IMP: Integrative Multi-species Prediction

Rattus norvegicus

4 genes annotated in rat

regulation of systemic arterial blood pressure by circulatory renin angiotensin

GO:0001991

The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of systemic arterial blood pressure by circulatory renin angiotensin"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "regulation of systemic arterial blood pressure by circulatory renin angiotensin" (in gray)

Name	Description	Probability	Func Analog Organism
Cma1	chymase 1, mast cell	0.240
Grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.100
Psap	prosaposin	0.062
Olr287	olfactory receptor 287	0.060
Nucb1	nucleobindin 1	0.059
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.057
Crhbp	corticotropin releasing hormone binding protein	0.055
Hoxa2	homeo box A2	0.053
Pth	parathyroid hormone	0.045
Dnase1l3	deoxyribonuclease 1-like 3	0.044
Ctsb	cathepsin B	0.043
Pmfbp1	polyamine modulated factor 1 binding protein 1	0.042
Foxe3	forkhead box E3	0.038
Mcpt1	mast cell protease 1	0.037
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.036
Cga	glycoprotein hormones, alpha polypeptide	0.036
Col10a1	collagen, type X, alpha 1	0.035
Zp1	zona pellucida glycoprotein 1 (sperm receptor)	0.035
Cyp21a1	cytochrome P450, family 21, subfamily a, polypeptide 1	0.034
Olr1500	olfactory receptor 1500	0.033
Fgf2	fibroblast growth factor 2	0.032
Plau	plasminogen activator, urokinase	0.031
Tpsab1	tryptase alpha/beta 1	0.030
Ucp1	uncoupling protein 1 (mitochondrial, proton carrier)	0.030
Prp15	proline-rich protein 15	0.029
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.029
Sstr1	somatostatin receptor 1	0.029
Kcnmb1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	0.029
Slc9a4	solute carrier family 9 (sodium/hydrogen exchanger), member 4	0.029
Htr2b	5-hydroxytryptamine (serotonin) receptor 2B	0.028	Rat
Slc34a1	solute carrier family 34 (sodium phosphate), member 1	0.028
Il1rn	interleukin 1 receptor antagonist	0.028
Hrh1	histamine receptor H 1	0.028
Chrna6	cholinergic receptor, nicotinic, alpha 6	0.027
Cyp4f4	cytochrome P450, family 4, subfamily f, polypeptide 4	0.027
Testin	testin gene	0.027
RGD1564327	similar to integrin alpha 8	0.026
Ltb4r2	leukotriene B4 receptor 2	0.026
Pdc	phosducin	0.026
Kitlg	KIT ligand	0.026
Ar	androgen receptor	0.025
Grm6	glutamate receptor, metabotropic 6	0.025
Ier5	immediate early response 5	0.025
Kcna3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.025
Akr1c18	aldo-keto reductase family 1, member C18	0.025
Syt8	synaptotagmin VIII	0.024
Dusp4	dual specificity phosphatase 4	0.024
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.024
Dock8	dedicator of cytokinesis 8	0.023
Cntn5	contactin 5	0.023
Il8ra	interleukin 8 receptor, alpha	0.023
C1qtnf6	C1q and tumor necrosis factor related protein 6	0.023
Cckar	cholecystokinin A receptor	0.023
Sod3	superoxide dismutase 3, extracellular	0.022
LOC60591	calcium-activated potassium channel beta subunit	0.022
Igfbp3	insulin-like growth factor binding protein 3	0.022
Cckbr	cholecystokinin B receptor	0.022
Edn2	endothelin 2	0.022
Atp6v1h	ATPase, H+ transporting, lysosomal V1 subunit H	0.022
Egr3	early growth response 3	0.022
Acox2	acyl-Coenzyme A oxidase 2, branched chain	0.022
Lmbrd1	LMBR1 domain containing 1	0.021
Hnmt	histamine N-methyltransferase	0.021
Gabrr1	gamma-aminobutyric acid (GABA) receptor, rho 1	0.021
Gja3	gap junction protein, alpha 3	0.021
Sycn	syncollin	0.021
Chrna7	cholinergic receptor, nicotinic, alpha 7	0.021
Tpsb2	tryptase beta 2	0.020
Klk8	kallikrein related-peptidase 8	0.020
Trhr2	thyrotropin releasing hormone receptor 2	0.020
Insrr	insulin receptor-related receptor	0.020
Cyp2b12	cytochrome P450, family 2, subfamily b, polypeptide 12	0.020
Ghrhr	growth hormone releasing hormone receptor	0.020
Olr416	olfactory receptor 416	0.020
Sstr5	somatostatin receptor 5	0.020
Epha8	Eph receptor A8	0.020
Fgf14	fibroblast growth factor 14	0.020
Kmo	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.020
Aqp2	aquaporin 2 (collecting duct)	0.020
Kcna6	potassium voltage gated channel, shaker related subfamily, member 6	0.019
Sult5a1	sulfotransferase family 5A, member 1	0.019
Rph3a	rabphilin 3A	0.019
Phkg1	phosphorylase kinase, gamma 1	0.019
Cmklr1	chemokine-like receptor 1	0.019
Atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	0.019
Tinagl1	tubulointerstitial nephritis antigen-like 1	0.019
RGD1562234	similar to S100 calcium-binding protein, ventral prostate	0.018
Olr1078	olfactory receptor 1078	0.018
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.018
P2ry14	purinergic receptor P2Y, G-protein coupled, 14	0.018
LOC286992	peptide HP (rs14)	0.018
Cpa3	carboxypeptidase A3, mast cell	0.018	Mouse
Akap4	A kinase (PRKA) anchor protein 4	0.018
Srpx	sushi-repeat-containing protein, X-linked	0.018
Chrna1	cholinergic receptor, nicotinic, alpha 1 (muscle)	0.018
Sgp158	proline-rich glycoprotein (sgp158)	0.018
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	0.018
Gfi1	growth factor independent 1 transcription repressor	0.018
Gck	glucokinase	0.017
Flnb	filamin, beta	0.017
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.017
Odf4	outer dense fiber of sperm tails 4	0.017
Agtr1a	angiotensin II receptor, type 1a	0.017	Mouse Rat
Avpr2	arginine vasopressin receptor 2	0.017
Pou3f2	POU class 3 homeobox 2	0.017
Adra1a	adrenergic, alpha-1A-, receptor	0.017
Ugt2b	UDP glycosyltransferase 2 family, polypeptide B	0.017
Ngf	nerve growth factor (beta polypeptide)	0.016
Glycam1	glycosylation dependent cell adhesion molecule 1	0.016
Cxcr5	chemokine (C-X-C motif) receptor 5	0.016
Ccr2	chemokine (C-C motif) receptor 2	0.016
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.016
Strn	striatin, calmodulin binding protein	0.016
Synpo	synaptopodin	0.016
Plcd4	phospholipase C, delta 4	0.016
Pnlip	pancreatic lipase	0.016
Cd79b	Cd79b molecule, immunoglobulin-associated beta	0.016
Gjb5	gap junction protein, beta 5	0.016
Kcnab1	potassium voltage-gated channel, shaker-related subfamily, beta member 1	0.016
Npr3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	0.016
Myog	myogenin	0.016
Tusc5	tumor suppressor candidate 5	0.016
Tnp2	transition protein 2	0.016
Prss21	protease, serine, 21	0.016
Kcnab2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	0.016
Chrm1	cholinergic receptor, muscarinic 1	0.016
Foxi2	forkhead box I2	0.016
Svs1	seminal vesicle secretory protein 1	0.016
Thrsp	thyroid hormone responsive	0.016
Cmtm2a	CKLF-like MARVEL transmembrane domain containing 2A	0.016
Tlr4	toll-like receptor 4	0.015
Svs3a	seminal vesicle secretory protein 3A	0.015
Vom2r44	vomeronasal 2 receptor 44	0.015
Cpb1	carboxypeptidase B1 (tissue)	0.015
Gabrp	gamma-aminobutyric acid (GABA-A) receptor, pi	0.015
Syt10	synaptotagmin X	0.015
Clec11a	C-type lectin domain family 11, member a	0.015
LOC24906	RoBo-1	0.015
Pgc	progastricsin (pepsinogen C)	0.015	Rat
Ptger3	prostaglandin E receptor 3 (subtype EP3)	0.015
Il17re	interleukin 17 receptor E	0.015
Olr1654	olfactory receptor 1654	0.015
Gjd2	gap junction protein, delta 2	0.015
Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	0.015
Taf13	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.015
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.015
Olr1496	olfactory receptor 1496	0.015
Fxyd3	FXYD domain-containing ion transport regulator 3	0.015
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.015
Slc4a2	solute carrier family 4 (anion exchanger), member 2	0.014
Oprd1	opioid receptor, delta 1	0.014
Cercam	cerebral endothelial cell adhesion molecule	0.014
Trpm1	transient receptor potential cation channel, subfamily M, member 1	0.014
Prok2	prokineticin 2	0.014
Sftpa1	surfactant protein A1	0.014
Slc22a2	solute carrier family 22 (organic cation transporter), member 2	0.014
Twist2	twist homolog 2 (Drosophila)	0.014
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.014
Cd5	Cd5 molecule	0.014
Prg2	proteoglycan 2, bone marrow	0.014
Mmp9	matrix metallopeptidase 9	0.014
Olr1278	olfactory receptor 1278	0.014
Tcrb	T-cell receptor beta chain	0.014
Pbsn	probasin	0.014
Prl4a1	prolactin family 4, subfamily a, member 1	0.014
Cmpk1	cytidine monophosphate (UMP-CMP) kinase 1	0.014
Fcer2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.014
Gria1	glutamate receptor, ionotropic, AMPA 1	0.014
Nrg1	neuregulin 1	0.014
Ccl4	chemokine (C-C motif) ligand 4	0.014
Cubn	cubilin (intrinsic factor-cobalamin receptor)	0.014
Il7	interleukin 7	0.014
LOC246267	resection-induced TPI (rs11)	0.014
Scnn1b	sodium channel, nonvoltage-gated 1, beta	0.014
Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	0.014	Rat
Mc5r	melanocortin 5 receptor	0.014
Opn1mw	opsin 1 (cone pigments), medium-wave-sensitive	0.014
Sfrp4	secreted frizzled-related protein 4	0.014
Gpihbp1	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	0.014
Lrg1	leucine-rich alpha-2-glycoprotein 1	0.013
Amh	anti-Mullerian hormone	0.013
Kcnk13	potassium channel, subfamily K, member 13	0.013
Abp10	annexin V-binding protein ABP-10	0.013
Rab38	RAB38, member RAS oncogene family	0.013
Icos	inducible T-cell co-stimulator	0.013
Nrp2	neuropilin 2	0.013
Upk3bl	uroplakin 3B-like	0.013
Acsm5	acyl-CoA synthetase medium-chain family member 5	0.013
Gad2	glutamate decarboxylase 2	0.013
Atp4b	ATPase, H+/K+ exchanging, beta polypeptide	0.013
Ddn	dendrin	0.013
Kcnk4	potassium channel, subfamily K, member 4	0.013
C1qtnf1	C1q and tumor necrosis factor related protein 1	0.013
Abl1	c-abl oncogene 1, receptor tyrosine kinase	0.013
Mdga1	MAM domain containing glycosylphosphatidylinositol anchor 1	0.013
Rbp7	retinol binding protein 7, cellular	0.013
Grin2b	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.013
Drd1a	dopamine receptor D1A	0.013
Eif1a	eukaryotic translation initiation factor 1A	0.013
Bsg	basigin	0.013
Krt5	keratin 5	0.013
Tmem30a	transmembrane protein 30A	0.013
Fcer1a	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	0.013
Mrgprx3	MAS-related GPR, member X3	0.013
Sprr1al	small proline-rich protein 1A-like	0.013
Kcnk15	potassium channel, subfamily K, member 15	0.013
Alb	albumin	0.013
Itgam	integrin, alpha M	0.013
Pparg	peroxisome proliferator-activated receptor gamma	0.013
Ccbp2	chemokine binding protein 2	0.013
Il13ra2	interleukin 13 receptor, alpha 2	0.013
Pthlh	parathyroid hormone-like hormone	0.013
Il10	interleukin 10	0.013
Gna15	guanine nucleotide binding protein, alpha 15	0.013
Il1r1	interleukin 1 receptor, type I	0.012
Pigz	phosphatidylinositol glycan anchor biosynthesis, class Z	0.012
Il12b	interleukin 12B	0.012
Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	0.012
Lim2	lens intrinsic membrane protein 2	0.012
Plbd2	phospholipase B domain containing 2	0.012
Npy1r	neuropeptide Y receptor Y1	0.012
Kcnj8	potassium inwardly-rectifying channel, subfamily J, member 8	0.012
Adam3a	ADAM metallopeptidase domain 3A (cyritestin 1)	0.012
Atp6v0c	ATPase, H+ transporting, lysosomal V0 subunit C	0.012
Pla1a	phospholipase A1 member A	0.012
Znf503	zinc finger protein 503	0.012
Orai1	ORAI calcium release-activated calcium modulator 1	0.012
Chrm5	cholinergic receptor, muscarinic 5	0.012
Akr1c14	aldo-keto reductase family 1, member C14	0.012
Dpep1	dipeptidase 1 (renal)	0.012
Mobp	myelin-associated oligodendrocyte basic protein	0.012
Kcnh7	potassium voltage-gated channel, subfamily H (eag-related), member 7	0.012
Nmu	neuromedin U	0.012
Cartpt	CART prepropeptide	0.012
Btc	betacellulin	0.012
Mchr1	melanin-concentrating hormone receptor 1	0.012
Otp	orthopedia homeobox	0.012
Drd5	dopamine receptor D5	0.012
Gcg	glucagon	0.012
Folh1	folate hydrolase 1	0.012
Upk1b	uroplakin 1B	0.012
Slc2a13	solute carrier family 2 (facilitated glucose transporter), member 13	0.012
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.012
Lif	leukemia inhibitory factor	0.012
Rgs9	regulator of G-protein signaling 9	0.012
Tekt5	tektin 5	0.012
Npw	neuropeptide W	0.012
Obp3	alpha-2u globulin PGCL4	0.012
Iapp	islet amyloid polypeptide	0.012
Insl3	insulin-like 3	0.012
Adarb2	adenosine deaminase, RNA-specific, B2	0.012
Ptch1	patched homolog 1 (Drosophila)	0.012
Vegp2	von Ebners gland protein 2	0.012
Ptgfr	prostaglandin F receptor	0.012
Grik3	glutamate receptor, ionotropic, kainate 3	0.012
Asah1	N-acylsphingosine amidohydrolase (acid ceramidase) 1	0.012
Ahsg	alpha-2-HS-glycoprotein	0.012
Avp	arginine vasopressin	0.012
Fut9	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	0.012
Atxn1	ataxin 1	0.012
Scgb1c1	secretoglobin, family 1C, member 1	0.011
Sert1	Sertoli cell protein 1	0.011
Fgf5	fibroblast growth factor 5	0.011
Pnmt	phenylethanolamine-N-methyltransferase	0.011
Ppp2r2c	protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform	0.011
Por	P450 (cytochrome) oxidoreductase	0.011
Sell	selectin L	0.011
Man2b1	mannosidase, alpha, class 2B, member 1	0.011
Nhlh1	nescient helix loop helix 1	0.011
Itih3	inter-alpha trypsin inhibitor, heavy chain 3	0.011
Tmem163	transmembrane protein 163	0.011
Tnp1	transition protein 1	0.011
Tff1	trefoil factor 1	0.011
LOC286987	hemiferrin, transferrin-like protein	0.011
Necab1	N-terminal EF-hand calcium binding protein 1	0.011
Gapdh	glyceraldehyde-3-phosphate dehydrogenase	0.011
Ivl	involucrin	0.011
Musk	muscle, skeletal, receptor tyrosine kinase	0.011
Col18a1	collagen, type XVIII, alpha 1	0.011
Vcsa1	variable coding sequence A1	0.011
Cd244	Cd244 molecule, natural killer cell receptor 2B4	0.011
Gpr116	G protein-coupled receptor 116	0.011
Edn1	endothelin 1	0.011
Clrn3	clarin 3	0.011
Aqp9	aquaporin 9	0.011
Cybb	cytochrome b-245, beta polypeptide	0.011
Car3	carbonic anhydrase 3	0.011
Adora1	adenosine A1 receptor	0.011
Htr6	5-hydroxytryptamine (serotonin) receptor 6	0.011
Ftl	ferritin, light polypeptide	0.011
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.011
Adam2	ADAM metallopeptidase domain 2	0.011
Galnt5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	0.011
Csad	cysteine sulfinic acid decarboxylase	0.011
Sult1d1	sulfotransferase family 1D, member 1	0.011
Ccl11	chemokine (C-C motif) ligand 11	0.011
Adrb2	adrenergic, beta-2-, receptor, surface	0.011	Rat
S100b	S100 calcium binding protein B	0.011
Gpr88	G-protein coupled receptor 88	0.011
Trh	thyrotropin releasing hormone	0.011
Adrb3	adrenergic, beta-3-, receptor	0.011	Rat
RT1-Cl	RT1 class Ib, locus Cl	0.011
Nmbr	neuromedin B receptor	0.011
C5ar1	complement component 5a receptor 1	0.011
Olr1523	olfactory receptor 1523	0.011
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.011
Fgf8	fibroblast growth factor 8	0.011
Capn5	calpain 5	0.011
Mep1b	meprin 1 beta	0.011
Cdh6	cadherin 6	0.011
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.011
Omd	osteomodulin	0.011
Lalba	lactalbumin, alpha	0.011
Shc2	SHC (Src homology 2 domain containing) transforming protein 2	0.011
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.011
Acp5	acid phosphatase 5, tartrate resistant	0.011
Gper	G protein-coupled estrogen receptor 1	0.011
Adora3	adenosine A3 receptor	0.010
RGD1564664	similar to LOC387763 protein	0.010
Prrx1	paired related homeobox 1	0.010
Adam7	ADAM metallopeptidase domain 7	0.010
Ifna1	interferon-alpha 1	0.010
Slco2b1	solute carrier organic anion transporter family, member 2b1	0.010
Gata6	GATA binding protein 6	0.010
Aspa	aspartoacylase	0.010
Fcgrt	Fc fragment of IgG, receptor, transporter, alpha	0.010
Cltc	clathrin, heavy chain (Hc)	0.010
Slc7a3	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	0.010
Trpc4	transient receptor potential cation channel, subfamily C, member 4	0.010
Wt1	Wilms tumor 1	0.010
Sry	sex determining region Y	0.010
RT1-DMa	RT1 class II, locus DMa	0.010
Shbg	sex hormone binding globulin	0.010
Dmrt1	doublesex and mab-3 related transcription factor 1	0.010
Agxt	alanine-glyoxylate aminotransferase	0.010
Aoc3	amine oxidase, copper containing 3 (vascular adhesion protein 1)	0.010
Tspan1	tetraspanin 1	0.010
Vip	vasoactive intestinal peptide	0.010
Grik1	glutamate receptor, ionotropic, kainate 1	0.010
Cntn2	contactin 2 (axonal)	0.010
Figf	c-fos induced growth factor	0.010
Acvr1c	activin A receptor, type IC	0.010
P2rx3	purinergic receptor P2X, ligand-gated ion channel, 3	0.010
LOC100361864	UDP-glucuronosyltransferase 2B3-like	0.010
Hnf4a	hepatocyte nuclear factor 4, alpha	0.010
Clca1	chloride channel accessory 1	0.010
LOC100363662	6-phosphogluconate dehydrogenase, decarboxylating-like	0.010
Prkcg	protein kinase C, gamma	0.010
Arl11	ADP-ribosylation factor-like 11	0.010
Zfp36	zinc finger protein 36	0.010
Cdkn2b	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.010
Sftpc	surfactant protein C	0.010
Olr1082	olfactory receptor 1082	0.010
Pkp1	plakophilin 1	0.010
Arhgap23	Rho GTPase activating protein 23	0.010
Pyy	peptide YY (mapped)	0.010
Lilrb3l	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like	0.010
Selp	selectin P	0.010