IMP
Process View
necroptotic process
A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "necroptotic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Mcpt8 | mast cell protease 8 | 0.844 | Rat | |
| Cma1 | chymase 1, mast cell | 0.319 | ||
| Cpa3 | carboxypeptidase A3, mast cell | 0.213 | ||
| Prf1 | perforin 1 (pore forming protein) | 0.205 | ||
| Il1b | interleukin 1 beta | 0.191 | ||
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.180 | ||
| Ccl5 | chemokine (C-C motif) ligand 5 | 0.158 | ||
| Ppp3r1 | protein phosphatase 3, regulatory subunit B, alpha isoform | 0.118 | ||
| Nkg7 | natural killer cell group 7 sequence | 0.105 | ||
| Mcpt10 | mast cell protease 10 | 0.092 | Rat | |
| Klrg1 | killer cell lectin-like receptor subfamily G, member 1 | 0.088 | ||
| Xcl1 | chemokine (C motif) ligand 1 | 0.083 | ||
| Clca4 | chloride channel accessory 4 | 0.073 | ||
| LOC100361261 | rCG23560-like | 0.071 | ||
| Tmigd1 | transmembrane and immunoglobulin domain containing 1 | 0.066 | ||
| Mdh1 | malate dehydrogenase 1, NAD (soluble) | 0.066 | ||
| Tcrb | T-cell receptor beta chain | 0.063 | ||
| Rabac1 | Rab acceptor 1 (prenylated) | 0.059 | ||
| Slc25a3 | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 | 0.053 | ||
| Gapdh | glyceraldehyde-3-phosphate dehydrogenase | 0.051 | ||
| Mcpt2 | mast cell protease 2 | 0.051 | Rat | |
| Slfn2 | schlafen 2 | 0.050 | ||
| Ms4a2 | membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) | 0.050 | ||
| Prm2 | protamine 2 | 0.047 | ||
| LOC100361706 | lambda-chain C1-region-like | 0.046 | ||
| Art2 | ADP-ribosyltransferase 2 | 0.045 | ||
| Rps6kb1 | ribosomal protein S6 kinase, polypeptide 1 | 0.044 | ||
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.042 | ||
| Aldoa | aldolase A, fructose-bisphosphate | 0.041 | ||
| Klrb1a | killer cell lectin-like receptor subfamily B, member 1A | 0.041 | ||
| Dnase1l3 | deoxyribonuclease 1-like 3 | 0.041 | ||
| Spam1 | sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) | 0.040 | ||
| Ifit3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.040 | ||
| Cd2 | Cd2 molecule | 0.038 | ||
| Cd3g | CD3 molecule, gamma | 0.035 | ||
| Neurl3 | neuralized homolog 3 (Drosophila) | 0.035 | ||
| Oas1b | 2-5 oligoadenylate synthetase 1B | 0.034 | ||
| Mcpt9 | mast cell protease 9 | 0.033 | Rat | |
| Zcchc6 | zinc finger, CCHC domain containing 6 | 0.033 | ||
| Cd247 | Cd247 molecule | 0.031 | ||
| Myd88 | myeloid differentiation primary response gene 88 | 0.029 | ||
| LOC24906 | RoBo-1 | 0.028 | ||
| Il6 | interleukin 6 | 0.028 | ||
| Ubd | ubiquitin D | 0.028 | ||
| RGD1564878 | similar to natural killer cell protease 7 | 0.028 | ||
| RGD1309621 | similar to hypothetical protein FLJ10652 | 0.026 | ||
| Il2rb | interleukin 2 receptor, beta | 0.026 | ||
| Cd52 | CD52 antigen | 0.026 | ||
| Cd8a | CD8a molecule | 0.026 | ||
| Tmf1 | TATA element modulatory factor 1 | 0.025 | ||
| Gzma | granzyme A | 0.025 | Rat | |
| Lilrb3 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 | 0.025 | ||
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.024 | ||
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.024 | ||
| Hck | hemopoietic cell kinase | 0.024 | ||
| Bcl10 | B-cell CLL/lymphoma 10 | 0.024 | ||
| Cela1 | chymotrypsin-like elastase family, member 1 | 0.023 | ||
| Klrc2 | killer cell lectin-like receptor subfamily C, member 2 | 0.023 | ||
| Igh-6 | immunoglobulin heavy chain 6 | 0.023 | ||
| Atp5b | ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide | 0.022 | ||
| Hist1h2ba | histone cluster 1, H2ba | 0.022 | ||
| Spink1 | serine peptidase inhibitor, Kazal type 1 | 0.022 | ||
| Tsx | testis specific X-linked gene | 0.022 | ||
| Cdh17 | cadherin 17 | 0.022 | ||
| Lgals4 | lectin, galactoside-binding, soluble, 4 | 0.022 | ||
| Got1 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 0.022 | ||
| Lmna | lamin A | 0.022 | ||
| Grina | glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) | 0.021 | ||
| RatNP-3b | defensin RatNP-3 precursor | 0.021 | ||
| Nr1h3 | nuclear receptor subfamily 1, group H, member 3 | 0.021 | ||
| Cox4i1 | cytochrome c oxidase subunit IV isoform 1 | 0.021 | ||
| Stip1 | stress-induced phosphoprotein 1 | 0.021 | ||
| Hnf1a | HNF1 homeobox A | 0.021 | ||
| Clec9a | C-type lectin domain family 9, member a | 0.020 | ||
| Trpv1 | transient receptor potential cation channel, subfamily V, member 1 | 0.020 | ||
| Stat4 | signal transducer and activator of transcription 4 | 0.020 | ||
| Gzmb | granzyme B | 0.020 | ||
| Olr1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.020 | ||
| Pla2g2a | phospholipase A2, group IIA (platelets, synovial fluid) | 0.020 | ||
| Ton | tonin | 0.020 | ||
| Pttg1ip | pituitary tumor-transforming 1 interacting protein | 0.020 | ||
| Fcnb | ficolin B | 0.020 | ||
| Tgm1 | transglutaminase 1, K polypeptide | 0.019 | ||
| Tpsab1 | tryptase alpha/beta 1 | 0.019 | ||
| Klre1 | killer cell lectin-like receptor, family E, member 1 | 0.019 | ||
| Ear11 | eosinophil-associated, ribonuclease A family, member 11 | 0.019 | ||
| PVR | poliovirus receptor | 0.019 | ||
| Irgm | immunity-related GTPase family, M | 0.018 | ||
| Zap70 | zeta-chain (TCR) associated protein kinase | 0.018 | ||
| Semg1 | semenogelin I | 0.018 | ||
| Gzmm | granzyme M (lymphocyte met-ase 1) | 0.018 | ||
| Fabp4 | fatty acid binding protein 4, adipocyte | 0.018 | ||
| Trim23 | tripartite motif-containing 23 | 0.018 | ||
| Gzmc | granzyme C | 0.018 | ||
| Arhgef5 | Rho guanine nucleotide exchange factor (GEF) 5 | 0.018 | ||
| Rnf10 | ring finger protein 10 | 0.018 | ||
| Gfi1 | growth factor independent 1 transcription repressor | 0.018 | ||
| Sh2d2a | SH2 domain protein 2A | 0.018 | ||
| Adora2a | adenosine A2a receptor | 0.018 | ||
| Tbc1d15 | TBC1 domain family, member 15 | 0.017 | ||
| Fas | Fas (TNF receptor superfamily, member 6) | 0.017 | Human Mouse | |
| Arl13b | ADP-ribosylation factor-like 13B | 0.017 | ||
| Apobec1 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 | 0.017 | ||
| Adipor1 | adiponectin receptor 1 | 0.017 | ||
| Tec | tec protein tyrosine kinase | 0.017 | ||
| Fcn1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.017 | ||
| Tpm1 | tropomyosin 1, alpha | 0.016 | ||
| Tnp2 | transition protein 2 | 0.016 | ||
| Cldn7 | claudin 7 | 0.016 | ||
| Il7r | interleukin 7 receptor | 0.016 | ||
| Thop1 | thimet oligopeptidase 1 | 0.016 | ||
| Il1r2 | interleukin 1 receptor, type II | 0.016 | ||
| Slc48a1 | solute carrier family 48 (heme transporter), member 1 | 0.016 | ||
| Ldhb | lactate dehydrogenase B | 0.016 | ||
| Slc27a1 | solute carrier family 27 (fatty acid transporter), member 1 | 0.016 | ||
| Ncf4 | neutrophil cytosolic factor 4 | 0.015 | ||
| Serpinb5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.015 | ||
| Pdk2 | pyruvate dehydrogenase kinase, isozyme 2 | 0.015 | ||
| S100a8 | S100 calcium binding protein A8 | 0.015 | ||
| Plcb2 | phospholipase C, beta 2 | 0.015 | ||
| Ctdsp1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 | 0.015 | ||
| Cnksr1 | connector enhancer of kinase suppressor of Ras 1 | 0.015 | ||
| Eraf | erythroid associated factor | 0.015 | ||
| Prl3d4 | prolactin family 3, subfamily d, member 4 | 0.015 | ||
| Igsf6 | immunoglobulin superfamily, member 6 | 0.015 | ||
| Fgr | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.015 | ||
| Cxcl11 | chemokine (C-X-C motif) ligand 11 | 0.015 | ||
| Tfrc | transferrin receptor | 0.015 | ||
| Arl5c | ADP-ribosylation factor-like 5C | 0.015 | ||
| Tnfrsf14 | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) | 0.014 | ||
| Hk2 | hexokinase 2 | 0.014 | ||
| Cops7a | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) | 0.014 | ||
| Il2 | interleukin 2 | 0.014 | ||
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.014 | ||
| Il10 | interleukin 10 | 0.014 | ||
| Smc5 | structural maintenance of chromosomes 5 | 0.014 | ||
| Gpx4 | glutathione peroxidase 4 | 0.014 | ||
| Pml | promyelocytic leukemia | 0.014 | ||
| Slc43a1 | solute carrier family 43, member 1 | 0.014 | ||
| Angptl4 | angiopoietin-like 4 | 0.014 | ||
| Fam115c | family with sequence similarity 115, member C | 0.013 | ||
| Lamtor1 | RhoA activator C11orf59 homolog | 0.013 | ||
| Snurf | SNRPN upstream reading frame | 0.013 | ||
| Dctn1 | dynactin 1 | 0.013 | ||
| Il1a | interleukin 1 alpha | 0.013 | ||
| Rsrc2 | arginine/serine-rich coiled-coil 2 | 0.013 | ||
| Rnase1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.013 | ||
| Pparg | peroxisome proliferator-activated receptor gamma | 0.013 | ||
| Birc3 | baculoviral IAP repeat-containing 3 | 0.013 | Human | |
| Aadac | arylacetamide deacetylase (esterase) | 0.013 | ||
| Dmrta1 | DMRT-like family A1 | 0.013 | ||
| Hbb | hemoglobin, beta | 0.013 | ||
| RGD1564599 | RGD1564599 | 0.013 | ||
| Map4k1 | mitogen activated protein kinase kinase kinase kinase 1 | 0.013 | ||
| Sh2d1a | SH2 domain protein 1A | 0.013 | ||
| Amy2 | amylase 2, pancreatic | 0.013 | ||
| Dpep1 | dipeptidase 1 (renal) | 0.013 | ||
| Fli1 | Friend leukemia virus integration 1 | 0.013 | ||
| Dlg1 | discs, large homolog 1 (Drosophila) | 0.013 | ||
| Fcer1a | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 0.012 | ||
| Klk1c10 | T-kininogenase | 0.012 | ||
| Bpgm | 2,3-bisphosphoglycerate mutase | 0.012 | ||
| Klrb1b | killer cell lectin-like receptor subfamily B member 1B | 0.012 | ||
| Fmo5 | flavin containing monooxygenase 5 | 0.012 | ||
| Pdzk1ip1 | PDZK1 interacting protein 1 | 0.012 | ||
| Rmt1 | mammary cancer associated protein RMT-1 | 0.012 | ||
| Lck | lymphocyte-specific protein tyrosine kinase | 0.012 | ||
| Nrd1 | nardilysin 1 | 0.012 | ||
| Prl8a2 | prolactin family 8, subfamily a, member 2 | 0.012 | ||
| Zc3h12a | zinc finger CCCH type containing 12A | 0.012 | ||
| Krt19 | keratin 19 | 0.012 | ||
| Fabp9 | fatty acid binding protein 9, testis | 0.012 | ||
| Cryab | crystallin, alpha B | 0.012 | ||
| Bid | BH3 interacting domain death agonist | 0.012 | ||
| Cxcl1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.012 | ||
| Gzmk | granzyme K | 0.012 | Rat | |
| Gnas | GNAS complex locus | 0.012 | ||
| Hpgds | hematopoietic prostaglandin D synthase | 0.012 | ||
| Exoc5 | exocyst complex component 5 | 0.012 | ||
| Alox15 | arachidonate 15-lipoxygenase | 0.012 | ||
| C6 | complement component 6 | 0.012 | ||
| Gzmf | granzyme F | 0.012 | Rat | |
| Ybx1 | Y box binding protein 1 | 0.012 | ||
| Tecr | trans-2,3-enoyl-CoA reductase | 0.011 | ||
| Fcho2 | FCH domain only 2 | 0.011 | ||
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.011 | ||
| Ppp1r2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.011 | ||
| Rnf4 | ring finger protein 4 | 0.011 | ||
| Cd3d | CD3 molecule, delta | 0.011 | ||
| Fnbp4 | formin binding protein 4 | 0.011 | ||
| Gys2 | glycogen synthase 2 | 0.011 | ||
| Ccl24 | chemokine (C-C motif) ligand 24 | 0.011 | ||
| Zg16 | zymogen granule protein 16 | 0.011 | ||
| Tfec | transcription factor EC | 0.011 | ||
| Prl8a7 | prolactin family 8, subfamily a, member 7 | 0.011 | ||
| Ehmt2 | euchromatic histone lysine N-methyltransferase 2 | 0.011 | ||
| Krt20 | keratin 20 | 0.011 | ||
| Edem1 | ER degradation enhancer, mannosidase alpha-like 1 | 0.011 | ||
| Enpp3 | ectonucleotide pyrophosphatase/phosphodiesterase 3 | 0.011 | ||
| Tp63 | tumor protein p63 | 0.011 | ||
| Dld | dihydrolipoamide dehydrogenase | 0.011 | ||
| Np4 | defensin NP-4 precursor | 0.011 | ||
| Sbp | spermine binding protein | 0.011 | ||
| Pkn2 | protein kinase N2 | 0.011 | ||
| LOC300024 | similar to Ly6-B antigen gene | 0.011 | ||
| Zfp36l2 | zinc finger protein 36, C3H type-like 2 | 0.011 | ||
| Vdac1 | voltage-dependent anion channel 1 | 0.011 | ||
| Ythdf3 | YTH domain family, member 3 | 0.011 | ||
| Stfa2l3 | stefin A2-like 3 | 0.011 | ||
| Ces1e | carboxylesterase 1E | 0.011 | ||
| Tmem72 | transmembrane protein 72 | 0.011 | ||
| Cd79b | Cd79b molecule, immunoglobulin-associated beta | 0.011 | ||
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.011 | ||
| Lilrb4 | leukocyte immunoglobulin-like receptor, subfamily B, member 4 | 0.011 | ||
| LOC100363783 | rCG53773-like | 0.011 | ||
| Pdha1 | pyruvate dehydrogenase (lipoamide) alpha 1 | 0.011 | ||
| Dync1h1 | dynein cytoplasmic 1 heavy chain 1 | 0.010 | ||
| Eif4b | eukaryotic translation initiation factor 4B | 0.010 | ||
| Cd7 | Cd7 molecule | 0.010 | ||
| Rpl3l | ribosomal protein L3-like | 0.010 | ||
| Sectm1b | secreted and transmembrane 1B | 0.010 | ||
| Slc25a5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.010 | ||
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.010 | ||
| Asgr2 | asialoglycoprotein receptor 2 | 0.010 | ||
| Ireb2 | iron responsive element binding protein 2 | 0.010 | ||
| Prl4a1 | prolactin family 4, subfamily a, member 1 | 0.010 | ||
| Col11a2 | collagen, type XI, alpha 2 | 0.010 | ||
| RGD1559588 | similar to cell surface receptor FDFACT | 0.010 | ||
| Ssrp1 | structure specific recognition protein 1 | 0.010 | ||
| Epor | erythropoietin receptor | 0.010 | ||
| Smc1a | structural maintenance of chromosomes 1A | 0.010 | ||
| Tnpo1 | transportin 1 | 0.010 | ||
| Chd1 | chromodomain helicase DNA binding protein 1 | 0.010 | ||
| P2ry2 | purinergic receptor P2Y, G-protein coupled, 2 | 0.010 | ||
| Sdc1 | syndecan 1 | 0.010 | ||
| Tpo | thyroid peroxidase | 0.010 | ||
| RGD1308065 | hypothetical LOC287935 | 0.010 | ||
| Atp5a1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | 0.010 |