IMP: Integrative Multi-species Prediction

Rattus norvegicus

25 genes annotated in rat

Multi-species View

positive regulation of lymphocyte activation

GO:0051251

Any process that activates or increases the frequency, rate or extent of lymphocyte activation.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of lymphocyte activation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of lymphocyte activation" (in gray)

Name	Description	Probability	Func Analog Organism
RT1-Da	RT1 class II, locus Da	0.658
RT1-Ba	RT1 class II, locus Ba	0.436	Mouse
Cd37	CD37 molecule	0.416
Cd247	Cd247 molecule	0.311
RT1-Bb	RT1 class II, locus Bb	0.302	Mouse
RT1-Db1	RT1 class II, locus Db1	0.270
Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.248
Itgb7	integrin, beta 7	0.189
Cd5	Cd5 molecule	0.140
Ptprc	protein tyrosine phosphatase, receptor type, C	0.102	Human Mouse
Cd2	Cd2 molecule	0.086
Il2rb	interleukin 2 receptor, beta	0.081
Calcr	calcitonin receptor	0.075
Il2rg	interleukin 2 receptor, gamma	0.070
RT1-DMb	RT1 class II, locus DMb	0.061
Ptger4	prostaglandin E receptor 4 (subtype EP4)	0.057
Ciita	class II, major histocompatibility complex, transactivator	0.057
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.055
Reg3g	regenerating islet-derived 3 gamma	0.055
Il10	interleukin 10	0.055
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.049
Calcrl	calcitonin receptor-like	0.045
Kcnv1	potassium channel, subfamily V, member 1	0.045
Ccr5	chemokine (C-C motif) receptor 5	0.045
Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	0.043
Map4k1	mitogen activated protein kinase kinase kinase kinase 1	0.043
Zbp1	Z-DNA binding protein 1	0.043
Cxcr3	chemokine (C-X-C motif) receptor 3	0.041
Scn11a	sodium channel, voltage-gated, type XI, alpha	0.039
Tcrb	T-cell receptor beta chain	0.039
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.039
Fmnl1	formin-like 1	0.038
Il1b	interleukin 1 beta	0.038
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.037
Ptafr	platelet-activating factor receptor	0.036
Cd38	CD38 molecule	0.036
Nkg7	natural killer cell group 7 sequence	0.035
Gzmk	granzyme K	0.035
Cd53	Cd53 molecule	0.034
Alox5	arachidonate 5-lipoxygenase	0.034
Napsa	napsin A aspartic peptidase	0.033
Vip	vasoactive intestinal peptide	0.032
Socs3	suppressor of cytokine signaling 3	0.030
Add2	adducin 2 (beta)	0.030
Casp1	caspase 1	0.030
Icos	inducible T-cell co-stimulator	0.029
Cd3g	CD3 molecule, gamma	0.029
Arhgap4	Rho GTPase activating protein 4	0.029
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.029
Prl8a9	prolactin family 8, subfamily a, member 9	0.029
Cd22	CD22 molecule	0.029
Flt1	FMS-related tyrosine kinase 1	0.028
Dnase1l3	deoxyribonuclease 1-like 3	0.028
Il6	interleukin 6	0.028
Arrb2	arrestin, beta 2	0.027
Mmp10	matrix metallopeptidase 10	0.027
Kcnh7	potassium voltage-gated channel, subfamily H (eag-related), member 7	0.027
Gja4	gap junction protein, alpha 4	0.027
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.026
Csn1s1	casein alpha s1	0.026
Il17ra	interleukin 17 receptor A	0.025
Met	met proto-oncogene	0.025
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.025
Itgad	integrin, alpha D	0.024
Il9r	interleukin 9 receptor	0.024
Cd4	Cd4 molecule	0.024	Mouse
Cfp	complement factor properdin	0.024
Csf1	colony stimulating factor 1 (macrophage)	0.024
Il6st	interleukin 6 signal transducer	0.023	Human
Kl	Klotho	0.023
Spn	sialophorin	0.023
Gdnf	glial cell derived neurotrophic factor	0.022
Il1r1	interleukin 1 receptor, type I	0.022
Rin1	Ras and Rab interactor 1	0.022
Aif1	allograft inflammatory factor 1	0.022	Human
Dock8	dedicator of cytokinesis 8	0.021
Npy5r	neuropeptide Y receptor Y5	0.021	Rat
Psp	parotid secretory protein	0.020
Syt8	synaptotagmin VIII	0.020
Ccl5	chemokine (C-C motif) ligand 5	0.020	Human
Prkcq	protein kinase C, theta	0.020	Mouse
Slfn2	schlafen 2	0.020
Olr1500	olfactory receptor 1500	0.020
Inpp5d	inositol polyphosphate-5-phosphatase D	0.020	Mouse
Il2ra	interleukin 2 receptor, alpha	0.019
Hmha1	histocompatibility (minor) HA-1	0.019
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.019
Psd4	pleckstrin and Sec7 domain containing 4	0.019
Apol3	apolipoprotein L, 3	0.019
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.019
Sell	selectin L	0.019
Hcst	hematopoietic cell signal transducer	0.019
Ereg	epiregulin	0.019
Ido1	indoleamine 2,3-dioxygenase 1	0.019
Ly6g6c	lymphocyte antigen 6 complex, locus G6C	0.018
Srd5a2	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)	0.018
Nek9	NIMA (never in mitosis gene a)- related kinase 9	0.018
Faslg	Fas ligand (TNF superfamily, member 6)	0.018
Cd74	Cd74 molecule, major histocompatibility complex, class II invariant chain	0.018	Human Mouse
Il7r	interleukin 7 receptor	0.018
Laptm5	lysosomal protein transmembrane 5	0.018
Anpep	alanyl (membrane) aminopeptidase	0.018
Gzmf	granzyme F	0.018
Plin	perilipin	0.018
Testin	testin gene	0.018
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.017
Mca32	mast cell antigen 32	0.017
Lepr	leptin receptor	0.017
Gpr114	G protein-coupled receptor 114	0.017
Gfra2	GDNF family receptor alpha 2	0.017
Casp3	caspase 3	0.017
Trpm8	transient receptor potential cation channel, subfamily M, member 8	0.017
Efnb1	ephrin B1	0.017
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.017
Mamdc4	MAM domain containing 4	0.017
Rgs14	regulator of G-protein signaling 14	0.016
Ctsj	cathepsin J	0.016
Fam26f	family with sequence similarity 26, member F	0.016
Cd83	CD83 molecule	0.016
Crhbp	corticotropin releasing hormone binding protein	0.016
Scp2	sterol carrier protein 2	0.016
Mobp	myelin-associated oligodendrocyte basic protein	0.016
Iqgap1	IQ motif containing GTPase activating protein 1	0.016
Slco1a5	solute carrier organic anion transporter family, member 1a5	0.016
Ndufs1	NADH dehydrogenase (ubiquinone) Fe-S protein 1	0.016
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.015
Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.015	Rat
Clic5	chloride intracellular channel 5	0.015
Arrb1	arrestin, beta 1	0.015
Gimap4	GTPase, IMAP family member 4	0.015
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.015
Pde6h	phosphodiesterase 6H, cGMP-specific, cone, gamma	0.015
Fgf15	fibroblast growth factor 15	0.015
Zcwpw1	zinc finger, CW-type with PWWP domain 1	0.015
P2rx2	purinergic receptor P2X, ligand-gated ion channel, 2	0.015
Hdac7	histone deacetylase 7	0.015
Prkcb	protein kinase C, beta	0.015
RGD1559748	similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)	0.015
Pax8	paired box 8	0.014
Reg3b	regenerating islet-derived 3 beta	0.014
Map3k3	mitogen activated protein kinase kinase kinase 3	0.014
Kif6	kinesin family member 6	0.014
Fgfr2	fibroblast growth factor receptor 2	0.014
Ccr2	chemokine (C-C motif) receptor 2	0.014	Mouse
Adrb1	adrenergic, beta-1-, receptor	0.014
Lifr	leukemia inhibitory factor receptor alpha	0.014
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.014
Cd8a	CD8a molecule	0.014
Il5ra	interleukin 5 receptor, alpha	0.014	Rat
Myl1	myosin, light chain 1	0.014
RT1-M3-1	RT1 class Ib, locus M3, gene 1	0.014
Serpinb2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.014
Chrne	cholinergic receptor, nicotinic, epsilon	0.014
Fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.014
Rxra	retinoid X receptor alpha	0.014
Ptpro	protein tyrosine phosphatase, receptor type, O	0.014
Cxcr4	chemokine (C-X-C motif) receptor 4	0.014
Fgf11	fibroblast growth factor 11	0.013
Gpr182	G protein-coupled receptor 182	0.013
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.013
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.013
Scn4a	sodium channel, voltage-gated, type IV, alpha subunit	0.013
Psbpc2	prostatic steroid-binding protein C2	0.013
Acr	acrosin	0.013
Tnf	tumor necrosis factor (TNF superfamily, member 2)	0.013
RGD1559588	similar to cell surface receptor FDFACT	0.013
Olr1078	olfactory receptor 1078	0.013
Il1rl2	interleukin 1 receptor-like 2	0.013	Mouse
Cxcl9	chemokine (C-X-C motif) ligand 9	0.013
Phemx	pan hematopoietic expression	0.013
Ddr1	discoidin domain receptor tyrosine kinase 1	0.013
Runx3	runt-related transcription factor 3	0.013
Pth	parathyroid hormone	0.013
Lat	linker for activation of T cells	0.013
Arhgap25	Rho GTPase activating protein 25	0.013
Col10a1	collagen, type X, alpha 1	0.013
Impg2	interphotoreceptor matrix proteoglycan 2	0.013
Tm4sf20	transmembrane 4 L six family member 20	0.013
Ugt2b7	UDP glucuronosyltransferase 2 family, polypeptide B7	0.013
Lypd3	Ly6/Plaur domain containing 3	0.013
Cd8b	CD8b molecule	0.012
Kcns1	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1	0.012
Il16	interleukin 16	0.012
Sh2d1a	SH2 domain protein 1A	0.012
Prf1	perforin 1 (pore forming protein)	0.012
Slc36a2	solute carrier family 36 (proton/amino acid symporter), member 2	0.012
Slco2b1	solute carrier organic anion transporter family, member 2b1	0.012
Aqp5	aquaporin 5	0.012
Mmp12	matrix metallopeptidase 12	0.012
Pecam1	platelet/endothelial cell adhesion molecule 1	0.012
Egr3	early growth response 3	0.012	Mouse
Arl5c	ADP-ribosylation factor-like 5C	0.012
Ugt8	UDP glycosyltransferase 8	0.012
Itgb4	integrin, beta 4	0.012
Il1rl1	interleukin 1 receptor-like 1	0.012
Smad1	SMAD family member 1	0.011
Lrrc33	leucine rich repeat containing 33	0.011
Abcc2	ATP-binding cassette, subfamily C (CFTR/MRP), member 2	0.011
Nrg1	neuregulin 1	0.011
Crh	corticotropin releasing hormone	0.011
Slc10a2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	0.011
B4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.011
Inhbe	inhibin beta E	0.011
Sat1	spermidine/spermine N1-acetyl transferase 1	0.011
Lgals8	lectin, galactoside-binding, soluble, 8	0.011
Prss22	protease, serine, 22	0.011
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.011
RGD1561143	similar to cell surface receptor FDFACT	0.011
Svs3a	seminal vesicle secretory protein 3A	0.011
Gabrr2	gamma-aminobutyric acid (GABA) receptor, rho 2	0.011
Ncr1	natural cytotoxicity triggering receptor 1	0.011
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.011
Fam65b	family with sequence similarity 65, member B	0.011
Lef1	lymphoid enhancer binding factor 1	0.011
Cd7	Cd7 molecule	0.011
Prm1	protamine 1	0.011
Fgf10	fibroblast growth factor 10	0.011	Human
Tgfbr3	transforming growth factor, beta receptor III	0.011
Mcpt2	mast cell protease 2	0.011
Matk	megakaryocyte-associated tyrosine kinase	0.011
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.011	Rat
Pou2af1	POU class 2 associating factor 1	0.011
Hck	hemopoietic cell kinase	0.011
Prlh	prolactin releasing hormone	0.011
Pbsn	probasin	0.011
Dtx3l	deltex 3-like (Drosophila)	0.011
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.010
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.010
Sele	selectin E	0.010
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.010
Grap2	GRB2-related adaptor protein 2	0.010
Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	0.010
Hbp1	HMG-box transcription factor 1	0.010
Prl7a4	prolactin family 7, subfamily a, member 4	0.010
Slc1a3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	0.010
Vcam1	vascular cell adhesion molecule 1	0.010	Human
Ret	ret proto-oncogene	0.010
Cmklr1	chemokine-like receptor 1	0.010
Pde3a	phosphodiesterase 3A, cGMP inhibited	0.010
Cryge	crystallin, gamma E	0.010
Bpil1	bactericidal/permeability-increasing protein-like 1	0.010
Dnah8	dynein, axonemal, heavy chain 8	0.010
Fh1	fumarate hydratase 1	0.010