IMP
Process View
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.958 | ||
| Klra5 | killer cell lectin-like receptor, subfamily A, member 5 | 0.861 | Rat | |
| Gzmk | granzyme K | 0.677 | ||
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.670 | ||
| Il7r | interleukin 7 receptor | 0.377 | ||
| Igsf6 | immunoglobulin superfamily, member 6 | 0.374 | ||
| Gzmb | granzyme B | 0.277 | ||
| Mcpt8 | mast cell protease 8 | 0.241 | ||
| Clec12a | C-type lectin domain family 12, member A | 0.209 | ||
| Vom1r93 | vomeronasal 1 receptor 93 | 0.208 | ||
| Cd2 | Cd2 molecule | 0.203 | ||
| Mmp12 | matrix metallopeptidase 12 | 0.198 | ||
| Sell | selectin L | 0.160 | ||
| Xcl1 | chemokine (C motif) ligand 1 | 0.159 | ||
| Nkg7 | natural killer cell group 7 sequence | 0.159 | ||
| Cd8a | CD8a molecule | 0.147 | ||
| Gzmm | granzyme M (lymphocyte met-ase 1) | 0.147 | ||
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.147 | ||
| Cd72 | Cd72 molecule | 0.113 | ||
| St8sia4 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | 0.113 | ||
| Serpinb3a | serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A | 0.110 | ||
| Prf1 | perforin 1 (pore forming protein) | 0.109 | ||
| Sit1 | signaling threshold regulating transmembrane adaptor 1 | 0.107 | ||
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.106 | Rat | |
| Klrc2 | killer cell lectin-like receptor subfamily C, member 2 | 0.106 | Rat | |
| Cyp2c13 | cytochrome P450, family 2, subfamily c, polypeptide 13 | 0.098 | ||
| Acap1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 | 0.092 | ||
| Ifng | interferon gamma | 0.090 | ||
| Lilrb3 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 | 0.087 | ||
| Olr1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.076 | Rat | |
| Samsn1 | SAM domain, SH3 domain and nuclear localization signals, 1 | 0.074 | ||
| Igfl3 | IGF-like family member 3 | 0.072 | ||
| Slc17a1 | solute carrier family 17 (sodium phosphate), member 1 | 0.072 | ||
| Zap70 | zeta-chain (TCR) associated protein kinase | 0.069 | ||
| Klrb1a | killer cell lectin-like receptor subfamily B, member 1A | 0.067 | ||
| Klra17 | killer cell lectin-like receptor, subfamily A, member 17 | 0.067 | ||
| Ugt2a1 | UDP glucuronosyltransferase 2 family, polypeptide A1 | 0.064 | ||
| Slamf9 | SLAM family member 9 | 0.063 | ||
| Rgs1 | regulator of G-protein signaling 1 | 0.062 | ||
| Sh2d2a | SH2 domain protein 2A | 0.056 | ||
| Ccl5 | chemokine (C-C motif) ligand 5 | 0.055 | ||
| Cyp2c12 | cytochrome P450, family 2, subfamily c, polypeptide 12 | 0.053 | ||
| Spn | sialophorin | 0.052 | ||
| Cd3g | CD3 molecule, gamma | 0.051 | ||
| Trpv1 | transient receptor potential cation channel, subfamily V, member 1 | 0.051 | ||
| Ccl9 | chemokine (C-C motif) ligand 9 | 0.048 | ||
| Scin | scinderin | 0.047 | ||
| Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.044 | ||
| Mos | Moloney sarcoma oncogene | 0.043 | ||
| Tcrb | T-cell receptor beta chain | 0.043 | ||
| Slc9a4 | solute carrier family 9 (sodium/hydrogen exchanger), member 4 | 0.041 | ||
| Tlr7 | toll-like receptor 7 | 0.041 | ||
| Reg3g | regenerating islet-derived 3 gamma | 0.040 | ||
| Ubd | ubiquitin D | 0.039 | ||
| Ctsj | cathepsin J | 0.038 | ||
| Cst7 | cystatin F (leukocystatin) | 0.038 | ||
| Pcsk1 | proprotein convertase subtilisin/kexin type 1 | 0.037 | ||
| Pik3cd | phosphoinositide-3-kinase, catalytic, delta polypeptide | 0.036 | ||
| Il1rl1 | interleukin 1 receptor-like 1 | 0.036 | ||
| Il18r1 | interleukin 18 receptor 1 | 0.035 | ||
| Slc13a1 | solute carrier family 13 (sodium/sulfate symporters), member 1 | 0.033 | ||
| Mcpt4 | mast cell protease 4 | 0.029 | ||
| Ccl19 | chemokine (C-C motif) ligand 19 | 0.029 | ||
| P2ry14 | purinergic receptor P2Y, G-protein coupled, 14 | 0.026 | ||
| Tnni3k | TNNI3 interacting kinase | 0.026 | ||
| Gpr114 | G protein-coupled receptor 114 | 0.025 | ||
| Cxcl11 | chemokine (C-X-C motif) ligand 11 | 0.025 | ||
| Itgal | integrin, alpha L | 0.025 | ||
| Reg3b | regenerating islet-derived 3 beta | 0.024 | ||
| Cd247 | Cd247 molecule | 0.024 | ||
| Gfra3 | GDNF family receptor alpha 3 | 0.023 | ||
| Mcpt3 | mast cell peptidase 3 | 0.023 | ||
| Clec4f | C-type lectin domain family 4, member f | 0.023 | ||
| Oas1b | 2-5 oligoadenylate synthetase 1B | 0.023 | ||
| Spic | Spi-C transcription factor (Spi-1/PU.1 related) | 0.023 | ||
| Havcr1 | hepatitis A virus cellular receptor 1 | 0.023 | ||
| Slfn3 | schlafen 3 | 0.022 | ||
| Gimap4 | GTPase, IMAP family member 4 | 0.022 | ||
| Nkx6-1 | NK6 homeobox 1 | 0.022 | ||
| Klra22 | killer cell lectin-like receptor subfamily A, member 22 | 0.022 | Rat | |
| Parvg | parvin, gamma | 0.022 | ||
| Nox4 | NADPH oxidase 4 | 0.021 | ||
| Epsti1 | epithelial stromal interaction 1 (breast) | 0.021 | ||
| LOC100361053 | mCG1039741-like | 0.020 | ||
| Ambn | ameloblastin | 0.020 | ||
| Oprm1 | opioid receptor, mu 1 | 0.020 | ||
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.019 | ||
| Il10ra | interleukin 10 receptor, alpha | 0.019 | ||
| Fcrla | Fc receptor-like A | 0.019 | ||
| Tmigd1 | transmembrane and immunoglobulin domain containing 1 | 0.019 | ||
| LOC300024 | similar to Ly6-B antigen gene | 0.019 | ||
| Unc5cl | unc-5 homolog C (C. elegans)-like | 0.019 | ||
| Gucy2g | guanylate cyclase 2G | 0.019 | ||
| Gzma | granzyme A | 0.018 | ||
| Klrc1 | killer cell lectin-like receptor subfamily C, member 1 | 0.018 | Rat | |
| Il2 | interleukin 2 | 0.018 | ||
| Olr1226 | olfactory receptor 1226 | 0.018 | ||
| RT1-Ha | RT1 class II, locus Ha | 0.018 | ||
| Art2 | ADP-ribosyltransferase 2 | 0.017 | ||
| Tnfrsf14 | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) | 0.017 | ||
| Fam65b | family with sequence similarity 65, member B | 0.017 | ||
| Vom1r102 | vomeronasal 1 receptor 102 | 0.017 | ||
| Skap1 | src kinase associated phosphoprotein 1 | 0.017 | ||
| Cd22 | CD22 molecule | 0.017 | ||
| Zfp37 | zinc finger protein 37 | 0.017 | ||
| LOC689770 | similar to osteoclast inhibitory lectin | 0.017 | ||
| Tmem26 | transmembrane protein 26 | 0.016 | ||
| Spink1 | serine peptidase inhibitor, Kazal type 1 | 0.016 | ||
| LOC691708 | similar to ubiquitin-conjugating enzyme E2R 2 | 0.016 | ||
| Slco1b3 | solute carrier organic anion transporter family, member 1b3 | 0.016 | ||
| Cyp7b1 | cytochrome P450, family 7, subfamily b, polypeptide 1 | 0.016 | ||
| LOC100362325 | rCG28200-like | 0.016 | ||
| Cd244 | Cd244 molecule, natural killer cell receptor 2B4 | 0.015 | ||
| LOC100364835 | histone cluster 1, H2bd-like | 0.015 | ||
| LOC685157 | similar to paired immunoglobin-like type 2 receptor beta | 0.015 | ||
| Il1rn | interleukin 1 receptor antagonist | 0.015 | ||
| Cyp3a2 | cytochrome P450, family 3, subfamily a, polypeptide 2 | 0.015 | ||
| RGD1311300 | similar to T cell receptor V delta 6 | 0.015 | ||
| RT1-A3 | RT1 class I, locus A3 | 0.015 | ||
| Phemx | pan hematopoietic expression | 0.014 | ||
| Hcls1 | hematopoietic cell specific Lyn substrate 1 | 0.014 | ||
| Rpl35 | ribosomal protein L35 | 0.014 | ||
| Gpr64 | G protein-coupled receptor 64 | 0.014 | ||
| Rhoh | ras homolog gene family, member H | 0.014 | ||
| Dclre1c | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) | 0.014 | ||
| Dppa3 | developmental pluripotency-associated 3 | 0.014 | ||
| Gem | GTP binding protein (gene overexpressed in skeletal muscle) | 0.014 | ||
| Il1f8 | interleukin 1 family, member 8 | 0.013 | ||
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.013 | ||
| Rpl19 | ribosomal protein L19 | 0.013 | ||
| Clec9a | C-type lectin domain family 9, member a | 0.013 | Rat | |
| LOC100364854 | similar to RIKEN cDNA A430107P09 gene-like | 0.013 | ||
| Stap1 | signal transducing adaptor family member 1 | 0.013 | ||
| Ecel1 | endothelin converting enzyme-like 1 | 0.013 | ||
| Stab2 | stabilin 2 | 0.013 | ||
| Mageb16 | melanoma antigen family B, 16 | 0.013 | ||
| Cd200r2 | Cd200 receptor 2 | 0.013 | ||
| Lck | lymphocyte-specific protein tyrosine kinase | 0.013 | ||
| Tnf | tumor necrosis factor (TNF superfamily, member 2) | 0.013 | ||
| Atp6v1g3 | ATPase, H+ transporting, lysosomal V1 subunit G3 | 0.012 | ||
| Cd86 | CD86 molecule | 0.012 | ||
| Serpinb2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.012 | ||
| Ctla2a | cytotoxic T lymphocyte-associated protein 2 alpha | 0.012 | ||
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.012 | ||
| C7 | complement component 7 | 0.012 | ||
| Gcgr | glucagon receptor | 0.012 | ||
| Epb41l4b | erythrocyte membrane protein band 4.1 like 4B | 0.012 | ||
| Tas2r105 | taste receptor, type 2, member 105 | 0.012 | ||
| Slc22a25 | solute carrier family 22, member 25 | 0.012 | ||
| LOC363326 | hypothetical LOC363326 | 0.012 | ||
| Klre1 | killer cell lectin-like receptor, family E, member 1 | 0.012 | ||
| Usp40 | ubiquitin specific peptidase 40 | 0.012 | ||
| Card6 | caspase recruitment domain family, member 6 | 0.012 | ||
| Asb12 | ankyrin repeat and SOCS box-containing 12 | 0.012 | ||
| Sh2d1a | SH2 domain protein 1A | 0.012 | ||
| LOC100361765 | homeobox B2 | 0.012 | ||
| Kynu | kynureninase (L-kynurenine hydrolase) | 0.011 | ||
| Olr1283 | olfactory receptor 1283 | 0.011 | ||
| Sucnr1 | succinate receptor 1 | 0.011 | ||
| Olr1530 | olfactory receptor 1530 | 0.011 | ||
| Pou1f1 | POU class 1 homeobox 1 | 0.011 | ||
| Il27ra | interleukin 27 receptor, alpha | 0.011 | ||
| Itgb2 | integrin, beta 2 | 0.011 | ||
| Il1b | interleukin 1 beta | 0.011 | ||
| Ly49si1 | immunoreceptor Ly49si1 | 0.011 | Rat | |
| Lrrc8c | leucine rich repeat containing 8 family, member C | 0.011 | ||
| Inpp4b | inositol polyphosphate-4-phosphatase, type II | 0.011 | ||
| Fcgr1a | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 0.011 | ||
| Vom1r101 | vomeronasal 1 receptor 101 | 0.010 | ||
| Testin | testin gene | 0.010 | ||
| Psgb1 | pregnancy-specific beta 1-glycoprotein | 0.010 | ||
| Fcer1a | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 0.010 | ||
| Stx11 | syntaxin 11 | 0.010 |