IMP: Integrative Multi-species Prediction

Rattus norvegicus

11 genes annotated in rat

tetrapyrrole metabolic process

The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "tetrapyrrole metabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "tetrapyrrole metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Hmbs	hydroxymethylbilane synthase	0.806
Alad	aminolevulinate, delta-, dehydratase	0.707
Atp5f1	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1	0.705
Mdh1	malate dehydrogenase 1, NAD (soluble)	0.395
Slc25a3	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3	0.328
Trap1	TNF receptor-associated protein 1	0.289
Akr7a2	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	0.279
Mpst	mercaptopyruvate sulfurtransferase	0.225
Apeh	N-acylaminoacyl-peptide hydrolase	0.224
Mosc2	MOCO sulphurase C-terminal domain containing 2	0.208
Fech	ferrochelatase	0.202
Oaz1	ornithine decarboxylase antizyme 1	0.156
Urod	uroporphyrinogen decarboxylase	0.150
Litaf	lipopolysaccharide-induced TNF factor	0.143
Icam1	intercellular adhesion molecule 1	0.137
Apob	apolipoprotein B	0.136
LOC293989	cytochrome P450-like	0.134
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.106
Fh1	fumarate hydratase 1	0.096
Ppox	protoporphyrinogen oxidase	0.093
Hspd1	heat shock protein 1 (chaperonin)	0.090
Tmem14c	transmembrane protein 14C	0.087
Sult1b1	sulfotransferase family, cytosolic, 1B, member 1	0.084
Gpx4	glutathione peroxidase 4	0.084
Srxn1	sulfiredoxin 1 homolog (S. cerevisiae)	0.083
Ppif	peptidylprolyl isomerase F	0.076
Mipep	mitochondrial intermediate peptidase	0.073
Stat3	signal transducer and activator of transcription 3	0.071
Ccs	copper chaperone for superoxide dismutase	0.068
RGD1308134	similar to RIKEN cDNA 1110020A23	0.066
Fabp1	fatty acid binding protein 1, liver	0.065
Cyp4a10	cytochrome P450, family 4, subfamily a, polypeptide 10	0.064
Esr2	estrogen receptor 2 (ER beta)	0.060
Timp1	TIMP metallopeptidase inhibitor 1	0.057
Grhpr	glyoxylate reductase/hydroxypyruvate reductase	0.054
Prm2	protamine 2	0.053
Uqcrfs1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.052
Atp5a1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.052
Mri1	methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)	0.049
Hmox1	heme oxygenase (decycling) 1	0.048
Kng1	kininogen 1	0.047
Ube2a	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.043
Cyp4a8	cytochrome P450, family 4, subfamily a, polypeptide 8	0.043
Cyp2b1	cytochrome P450, family 2, subfamily b, polypeptide 1	0.039
Dmgdh	dimethylglycine dehydrogenase	0.039
Ftl	ferritin, light polypeptide	0.039
Dnpep	aspartyl aminopeptidase	0.036
Slc25a4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	0.036	Yeast
Acr	acrosin	0.035
Hp	haptoglobin	0.035
Hbxip	hepatitis B virus x interacting protein	0.035
A1i3	alpha-1-inhibitor III	0.034
Cryab	crystallin, alpha B	0.032
Mt2A	metallothionein 2A	0.031
Prdx1	peroxiredoxin 1	0.030
Mettl7b	methyltransferase like 7B	0.030
RGD1311910	similar to hypothetical p38 protein	0.030
Sord	sorbitol dehydrogenase	0.029
Iah1	isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)	0.029
Ciao1	cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)	0.028
Idh2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	0.028
Fbp1	fructose-1,6-bisphosphatase 1	0.028
Gns	glucosamine (N-acetyl)-6-sulfatase	0.027
Ier3	immediate early response 3	0.027
Tmem205	transmembrane protein 205	0.027
Pttg1ip	pituitary tumor-transforming 1 interacting protein	0.024
Fga	fibrinogen alpha chain	0.024
Ltbr	lymphotoxin beta receptor (TNFR superfamily, member 3)	0.023
Cyp3a23/3a1	cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1	0.023
Alkbh7	alkB, alkylation repair homolog 7 (E. coli)	0.023
Cd151	CD151 molecule (Raph blood group)	0.023
Hspa8	heat shock protein 8	0.022
mrpl11	mitochondrial ribosomal protein L11	0.022
Slc25a5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5	0.022	Yeast
Tst	thiosulfate sulfurtransferase	0.021
Grn	granulin	0.020
Cyp2b3	cytochrome P450, family 2, subfamily b, polypeptide 3	0.019
Ctsa	cathepsin A	0.019
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.019
Asgr1	asialoglycoprotein receptor 1	0.019
Fgg	fibrinogen gamma chain	0.019
Pcyt2	phosphate cytidylyltransferase 2, ethanolamine	0.019
Slc3a2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.018
Akr1a1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	0.018
Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2	0.018
Ppia	peptidylprolyl isomerase A (cyclophilin A)	0.018
Apoa1	apolipoprotein A-I	0.018
Apoh	apolipoprotein H (beta-2-glycoprotein I)	0.018
Lgals3	lectin, galactoside-binding, soluble, 3	0.017
Acp2	acid phosphatase 2, lysosomal	0.017
Cnbp	CCHC-type zinc finger, nucleic acid binding protein	0.017
Mtr	5-methyltetrahydrofolate-homocysteine methyltransferase	0.017
Galt	galactose-1-phosphate uridylyltransferase	0.016
Park7	Parkinson disease (autosomal recessive, early onset) 7	0.016
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.016
Galm	galactose mutarotase (aldose 1-epimerase)	0.016
Abcb11	ATP-binding cassette, subfamily B (MDR/TAP), member 11	0.015
Crisp2	cysteine-rich secretory protein 2	0.015
Setd6	SET domain containing 6	0.015
Gsta4	glutathione S-transferase alpha 4	0.015
Sephs2	selenophosphate synthetase 2	0.015
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.015
Adfp	adipose differentiation related protein	0.015
Mecr	mitochondrial trans-2-enoyl-CoA reductase	0.015
Psmb2	proteasome (prosome, macropain) subunit, beta type 2	0.015
Tsta3	tissue specific transplantation antigen P35B	0.015
Aldob	aldolase B, fructose-bisphosphate	0.015
Jtb	jumping translocation breakpoint	0.014
Atp5h	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d	0.014
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.014
Adh5	alcohol dehydrogenase 5 (class III), chi polypeptide	0.014
Ndufv2	NADH dehydrogenase (ubiquinone) flavoprotein 2	0.014
Cyp4f6	cytochrome P450, family 4, subfamily f, polypeptide 6	0.014
Pgam1	phosphoglycerate mutase 1 (brain)	0.014
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.014
Mcpt2	mast cell protease 2	0.014
Plaur	plasminogen activator, urokinase receptor	0.014
Gstt1	glutathione S-transferase theta 1	0.013
LOC100361261	rCG23560-like	0.013
Cps1	carbamoyl-phosphate synthetase 1	0.013
Galr1	galanin receptor 1	0.013
Fuca1	fucosidase, alpha-L- 1, tissue	0.013
Dnase1	deoxyribonuclease I	0.013
Aldh7a1	aldehyde dehydrogenase 7 family, member A1	0.013
Ambp	alpha-1-microglobulin/bikunin precursor	0.013
Serpina6	serine (or cysteine) peptidase inhibitor, clade A, member 6	0.013
Hnf1a	HNF1 homeobox A	0.012	Mouse
Smpd1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.012
Ccbl1	cysteine conjugate-beta lyase, cytoplasmic	0.012
Myc	myelocytomatosis oncogene	0.012
Sycp1	synaptonemal complex protein 1	0.012
Gc	group specific component	0.012
Ctsb	cathepsin B	0.012
Fam125a	family with sequence similarity 125, member A	0.012
Selp	selectin P	0.012
Prl2b1	Prolactin family 2, subfamily b, member 1	0.012
Zfand2a	zinc finger, AN1-type domain 2A	0.011
Cyp3a9	cytochrome P450, family 3, subfamily a, polypeptide 9	0.011
Ninj1	ninjurin 1	0.011
Prkab1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.011
F9	coagulation factor IX	0.011
Ppt1	palmitoyl-protein thioesterase 1	0.011
Cfi	complement factor I	0.011
Klks3	kallikrein, submaxillary gland S3	0.011
Tmem223	transmembrane protein 223	0.011
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.011
Mt1a	metallothionein 1a	0.010
Gapdh	glyceraldehyde-3-phosphate dehydrogenase	0.010
Slc22a7	solute carrier family 22 (organic anion transporter), member 7	0.010
Klk1c10	T-kininogenase	0.010
Ssna1	Sjogren syndrome nuclear autoantigen 1	0.010
Hmgcs2	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)	0.010
Ren	renin	0.010
Sult2al1	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring-like 1	0.010
Akr7a3	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)	0.010
Ugt2b	UDP glycosyltransferase 2 family, polypeptide B	0.010