0.042
Map3k5	mitogen-activated protein kinase kinase kinase 5	0.042	Human Fly
Tlr2	toll-like receptor 2	0.042	Mouse
Cnga2	cyclic nucleotide gated channel alpha 2	0.042
Ltbr	lymphotoxin B receptor	0.042	Human
Epha3	Eph receptor A3	0.042	Mouse
C77370	expressed sequence C77370	0.041
Usp47	ubiquitin specific peptidase 47	0.041
Zfp518b	zinc finger protein 518B	0.041
Ptch1	patched homolog 1	0.041
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.041
Mark4	MAP/microtubule affinity-regulating kinase 4	0.041
Cyp26c1	cytochrome P450, family 26, subfamily c, polypeptide 1	0.041
Psen1	presenilin 1	0.041
Gp49a	glycoprotein 49 A	0.041
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.041
Tg	thyroglobulin	0.041
Cops6	COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)	0.041
Ets2	E26 avian leukemia oncogene 2, 3' domain	0.041
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.041
Cx3cr1	chemokine (C-X3-C) receptor 1	0.041
Daxx	Fas death domain-associated protein	0.041
Igfbp2	insulin-like growth factor binding protein 2	0.041
Clec5a	C-type lectin domain family 5, member a	0.041
Nlrp3	NLR family, pyrin domain containing 3	0.041	Mouse
Tbc1d4	TBC1 domain family, member 4	0.040
Wdr26	WD repeat domain 26	0.040
Ier5	immediate early response 5	0.040
Srcin1	SRC kinase signaling inhibitor 1	0.040
Heg1	HEG homolog 1 (zebrafish)	0.040
Rapgef1	Rap guanine nucleotide exchange factor (GEF) 1	0.040
Nfia	nuclear factor I/A	0.040
Rai1	retinoic acid induced 1	0.040
Bmi1	Bmi1 polycomb ring finger oncogene	0.040
Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.040
Anxa3	annexin A3	0.040
Foxk1	forkhead box K1	0.040
Ppp1r15a	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.039
Tifa	TRAF-interacting protein with forkhead-associated domain	0.039
Mast2	microtubule associated serine/threonine kinase 2	0.039
Celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.039
Plk2	polo-like kinase 2 (Drosophila)	0.039
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.039
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.039
Clec4a2	C-type lectin domain family 4, member a2	0.039
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.039
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.039
Rnf41	ring finger protein 41	0.039
Pla2g4a	phospholipase A2, group IVA (cytosolic, calcium-dependent)	0.039
Smad4	MAD homolog 4 (Drosophila)	0.039
Mark2	MAP/microtubule affinity-regulating kinase 2	0.039
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.039
Cblb	Casitas B-lineage lymphoma b	0.039
Wnt10b	wingless related MMTV integration site 10b	0.039	Mouse
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.038
Fut7	fucosyltransferase 7	0.038
Gas1	growth arrest specific 1	0.038
Apoc2	apolipoprotein C-II	0.038
Mapk7	mitogen-activated protein kinase 7	0.038
Foxo1	forkhead box O1	0.038
Gzmb	granzyme B	0.038
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.038
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.038
Gm10229	predicted gene 10229	0.038
Nkd1	naked cuticle 1 homolog (Drosophila)	0.038
Mllt1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.038
Ifitm6	interferon induced transmembrane protein 6	0.038
Wnt3	wingless-related MMTV integration site 3	0.038	Mouse
Bin1	bridging integrator 1	0.037
Ptprc	protein tyrosine phosphatase, receptor type, C	0.037
Pdcd1lg2	programmed cell death 1 ligand 2	0.037
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.037
AI607873	expressed sequence AI607873	0.037
Foxa1	forkhead box A1	0.037
Zfpm1	zinc finger protein, multitype 1	0.037
Iqgap1	IQ motif containing GTPase activating protein 1	0.037
Bmp6	bone morphogenetic protein 6	0.037
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.037
Csnk1d	casein kinase 1, delta	0.037
Ate1	arginyltransferase 1	0.037
Bmp5	bone morphogenetic protein 5	0.037
Rap2b	RAP2B, member of RAS oncogene family	0.037
Tbl1x	transducin (beta)-like 1 X-linked	0.037
Numb	numb gene homolog (Drosophila)	0.037
Hif1a	hypoxia inducible factor 1, alpha subunit	0.037
Ccl17	chemokine (C-C motif) ligand 17	0.037	Mouse
Bmp8a	bone morphogenetic protein 8a	0.037
Emp1	epithelial membrane protein 1	0.037
Cmklr1	chemokine-like receptor 1	0.037
Cdh3	cadherin 3	0.037
Mprip	myosin phosphatase Rho interacting protein	0.037
Plau	plasminogen activator, urokinase	0.036
Foxf2	forkhead box F2	0.036
Mtap2	microtubule-associated protein 2	0.036
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.036
Card11	caspase recruitment domain family, member 11	0.036	Mouse
Ulk1	Unc-51 like kinase 1 (C. elegans)	0.036
Shox2	short stature homeobox 2	0.036
Efna1	ephrin A1	0.036
Mobkl3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.036
Angptl1	angiopoietin-like 1	0.036
Irf4	interferon regulatory factor 4	0.036
Zswim6	zinc finger, SWIM domain containing 6	0.036
Cxcl10	chemokine (C-X-C motif) ligand 10	0.036
Per3	period homolog 3 (Drosophila)	0.036
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.036	Mouse
Hoxb1	homeobox B1	0.036
Pim1	proviral integration site 1	0.036
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.036
Ncor2	nuclear receptor co-repressor 2	0.036
P2ry2	purinergic receptor P2Y, G-protein coupled 2	0.036
3110079O15Rik	RIKEN cDNA 3110079O15 gene	0.036
Grid1	glutamate receptor, ionotropic, delta 1	0.036
Dppa5a	developmental pluripotency associated 5A	0.035
Nab2	Ngfi-A binding protein 2	0.035
Klf5	Kruppel-like factor 5	0.035
Cacna1g	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.035
Zfp185	zinc finger protein 185	0.035
Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	0.035
Rasa1	RAS p21 protein activator 1	0.035
Slc25a25	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25	0.035
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.035
Sec14l1	SEC14-like 1 (S. cerevisiae)	0.035
Smtn	smoothelin	0.035
Tnk2	tyrosine kinase, non-receptor, 2	0.035
Il17d	interleukin 17D	0.035
Plekhg5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	0.035
Eif4g2	eukaryotic translation initiation factor 4, gamma 2	0.035
Peli2	pellino 2	0.035
Rap2a	RAS related protein 2a	0.035	Human
Mmp9	matrix metallopeptidase 9	0.035
Foxq1	forkhead box Q1	0.035
Rhou	ras homolog gene family, member U	0.035
Lamc2	laminin, gamma 2	0.035
Cxcr2	chemokine (C-X-C motif) receptor 2	0.035
Tal2	T-cell acute lymphocytic leukemia 2	0.035
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.035
Ctsh	cathepsin H	0.035
Wdr1	WD repeat domain 1	0.034
Lad1	ladinin	0.034
Neo1	neogenin	0.034
B230219D22Rik	RIKEN cDNA B230219D22 gene	0.034
Nfam1	Nfat activating molecule with ITAM motif 1	0.034
Rgs6	regulator of G-protein signaling 6	0.034
Sit1	suppression inducing transmembrane adaptor 1	0.034
Col5a2	collagen, type V, alpha 2	0.034
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.034
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.034
Kdm5a	lysine (K)-specific demethylase 5A	0.034
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.034
Wnt9a	wingless-type MMTV integration site 9A	0.034	Mouse
Ptprf	protein tyrosine phosphatase, receptor type, F	0.034
Bcl7a	B-cell CLL/lymphoma 7A	0.034
Tnfsf9	tumor necrosis factor (ligand) superfamily, member 9	0.034
Guca2b	guanylate cyclase activator 2b (retina)	0.034