IMP: Integrative Multi-species Prediction

Rattus norvegicus

28 genes annotated in rat

response to lithium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to lithium ion"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "response to lithium ion" (in gray)

Name	Description	Probability	Func Analog Organism
Ephx1	epoxide hydrolase 1, microsomal	0.559
Gstm1	glutathione S-transferase mu 1	0.418
Gsta3	glutathione S-transferase A3	0.302	Rat
Actb	actin, beta	0.275	Rat
Grip1	glutamate receptor interacting protein 1	0.111
Mgst1	microsomal glutathione S-transferase 1	0.102
Aldoa	aldolase A, fructose-bisphosphate	0.079
Cfl1	cofilin 1, non-muscle	0.071
Actg1	actin, gamma 1	0.062	Rat
Selenbp1	selenium binding protein 1	0.054
Tuba1c	tubulin, alpha 1C	0.051
Gstp1	glutathione S-transferase pi 1	0.038	Rat
Gria2	glutamate receptor, ionotropic, AMPA 2	0.035
Sult1a1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	0.035
Il3	interleukin 3	0.031
Acaa1b	acetyl-Coenzyme A acyltransferase 1B	0.030
Tmsb4x	thymosin beta 4, X-linked	0.030
Grin2a	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.029
Epor	erythropoietin receptor	0.028
Ckb	creatine kinase, brain	0.027
Atp6v0c	ATPase, H+ transporting, lysosomal V0 subunit C	0.027
Agtr2	angiotensin II receptor, type 2	0.025
Tagln	transgelin	0.025
Cfd	complement factor D (adipsin)	0.025
Pfn1	profilin 1	0.022
Htr5b	5-hydroxytryptamine (serotonin) receptor 5B	0.022
Cnn1	calponin 1, basic, smooth muscle	0.021
Haao	3-hydroxyanthranilate 3,4-dioxygenase	0.021
Si	sucrase-isomaltase (alpha-glucosidase)	0.021
Gapdh	glyceraldehyde-3-phosphate dehydrogenase	0.021
Tacr3	tachykinin receptor 3	0.021
Eln	elastin	0.021
Tpm1	tropomyosin 1, alpha	0.021
Klf2	Kruppel-like factor 2 (lung)	0.020
Mc4r	melanocortin 4 receptor	0.018
Dchs1	dachsous 1 (Drosophila)	0.018
Gstt1	glutathione S-transferase theta 1	0.018
Gabbr1	gamma-aminobutyric acid (GABA) B receptor 1	0.017
Aldh2	aldehyde dehydrogenase 2 family (mitochondrial)	0.017
Gstm2	glutathione S-transferase mu 2	0.017	Rat
Rhox5	reproductive homeobox 5	0.017
Olr287	olfactory receptor 287	0.017
Pitx3	paired-like homeodomain 3	0.017
Kcnd3	potassium voltage-gated channel, Shal-related subfamily, member 3	0.017
Nlgn2	neuroligin 2	0.017
Col10a1	collagen, type X, alpha 1	0.016
Prpg1	proline-rich proteoglycan 1	0.016
Gstm5	glutathione S-transferase, mu 5	0.016	Rat
Des	desmin	0.016
Krt5	keratin 5	0.016
Nqo1	NAD(P)H dehydrogenase, quinone 1	0.016
Cyp4a10	cytochrome P450, family 4, subfamily a, polypeptide 10	0.015
Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11	0.015
Sprr1al	small proline-rich protein 1A-like	0.015
Adh1	alcohol dehydrogenase 1 (class I)	0.015
Gria3	glutamate receptor, ionotrophic, AMPA 3	0.015
Acta2	smooth muscle alpha-actin	0.015
Foxi2	forkhead box I2	0.015
RGD1305347	similar to RIKEN cDNA 2610528J11	0.015
Gria4	glutamate receptor, ionotrophic, AMPA 4	0.015	Rat
Pick1	protein interacting with PRKCA 1	0.015
Cpb1	carboxypeptidase B1 (tissue)	0.015
Eno1	enolase 1, (alpha)	0.015
Ucp1	uncoupling protein 1 (mitochondrial, proton carrier)	0.014
Pou3f1	POU class 3 homeobox 1	0.014
Htr4	5-hydroxytryptamine (serotonin) receptor 4	0.014
Ms4a8a	membrane-spanning 4-domains, subfamily A, member 8A	0.014
Gsta4	glutathione S-transferase alpha 4	0.014
Tnnt2	troponin T type 2 (cardiac)	0.014
Trhr	thyrotropin releasing hormone receptor	0.014
Ttn	titin	0.014
Vegp2	von Ebners gland protein 2	0.014
Barhl2	BarH-like homeobox 2	0.014
Mgst2	microsomal glutathione S-transferase 2	0.014
Orm1	orosomucoid 1	0.014
Nr4a3	nuclear receptor subfamily 4, group A, member 3	0.014
Hist1h2aa	histone cluster 1, H2aa	0.013
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.013
Akr7a3	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)	0.013
Ppyr1	pancreatic polypeptide receptor 1	0.013
Pecr	peroxisomal trans-2-enoyl-CoA reductase	0.012
Pyy	peptide YY (mapped)	0.012
Fgf18	fibroblast growth factor 18	0.012
Mettl7b	methyltransferase like 7B	0.012
Atp6v0a1	ATPase, H+ transporting, lysosomal V0 subunit A1	0.012
Prdx6	peroxiredoxin 6	0.012
Prok2	prokineticin 2	0.012
Gnmt	glycine N-methyltransferase	0.012
RT1-DOa	RT1 class II, locus DOa	0.012
Ap3m1	adaptor-related protein complex 3, mu 1 subunit	0.012
Tcp11	t-complex protein 11	0.012
Tfpi	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	0.012
Grin2d	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	0.012
Lipe	lipase, hormone sensitive	0.012
Alx1	ALX homeobox 1	0.012
Cnr1	cannabinoid receptor 1 (brain)	0.012
Sema6b	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	0.012
Serpina4	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	0.012
Cd40lg	CD40 ligand	0.011
Cidea	cell death-inducing DFFA-like effector a	0.011
Gzmf	granzyme F	0.011
Sstr1	somatostatin receptor 1	0.011
Gdf10	growth differentiation factor 10	0.011
Cyp1a1	cytochrome P450, family 1, subfamily a, polypeptide 1	0.011
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.011
Add2	adducin 2 (beta)	0.011
Klhl17	kelch-like 17 (Drosophila)	0.011
Cyb5r3	cytochrome b5 reductase 3	0.011
Fut1	fucosyltransferase 1	0.011
Lyve1	lymphatic vessel endothelial hyaluronan receptor 1	0.011
Drd1a	dopamine receptor D1A	0.011
Aadat	aminoadipate aminotransferase	0.011
Cd80	Cd80 molecule	0.011
Car2	carbonic anhydrase II	0.011
Tsx	testis specific X-linked gene	0.011
Tst	thiosulfate sulfurtransferase	0.011
Slc6a18	solute carrier family 6, member 18	0.011
Cckar	cholecystokinin A receptor	0.011
Atp4b	ATPase, H+/K+ exchanging, beta polypeptide	0.011
S100a1	S100 calcium binding protein A1	0.011
Pgc	progastricsin (pepsinogen C)	0.011
Ugt8	UDP glycosyltransferase 8	0.011
Acpp	acid phosphatase, prostate	0.011
Ptger4	prostaglandin E receptor 4 (subtype EP4)	0.011
Hdac1l	histone deacetylase 1-like	0.010
Il4	interleukin 4	0.010
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.010
Krt14l	keratin 14-like	0.010
Casq2	calsequestrin 2 (cardiac muscle)	0.010
LOC686539	similar to immunoglobulin superfamily containing leucine-rich repeat	0.010
Gad2	glutamate decarboxylase 2	0.010
Nppc	natriuretic peptide precursor C	0.010
Grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.010
Slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	0.010
Gprc5a	G protein-coupled receptor, family C, group 5, member A	0.010
Prss2	protease, serine, 2	0.010
Clu	clusterin	0.010
Nae1	NEDD8 activating enzyme E1 subunit 1	0.010