IMP: Integrative Multi-species Prediction

Rattus norvegicus

2 genes annotated in rat

activation of jak2 kinase activity

The process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "activation of jak2 kinase activity"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "activation of jak2 kinase activity" (in gray)

Name	Description	Probability	Func Analog Organism
Rara	retinoic acid receptor, alpha	0.135
Pcnxl3	pecanex-like 3 (Drosophila)	0.105
Ireb2	iron responsive element binding protein 2	0.074
Cast	calpastatin	0.074
Agtr1a	angiotensin II receptor, type 1a	0.068
Emp1	epithelial membrane protein 1	0.066
Acacb	acetyl-Coenzyme A carboxylase beta	0.061
Aldh6a1	aldehyde dehydrogenase 6 family, member A1	0.060
Tgfbr2	transforming growth factor, beta receptor II	0.060
Nfia	nuclear factor I/A	0.059
Slc9a1	solute carrier family 9 (sodium/hydrogen exchanger), member 1	0.048
Hpn	hepsin	0.046
Fgfr4	fibroblast growth factor receptor 4	0.043
Acsm5	acyl-CoA synthetase medium-chain family member 5	0.042
Slc20a2	solute carrier family 20 (phosphate transporter), member 2	0.040
Pzp	pregnancy-zone protein	0.039
Notch4	Notch homolog 4 (Drosophila)	0.031
A1cf	APOBEC1 complementation factor	0.029
Cyp2a1	cytochrome P450, family 2, subfamily a, polypeptide 1	0.029
Cbs	cystathionine beta synthase	0.026
Epn1	Epsin 1	0.026
Usf2	upstream transcription factor 2, c-fos interacting	0.026
Sdc3	syndecan 3	0.025
Hao2	hydroxyacid oxidase 2 (long chain)	0.024
Slco2b1	solute carrier organic anion transporter family, member 2b1	0.023
Thra	thyroid hormone receptor alpha	0.023
Stat6	signal transducer and activator of transcription 6	0.022
Efnb1	ephrin B1	0.022
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.022
Thpo	thrombopoietin	0.021
Srebf1	sterol regulatory element binding transcription factor 1	0.021
Fat2	FAT tumor suppressor homolog 2 (Drosophila)	0.021
Stx2	syntaxin 2	0.020
Espn	espin	0.020
Wdr26	WD repeat domain 26	0.020
Gulo	gulonolactone (L-) oxidase	0.020
Hand2	heart and neural crest derivatives expressed 2	0.020
Apoa5	apolipoprotein A-V	0.019
Gja3	gap junction protein, alpha 3	0.019
Masp1	mannan-binding lectin serine peptidase 1	0.019
Nfib	nuclear factor I/B	0.019
Igfals	insulin-like growth factor binding protein, acid labile subunit	0.018
Socs2	suppressor of cytokine signaling 2	0.018
Akr1c14	aldo-keto reductase family 1, member C14	0.018
Tcf3	transcription factor 3	0.018
Syt8	synaptotagmin VIII	0.018
RGD1565591	similar to Ski protein	0.018
Apoc4	apolipoprotein C-IV	0.018
Scn11a	sodium channel, voltage-gated, type XI, alpha	0.017
Sardh	sarcosine dehydrogenase	0.017
Myo10	myosin X	0.017
Slc26a1	solute carrier family 26 (sulfate transporter), member 1	0.017
Pex14	peroxisomal biogenesis factor 14	0.017
Thrsp	thyroid hormone responsive	0.016
Cd44	Cd44 molecule	0.016
Acot12	acyl-CoA thioesterase 12	0.016
Enpep	glutamyl aminopeptidase	0.016
Itpr2	inositol 1,4,5-triphosphate receptor, type 2	0.016
Deaf1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.016
Amn	amnionless homolog (mouse)	0.016
Mylk2	myosin light chain kinase 2	0.016
Nr1i2	nuclear receptor subfamily 1, group I, member 2	0.015
Neu2	sialidase 2 (cytosolic sialidase)	0.015
Jak1	Janus kinase 1	0.015
Csad	cysteine sulfinic acid decarboxylase	0.015
Nr2f6	nuclear receptor subfamily 2, group F, member 6	0.014	Rat
Cald1	caldesmon 1	0.014
Fgf17	fibroblast growth factor 17	0.014
Myo1b	myosin Ib	0.014
Rxra	retinoid X receptor alpha	0.014	Rat
Skiv2l	superkiller viralicidic activity 2-like (S. cerevisiae )	0.014
Adhfe1	alcohol dehydrogenase, iron containing, 1	0.014
Slc22a7	solute carrier family 22 (organic anion transporter), member 7	0.014
Ddc	dopa decarboxylase (aromatic L-amino acid decarboxylase)	0.013
Ldlr	low density lipoprotein receptor	0.013
Nfic	nuclear factor I/C	0.013
Dao	D-amino-acid oxidase	0.013
Cd4	Cd4 molecule	0.013
St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	0.013
Pygm	phosphorylase, glycogen, muscle	0.013
RGD1564865	similar to 20-alpha-hydroxysteroid dehydrogenase	0.013
Cyp2f4	cytochrome P450, family 2, subfamily f, polypeptide 4	0.013
Vegfa	vascular endothelial growth factor A	0.013
Rab1b	RAB1B, member RAS oncogene family	0.013
Ptger3	prostaglandin E receptor 3 (subtype EP3)	0.013
Acot2	acyl-CoA thioesterase 2	0.013
Mosc1	MOCO sulphurase C-terminal domain containing 1	0.012
Nr1i3	nuclear receptor subfamily 1, group I, member 3	0.012
Cyp4f4	cytochrome P450, family 4, subfamily f, polypeptide 4	0.012
Slc6a1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.012
Akt2	v-akt murine thymoma viral oncogene homolog 2	0.012
Hrh2	histamine receptor H 2	0.012
Notch3	Notch homolog 3 (Drosophila)	0.012
Ppap2b	phosphatidic acid phosphatase type 2B	0.012
Sox13	SRY (sex determining region Y)-box 13	0.012
Il1rl2	interleukin 1 receptor-like 2	0.012
Ky	kyphoscoliosis peptidase	0.012
Cyp3a18	cytochrome P450, family 3, subfamily a, polypeptide 18	0.012
Acsl1	acyl-CoA synthetase long-chain family member 1	0.012
Plin	perilipin	0.012
Syt3	synaptotagmin III	0.012
Gpam	glycerol-3-phosphate acyltransferase, mitochondrial	0.012
Hand1	heart and neural crest derivatives expressed 1	0.012
Crp	C-reactive protein, pentraxin-related	0.012
Gga1	golgi associated, gamma adaptin ear containing, ARF binding protein 1	0.011
Lipe	lipase, hormone sensitive	0.011
Chst3	carbohydrate (chondroitin 6) sulfotransferase 3	0.011
Gigyf1	GRB10 interacting GYF protein 1	0.011
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.011
Cort	cortistatin	0.011
Rfc1	replication factor C (activator 1) 1	0.011
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.011
Mgat3	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	0.011
Csnk1g2	casein kinase 1, gamma 2	0.011
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.011
Sdc2	syndecan 2	0.011
Cxcl12	chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)	0.011
Grp	gastrin releasing peptide	0.011
Map3k7ip1	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	0.010
Rnase4	ribonuclease, RNase A family 4	0.010
Znf574	zinc finger protein 574	0.010
Slc25a10	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	0.010
Lrrc7	leucine rich repeat containing 7	0.010
Car3	carbonic anhydrase 3	0.010
Cdkn2b	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.010
Prrt4	proline-rich transmembrane protein 4	0.010
Cish	cytokine inducible SH2-containing protein	0.010
Pde4a	phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)	0.010
Tceb3	transcription elongation factor B (SIII), polypeptide 3	0.010
Ntn1	netrin 1	0.010
Syngr2	synaptogyrin 2	0.010
Extl1	exostoses (multiple)-like 1	0.010
Prlr	prolactin receptor	0.010
Kdr	kinase insert domain receptor	0.010