IMP: Integrative Multi-species Prediction

Rattus norvegicus

14 genes annotated in rat

modification dependent protein catabolic process

GO:0019941

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "modification dependent protein catabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "modification dependent protein catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Psma3	proteasome (prosome, macropain) subunit, alpha type 3	0.993	Yeast
Psma5	proteasome (prosome, macropain) subunit, alpha type 5	0.974	Yeast
Psma4	proteasome (prosome, macropain) subunit, alpha type 4	0.928	Yeast
Psmb3	proteasome (prosome, macropain) subunit, beta type 3	0.925	Yeast
Psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.725	Human Yeast
Dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.724	Yeast
Psma7	proteasome (prosome, macropain) subunit, alpha type 7	0.604	Yeast
Cnbp	CCHC-type zinc finger, nucleic acid binding protein	0.509
Psme2	proteasome (prosome, macropain) activator subunit 2	0.375
Psmb7	proteasome (prosome, macropain) subunit, beta type 7	0.373	Yeast
Psmb2	proteasome (prosome, macropain) subunit, beta type 2	0.311	Yeast
Psmc1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.308
Psmb6	proteasome (prosome, macropain) subunit, beta type 6	0.222	Yeast
Psma2	proteasome (prosome, macropain) subunit, alpha type 2	0.216	Yeast
Psmd14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.202
Acyp2	acylphosphatase 2, muscle type	0.174
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.171	Yeast
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.166	Yeast
Psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.159
Mapre1	microtubule-associated protein, RP/EB family, member 1	0.156
Dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.145
Ptges3	prostaglandin E synthase 3 (cytosolic)	0.131
Psmc4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.124	Yeast
Zfand5	zinc finger, AN1-type domain 5	0.113
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.107	Yeast
Psmc5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.106	Human Yeast
Ube2d2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.100
Psmd13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.099
Hsp90b1	heat shock protein 90, beta, member 1	0.094	Human
Eef2	eukaryotic translation elongation factor 2	0.087
Ppp1cb	protein phosphatase 1, catalytic subunit, beta isoform	0.086
Pomp	proteasome maturation protein	0.082
Pdia4	protein disulfide isomerase family A, member 4	0.081
Creld2	cysteine-rich with EGF-like domains 2	0.081
Manf	mesencephalic astrocyte-derived neurotrophic factor	0.080
Csnk1d	casein kinase 1, delta	0.077	Mouse Fly
Psmb5	proteasome (prosome, macropain) subunit, beta type 5	0.072	Yeast Mouse
Txnl1	thioredoxin-like 1	0.071
Nsfl1c	NSFL1 (p97) cofactor (p47)	0.070
Psmd1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.064
Psma1	proteasome (prosome, macropain) subunit, alpha type 1	0.063	Yeast
Dnaja1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.060	Yeast
Cdk4	cyclin-dependent kinase 4	0.057
Psmd4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.056
Phax	phosphorylated adaptor for RNA export	0.056
Jtb	jumping translocation breakpoint	0.054
Dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.053
Hspa5	heat shock protein 5	0.053	Yeast
LOC100364212	heterogeneous nuclear ribonucleoprotein K-like	0.051
Cmtm6	CKLF-like MARVEL transmembrane domain containing 6	0.049
LOC100366237	prefoldin subunit 4-like	0.048
Psmd7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.046
Taok1	TAO kinase 1	0.045
Rab5a	RAB5A, member RAS oncogene family	0.042
Dusp11	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	0.041
Pfn1	profilin 1	0.040
Txnrd1	thioredoxin reductase 1	0.039
Clic4	chloride intracellular channel 4	0.038
Ppm1a	protein phosphatase 1A, magnesium dependent, alpha isoform	0.037
Dnajb9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.037	Human Mouse
Ube2b	ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)	0.037
Dnajc5	DnaJ (Hsp40) homolog, subfamily C, member 5	0.036
Foxm1	forkhead box M1	0.034
Kars	lysyl-tRNA synthetase	0.033
Calr	calreticulin	0.033
Tollip	toll interacting protein	0.030
Dctn4	dynactin 4	0.030
Ube2d3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.030
Ppp1r2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.029
Pdia3	protein disulfide isomerase family A, member 3	0.029
Ccnb1	cyclin B1	0.029
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.028	Human Yeast Worm Fly
Spcs2	signal peptidase complex subunit 2 homolog (S. cerevisiae)	0.028
Tiprl	TIP41, TOR signaling pathway regulator-like (S. cerevisiae)	0.027
Ube2g1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.027
Rab11a	RAB11a, member RAS oncogene family	0.026
Sumo1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.026	Human
Golph3	golgi phosphoprotein 3 (coat-protein)	0.026
Serinc1	serine incorporator 1	0.025
Cand1	cullin-associated and neddylation-dissociated 1	0.024
March5	membrane-associated ring finger (C3HC4) 5	0.024
Mgat2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	0.024
Azi2	5-azacytidine induced 2	0.024
Psmd5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	0.023
RGD1309102	similar to TRS85 homolog	0.023
Sec61a1	Sec61 alpha 1 subunit (S. cerevisiae)	0.023
Ube2i	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.023
Ubc	ubiquitin C	0.023
Pex13	peroxisomal biogenesis factor 13	0.023
Rgs19	regulator of G-protein signaling 19	0.023
Psmd3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.021
Hprt1	hypoxanthine phosphoribosyltransferase 1	0.021
Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	0.021
Ifi27l2b	interferon, alpha-inducible protein 27 like 2B	0.020
Zfp364	zinc finger protein 364	0.020	Human
Pdia6	protein disulfide isomerase family A, member 6	0.020
Top2a	topoisomerase (DNA) II alpha	0.019
Psmb1	proteasome (prosome, macropain) subunit, beta type 1	0.019	Yeast
Nploc4	nuclear protein localization 4 homolog (S. cerevisiae)	0.019
Cops5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.019
Hsph1	heat shock 105/110 protein 1	0.018
Usp15	ubiquitin specific peptidase 15	0.018
Higd1a	HIG1 hypoxia inducible domain family, member 1A	0.018
Psmc3	proteasome (prosome, macropain) 26S subunit, ATPase 3	0.018	Yeast
Psma6	proteasome (prosome, macropain) subunit, alpha type 6	0.017	Yeast
Mapk1	mitogen activated protein kinase 1	0.017
Rab21	RAB21, member RAS oncogene family	0.017
Tpm3	tropomyosin 3, gamma	0.016
Usp14	ubiquitin specific peptidase 14	0.016
Il13ra1	interleukin 13 receptor, alpha 1	0.016
Tcea2	transcription elongation factor A (SII), 2	0.016
RGD1303142	oxidative stress responsive gene	0.016
Mtx2	metaxin 2	0.016
Canx	calnexin	0.016
Coro1b	coronin, actin-binding protein, 1B	0.016
Smad4	SMAD family member 4	0.016
Ghitm	growth hormone inducible transmembrane protein	0.015
Slc35b1	solute carrier family 35, member B1	0.015
Kif22	kinesin family member 22	0.015
Tbcb	tubulin folding cofactor B	0.015
Btg1	B-cell translocation gene 1, anti-proliferative	0.015
Herpud1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.015
Gclm	glutamate cysteine ligase, modifier subunit	0.014
Ifi35	interferon-induced protein 35	0.014
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.014
Irf1	interferon regulatory factor 1	0.014
Psme3	proteasome (prosome, macropain) activator subunit 3	0.014
Rnf2	ring finger protein 2	0.014
Rnf4	ring finger protein 4	0.014	Human
Cdca2	cell division cycle associated 2	0.013
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.013
Rabac1	Rab acceptor 1 (prenylated)	0.013
Wdr26	WD repeat domain 26	0.013
Tbpl1	TATA box binding protein-like 1	0.013
Ifrd1	interferon-related developmental regulator 1	0.013
Parp14	poly (ADP-ribose) polymerase family, member 14	0.013
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.013
Hk1	hexokinase 1	0.012
Rnf19a	ring finger protein 19A	0.012
Serp1	stress-associated endoplasmic reticulum protein 1	0.012
Eif4g2	eukaryotic translation initiation factor 4, gamma 2	0.012
Rbbp7	retinoblastoma binding protein 7	0.012
Ehmt2	euchromatic histone lysine N-methyltransferase 2	0.012
Ergic3	ERGIC and golgi 3	0.012
Psmd11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.012
Ufd1l	ubiquitin fusion degradation 1 like (yeast)	0.012
Dnpep	aspartyl aminopeptidase	0.012
Dhx9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.012
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.012
Mdm2	Mdm2 p53 binding protein homolog (mouse)	0.012
Vps37a	vacuolar protein sorting 37 homolog A (S. cerevisiae)	0.012	Human
Tor1aip2	torsin A interacting protein 2	0.012
Ndfip2	Nedd4 family interacting protein 2	0.011
Pctk2	PCTAIRE protein kinase 2	0.011
Pdp1	pyruvate dehyrogenase phosphatase catalytic subunit 1	0.011
Pdcd6	programmed cell death 6	0.011
Psmb4	proteasome (prosome, macropain) subunit, beta type 4	0.011	Yeast
Mrpl22	mitochondrial ribosomal protein L22	0.011
Tspyl1	TSPY-like 1	0.011
Arih2	ariadne homolog 2 (Drosophila)	0.011	Human Mouse
Myo1b	myosin Ib	0.011
Camk2b	calcium/calmodulin-dependent protein kinase II beta	0.011
Rab10	RAB10, member RAS oncogene family	0.011
Spc25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.011
Rbm18	RNA binding motif protein 18	0.011
LOC362855	P55	0.011
Prdx5	peroxiredoxin 5	0.010
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.010
Rac1	ras-related C3 botulinum toxin substrate 1	0.010
Cugbp1	CUG triplet repeat, RNA binding protein 1	0.010
Ell2	elongation factor RNA polymerase II 2	0.010
Rpl36	ribosomal protein L36	0.010
Rpn2	ribophorin II	0.010
Kif2c	kinesin family member 2C	0.010
Arpc1b	actin related protein 2/3 complex, subunit 1B	0.010
Traf4af1	TRAF4 associated factor 1	0.010