IMP: Integrative Multi-species Prediction

Rattus norvegicus

150 genes annotated in rat

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "inflammatory response"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "inflammatory response" (in gray)

Name	Description	Probability	Func Analog Organism
Il1b	interleukin 1 beta	0.973
Cd14	CD14 molecule	0.899
Ccr5	chemokine (C-C motif) receptor 5	0.749
Pla2g4a	phospholipase A2, group IVA (cytosolic, calcium-dependent)	0.748
Slco2a1	solute carrier organic anion transporter family, member 2a1	0.739
Pla2g2a	phospholipase A2, group IIA (platelets, synovial fluid)	0.720
Cp	ceruloplasmin	0.695
Fn1	fibronectin 1	0.661
Tnf	tumor necrosis factor (TNF superfamily, member 2)	0.655
Apoa5	apolipoprotein A-V	0.632
Ccr2	chemokine (C-C motif) receptor 2	0.630
Il1rn	interleukin 1 receptor antagonist	0.596
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.591
Sell	selectin L	0.587	Rat
Ahsg	alpha-2-HS-glycoprotein	0.562
Lst1	leukocyte specific transcript 1	0.560
Timp1	TIMP metallopeptidase inhibitor 1	0.532
Cxcr5	chemokine (C-X-C motif) receptor 5	0.522	Rat
Ccl2	chemokine (C-C motif) ligand 2	0.522
Cxcl2	chemokine (C-X-C motif) ligand 2	0.507	Rat
Il1r1	interleukin 1 receptor, type I	0.505	Mouse
Ccl3	chemokine (C-C motif) ligand 3	0.504
Mmp9	matrix metallopeptidase 9	0.504
S100a8	S100 calcium binding protein A8	0.490
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.479	Rat
Ptafr	platelet-activating factor receptor	0.470	Mouse Rat
LOC293989	cytochrome P450-like	0.463
Cfd	complement factor D (adipsin)	0.456
Itgam	integrin, alpha M	0.455	Mouse Rat
Cd4	Cd4 molecule	0.454
Igsf6	immunoglobulin superfamily, member 6	0.434
Cxcl6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.433
Cxcl1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.432
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.429
Cd44	Cd44 molecule	0.424
Anxa2	annexin A2	0.417
Flt1	FMS-related tyrosine kinase 1	0.412
Itgad	integrin, alpha D	0.408	Rat
Agtr1a	angiotensin II receptor, type 1a	0.402	Mouse Rat
Socs3	suppressor of cytokine signaling 3	0.397	Mouse
Casp1	caspase 1	0.390	Mouse Rat
Mpeg1	macrophage expressed 1	0.388
A2m	alpha-2-macroglobulin	0.386
Stat3	signal transducer and activator of transcription 3	0.379
Met	met proto-oncogene	0.366
Cpb2	carboxypeptidase B2 (plasma)	0.365
Gzmk	granzyme K	0.364
Vom2r27	vomeronasal 2 receptor, 27	0.362
Crhbp	corticotropin releasing hormone binding protein	0.360
Alb	albumin	0.360
Folh1	folate hydrolase 1	0.358	Rat
Cd2	Cd2 molecule	0.356
Pon1	paraoxonase 1	0.355
Faslg	Fas ligand (TNF superfamily, member 6)	0.350	Rat
Lepr	leptin receptor	0.345
Hes2	hairy and enhancer of split 2 (Drosophila)	0.345
Adora2a	adenosine A2a receptor	0.340	Mouse Rat
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.337
Si	sucrase-isomaltase (alpha-glucosidase)	0.336
Ceacam10	carcinoembryonic antigen-related cell adhesion molecule 10	0.331
Mas1	MAS1 oncogene	0.325	Mouse
Mbl1	mannose-binding lectin (protein A) 1	0.324
Pcsk1	proprotein convertase subtilisin/kexin type 1	0.320
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.310	Rat
Vcan	versican	0.306
LOC24906	RoBo-1	0.304
Cfi	complement factor I	0.303
S1pr2	sphingosine-1-phosphate receptor 2	0.295
RT1-Ba	RT1 class II, locus Ba	0.294
Cfb	complement factor B	0.291
Ccl20	chemokine (C-C motif) ligand 20	0.291	Rat
Fga	fibrinogen alpha chain	0.289
Spink1	serine peptidase inhibitor, Kazal type 1	0.289
S100a9	S100 calcium binding protein A9	0.289
Aqp8	aquaporin 8	0.282
Adam17	ADAM metallopeptidase domain 17	0.281
Gc	group specific component	0.280
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.276	Rat
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.273
Il1r2	interleukin 1 receptor, type II	0.265
Gfap	glial fibrillary acidic protein	0.264
Neurl3	neuralized homolog 3 (Drosophila)	0.262
Ifi204	interferon activated gene 204	0.259
Trim47	tripartite motif-containing 47	0.258
Cckar	cholecystokinin A receptor	0.255
Ccl4	chemokine (C-C motif) ligand 4	0.252
Fcnb	ficolin B	0.245
Icam1	intercellular adhesion molecule 1	0.242
Jak1	Janus kinase 1	0.241
Kng1	kininogen 1	0.240
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.240
Iapp	islet amyloid polypeptide	0.238
Tfec	transcription factor EC	0.237
Apba1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.234
Proc	protein C	0.234
Il7r	interleukin 7 receptor	0.233
Serpini2	serine (or cysteine) peptidase inhibitor, clade I, member 2	0.232	Rat
Bcl2a1d	B-cell leukemia/lymphoma 2 related protein A1d	0.229
Il6	interleukin 6	0.228
Anxa1	annexin A1	0.224
Il4ra	interleukin 4 receptor, alpha	0.222
Gabrg1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	0.221
Rup2	urinary protein 2	0.217
Casp3	caspase 3	0.216	Rat
Sgp158	proline-rich glycoprotein (sgp158)	0.215
Gucy2d	guanylate cyclase 2d	0.215
Ccr1	chemokine (C-C motif) receptor 1	0.214
Cd38	CD38 molecule	0.214
Lif	leukemia inhibitory factor	0.214
Prrx1	paired related homeobox 1	0.214
Dnase1l3	deoxyribonuclease 1-like 3	0.212
Fxyd2	FXYD domain-containing ion transport regulator 2	0.211
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.211
Hpx	hemopexin	0.210
Gpx3	glutathione peroxidase 3	0.209
Fgg	fibrinogen gamma chain	0.206
Prl8a9	prolactin family 8, subfamily a, member 9	0.206
Cxcl10	chemokine (C-X-C motif) ligand 10	0.206	Rat
Aldob	aldolase B, fructose-bisphosphate	0.203
Cyp2d2	cytochrome P450, family 2, subfamily d, polypeptide 2	0.203
Aspg	asparaginase homolog (S. cerevisiae)	0.202
Fkbp4	FK506 binding protein 4	0.201
Aqp9	aquaporin 9	0.195
Psg19	pregnancy specific glycoprotein 19	0.194
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.194
Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.194
Hnrnpk	heterogeneous nuclear ribonucleoprotein K	0.193
Fgfr2	fibroblast growth factor receptor 2	0.190
Ednrb	endothelin receptor type B	0.189
Fxyd1	FXYD domain-containing ion transport regulator 1	0.188
Cpb1	carboxypeptidase B1 (tissue)	0.188
Il7	interleukin 7	0.186
Kcnj8	potassium inwardly-rectifying channel, subfamily J, member 8	0.184	Rat
Fcgrt	Fc fragment of IgG, receptor, transporter, alpha	0.184	Rat
Igsf7	immunoglobulin superfamily, member 7	0.184
Ifitm3	interferon induced transmembrane protein 3	0.182
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.181
Cd244	Cd244 molecule, natural killer cell receptor 2B4	0.181
Slc9a1	solute carrier family 9 (sodium/hydrogen exchanger), member 1	0.180
Crx	cone-rod homeobox	0.177
Ppbp	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.177	Mouse Rat
Hand2	heart and neural crest derivatives expressed 2	0.176
Foxa3	forkhead box A3	0.176
Trh	thyrotropin releasing hormone	0.176
Mmp3	matrix metallopeptidase 3	0.176
Plp1	proteolipid protein 1	0.174
Obp1f	odorant binding protein I f	0.172
Csn1s1	casein alpha s1	0.172
Il9r	interleukin 9 receptor	0.172
Hrh3	histamine receptor H3	0.171	Rat
Reg3b	regenerating islet-derived 3 beta	0.170
Cfp	complement factor properdin	0.170
Hnmt	histamine N-methyltransferase	0.168
F2	coagulation factor II (thrombin)	0.166
Cysltr2	cysteinyl leukotriene receptor 2	0.166	Rat
Pzp	pregnancy-zone protein	0.164	Rat
Serpina1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.164
Has2	hyaluronan synthase 2	0.164
Ptprz1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.163
Testin	testin gene	0.163
Alox5ap	arachidonate 5-lipoxygenase activating protein	0.162
Mcpt2	mast cell protease 2	0.162
Fshb	follicle stimulating hormone, beta polypeptide	0.161
Cyp2c23	cytochrome P450, family 2, subfamily c, polypeptide 23	0.161
Degs2	degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)	0.161
Il1a	interleukin 1 alpha	0.161
Gzmb	granzyme B	0.161
Tlr7	toll-like receptor 7	0.160
Ncr1	natural cytotoxicity triggering receptor 1	0.160
Gzmm	granzyme M (lymphocyte met-ase 1)	0.158
P2rx2	purinergic receptor P2X, ligand-gated ion channel, 2	0.158
Ifng	interferon gamma	0.158
Galr1	galanin receptor 1	0.158	Rat
Slc6a7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.158
Myh9	myosin, heavy chain 9, non-muscle	0.158
Apcs	amyloid P component, serum	0.157
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.155
Pebp1	phosphatidylethanolamine binding protein 1	0.155
Vcam1	vascular cell adhesion molecule 1	0.155
Nkg7	natural killer cell group 7 sequence	0.154
Apol3	apolipoprotein L, 3	0.154
Svs4	seminal vesicle secretory protein 4	0.153
Cacng8	calcium channel, voltage-dependent, gamma subunit 8	0.153
Cmtm6	CKLF-like MARVEL transmembrane domain containing 6	0.152
Plin	perilipin	0.150
Pla1a	phospholipase A1 member A	0.149
Lilrb4	leukocyte immunoglobulin-like receptor, subfamily B, member 4	0.149
Cd80	Cd80 molecule	0.148
Mcpt3	mast cell peptidase 3	0.147
C5ar1	complement component 5a receptor 1	0.147
C9	complement component 9	0.147
Agxt2	alanine-glyoxylate aminotransferase 2	0.147
Anpep	alanyl (membrane) aminopeptidase	0.146
Scn11a	sodium channel, voltage-gated, type XI, alpha	0.146
Rhox5	reproductive homeobox 5	0.146
LOC100364212	heterogeneous nuclear ribonucleoprotein K-like	0.146
Gpnmb	glycoprotein (transmembrane) nmb	0.146
Bcan	brevican	0.146
Ugt2b1	UDP glucuronosyltransferase 2 family, polypeptide B1	0.145	Rat
Notch3	Notch homolog 3 (Drosophila)	0.143
P2rx5	purinergic receptor P2X, ligand-gated ion channel, 5	0.142
Tcf21	transcription factor 21	0.142
RGD1310262	hypothetical LOC304650	0.142
S100a6	S100 calcium binding protein A6	0.141	Rat
Rab32	RAB32, member RAS oncogene family	0.141
Oprd1	opioid receptor, delta 1	0.141	Rat
Smr3a	submaxillary gland androgen regulated protein 3A	0.140
Hnf4a	hepatocyte nuclear factor 4, alpha	0.140	Rat
Slc6a12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.140
P2ry14	purinergic receptor P2Y, G-protein coupled, 14	0.139
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.139
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.138
Scn4a	sodium channel, voltage-gated, type IV, alpha subunit	0.138
Kl	Klotho	0.138
Tgm1	transglutaminase 1, K polypeptide	0.136	Rat
Fam38a	family with sequence similarity 38, member A	0.135
Rnase4	ribonuclease, RNase A family 4	0.135
Ifnb1	interferon beta 1, fibroblast	0.134
Asgr2	asialoglycoprotein receptor 2	0.132
Il8rb	interleukin 8 receptor, beta	0.132
Dao	D-amino-acid oxidase	0.132
Hoxa2	homeo box A2	0.132
Alox5	arachidonate 5-lipoxygenase	0.131
Itih3	inter-alpha trypsin inhibitor, heavy chain 3	0.131
Otp	orthopedia homeobox	0.130
Ereg	epiregulin	0.130
Grm6	glutamate receptor, metabotropic 6	0.130
Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	0.130	Rat
Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	0.129
Ltbp2	latent transforming growth factor beta binding protein 2	0.129
Uox	urate oxidase	0.128
Apob	apolipoprotein B	0.127
Glra1	glycine receptor, alpha 1	0.127
Serpinb5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	0.126
Il18	interleukin 18	0.126
Accn2	amiloride-sensitive cation channel 2, neuronal	0.125
Gabra3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.124
LOC259244	alpha-2u globulin PGCL3	0.124
Sstr2	somatostatin receptor 2	0.124	Rat
Cdkn2b	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.124
Scn10a	sodium channel, voltage-gated, type X, alpha subunit	0.123
Slc8a3	solute carrier family 8 (sodium/calcium exchanger), member 3	0.122
Notch2	Notch homolog 2 (Drosophila)	0.122	Mouse
Nfe2	nuclear factor, erythroid derived 2	0.122
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, beta 3	0.121
P2ry6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.121
Lbp	lipopolysaccharide binding protein	0.121	Human
Casp8	caspase 8	0.121	Rat
Ncan	neurocan	0.120
Kcnq3	potassium voltage-gated channel, KQT-like subfamily, member 3	0.120
Itpr2	inositol 1,4,5-triphosphate receptor, type 2	0.119
Ccl5	chemokine (C-C motif) ligand 5	0.119
Mrgprf	MAS-related GPR, member F	0.119
Gabrp	gamma-aminobutyric acid (GABA-A) receptor, pi	0.119
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.118
Ripk3	receptor-interacting serine-threonine kinase 3	0.118
Ecel1	endothelin converting enzyme-like 1	0.118
Foxe1	forkhead box E1 (thyroid transcription factor 2)	0.117
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.117
Mgst2	microsomal glutathione S-transferase 2	0.117	Rat
Cybb	cytochrome b-245, beta polypeptide	0.116
Plau	plasminogen activator, urokinase	0.116
Nrgn	neurogranin	0.115
Dok2	docking protein 2	0.114
Cd8a	CD8a molecule	0.114
Inhbc	inhibin beta C	0.114
Lrg1	leucine-rich alpha-2-glycoprotein 1	0.114
Rims1	regulating synaptic membrane exocytosis 1	0.114
Grpcb	glutamine/glutamic acid-rich protein A	0.113
Tlr4	toll-like receptor 4	0.113
Cldn7	claudin 7	0.113
Fabp1	fatty acid binding protein 1, liver	0.113
Phox2a	paired-like homeobox 2a	0.113
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.112
Sult2al1	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring-like 1	0.112
C4bpa	complement component 4 binding protein, alpha	0.112	Human Rat
Gja5	gap junction protein, alpha 5	0.112	Rat
Gad2	glutamate decarboxylase 2	0.112
Calcrl	calcitonin receptor-like	0.112
Bst1	bone marrow stromal cell antigen 1	0.111
Slc9a4	solute carrier family 9 (sodium/hydrogen exchanger), member 4	0.111
Gabra5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	0.111
Egfr	epidermal growth factor receptor	0.110
Myf6	myogenic factor 6	0.110
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.110
Fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.109	Rat
Myd88	myeloid differentiation primary response gene 88	0.109	Mouse
Dio2	deiodinase, iodothyronine, type II	0.109
Sst	somatostatin	0.109
Ucn2	urocortin 2	0.108
Oas1a	2'-5' oligoadenylate synthetase 1A	0.108
C1qc	complement component 1, q subcomponent, C chain	0.107
LOC100360019	hypothetical protein LOC100360019	0.107
Lcn2	lipocalin 2	0.107
Ptpn7	protein tyrosine phosphatase, non-receptor type 7	0.106
Kcnq2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.106
Galr3	galanin receptor 3	0.106
Sult1b1	sulfotransferase family, cytosolic, 1B, member 1	0.106
Ccl7	chemokine (C-C motif) ligand 7	0.105	Rat
Htr2b	5-hydroxytryptamine (serotonin) receptor 2B	0.105	Rat
Tdo2	tryptophan 2,3-dioxygenase	0.105
Bcl3	B-cell CLL/lymphoma 3	0.104
Cmklr1	chemokine-like receptor 1	0.104	Rat
Guca2a	guanylate cyclase activator 2a (guanylin)	0.104
Gpr1	G protein-coupled receptor 1	0.104
Hoxc8	homeo box C8	0.104
Cel	carboxyl ester lipase	0.104
Cxcr3	chemokine (C-X-C motif) receptor 3	0.103	Rat
Gper	G protein-coupled estrogen receptor 1	0.103	Human
Hsd3b5	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	0.103
Gal	galanin prepropeptide	0.103
Cdh22	cadherin 22	0.102
Slpi	secretory leukocyte peptidase inhibitor	0.102
Insrr	insulin receptor-related receptor	0.102
Gnat1	guanine nucleotide binding protein (G protein), alpha transducing 1	0.102
Sox17	SRY (sex determining region Y)-box 17	0.102
Ctsc	cathepsin C	0.101
F13a1	coagulation factor XIII, A1 polypeptide	0.101	Rat
Il1rap	interleukin 1 receptor accessory protein	0.099
Syt4	synaptotagmin IV	0.099
Cd3g	CD3 molecule, gamma	0.099
LOC100363783	rCG53773-like	0.099
Vdr	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.098	Rat
Ugt2b36	UDP glucuronosyltransferase 2 family, polypeptide B36	0.098	Rat
Clec4f	C-type lectin domain family 4, member f	0.098
Pmch	pro-melanin-concentrating hormone	0.097
Cyp4b1	cytochrome P450, family 4, subfamily b, polypeptide 1	0.097
Plg	plasminogen	0.097
Grm5	glutamate receptor, metabotropic 5	0.097
Calcr	calcitonin receptor	0.097	Rat
Atp12a	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	0.096
Lrrc4b	leucine rich repeat containing 4B	0.096
Cnga3	cyclic nucleotide gated channel alpha 3	0.096
Runx1	runt-related transcription factor 1	0.096
Mbp	myelin basic protein	0.095
Serpinb2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.095
Cd79b	Cd79b molecule, immunoglobulin-associated beta	0.095
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.095
Cd40lg	CD40 ligand	0.095
Il13ra1	interleukin 13 receptor, alpha 1	0.095
Mrc1	mannose receptor, C type 1	0.095
RGD1304644	similar to RIKEN cDNA 2310046K01	0.095
Abcc3	ATP-binding cassette, subfamily C (CFTR/MRP), member 3	0.095
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.094
Fgl2	fibrinogen-like 2	0.094
Fabp2	fatty acid binding protein 2, intestinal	0.094
Ddc	dopa decarboxylase (aromatic L-amino acid decarboxylase)	0.094
Gkn1	gastrokine 1	0.094
Fgf11	fibroblast growth factor 11	0.093
Gpr182	G protein-coupled receptor 182	0.093
Selp	selectin P	0.093
Prkg2	protein kinase, cGMP-dependent, type II	0.093
Cyp2c7	cytochrome P450, family 2, subfamily c, polypeptide 7	0.093
Ccl17	chemokine (C-C motif) ligand 17	0.093
Mapk6	mitogen-activated protein kinase 6	0.092
Gja4	gap junction protein, alpha 4	0.092	Rat
Clec2d	C-type lectin domain family 2, member d	0.092
Kcnj16	potassium inwardly-rectifying channel, subfamily J, member 16	0.092	Rat
Anxa4	annexin A4	0.091
Gpr125	G protein-coupled receptor 125	0.091
Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.090
Sele	selectin E	0.090
Apoh	apolipoprotein H (beta-2-glycoprotein I)	0.090	Rat
Cyp21a1	cytochrome P450, family 21, subfamily a, polypeptide 1	0.090
Cd53	Cd53 molecule	0.090
RGD1564327	similar to integrin alpha 8	0.090	Rat
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.090
Fcer1a	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	0.089
Olr1654	olfactory receptor 1654	0.089
Gfra2	GDNF family receptor alpha 2	0.089
Lyve1	lymphatic vessel endothelial hyaluronan receptor 1	0.089	Rat
Rhob	ras homolog gene family, member B	0.089
Smpdl3a	sphingomyelin phosphodiesterase, acid-like 3A	0.089
Serpina3m	serine (or cysteine) proteinase inhibitor, clade A, member 3M	0.089	Rat
Myo1a	myosin IA	0.089
Itgb7	integrin, beta 7	0.089	Rat
Nlrp6	NLR family, pyrin domain containing 6	0.089
Cd40	CD40 molecule, TNF receptor superfamily member 5	0.089
Mmp8	matrix metallopeptidase 8	0.089
Efnb1	ephrin B1	0.088
Mmp12	matrix metallopeptidase 12	0.088
Cyp2c12	cytochrome P450, family 2, subfamily c, polypeptide 12	0.088
Pik3cd	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.088
Slc10a1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.088
Morf4l2	mortality factor 4 like 2	0.088
Vegp2	von Ebners gland protein 2	0.087
Sod2	superoxide dismutase 2, mitochondrial	0.087
Calca	calcitonin-related polypeptide alpha	0.087
Semg1	semenogelin I	0.087
Rarres2	retinoic acid receptor responder (tazarotene induced) 2	0.087
Padi3	peptidyl arginine deiminase, type III	0.086
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.086
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.086	Rat
Hoxa1	homeo box A1	0.085
Mstn	myostatin	0.085
Rarb	retinoic acid receptor, beta	0.085
Cdh6	cadherin 6	0.085
Ngf	nerve growth factor (beta polypeptide)	0.085
Dmgdh	dimethylglycine dehydrogenase	0.085
Hcrtr1	hypocretin (orexin) receptor 1	0.084	Rat
Gch1	GTP cyclohydrolase 1	0.084
Fut2	fucosyltransferase 2 (secretor status included)	0.084
Ces1c	carboxylesterase 1C	0.084
C1qtnf1	C1q and tumor necrosis factor related protein 1	0.084
Col10a1	collagen, type X, alpha 1	0.084
Ugt1a5	UDP glucuronosyltransferase 1 family, polypeptide A5	0.083	Rat
Abcc2	ATP-binding cassette, subfamily C (CFTR/MRP), member 2	0.083
Mog	myelin oligodendrocyte glycoprotein	0.083
Wdr1	WD repeat domain 1	0.083
Xcl1	chemokine (C motif) ligand 1	0.083	Human Rat
Ccl28	chemokine (C-C motif) ligand 28	0.083
C3ar1	complement component 3a receptor 1	0.082	Rat
Ambp	alpha-1-microglobulin/bikunin precursor	0.082
Cd200r1	CD200 receptor 1	0.082
Ppyr1	pancreatic polypeptide receptor 1	0.082	Rat
Slc12a1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	0.082
Plscr1	phospholipid scramblase 1	0.081
Haao	3-hydroxyanthranilate 3,4-dioxygenase	0.081
Cacna1d	calcium channel, voltage-dependent, L type, alpha 1D subunit	0.081
Ifna1	interferon-alpha 1	0.081
Pax6	paired box 6	0.081
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.081
Adra1b	adrenergic, alpha-1B-, receptor	0.081
Ntsr2	neurotensin receptor 2	0.081
Creb1	cAMP responsive element binding protein 1	0.081
Btc	betacellulin	0.081
Man2b1	mannosidase, alpha, class 2B, member 1	0.081
Fgf18	fibroblast growth factor 18	0.081
Gnat3	guanine nucleotide binding protein, alpha transducing 3	0.081
Kcna5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.081
Lrrc33	leucine rich repeat containing 33	0.080	Mouse
Uncx	UNC homeobox	0.080
Gcgr	glucagon receptor	0.080	Rat
Slc1a2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.080
Gpr88	G-protein coupled receptor 88	0.080
Rbp4	retinol binding protein 4, plasma	0.080
Sstr4	somatostatin receptor 4	0.080
Grpr	gastrin releasing peptide receptor	0.079	Rat
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.079
Clca4	chloride channel accessory 4	0.079
Havcr1	hepatitis A virus cellular receptor 1	0.079
Fgf16	fibroblast growth factor 16	0.078
Sult2a2	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2	0.078
Gcnt3	glucosaminyl (N-acetyl) transferase 3, mucin type	0.078
Mr1	major histocompatibility complex, class I-related	0.078	Rat
S100a4	S100 calcium-binding protein A4	0.078	Rat
Ppy	pancreatic polypeptide	0.078
Gad1	glutamate decarboxylase 1	0.077
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.077
Slc6a1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.077
Rarres1	retinoic acid receptor responder (tazarotene induced) 1	0.077
Arl11	ADP-ribosylation factor-like 11	0.077
Sim1	single-minded homolog 1 (Drosophila)	0.077
Efemp1	EGF-containing fibulin-like extracellular matrix protein 1	0.077
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.077
Oprm1	opioid receptor, mu 1	0.076
Nrarp	Notch-regulated ankyrin repeat protein	0.076
Serpina11	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	0.076	Rat
Cxcl3	chemokine (C-X-C motif) ligand 3	0.076
C3	complement component 3	0.076
Nmur1	neuromedin U receptor 1	0.076
Gcm1	glial cells missing homolog 1 (Drosophila)	0.076
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.075
Tbxas1	thromboxane A synthase 1, platelet	0.075
Smad1	SMAD family member 1	0.075
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.075
Slco2b1	solute carrier organic anion transporter family, member 2b1	0.075
Pcyt1b	phosphate cytidylyltransferase 1, choline, beta	0.075
Olr1468	olfactory receptor 1468	0.075
C1s	complement component 1, s subcomponent	0.075
Slc1a3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	0.075
Tnni3	troponin I type 3 (cardiac)	0.075
Dusp4	dual specificity phosphatase 4	0.075
Cd3e	CD3 molecule, epsilon	0.074
Chrna3	cholinergic receptor, nicotinic, alpha 3	0.074
Cdk2	cyclin dependent kinase 2	0.074
Cadps	Ca++-dependent secretion activator	0.074
Hpgds	hematopoietic prostaglandin D synthase	0.074
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.074
Gata6	GATA binding protein 6	0.074
Tgif1	TGFB-induced factor homeobox 1	0.074
Tpsb2	tryptase beta 2	0.074
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.074
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b	0.074	Rat
Rab3b	RAB3B, member RAS oncogene family	0.074
LOC100360587	hypothetical protein LOC100360587	0.074
Sirpa	signal-regulatory protein alpha	0.073
Tmem37	transmembrane protein 37	0.073
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.073
Arid5a	AT rich interactive domain 5A (Mrf1 like)	0.073
Adar	adenosine deaminase, RNA-specific	0.073
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.073	Rat
Kitlg	KIT ligand	0.073
Tac2	tachykinin 2	0.072
Pgam1	phosphoglycerate mutase 1 (brain)	0.072
Prlh	prolactin releasing hormone	0.072
Ccnd3	cyclin D3	0.072
Pemt	phosphatidylethanolamine N-methyltransferase	0.072
Thpo	thrombopoietin	0.072
C8b	complement component 8, beta polypeptide	0.072
Htr3a	5-hydroxytryptamine (serotonin) receptor 3a	0.072
Acmsd	aminocarboxymuconate semialdehyde decarboxylase	0.072
Lrp1	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	0.071
Eif4h	eukaryotic translation initiation factor 4H	0.071
Psg29	pregnancy-specific glycoprotein 29	0.071
RGD1559748	similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)	0.071
Prp15	proline-rich protein 15	0.071
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.071	Mouse
RGD1307396	similar to RIKEN cDNA 6330406I15	0.071
Acox2	acyl-Coenzyme A oxidase 2, branched chain	0.071
Olr1082	olfactory receptor 1082	0.071
Mc4r	melanocortin 4 receptor	0.071
Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11	0.070
Abi3	ABI family, member 3	0.070
Neurog3	neurogenin 3	0.070
RT1-EC2	RT1 class Ib, locus EC2	0.070
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.070
Pou5f2	POU domain class 5, transcription factor 2	0.070
Ptma	prothymosin alpha	0.070
Btf3	basic transcription factor 3	0.070
Lmna	lamin A	0.070
Aqp4	aquaporin 4	0.070
LOC286992	peptide HP (rs14)	0.070
Serpina4	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	0.070	Rat
LOC100360169	rCG21044-like	0.069
Shank2	SH3 and multiple ankyrin repeat domains 2	0.069
Klf13	Kruppel-like factor 13	0.069
Cntn3	contactin 3 (plasmacytoma associated)	0.069
LOC299282	Serine protease inhibitor	0.069	Rat
Rcsd1	RCSD domain containing 1	0.068
Nov	nephroblastoma overexpressed gene	0.068
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.068
Clu	clusterin	0.068
Cdkn1a	cyclin-dependent kinase inhibitor 1A	0.068
Foxg1	forkhead box G1	0.068
Prap1	proline-rich acidic protein 1	0.068
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.068	Rat
Psp	parotid secretory protein	0.068
F12	coagulation factor XII (Hageman factor)	0.067	Human
Prf1	perforin 1 (pore forming protein)	0.067
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.067
Gpr173	G-protein coupled receptor 173	0.067
Fibcd1	fibrinogen C domain containing 1	0.067
Ppap2b	phosphatidic acid phosphatase type 2B	0.067
Dgkg	diacylglycerol kinase, gamma	0.067
Prss1	protease, serine, 1 (trypsin 1)	0.067
Cd5	Cd5 molecule	0.067
Rrad	Ras-related associated with diabetes	0.067
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.067
Igf1	insulin-like growth factor 1	0.066
Oprl1	opiate receptor-like 1	0.066	Rat
Kif6	kinesin family member 6	0.066
Cyp3a2	cytochrome P450, family 3, subfamily a, polypeptide 2	0.066
Trhr	thyrotropin releasing hormone receptor	0.066
Csf1	colony stimulating factor 1 (macrophage)	0.066
Cd48	Cd48 molecule	0.066
Gabrb1	gamma-aminobutyric acid (GABA) A receptor, beta 1	0.066
Odf4	outer dense fiber of sperm tails 4	0.066
Tusc5	tumor suppressor candidate 5	0.066
Nrg1	neuregulin 1	0.066
Kmo	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.066
Pgcp	plasma glutamate carboxypeptidase	0.066
LOC100361864	UDP-glucuronosyltransferase 2B3-like	0.066
Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	0.066
Gckr	glucokinase (hexokinase 4) regulator	0.065
Cntn1	contactin 1	0.065
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	0.065
Ralgds	ral guanine nucleotide dissociation stimulator	0.065
Guca1b	guanylate cyclase activator 1B	0.065
Pros1	protein S (alpha)	0.065
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.064
RGD1305793	similar to hypothetical protein FLJ20154	0.064
Il33	interleukin 33	0.064
Bmpr1a	bone morphogenetic protein receptor, type IA	0.064
Ch25h	cholesterol 25-hydroxylase	0.064
Figf	c-fos induced growth factor	0.064
Arhgap4	Rho GTPase activating protein 4	0.064
Cd86	CD86 molecule	0.064
Prkch	protein kinase C, eta	0.064
RGD1559588	similar to cell surface receptor FDFACT	0.064
Fli1	Friend leukemia virus integration 1	0.064
Tcf4	transcription factor 4	0.064
Capg	capping protein (actin filament), gelsolin-like	0.063
Slc12a5	solute carrier family 12 (potassium-chloride transporter), member 5	0.063
Adora1	adenosine A1 receptor	0.063
Clec9a	C-type lectin domain family 9, member a	0.063	Rat
Hif1a	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.063	Mouse
Il2rb	interleukin 2 receptor, beta	0.063
Adam5	a disintegrin and metallopeptidase domain 5	0.063
Bcl2	B-cell CLL/lymphoma 2	0.063
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.063
Marcks	myristoylated alanine rich protein kinase C substrate	0.063
Ube2d4	ubiquitin-conjugating enzyme E2D 4	0.063
Krt12	keratin 12	0.063
Tgm2	transglutaminase 2, C polypeptide	0.063
C2	complement component 2	0.063
Dmbt1	deleted in malignant brain tumors 1	0.063
Hck	hemopoietic cell kinase	0.063	Rat
Rpe65	retinal pigment epithelium 65	0.063
Capn9	calpain 9	0.063
Rasgrf2	RAS protein-specific guanine nucleotide-releasing factor 2	0.062
Inpp5d	inositol polyphosphate-5-phosphatase D	0.062
Ldb3	LIM domain binding 3	0.062
Asl	argininosuccinate lyase	0.062
LOC100360986	mCG1035404-like	0.062
Ptger4	prostaglandin E receptor 4 (subtype EP4)	0.062
Slc30a2	solute carrier family 30 (zinc transporter), member 2	0.062
Crhr1	corticotropin releasing hormone receptor 1	0.062	Rat
Crisp2	cysteine-rich secretory protein 2	0.062
Star	steroidogenic acute regulatory protein	0.061
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.061
Cnp	2',3'-cyclic nucleotide 3' phosphodiesterase	0.061
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.061	Rat
Akr1c14	aldo-keto reductase family 1, member C14	0.061
Hspb1	heat shock protein 1	0.061
Rho	rhodopsin	0.061
Sycp1	synaptonemal complex protein 1	0.061
RGD1560559	similar to RIKEN cDNA 2310042E22	0.061
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.061	Rat
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.061	Rat
Tpo	thyroid peroxidase	0.061
Musk	muscle, skeletal, receptor tyrosine kinase	0.061	Rat
Oas1b	2-5 oligoadenylate synthetase 1B	0.061
Mchr1	melanin-concentrating hormone receptor 1	0.061
Rhd	Rh blood group, D antigen	0.061
Csn2	casein beta	0.061
Myo9b	myosin IXb	0.060
F9	coagulation factor IX	0.060
Slc9a2	solute carrier family 9 (sodium/hydrogen exchanger), member 2	0.060
Slc28a3	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3	0.060
Lypd3	Ly6/Plaur domain containing 3	0.060
Spink3	serine peptidase inhibitor, Kazal type 3	0.060
Pcsk9	proprotein convertase subtilisin/kexin type 9	0.060
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.060
Sepp1	selenoprotein P, plasma, 1	0.060
Ncf1	neutrophil cytosolic factor 1	0.060
Clec4a1	C-type lectin domain family 4, member a1	0.060
Acox3	acyl-Coenzyme A oxidase 3, pristanoyl	0.060
Aqp5	aquaporin 5	0.060
Scnn1b	sodium channel, nonvoltage-gated 1, beta	0.060
Zcwpw1	zinc finger, CW-type with PWWP domain 1	0.060
Vim	vimentin	0.060
Abcg5	ATP-binding cassette, subfamily G (WHITE), member 5	0.060
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.059	Rat
Kcna3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.059
Vip	vasoactive intestinal peptide	0.059
Znf483	zinc finger protein 483	0.059
Hp	haptoglobin	0.059
Prl8a2	prolactin family 8, subfamily a, member 2	0.059
RGD1309873	similar to hypothetical protein BC010003	0.059
Itga5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.059	Rat
Prdx1	peroxiredoxin 1	0.059
Il6st	interleukin 6 signal transducer	0.059
Lims1	LIM and senescent cell antigen-like domains 1	0.059
Clstn3	calsyntenin 3	0.059
Abcd1	ATP-binding cassette, subfamily D (ALD), member 1	0.059
Qpct	glutaminyl-peptide cyclotransferase	0.059
Gng7	guanine nucleotide binding protein (G protein), gamma 7	0.059
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.059
Vom1r101	vomeronasal 1 receptor 101	0.059
Ins1	insulin 1	0.059
Samsn1	SAM domain, SH3 domain and nuclear localization signals, 1	0.059
Lipe	lipase, hormone sensitive	0.059
Des	desmin	0.058
Chrne	cholinergic receptor, nicotinic, epsilon	0.058
C6	complement component 6	0.058	Mouse
Fkbp10	FK506 binding protein 10	0.058
Fgf1	fibroblast growth factor 1	0.058
Grin2c	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.058
Krt14	keratin 14	0.058
Epn2	epsin 2	0.058
Fgf21	fibroblast growth factor 21	0.058
Fosl1	fos-like antigen 1	0.058
Gpr6	G protein-coupled receptor 6	0.058
Il1rl1	interleukin 1 receptor-like 1	0.057	Mouse
Pex1	peroxisomal biogenesis factor 1	0.057
Slc22a18	solute carrier family 22, member 18	0.057
Gsta3	glutathione S-transferase A3	0.057
LOC680875	similar to dystonin isoform 1	0.057
Ugt2b7	UDP glucuronosyltransferase 2 family, polypeptide B7	0.057	Rat
Ugdh	UDP-glucose dehydrogenase	0.057
Trhr2	thyrotropin releasing hormone receptor 2	0.057
Hnrnpf	heterogeneous nuclear ribonucleoprotein F	0.057
Ttll9	tubulin tyrosine ligase-like family, member 9	0.057
Rab10	RAB10, member RAS oncogene family	0.057
Plaur	plasminogen activator, urokinase receptor	0.057
Calm1	calmodulin 1	0.057
Sp1	Sp1 transcription factor	0.057
Rhov	ras homolog gene family, member V	0.057
Sod1	superoxide dismutase 1, soluble	0.056
Aebp1	AE binding protein 1	0.056
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	0.056	Rat
RGD1564865	similar to 20-alpha-hydroxysteroid dehydrogenase	0.056
Ddx17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.056
Krtap1-5	keratin associated protein 1-5	0.056
Bcar1	breast cancer anti-estrogen resistance 1	0.056
Dclk2	doublecortin-like kinase 2	0.056
Fcgr3a	Fc fragment of IgG, low affinity IIIa, receptor	0.056
Tifa	TRAF-interacting protein with forkhead-associated domain	0.056
Sh3tc1	SH3 domain and tetratricopeptide repeats 1	0.056
Gimap4	GTPase, IMAP family member 4	0.056
Mamdc4	MAM domain containing 4	0.056
Dact3	dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)	0.055
Cyp2a1	cytochrome P450, family 2, subfamily a, polypeptide 1	0.055
Il9	interleukin 9	0.055
Tuba1c	tubulin, alpha 1C	0.055
Camkv	CaM kinase-like vesicle-associated	0.055
Gda	guanine deaminase	0.055
Krt31	keratin 31	0.055
Nod1	nucleotide-binding oligomerization domain containing 1	0.055	Rat
Erap1	endoplasmic reticulum aminopeptidase 1	0.054
Nckap1	NCK-associated protein 1	0.054
Hrh1	histamine receptor H 1	0.054
LOC100364854	similar to RIKEN cDNA A430107P09 gene-like	0.054
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.054	Rat
Adarb2	adenosine deaminase, RNA-specific, B2	0.054
Rhobtb2	Rho-related BTB domain containing 2	0.054
Gpr114	G protein-coupled receptor 114	0.054
Ptk2b	PTK2B protein tyrosine kinase 2 beta	0.054
Alox12e	arachidonate 12-lipoxygenase, epidermal	0.054	Rat
Itgb3	integrin, beta 3	0.054
Ugt1a7c	UDP glucuronosyltransferase 1 family, polypeptide A7C	0.054	Rat
Slc18a3	solute carrier family 18 (vesicular acetylcholine), member 3	0.054
Slc22a7	solute carrier family 22 (organic anion transporter), member 7	0.054
Cyp2c22	cytochrome P450, family 2, subfamily c, polypeptide 22	0.054
Cnksr2	connector enhancer of kinase suppressor of Ras 2	0.053
Mycs	myc-like oncogene, s-myc protein	0.053
Nmur2	neuromedin U receptor 2	0.053
Adamts4	ADAM metallopeptidase with thrombospondin type 1 motif, 4	0.053
Mk1	Mk1 protein	0.053
Dnah2	dynein, axonemal, heavy chain 2	0.053
Gabrr3	gamma-aminobutyric acid (GABA) receptor, rho 3	0.053
Cd37	CD37 molecule	0.053
Pou3f2	POU class 3 homeobox 2	0.053
Cyp2g1	cytochrome P450, family 2, subfamily g, polypeptide 1	0.053
Neurog1	neurogenin 1	0.053
Tbxa2r	thromboxane A2 receptor	0.053
Stat2	signal transducer and activator of transcription 2	0.053	Rat
Gucy2e	guanylate cyclase 2E	0.053
Cryba4	crystallin, beta A4	0.053
Pafah1b2	platelet-activating factor acetylhydrolase, isoform 1b, subunit 2	0.053
Dlk1	delta-like 1 homolog (Drosophila)	0.053
Kcng2	potassium voltage-gated channel, subfamily G, member 2	0.053
Fcn1	ficolin (collagen/fibrinogen domain containing) 1	0.052
Hcst	hematopoietic cell signal transducer	0.052
Bgn	biglycan	0.052
Nap1l5	nucleosome assembly protein 1-like 5	0.052
Cd22	CD22 molecule	0.052
Ucn	urocortin	0.052
C4b	complement component 4B (Chido blood group)	0.052	Rat