IMP
Process View
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
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Click on a gene's description to view its network relationships with genes known to be involved in "anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Foxm1 | forkhead box M1 | 0.145 | ||
| Plk1 | polo-like kinase 1 (Drosophila) | 0.115 | Human | |
| Bub1b | budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) | 0.089 | ||
| Asf1b | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | 0.086 | ||
| Ccnb1 | cyclin B1 | 0.079 | ||
| Top2a | topoisomerase (DNA) II alpha | 0.077 | ||
| Ube2c | ubiquitin-conjugating enzyme E2C | 0.062 | ||
| Spag5 | sperm associated antigen 5 | 0.061 | ||
| LOC100310874 | antisense RNA overlapping MCH | 0.061 | ||
| Espl1 | extra spindle pole bodies homolog 1 (S. cerevisiae) | 0.057 | ||
| Tpm4 | tropomyosin 4 | 0.052 | ||
| Kif2c | kinesin family member 2C | 0.051 | ||
| Zfp91 | zinc finger protein 91 | 0.048 | ||
| Pbk | PDZ binding kinase | 0.046 | ||
| Dlgap5 | discs, large (Drosophila) homolog-associated protein 5 | 0.042 | ||
| Pttg1 | pituitary tumor-transforming 1 | 0.040 | ||
| Kif22 | kinesin family member 22 | 0.039 | ||
| Troap | trophinin associated protein | 0.039 | ||
| Spc25 | SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) | 0.039 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.038 | ||
| Eif2c2 | eukaryotic translation initiation factor 2C, 2 | 0.037 | ||
| Cdca3 | cell division cycle associated 3 | 0.036 | ||
| Cdkn3 | cyclin-dependent kinase inhibitor 3 | 0.034 | ||
| Ppp4r2 | protein phosphatase 4, regulatory subunit 2 | 0.034 | ||
| Lbr | lamin B receptor | 0.033 | ||
| LOC689399 | hypothetical protein LOC689399 | 0.033 | ||
| Kif18b | kinesin family member 18B | 0.032 | ||
| Cenpt | centromere protein T | 0.031 | ||
| Mcm5 | minichromosome maintenance complex component 5 | 0.030 | ||
| Taok1 | TAO kinase 1 | 0.030 | ||
| Racgap1 | Rac GTPase-activating protein 1 | 0.029 | ||
| E2f1 | E2F transcription factor 1 | 0.028 | ||
| Ccnb2 | cyclin B2 | 0.027 | ||
| Haus4 | HAUS augmin-like complex, subunit 4 | 0.026 | ||
| Dhfr | dihydrofolate reductase | 0.025 | ||
| Rac1 | ras-related C3 botulinum toxin substrate 1 | 0.024 | ||
| Traf4af1 | TRAF4 associated factor 1 | 0.024 | ||
| Cdca2 | cell division cycle associated 2 | 0.023 | ||
| Syncrip | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.022 | ||
| Arfip1 | ADP-ribosylation factor interacting protein 1 | 0.022 | ||
| Ppm1b | protein phosphatase 1B, magnesium dependent, beta isoform | 0.022 | ||
| Akap11 | A kinase (PRKA) anchor protein 11 | 0.021 | ||
| Itgb1 | integrin, beta 1 | 0.020 | ||
| Ripk3 | receptor-interacting serine-threonine kinase 3 | 0.020 | ||
| Nuf2 | NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) | 0.020 | ||
| Cenpi | centromere protein I | 0.020 | ||
| Ttk | Ttk protein kinase | 0.020 | ||
| Ube2t | ubiquitin-conjugating enzyme E2T (putative) | 0.020 | ||
| Kif4 | kinesin family member 4 | 0.020 | ||
| Kifc1 | kinesin family member C1 | 0.020 | ||
| Eif5a | eukaryotic translation initiation factor 5A | 0.019 | ||
| Arih1 | ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila) | 0.019 | ||
| Slain2 | SLAIN motif family, member 2 | 0.019 | ||
| Znf76 | zinc finger protein 76 (expressed in testis) | 0.019 | ||
| Clic4 | chloride intracellular channel 4 | 0.019 | ||
| Mlec | malectin | 0.019 | ||
| Kif20b | kinesin family member 20B | 0.019 | ||
| Ctxn1 | cortexin 1 | 0.019 | ||
| Traip | TRAF-interacting protein | 0.018 | ||
| Brca2 | breast cancer 2 | 0.018 | ||
| Aurka | aurora kinase A | 0.018 | ||
| Myh10 | myosin, heavy chain 10, non-muscle | 0.018 | ||
| Usp9x | ubiquitin specific peptidase 9, X-linked | 0.018 | ||
| Kcnn1 | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 | 0.018 | ||
| Usp12 | ubiquitin specific peptidase 12 | 0.018 | ||
| Ager | advanced glycosylation end product-specific receptor | 0.018 | ||
| Eftud2 | elongation factor Tu GTP binding domain containing 2 | 0.017 | ||
| Pkn2 | protein kinase N2 | 0.017 | ||
| Ska1 | spindle and kinetochore associated complex subunit 1 | 0.017 | ||
| Arf6 | ADP-ribosylation factor 6 | 0.017 | ||
| Tle4 | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 0.017 | ||
| Alx1 | ALX homeobox 1 | 0.017 | ||
| Cops2 | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) | 0.017 | ||
| Ccne1 | cyclin E1 | 0.016 | Fly | |
| Matr3 | matrin 3 | 0.016 | ||
| Mbd2 | methyl-CpG binding domain protein 2 | 0.016 | ||
| Bard1 | BRCA1 associated RING domain 1 | 0.016 | ||
| Dyrk1a | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.016 | ||
| Prc1 | protein regulator of cytokinesis 1 | 0.016 | ||
| Btg1 | B-cell translocation gene 1, anti-proliferative | 0.016 | ||
| Ect2 | epithelial cell transforming sequence 2 oncogene | 0.016 | ||
| Ccnf | cyclin F | 0.016 | ||
| LOC100365542 | rCG41957-like | 0.016 | ||
| Hmmr | hyaluronan mediated motility receptor (RHAMM) | 0.016 | ||
| Dlg4 | discs, large homolog 4 (Drosophila) | 0.016 | ||
| Zfr | zinc finger RNA binding protein | 0.016 | ||
| Wdr26 | WD repeat domain 26 | 0.016 | ||
| Melk | maternal embryonic leucine zipper kinase | 0.016 | ||
| Zfp364 | zinc finger protein 364 | 0.016 | ||
| Ralb | v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) | 0.015 | ||
| Depdc1b | DEP domain containing 1B | 0.015 | ||
| Prkaca | protein kinase, cAMP-dependent, catalytic, alpha | 0.015 | ||
| Zmym2 | zinc finger, MYM-type 2 | 0.015 | ||
| Birc5 | baculoviral IAP repeat-containing 5 | 0.015 | ||
| Pds5a | PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) | 0.015 | ||
| Ppard | peroxisome proliferator-activated receptor delta | 0.015 | ||
| Rgs19 | regulator of G-protein signaling 19 | 0.015 | ||
| Mybl2 | myeloblastosis oncogene-like 2 | 0.014 | ||
| Brca1 | breast cancer 1 | 0.014 | ||
| Plekha1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.014 | ||
| RGD1308127 | similar to 2700078E11Rik protein | 0.014 | ||
| Stk17b | serine/threonine kinase 17b | 0.014 | ||
| RGD1559690 | similar to hypothetical protein FLJ25416 | 0.014 | ||
| Ndrg2 | N-myc downstream regulated gene 2 | 0.014 | ||
| Cyth2 | cytohesin 2 | 0.014 | ||
| Gpr19 | G protein-coupled receptor 19 | 0.014 | ||
| Cdca8 | cell division cycle associated 8 | 0.014 | ||
| Eif4g2 | eukaryotic translation initiation factor 4, gamma 2 | 0.014 | ||
| Fdxr | ferredoxin reductase | 0.014 | ||
| Emx2 | empty spiracles homeobox 2 | 0.014 | ||
| Cdk2 | cyclin dependent kinase 2 | 0.014 | ||
| Eps15 | epidermal growth factor receptor pathway substrate 15 | 0.014 | ||
| Kntc1 | kinetochore associated 1 | 0.014 | ||
| Zfp189 | zinc finger protein 189 | 0.014 | ||
| Rab27a | RAB27A, member RAS oncogene family | 0.014 | ||
| Gmfb | glia maturation factor, beta | 0.014 | ||
| Ryk | receptor-like tyrosine kinase | 0.013 | ||
| Pi4k2b | phosphatidylinositol 4-kinase type 2 beta | 0.013 | ||
| Hras | Harvey rat sarcoma virus oncogene | 0.013 | ||
| Myc | myelocytomatosis oncogene | 0.013 | ||
| Myo1c | myosin IC | 0.013 | ||
| Rad51c | Rad51 homolog c (S. cerevisiae) | 0.013 | ||
| Gins4 | GINS complex subunit 4 (Sld5 homolog) | 0.013 | ||
| Man1a1 | mannosidase, alpha, class 1A, member 1 | 0.013 | ||
| Cenpe | centromere protein E | 0.013 | ||
| Ube2m | ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) | 0.013 | ||
| Arl6ip6 | ADP-ribosylation-like factor 6 interacting protein 6 | 0.013 | ||
| Prdm4 | PR domain containing 4 | 0.012 | ||
| Dnajb1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.012 | ||
| Vapa | VAMP (vesicle-associated membrane protein)-associated protein A | 0.012 | ||
| Cep78 | centrosomal protein 78 | 0.012 | ||
| Cbx1 | chromobox homolog 1 (HP1 beta homolog Drosophila ) | 0.012 | ||
| Aurkb | aurora kinase B | 0.012 | ||
| Ctnnd2 | catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) | 0.012 | ||
| Lfng | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.012 | ||
| Hspa1l | heat shock protein 1-like | 0.012 | ||
| Akt3 | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 0.012 | ||
| Prkaa1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | 0.012 | ||
| Mgat2 | mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase | 0.012 | ||
| Armc6 | armadillo repeat containing 6 | 0.012 | ||
| Pkmyt1 | protein kinase, membrane associated tyrosine/threonine 1 | 0.012 | ||
| Appbp2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 0.012 | ||
| Grk5 | G protein-coupled receptor kinase 5 | 0.012 | ||
| Cdk1 | cyclin-dependent kinase 1 | 0.011 | ||
| Hectd1 | HECT domain containing 1 | 0.011 | ||
| Wdhd1 | WD repeat and HMG-box DNA binding protein 1 | 0.011 | ||
| Rcc2 | regulator of chromosome condensation 2 | 0.011 | ||
| Spin1 | spindlin 1 | 0.011 | ||
| Suv420h1 | suppressor of variegation 4-20 homolog 1 (Drosophila) | 0.011 | ||
| Rad51 | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 0.011 | ||
| Taok2 | TAO kinase 2 | 0.011 | ||
| Tspy1 | testis specific protein, Y-linked 1 | 0.011 | ||
| Eif5b | eukaryotic translation initiation factor 5B | 0.011 | ||
| Kpnb1 | karyopherin (importin) beta 1 | 0.011 | ||
| Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | 0.011 | ||
| Cenpn | centromere protein N | 0.011 | ||
| Kpna3 | karyopherin alpha 3 | 0.011 | ||
| Rala | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.011 | ||
| Foxd4 | forkhead box D4 | 0.011 | ||
| Lrch4 | leucine-rich repeats and calponin homology (CH) domain containing 4 | 0.011 | ||
| Rad54l | RAD54 like (S. cerevisiae) | 0.011 | ||
| Wbp11 | WW domain binding protein 11 | 0.011 | ||
| Gipc1 | GIPC PDZ domain containing family, member 1 | 0.011 | ||
| Myo1b | myosin Ib | 0.011 | ||
| Ate1 | arginyltransferase 1 | 0.011 | ||
| Rrad | Ras-related associated with diabetes | 0.011 | ||
| Bcr | breakpoint cluster region | 0.011 | ||
| Cul1 | cullin 1 | 0.011 | ||
| Chaf1b | chromatin assembly factor 1, subunit B (p60) | 0.011 | ||
| Ppp1r9a | protein phosphatase 1, regulatory (inhibitor) subunit 9A | 0.011 | ||
| Bnip2 | BCL2/adenovirus E1B interacting protein 2 | 0.011 | ||
| Cenpf | centromere protein F | 0.011 | ||
| Ska3 | spindle and kinetochore associated complex subunit 3 | 0.011 | ||
| Mtr | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.011 | ||
| Plcl1 | phospholipase C-like 1 | 0.011 | ||
| Cenpm | centromere protein M | 0.011 | ||
| Tmem138 | transmembrane protein 138 | 0.011 | ||
| Mre11a | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 0.011 | ||
| Pdpk1 | 3-phosphoinositide dependent protein kinase-1 | 0.011 | ||
| Rai14 | retinoic acid induced 14 | 0.011 | ||
| Rbpj | recombination signal binding protein for immunoglobulin kappa J region | 0.011 | ||
| Lenep | lens epithelial protein | 0.010 | ||
| Pdhb | pyruvate dehydrogenase (lipoamide) beta | 0.010 | ||
| Maoa | monoamine oxidase A | 0.010 | ||
| Ccng1 | cyclin G1 | 0.010 | ||
| RGD1306704 | hypothetical LOC295483 | 0.010 | ||
| Nfkbie | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.010 | ||
| Foxp4 | forkhead box P4 | 0.010 | ||
| Mxd3 | Max dimerization protein 3 | 0.010 | ||
| Rybp | RING1 and YY1 binding protein | 0.010 | ||
| Ddx46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.010 | ||
| Mapre3 | microtubule-associated protein, RP/EB family, member 3 | 0.010 | ||
| Crk | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.010 | ||
| Dhx9 | DEAH (Asp-Glu-Ala-His) box polypeptide 9 | 0.010 | ||
| Wbp2 | WW domain binding protein 2 | 0.010 | ||
| Cdc20 | cell division cycle 20 homolog (S. cerevisiae) | 0.010 | Human Yeast Worm Fly | |
| Gata3 | GATA binding protein 3 | 0.010 | ||
| Cul3 | cullin 3 | 0.010 | Human | |
| Basp1 | brain abundant, membrane attached signal protein 1 | 0.010 | ||
| Erlin1 | ER lipid raft associated 1 | 0.010 | ||
| Gopc | golgi associated PDZ and coiled-coil motif containing | 0.010 | ||
| Ptpru | protein tyrosine phosphatase, receptor type, U | 0.010 | ||
| Igfbp3 | insulin-like growth factor binding protein 3 | 0.010 | ||
| Sh3yl1 | SH3 domain containing, Ysc84-like 1 (S. cerevisiae) | 0.010 | ||
| Pola2 | polymerase (DNA directed), alpha 2 | 0.010 | ||
| Iqgap3 | IQ motif containing GTPase activating protein 3 | 0.010 | ||
| Nes | nestin | 0.010 |