IMP
Process View
intrinsic apoptotic signaling pathway in response to dna damage
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "intrinsic apoptotic signaling pathway in response to dna damage"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| RT1-Db1 | RT1 class II, locus Db1 | 0.277 | ||
| RT1-Ba | RT1 class II, locus Ba | 0.179 | ||
| Timp1 | TIMP metallopeptidase inhibitor 1 | 0.099 | ||
| Plaur | plasminogen activator, urokinase receptor | 0.058 | ||
| PVR | poliovirus receptor | 0.058 | ||
| RT1-DMa | RT1 class II, locus DMa | 0.053 | ||
| Icam1 | intercellular adhesion molecule 1 | 0.045 | ||
| Ier3 | immediate early response 3 | 0.045 | ||
| Lgals3 | lectin, galactoside-binding, soluble, 3 | 0.044 | ||
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.041 | ||
| Txnrd1 | thioredoxin reductase 1 | 0.041 | ||
| RT1-DMb | RT1 class II, locus DMb | 0.039 | ||
| Ripk3 | receptor-interacting serine-threonine kinase 3 | 0.036 | ||
| RT1-Da | RT1 class II, locus Da | 0.035 | ||
| Cebpd | CCAAT/enhancer binding protein (C/EBP), delta | 0.035 | ||
| Ptbp1 | polypyrimidine tract binding protein 1 | 0.033 | ||
| Hmox1 | heme oxygenase (decycling) 1 | 0.032 | ||
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.030 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.029 | ||
| Anxa2 | annexin A2 | 0.028 | ||
| Cdc42bpb | CDC42 binding protein kinase beta (DMPK-like) | 0.028 | ||
| Atf3 | activating transcription factor 3 | 0.027 | ||
| Myc | myelocytomatosis oncogene | 0.027 | Mouse | |
| Litaf | lipopolysaccharide-induced TNF factor | 0.027 | ||
| Socs3 | suppressor of cytokine signaling 3 | 0.026 | ||
| S100a11 | S100 calcium binding protein A11 (calizzarin) | 0.025 | ||
| Tp53 | tumor protein p53 | 0.024 | Human | |
| Ifitm3 | interferon induced transmembrane protein 3 | 0.024 | ||
| Tnfrsf12a | tumor necrosis factor receptor superfamily, member 12a | 0.023 | ||
| Srxn1 | sulfiredoxin 1 homolog (S. cerevisiae) | 0.023 | ||
| Por | P450 (cytochrome) oxidoreductase | 0.023 | ||
| Pcolce | procollagen C-endopeptidase enhancer | 0.022 | ||
| Cxcl1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.022 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.021 | Mouse | |
| Klf4 | Kruppel-like factor 4 (gut) | 0.021 | ||
| Errfi1 | ERBB receptor feedback inhibitor 1 | 0.021 | ||
| Klhl24 | kelch-like 24 (Drosophila) | 0.021 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A | 0.021 | ||
| Gadd45a | growth arrest and DNA-damage-inducible, alpha | 0.021 | ||
| Pdp1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | 0.020 | ||
| Il6 | interleukin 6 | 0.020 | ||
| Junb | jun B proto-oncogene | 0.019 | ||
| Stxbp3 | syntaxin binding protein 3 | 0.019 | ||
| Nr1d2 | nuclear receptor subfamily 1, group D, member 2 | 0.019 | ||
| Plaa | phospholipase A2, activating protein | 0.019 | ||
| Cnot1 | CCR4-NOT transcription complex, subunit 1 | 0.018 | ||
| Lcn2 | lipocalin 2 | 0.018 | ||
| Vcan | versican | 0.018 | ||
| Zc3h11a | zinc finger CCCH-type containing 11A | 0.018 | ||
| Psme4 | proteasome (prosome, macropain) activator subunit 4 | 0.018 | ||
| Lyn | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.018 | ||
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.018 | ||
| RT1-Bb | RT1 class II, locus Bb | 0.017 | ||
| Serpine1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.017 | ||
| Csde1 | cold shock domain containing E1, RNA binding | 0.017 | ||
| Mt2A | metallothionein 2A | 0.016 | ||
| Ppp1r15a | protein phosphatase 1, regulatory (inhibitor) subunit 15A | 0.016 | ||
| Mobkl2a | MOB1, Mps One Binder kinase activator-like 2A (yeast) | 0.016 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.016 | ||
| Trim47 | tripartite motif-containing 47 | 0.015 | ||
| Pds5b | PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) | 0.015 | ||
| Ucp2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.015 | ||
| Cd14 | CD14 molecule | 0.015 | ||
| Zfp36 | zinc finger protein 36 | 0.015 | ||
| Pelo | pelota homolog (Drosophila) | 0.015 | ||
| Atl2 | atlastin GTPase 2 | 0.015 | ||
| Ngfr | nerve growth factor receptor (TNFR superfamily, member 16) | 0.014 | ||
| Adm | adrenomedullin | 0.014 | ||
| Coro1a | coronin, actin binding protein 1A | 0.014 | ||
| B4galt1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.014 | ||
| Sfrs12 | splicing factor, arginine/serine-rich 12 | 0.014 | ||
| Zfand5 | zinc finger, AN1-type domain 5 | 0.014 | ||
| Nolc1 | nucleolar and coiled-body phosphoprotein 1 | 0.014 | ||
| Phlda1 | pleckstrin homology-like domain, family A, member 1 | 0.014 | ||
| Akr1b8 | aldo-keto reductase family 1, member B8 | 0.014 | ||
| Pdlim1 | PDZ and LIM domain 1 | 0.014 | ||
| RGD1565310 | similar to RIKEN cDNA 1110018J12 | 0.014 | ||
| Spc25 | SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) | 0.014 | ||
| Zyx | zyxin | 0.013 | ||
| Mgp | matrix Gla protein | 0.013 | ||
| Epn1 | Epsin 1 | 0.013 | ||
| Runx1 | runt-related transcription factor 1 | 0.013 | ||
| Mybl2 | myeloblastosis oncogene-like 2 | 0.013 | ||
| Smad1 | SMAD family member 1 | 0.013 | ||
| Plscr3 | phospholipid scramblase 3 | 0.013 | ||
| Homer3 | homer homolog 3 (Drosophila) | 0.013 | ||
| Mt1a | metallothionein 1a | 0.013 | ||
| Tcp11l2 | t-complex 11 (mouse) like 2 | 0.013 | ||
| Dirc2 | disrupted in renal carcinoma 2 (human) | 0.013 | ||
| Ppard | peroxisome proliferator-activated receptor delta | 0.013 | ||
| Klf6 | Kruppel-like factor 6 | 0.013 | ||
| Daxx | death-domain associated protein | 0.013 | ||
| Rhoc | ras homolog gene family, member C | 0.012 | ||
| Ptpn1 | protein tyrosine phosphatase, non-receptor type 1 | 0.012 | ||
| Sf3b4 | splicing factor 3b, subunit 4 | 0.012 | ||
| Arhgap1 | Rho GTPase activating protein 1 | 0.012 | ||
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.012 | ||
| Jun | Jun oncogene | 0.012 | ||
| Stag2 | stromal antigen 2 | 0.012 | ||
| Mdm2 | Mdm2 p53 binding protein homolog (mouse) | 0.012 | ||
| Bak1 | BCL2-antagonist/killer 1 | 0.012 | ||
| Ghdc | GH3 domain containing | 0.012 | ||
| Has2 | hyaluronan synthase 2 | 0.012 | ||
| Nras | neuroblastoma ras oncogene | 0.012 | ||
| Il4ra | interleukin 4 receptor, alpha | 0.012 | ||
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.012 | ||
| Troap | trophinin associated protein | 0.011 | ||
| B4galt2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | 0.011 | ||
| S1pr2 | sphingosine-1-phosphate receptor 2 | 0.011 | ||
| Rara | retinoic acid receptor, alpha | 0.011 | ||
| C4-2 | complement component 4, gene 2 | 0.011 | ||
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.011 | ||
| Utp14a | UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) | 0.011 | ||
| Dnm2 | dynamin 2 | 0.011 | ||
| Rps6ka1 | ribosomal protein S6 kinase polypeptide 1 | 0.011 | ||
| Abhd2 | abhydrolase domain containing 2 | 0.011 | ||
| Clic1 | chloride intracellular channel 1 | 0.011 | ||
| Eif4enif1 | eukaryotic translation initiation factor 4E nuclear import factor 1 | 0.011 | ||
| Mfap4 | microfibrillar-associated protein 4 | 0.011 | ||
| Mcm3 | minichromosome maintenance complex component 3 | 0.011 | ||
| Maff | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | 0.011 | ||
| Mxd1 | max dimerization protein 1 | 0.011 | ||
| Tnks2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.011 | ||
| Mcm2 | minichromosome maintenance complex component 2 | 0.011 | ||
| Alox5ap | arachidonate 5-lipoxygenase activating protein | 0.010 | ||
| LOC690418 | similar to Acidic proline-rich protein PRP25 precursor | 0.010 | ||
| Ppif | peptidylprolyl isomerase F | 0.010 | ||
| Tgif1 | TGFB-induced factor homeobox 1 | 0.010 | ||
| Slc2a1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.010 | ||
| Hbegf | heparin-binding EGF-like growth factor | 0.010 | ||
| Msn | moesin | 0.010 | ||
| Fen1 | flap structure-specific endonuclease 1 | 0.010 | ||
| S100a6 | S100 calcium binding protein A6 | 0.010 | ||
| Bcl2l2 | Bcl2-like 2 | 0.010 | ||
| Heca | headcase homolog (Drosophila) | 0.010 | ||
| Galnt10 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) | 0.010 | ||
| Cenpt | centromere protein T | 0.010 |