IMP: Integrative Multi-species Prediction

Rattus norvegicus

28 genes annotated in rat

cofactor biosynthetic process

The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cofactor biosynthetic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "cofactor biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
Cycs	cytochrome c, somatic	0.860
Pdha1	pyruvate dehydrogenase (lipoamide) alpha 1	0.711
Ndufs1	NADH dehydrogenase (ubiquinone) Fe-S protein 1	0.701
Uqcrc2	ubiquinol cytochrome c reductase core protein 2	0.489
Mdh1	malate dehydrogenase 1, NAD (soluble)	0.482
Atp5a1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.445
Ola1	Obg-like ATPase 1	0.360
Sdha	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.323
Dlat	dihydrolipoamide S-acetyltransferase	0.313
Atp5f1	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1	0.288
Pdhb	pyruvate dehydrogenase (lipoamide) beta	0.213
Hmbs	hydroxymethylbilane synthase	0.208
Pdhx	pyruvate dehydrogenase complex, component X	0.207
Aifm1	apoptosis-inducing factor, mitochondrion-associated 1	0.189
Dld	dihydrolipoamide dehydrogenase	0.184
Fh1	fumarate hydratase 1	0.150
Slc25a3	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3	0.142
Sdhd	succinate dehydrogenase complex, subunit D, integral membrane protein	0.136
Dlst	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	0.135
Me1	malic enzyme 1, NADP(+)-dependent, cytosolic	0.128
Bpnt1	3'(2'), 5'-bisphosphate nucleotidase 1	0.115
Tmem14c	transmembrane protein 14C	0.106
Tst	thiosulfate sulfurtransferase	0.095
Ivd	isovaleryl coenzyme A dehydrogenase	0.086
Vdac1	voltage-dependent anion channel 1	0.085
Mosc2	MOCO sulphurase C-terminal domain containing 2	0.084
Ddt	D-dopachrome tautomerase	0.078
Slc16a1	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)	0.076
Tfrc	transferrin receptor	0.076
Idh3B	isocitrate dehydrogenase 3 (NAD+) beta	0.071
RGD1565095	similar to hypothetical protein MGC52110	0.069
Akr7a2	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	0.068
Mpst	mercaptopyruvate sulfurtransferase	0.065
Grhpr	glyoxylate reductase/hydroxypyruvate reductase	0.061
Apeh	N-acylaminoacyl-peptide hydrolase	0.059
Adk	adenosine kinase	0.056
Got1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.056
Pgk1	phosphoglycerate kinase 1	0.053
LOC100364212	heterogeneous nuclear ribonucleoprotein K-like	0.052
Vdac2	voltage-dependent anion channel 2	0.051
Zp3	zona pellucida glycoprotein 3 (sperm receptor)	0.047
Mipep	mitochondrial intermediate peptidase	0.046
Slc37a4	solute carrier family 37 (glucose-6-phosphate transporter), member 4	0.046
Coasy	Coenzyme A synthase	0.045	Human
Lias	lipoic acid synthetase	0.044
Abtb1	ankyrin repeat and BTB (POZ) domain containing 1	0.043
Acaa1a	acetyl-Coenzyme A acyltransferase 1A	0.042
Gfm1	G elongation factor, mitochondrial 1	0.041
Ccs	copper chaperone for superoxide dismutase	0.040
Ccbl1	cysteine conjugate-beta lyase, cytoplasmic	0.040
Atpaf1	ATP synthase mitochondrial F1 complex assembly factor 1	0.039
Gbe1	glucan (1,4-alpha-), branching enzyme 1	0.039
Slc30a2	solute carrier family 30 (zinc transporter), member 2	0.039
Hint2	histidine triad nucleotide binding protein 2	0.038
RGD1565784	RGD1565784	0.038
Sucla2	succinate-CoA ligase, ADP-forming, beta subunit	0.037
Pxmp2	peroxisomal membrane protein 2	0.035
Mtch2	mitochondrial carrier homolog 2 (C. elegans)	0.034
Pcyt2	phosphate cytidylyltransferase 2, ethanolamine	0.034
Oxct1	3-oxoacid CoA transferase 1	0.034
Pfkm	phosphofructokinase, muscle	0.034
Hspd1	heat shock protein 1 (chaperonin)	0.033
Eif4a2	eukaryotic translation initiation factor 4A, isoform 2	0.032
Prdx3	peroxiredoxin 3	0.031
Ccng1	cyclin G1	0.031
RGD1311910	similar to hypothetical p38 protein	0.029
Sephs2	selenophosphate synthetase 2	0.029
Slc25a4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	0.029	Yeast
Mapk6	mitogen-activated protein kinase 6	0.028
LOC100363376	rCG51296-like	0.026
Acp2	acid phosphatase 2, lysosomal	0.026
Abhd14b	abhydrolase domain containing 14b	0.026
Haao	3-hydroxyanthranilate 3,4-dioxygenase	0.025
Them4	thioesterase superfamily member 4	0.025
Pink1	PTEN induced putative kinase 1	0.025
Fdft1	farnesyl diphosphate farnesyl transferase 1	0.024
Slc7a5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	0.024
Mrps14	mitochondrial ribosomal protein S14	0.024
Fahd2a	fumarylacetoacetate hydrolase domain containing 2A	0.024
Hagh	hydroxyacyl glutathione hydrolase	0.024
Grsf1	G-rich RNA sequence binding factor 1	0.024
Nit2	nitrilase family, member 2	0.024
LOC100366121	rCG29408-like	0.023
Stradb	STE20-related kinase adaptor beta	0.023
Auh	AU RNA binding protein/enoyl-coenzyme A hydratase	0.023
Ppp2ca	protein phosphatase 2, catalytic subunit, alpha isoform	0.023
Pecr	peroxisomal trans-2-enoyl-CoA reductase	0.022
Acat1	acetyl-coenzyme A acetyltransferase 1	0.022
Suox	sulfite oxidase	0.022
Acy1	aminoacylase 1	0.022
Urod	uroporphyrinogen decarboxylase	0.022
Aldh1l1	aldehyde dehydrogenase 1 family, member L1	0.021
Oplah	5-oxoprolinase (ATP-hydrolysing)	0.021
Eif4e	eukaryotic translation initiation factor 4E	0.021
Aldob	aldolase B, fructose-bisphosphate	0.021
Bckdha	branched chain ketoacid dehydrogenase E1, alpha polypeptide	0.020
Macrod1	MACRO domain containing 1	0.020
Bckdk	branched chain ketoacid dehydrogenase kinase	0.020
Fam54b	family with sequence similarity 54, member B	0.020
Map2k1	mitogen activated protein kinase kinase 1	0.020
Pmpca	peptidase (mitochondrial processing) alpha	0.020
Gnmt	glycine N-methyltransferase	0.020
Brca1	breast cancer 1	0.019
Ephx2	epoxide hydrolase 2, cytoplasmic	0.019
Gp5	glycoprotein V (platelet)	0.019
Pex19	peroxisomal biogenesis factor 19	0.019
Cbr4	carbonyl reductase 4	0.018
Oxnad1	oxidoreductase NAD-binding domain containing 1	0.018
Trap1	TNF receptor-associated protein 1	0.018
Ppp1r3b	protein phosphatase 1, regulatory (inhibitor) subunit 3B	0.018
Dhcr7	7-dehydrocholesterol reductase	0.018
Aldh2	aldehyde dehydrogenase 2 family (mitochondrial)	0.018
Hpd	4-hydroxyphenylpyruvate dioxygenase	0.018
Tmem53	transmembrane protein 53	0.018
Hemgn	hemogen	0.018
Serpinf2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.017
Fam173a	family with sequence similarity 173, member A	0.017
Kel	Kell blood group, metallo-endopeptidase	0.017
Fech	ferrochelatase	0.017
Klc4	kinesin light chain 4	0.017
Cryab	crystallin, alpha B	0.017
Sardh	sarcosine dehydrogenase	0.017
RGD1308874	similar to RIKEN cDNA 2310001A20	0.016
RGD1310686	similar to chromosome 16 open reading frame 5	0.016
Apba3	amyloid beta (A4) precursor protein-binding, family A, member 3	0.016
F10	coagulation factor X	0.016
Slc25a20	solute carrier family 25 (carnitine/acylcarnitine translocase), member 20	0.016
Tsen34	tRNA splicing endonuclease 34 homolog (S. cerevisiae)	0.016
RGD620382	Nucleoside 2-deoxyribosyltransferase domain containing protein RGD620382	0.016
Gpx4	glutathione peroxidase 4	0.016
Dcxr	dicarbonyl L-xylulose reductase	0.016
Cdadc1	cytidine and dCMP deaminase domain containing 1	0.015
Ambp	alpha-1-microglobulin/bikunin precursor	0.015
Vars2	valyl-tRNA synthetase 2, mitochondrial (putative)	0.015
Cryz	crystallin, zeta	0.015
Ppcs	phosphopantothenoylcysteine synthetase	0.015
Idh3a	isocitrate dehydrogenase 3 (NAD+) alpha	0.015
Bmp7	bone morphogenetic protein 7	0.015
Mlh1	mutL homolog 1 (E. coli)	0.015
Morf4l2	mortality factor 4 like 2	0.015
Adh5	alcohol dehydrogenase 5 (class III), chi polypeptide	0.015
Pdss2	prenyl (decaprenyl) diphosphate synthase, subunit 2	0.015
Car2	carbonic anhydrase II	0.015
Gstk1	glutathione S-transferase kappa 1	0.015
Cnbp	CCHC-type zinc finger, nucleic acid binding protein	0.015
Ldha	lactate dehydrogenase A	0.015
Plaa	phospholipase A2, activating protein	0.015
Dynlt3	dynein light chain Tctex-type 3	0.015
Mtr	5-methyltetrahydrofolate-homocysteine methyltransferase	0.015
Gstp1	glutathione S-transferase pi 1	0.015
Shmt1	serine hydroxymethyltransferase 1 (soluble)	0.014
Aldh4a1	aldehyde dehydrogenase 4 family, member A1	0.014
Hnf4a	hepatocyte nuclear factor 4, alpha	0.014
Rtn4	reticulon 4	0.014
Acyp2	acylphosphatase 2, muscle type	0.014
Cpt2	carnitine palmitoyltransferase 2	0.014
Dph1	DPH1 homolog (S. cerevisiae)	0.014
Tsta3	tissue specific transplantation antigen P35B	0.014
Tkt	transketolase	0.014
Isoc2b	isochorismatase domain containing 2b	0.014
Khk	ketohexokinase	0.014
Cyp4f6	cytochrome P450, family 4, subfamily f, polypeptide 6	0.014
Ftcd	formiminotransferase cyclodeaminase	0.014
A1cf	APOBEC1 complementation factor	0.014
Acsl1	acyl-CoA synthetase long-chain family member 1	0.014
Slc25a42	solute carrier family 25, member 42	0.014
Dcaf11	DDB1 and CUL4 associated factor 11	0.013
S100a1	S100 calcium binding protein A1	0.013
Fah	fumarylacetoacetate hydrolase	0.013
Ube2b	ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)	0.013
Wdr77	WD repeat domain 77	0.013
Pnpo	pyridoxine 5'-phosphate oxidase	0.013
Slc19a1	solute carrier family 19 (folate transporter), member 1	0.013
Akr7a3	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)	0.013
Coq10b	coenzyme Q10 homolog B (S. cerevisiae)	0.013
Mecr	mitochondrial trans-2-enoyl-CoA reductase	0.013
Qprt	quinolinate phosphoribosyltransferase	0.013
Ciao1	cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)	0.013
Yars2	tyrosyl-tRNA synthetase 2 (mitochondrial)	0.013
Adam5	a disintegrin and metallopeptidase domain 5	0.013
Bpgm	2,3-bisphosphoglycerate mutase	0.013
Sfrs6	splicing factor, arginine/serine-rich 6	0.013
Josd2	Josephin domain containing 2	0.013
Hmgcs1	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	0.013
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.013
Slc2a5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	0.012
Ube2d2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.012
Chrnd	cholinergic receptor, nicotinic, delta	0.012
Isoc1	isochorismatase domain containing 1	0.012
Tm7sf2	transmembrane 7 superfamily member 2	0.012
Pex12	peroxisomal biogenesis factor 12	0.012
Mocs2	molybdenum cofactor synthesis 2	0.012
Mbl2	mannose-binding lectin (protein C) 2	0.012
Gdi1	GDP dissociation inhibitor 1	0.012
Opa1	optic atrophy 1 homolog (human)	0.012
Dusp19	dual specificity phosphatase 19	0.012
Mmaa	methylmalonic aciduria (cobalamin deficiency) cblA type	0.012
Lyplal1	lysophospholipase-like 1	0.012
Polr3h	polymerase (RNA) III (DNA directed) polypeptide H	0.012
Slc17a1	solute carrier family 17 (sodium phosphate), member 1	0.012
RGD1359600	LEA_4 domain containing protein RGD1359600	0.012
Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide	0.012
Ak2	adenylate kinase 2	0.012
Gaa	glucosidase, alpha, acid	0.012
Ptgr1	prostaglandin reductase 1	0.012
Ppox	protoporphyrinogen oxidase	0.012
Car14	carbonic anhydrase 14	0.012
Scrn2	secernin 2	0.012
Aadac	arylacetamide deacetylase (esterase)	0.012
Tmem150a	transmembrane protein 150A	0.012
Asns	asparagine synthetase	0.012
Fancc	Fanconi anemia, complementation group C	0.012
RGD1307279	similar to RIKEN cDNA 2700002I20	0.012
F2	coagulation factor II (thrombin)	0.012
Acsf3	acyl-CoA synthetase family member 3	0.012
S100a16	S100 calcium binding protein A16	0.012
Gss	glutathione synthetase	0.012
Galt	galactose-1-phosphate uridylyltransferase	0.012
Shmt2	serine hydroxymethyltransferase 2 (mitochondrial)	0.012
Mmachc	methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria	0.012
Tmem177	transmembrane protein 177	0.012
Dnase1	deoxyribonuclease I	0.011
RGD1565744	similar to RIKEN cDNA 0610007P22	0.011
Asb8	ankyrin repeat and SOCS box-containing 8	0.011
Sdhaf2	succinate dehydrogenase complex assembly factor 2	0.011
RGD1308147	similar to expressed sequence AW209491	0.011
Ppat	phosphoribosyl pyrophosphate amidotransferase	0.011
Lpgat1	lysophosphatidylglycerol acyltransferase 1	0.011
Klf15	Kruppel-like factor 15	0.011
Afm	afamin	0.011
LOC100361841	kynurenine aminotransferase III-like	0.011
Ercc3	excision repair cross-complementing rodent repair deficiency, complementation group 3	0.011
RGD1308134	similar to RIKEN cDNA 1110020A23	0.011
Cryl1	crystallin, lambda 1	0.011
RGD1306000	similar to CG8043-PA	0.011
Pbld	phenazine biosynthesis-like protein domain containing	0.011
Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	0.011
Adhfe1	alcohol dehydrogenase, iron containing, 1	0.011
Trpt1	tRNA phosphotransferase 1	0.011
Slc45a3	solute carrier family 45, member 3	0.011
LOC688297	similar to Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase gamma-subunit (GMP-PDE gamma)	0.011
Mri1	methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)	0.011
Ifi35	interferon-induced protein 35	0.011
Zadh2	zinc binding alcohol dehydrogenase, domain containing 2	0.011
Gjb2	gap junction protein, beta 2	0.011
Prmt3	protein arginine methyltransferase 3	0.011
Cfl2	cofilin 2, muscle	0.011
Acot1	acyl-CoA thioesterase 1	0.011
Cisd3	CDGSH iron sulfur domain 3	0.011
Setd6	SET domain containing 6	0.011
Mfsd3	major facilitator superfamily domain containing 3	0.011
Ipp	intracisternal A particle-promoted polypeptide	0.011
Vegfb	vascular endothelial growth factor B	0.011
Ndrg2	N-myc downstream regulated gene 2	0.011
Nqo1	NAD(P)H dehydrogenase, quinone 1	0.011
Ghr	growth hormone receptor	0.011
Ppp2r2a	protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform	0.011
Gsta4	glutathione S-transferase alpha 4	0.011
Wdr24	WD repeat domain 24	0.011
Lrpprc	leucine-rich PPR-motif containing	0.011
Sod2	superoxide dismutase 2, mitochondrial	0.011
RGD1563224	similar to 4930438D12Rik protein	0.011
Acn9	ACN9 homolog (S. cerevisiae)	0.011
Cdh23	cadherin 23 (otocadherin)	0.011
Dctpp1	dCTP pyrophosphatase 1	0.011
Cftr	cystic fibrosis transmembrane conductance regulator homolog (human)	0.011
Selenbp1	selenium binding protein 1	0.010
Slc27a1	solute carrier family 27 (fatty acid transporter), member 1	0.010
RGD1303003	homolog of zebrafish ES1	0.010
Nap1l4	nucleosome assembly protein 1-like 4	0.010
B3galt4	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4	0.010
Pth2r	parathyroid hormone 2 receptor	0.010
Aldh18a1	aldehyde dehydrogenase 18 family, member A1	0.010
Mrpl44	mitochondrial ribosomal protein L44	0.010
Prps1	phosphoribosyl pyrophosphate synthetase 1	0.010
Cdc25b	cell division cycle 25 homolog B (S. pombe)	0.010
RGD1308251	similar to RIKEN cDNA 2810405K02	0.010
Nqo2	NAD(P)H dehydrogenase, quinone 2	0.010
Gzmb	granzyme B	0.010
Agxt	alanine-glyoxylate aminotransferase	0.010
C1H6orf35	chromosome 1 open reading frame, human C6orf35	0.010
Apoc4	apolipoprotein C-IV	0.010
Alas1	aminolevulinate, delta-, synthase 1	0.010
Sectm1b	secreted and transmembrane 1B	0.010
Prg2	proteoglycan 2, bone marrow	0.010
Hspa9	heat shock protein 9	0.010
Hmgcl	3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase	0.010
Ilvbl	ilvB (bacterial acetolactate synthase)-like	0.010
Tmed1	transmembrane emp24 protein transport domain containing 1	0.010
Tfec	transcription factor EC	0.010