IMP: Integrative Multi-species Prediction

Mus musculus

11 genes annotated in mouse

response to interleukin 1

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to interleukin 1"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "response to interleukin 1" (in gray)

Name	Description	Probability	Func Analog Organism
Myd88	myeloid differentiation primary response gene 88	1.000	Human
Ccl2	chemokine (C-C motif) ligand 2	1.000
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.999
Il1r1	interleukin 1 receptor, type I	0.997	Human Rat
Cd44	CD44 antigen	0.975
Il6	interleukin 6	0.973
Tnf	tumor necrosis factor	0.972
Tlr4	toll-like receptor 4	0.949
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.939
Stat3	signal transducer and activator of transcription 3	0.929
Fas	Fas (TNF receptor superfamily member 6)	0.872	Rat
Ccr2	chemokine (C-C motif) receptor 2	0.848
Ptgs2	prostaglandin-endoperoxide synthase 2	0.823
Icam1	intercellular adhesion molecule 1	0.804	Rat
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.772
Csf1	colony stimulating factor 1 (macrophage)	0.694
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.680
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.653	Mouse
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.631	Human
Birc3	baculoviral IAP repeat-containing 3	0.605
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.600	Mouse
Il10	interleukin 10	0.572
Cxcl2	chemokine (C-X-C motif) ligand 2	0.551	Rat
Ccl7	chemokine (C-C motif) ligand 7	0.487
Apoe	apolipoprotein E	0.473
Nos2	nitric oxide synthase 2, inducible	0.450	Rat
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.444
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.426
Ifng	interferon gamma	0.399
Selp	selectin, platelet	0.268
Mmp9	matrix metallopeptidase 9	0.252	Rat
Junb	Jun-B oncogene	0.244
Ch25h	cholesterol 25-hydroxylase	0.243
Irak4	interleukin-1 receptor-associated kinase 4	0.221
Traf6	TNF receptor-associated factor 6	0.218
Lepr	leptin receptor	0.215
Prkce	protein kinase C, epsilon	0.213
Cyr61	cysteine rich protein 61	0.212
Osmr	oncostatin M receptor	0.210
Nlrp3	NLR family, pyrin domain containing 3	0.200
Cxcl1	chemokine (C-X-C motif) ligand 1	0.193
Gbp5	guanylate binding protein 5	0.184
Lox	lysyl oxidase	0.180
Fgfr2	fibroblast growth factor receptor 2	0.175
Il1rn	interleukin 1 receptor antagonist	0.155	Human Rat
Tlr2	toll-like receptor 2	0.137
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.137
Traf3ip2	TRAF3 interacting protein 2	0.133
Runx2	runt related transcription factor 2	0.127
Egr2	early growth response 2	0.123
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.119
Lmna	lamin A	0.111
Dab1	disabled homolog 1 (Drosophila)	0.111
Aim2	absent in melanoma 2	0.109
Timp1	tissue inhibitor of metalloproteinase 1	0.106
Ccl4	chemokine (C-C motif) ligand 4	0.104
Spp1	secreted phosphoprotein 1	0.100
Mapk1	mitogen-activated protein kinase 1	0.099
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.095
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.091
Lta	lymphotoxin A	0.090
Ar	androgen receptor	0.085
Casp1	caspase 1	0.084
Gfpt2	glutamine fructose-6-phosphate transaminase 2	0.082
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.070
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.067
Slc10a6	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	0.066
Lif	leukemia inhibitory factor	0.065
Ccl12	chemokine (C-C motif) ligand 12	0.064
Mef2d	myocyte enhancer factor 2D	0.062
Plaur	plasminogen activator, urokinase receptor	0.059
Trim55	tripartite motif-containing 55	0.053
Ticam1	toll-like receptor adaptor molecule 1	0.052
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.051	Human
Mmp3	matrix metallopeptidase 3	0.051	Rat
Cd40	CD40 antigen	0.050	Mouse
Tgif1	TGFB-induced factor homeobox 1	0.050
Clec4d	C-type lectin domain family 4, member d	0.048
Bcl3	B-cell leukemia/lymphoma 3	0.048
Ccl17	chemokine (C-C motif) ligand 17	0.047
Sfrp2	secreted frizzled-related protein 2	0.047
Socs3	suppressor of cytokine signaling 3	0.046
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.045
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.044
Ldlr	low density lipoprotein receptor	0.043
Il1b	interleukin 1 beta	0.043
Casp8	caspase 8	0.042
Ptk2	PTK2 protein tyrosine kinase 2	0.041
Irf1	interferon regulatory factor 1	0.041
Igh	immunoglobulin heavy chain complex	0.041
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.040
Il6st	interleukin 6 signal transducer	0.038
Fos	FBJ osteosarcoma oncogene	0.037
Irg1	immunoresponsive gene 1	0.036
Nos1	nitric oxide synthase 1, neuronal	0.036
Nos3	nitric oxide synthase 3, endothelial cell	0.034
Ccr1	chemokine (C-C motif) receptor 1	0.033
Fbn1	fibrillin 1	0.033
Irak3	interleukin-1 receptor-associated kinase 3	0.033
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.032	Rat
Ctsk	cathepsin K	0.031
Ccl3	chemokine (C-C motif) ligand 3	0.031	Human
Ngf	nerve growth factor	0.030
Actn2	actinin alpha 2	0.029
Csf3	colony stimulating factor 3 (granulocyte)	0.029
Has1	hyaluronan synthase1	0.026
Il12b	interleukin 12b	0.025
Vdr	vitamin D receptor	0.025
Cxcl10	chemokine (C-X-C motif) ligand 10	0.025
Prrx2	paired related homeobox 2	0.024
Timp3	tissue inhibitor of metalloproteinase 3	0.024
Il3	interleukin 3	0.024
Cxcl5	chemokine (C-X-C motif) ligand 5	0.023
Lrp8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	0.023
Mavs	mitochondrial antiviral signaling protein	0.023
Ptgir	prostaglandin I receptor (IP)	0.022
Saa3	serum amyloid A 3	0.022
Gli3	GLI-Kruppel family member GLI3	0.022
Cav1	caveolin 1, caveolae protein	0.022
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.022
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.022
Lep	leptin	0.021
Rel	reticuloendotheliosis oncogene	0.021
Vcan	versican	0.021
Thbs1	thrombospondin 1	0.021
Traf2	TNF receptor-associated factor 2	0.021	Mouse
Hspd1	heat shock protein 1 (chaperonin)	0.021
Ptx3	pentraxin related gene	0.020
Lbp	lipopolysaccharide binding protein	0.020
Fosl1	fos-like antigen 1	0.020
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.019
Klf4	Kruppel-like factor 4 (gut)	0.019
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.019	Rat
Plau	plasminogen activator, urokinase	0.019
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.018
S1pr2	sphingosine-1-phosphate receptor 2	0.018
Atf4	activating transcription factor 4	0.018
Arid5a	AT rich interactive domain 5A (MRF1-like)	0.017
Sykb	spleen tyrosine kinase	0.017
Clock	circadian locomotor output cycles kaput	0.017
Trafd1	TRAF type zinc finger domain containing 1	0.017
Il17a	interleukin 17A	0.016
Irak1	interleukin-1 receptor-associated kinase 1	0.016
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.016
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.016
Ccl11	chemokine (C-C motif) ligand 11	0.016
Crebbp	CREB binding protein	0.016
Pten	phosphatase and tensin homolog	0.015
Atf3	activating transcription factor 3	0.015
Max	Max protein	0.015
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.015
Btk	Bruton agammaglobulinemia tyrosine kinase	0.014
Il17f	interleukin 17F	0.014	Mouse
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.014
Plec	plectin	0.013
Sell	selectin, lymphocyte	0.013
Ptpn2	protein tyrosine phosphatase, non-receptor type 2	0.013
Ahr	aryl-hydrocarbon receptor	0.013
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.013
Mmp19	matrix metallopeptidase 19	0.013
Ereg	epiregulin	0.013
Nab2	Ngfi-A binding protein 2	0.012
Wisp2	WNT1 inducible signaling pathway protein 2	0.012
Socs1	suppressor of cytokine signaling 1	0.012
Tgfb1	transforming growth factor, beta 1	0.012
Slpi	secretory leukocyte peptidase inhibitor	0.012
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.012
Pcdh7	protocadherin 7	0.012
Fzd1	frizzled homolog 1 (Drosophila)	0.012
Mapk14	mitogen-activated protein kinase 14	0.012
Il1a	interleukin 1 alpha	0.012
Tnfaip2	tumor necrosis factor, alpha-induced protein 2	0.012
Pthlh	parathyroid hormone-like peptide	0.011
Snai1	snail homolog 1 (Drosophila)	0.011
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.011
Sele	selectin, endothelial cell	0.011	Human
Prkcd	protein kinase C, delta	0.011
Ldb3	LIM domain binding 3	0.011
Ttn	titin	0.011
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.011
Cry1	cryptochrome 1 (photolyase-like)	0.011
Cxcl16	chemokine (C-X-C motif) ligand 16	0.011
Serping1	serine (or cysteine) peptidase inhibitor, clade G, member 1	0.011
Cyld	cylindromatosis (turban tumor syndrome)	0.011
Col1a1	collagen, type I, alpha 1	0.011
Foxo1	forkhead box O1	0.011
Col4a2	collagen, type IV, alpha 2	0.011
Fadd	Fas (TNFRSF6)-associated via death domain	0.011
Il17ra	interleukin 17 receptor A	0.011
Adam8	a disintegrin and metallopeptidase domain 8	0.011
Map3k3	mitogen-activated protein kinase kinase kinase 3	0.010
Il1r2	interleukin 1 receptor, type II	0.010
H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	0.010
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.010
Zfp36	zinc finger protein 36	0.010