IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 genes annotated in rat

heart disease

DOID:114

A cardiovascular system disease that involves the heart.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "heart disease" (in gray)

Name	Description	Probability	Func Analog Organism
Csrp3	cysteine and glycine-rich protein 3	0.998	Human
Myoz2	myozenin 2	0.994	Human
Myh6	myosin, heavy chain 6, cardiac muscle, alpha	0.991	Human
Actc1	actin, alpha, cardiac muscle 1	0.979	Human
Actn2	actinin alpha 2	0.972
Cox6a2	cytochrome c oxidase, subunit VIa, polypeptide 2	0.963
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.940
Casq2	calsequestrin 2 (cardiac muscle)	0.924
Ankrd1	ankyrin repeat domain 1 (cardiac muscle)	0.923
Myh7	myosin, heavy chain 7, cardiac muscle, beta	0.921	Human
Ckm	creatine kinase, muscle	0.919
Mb	myoglobin	0.887
Cox8b	cytochrome c oxidase, subunit VIIIb	0.738
Smpx	small muscle protein, X-linked	0.717
Pgam2	phosphoglycerate mutase 2 (muscle)	0.547
Tpm1	tropomyosin 1, alpha	0.520
Myl3	myosin, light chain 3, alkali; ventricular, skeletal, slow	0.453	Human
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.436
Hspb1	heat shock protein 1	0.383
Tnnc1	troponin C type 1 (slow)	0.358	Human
Ckmt2	creatine kinase, mitochondrial 2, sarcomeric	0.319
Myom1	myomesin 1	0.228
Acta1	actin, alpha 1, skeletal muscle	0.215
Pygm	phosphorylase, glycogen, muscle	0.215
Flnc	filamin C, gamma	0.212
Tnni3	troponin I type 3 (cardiac)	0.189
Itgb1bp2	integrin beta 1 binding protein 2	0.170
Wipf3	WAS/WASL interacting protein family, member 3	0.162
Art1	ADP-ribosyltransferase 1	0.144
Nexn	nexilin (F actin binding protein)	0.132
Unc45b	unc-45 homolog B (C. elegans)	0.130
Lrch4	leucine-rich repeats and calponin homology (CH) domain containing 4	0.109
Des	desmin	0.104	Human
Xirp1	xin actin-binding repeat containing 1	0.104
Asb2	ankyrin repeat and SOCS box-containing 2	0.101
Nrap	nebulin-related anchoring protein	0.097
Ldb3	LIM domain binding 3	0.096	Human
Pdlim3	PDZ and LIM domain 3	0.089
Hspb2	heat shock protein beta 2	0.089
Myom2	myomesin 2	0.085
Fgfr1	Fibroblast growth factor receptor 1	0.076
Mybpc1	myosin binding protein C, slow type	0.076
Cav3	caveolin 3	0.074
Trim54	tripartite motif-containing 54	0.073
Plec	plectin	0.068
Sln	sarcolipin	0.063
Kcnd2	potassium voltage-gated channel, Shal-related subfamily, member 2	0.060
Hspb6	heat shock protein, alpha-crystallin-related, B6	0.057
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.057
Serpine1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.056
Fabp3	fatty acid binding protein 3, muscle and heart	0.054
Myadm	myeloid-associated differentiation marker	0.054
Myl1	myosin, light chain 1	0.052
Myh2	myosin, heavy chain 2, skeletal muscle, adult	0.051
P2rx5	purinergic receptor P2X, ligand-gated ion channel, 5	0.050
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.048
Mybph	myosin binding protein H	0.047
Anxa11	annexin A11	0.047
Phyhip	phytanoyl-CoA 2-hydroxylase interacting protein	0.047
Hspb3	heat shock protein 3	0.045
Hand2	heart and neural crest derivatives expressed 2	0.045
Rrbp1	ribosome binding protein 1	0.043
Tnnt2	troponin T type 2 (cardiac)	0.042	Human
Dag1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.042
Trim72	tripartite motif-containing 72	0.042
Bdkrb2	bradykinin receptor B2	0.041
Obscn	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.041
Gnrh1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	0.041
Myh9	myosin, heavy chain 9, non-muscle	0.041
Prkce	protein kinase C, epsilon	0.040
Nlgn3	neuroligin 3	0.040
Actg2	actin, gamma 2, smooth muscle, enteric	0.039
Lmod2	leiomodin 2 (cardiac)	0.037
Acacb	acetyl-Coenzyme A carboxylase beta	0.037
Flna	filamin A, alpha	0.037
Zyx	zyxin	0.037
LOC681849	similar to Protein C6orf142 homolog	0.035
Kcnip2	Kv channel-interacting protein 2	0.035
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.035
Myl7	myosin, light chain 7, regulatory	0.034
Ppp1r15a	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.034
Sh3bgr	SH3 domain binding glutamic acid-rich protein	0.031
Inpp5j	inositol polyphosphate-5-phosphatase J	0.031
Kbtbd10	kelch repeat and BTB (POZ) domain containing 10	0.030
Scn5a	sodium channel, voltage-gated, type V, alpha subunit	0.030	Human
Gpc1	glypican 1	0.028
PVR	poliovirus receptor	0.028
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.028
Slc12a7	solute carrier family 12 (potassium/chloride transporters), member 7	0.028
Lims1	LIM and senescent cell antigen-like domains 1	0.028
Hbegf	heparin-binding EGF-like growth factor	0.027
Slc6a8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	0.027
Lrp10	low-density lipoprotein receptor-related protein 10	0.026
Gata6	GATA binding protein 6	0.026
Gata4	GATA binding protein 4	0.026	Human
Plbd2	phospholipase B domain containing 2	0.025
Mybpc3	myosin binding protein C, cardiac	0.025
Gja3	gap junction protein, alpha 3	0.025
Col5a1	collagen, type V, alpha 1	0.024
Cnn1	calponin 1, basic, smooth muscle	0.024
Itga7	integrin, alpha 7	0.024
Fgf1	fibroblast growth factor 1	0.024
Ppp2r2c	protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform	0.023
Slc12a4	solute carrier family 12 (potassium/chloride transporters), member 4	0.023
Tmod1	tropomodulin 1	0.023
Kcng2	potassium voltage-gated channel, subfamily G, member 2	0.022
Cryab	crystallin, alpha B	0.022	Human
Anxa5	annexin A5	0.022
Slc25a4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	0.022
Mprip	myosin phosphatase Rho interacting protein	0.022
Tmbim1	transmembrane BAX inhibitor motif containing 1	0.021
Fsd2	fibronectin type III and SPRY domain containing 2	0.021
Neurl2	neuralized homolog 2 (Drosophila)	0.021
Rest	RE1-silencing transcription factor	0.021
Lad1	ladinin 1	0.021
Syt3	synaptotagmin III	0.021
Podxl	podocalyxin-like	0.021
Asph	aspartate-beta-hydroxylase	0.020
Aldh2	aldehyde dehydrogenase 2 family (mitochondrial)	0.020
Dusp27	dual specificity phosphatase 27 (putative)	0.020
Ceacam1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	0.019
Slc20a2	solute carrier family 20 (phosphate transporter), member 2	0.019
F2	coagulation factor II (thrombin)	0.019
Tnfrsf12a	tumor necrosis factor receptor superfamily, member 12a	0.019
Nudt8	nudix (nucleoside diphosphate linked moiety X)-type motif 8	0.019
Dhrs7c	dehydrogenase/reductase (SDR family) member 7C	0.019
Eif3b	eukaryotic translation initiation factor 3, subunit B	0.019
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.019
Gnb3	guanine nucleotide binding protein (G protein), beta polypeptide 3	0.019
Csda	cold shock domain protein A	0.018
Pdlim1	PDZ and LIM domain 1	0.018
Irx4	iroquois homeobox 4	0.018
Cnksr2	connector enhancer of kinase suppressor of Ras 2	0.018
Ninj1	ninjurin 1	0.018
Mylpf	myosin light chain, phosphorylatable, fast skeletal muscle	0.018
Dsg2	desmoglein 2	0.018
Tln1	talin 1	0.018
Pkia	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	0.017
Cpt1b	carnitine palmitoyltransferase 1b, muscle	0.017
Hspa1a	heat shock 70kD protein 1A	0.017
Vat1	vesicle amine transport protein 1 homolog (T californica)	0.017
RGD1564899	similar to chromosome 10 open reading frame 71	0.017
Mgp	matrix Gla protein	0.017
Igf2r	insulin-like growth factor 2 receptor	0.017
Cyb5r3	cytochrome b5 reductase 3	0.017
Sost	sclerosteosis	0.017
Pkp2	plakophilin 2	0.017	Human
Tmem38a	transmembrane protein 38a	0.017
Ehd4	EH-domain containing 4	0.017
Kcnq1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.017
Tnni1	troponin I type 1 (skeletal, slow)	0.016
Eln	elastin	0.016
Tgfb2	transforming growth factor, beta 2	0.016
Trim28	tripartite motif-containing 28	0.016
Tead3	TEA domain family member 3	0.016
Dsp	desmoplakin	0.015	Human
Hhatl	hedgehog acyltransferase-like	0.015
Rreb1	ras responsive element binding protein 1	0.015
Pln	phospholamban	0.015
Hes5	hairy and enhancer of split 5 (Drosophila)	0.015
Uqcrc1	ubiquinol-cytochrome c reductase core protein I	0.015
Ppm1g	protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform	0.015
Jup	junction plakoglobin	0.015	Human
Nos3	nitric oxide synthase 3, endothelial cell	0.014
Thbs4	thrombospondin 4	0.014
Jarid1a	jumonji, AT rich interactive domain 1A (Rbp2 like)	0.014
Lmo7	LIM domain 7	0.014
Map2k3	mitogen activated protein kinase kinase 3	0.014
Abtb2	ankyrin repeat and BTB (POZ) domain containing 2	0.014
Pmepa1	prostate transmembrane protein, androgen induced 1	0.014
Has2	hyaluronan synthase 2	0.014
Asb12	ankyrin repeat and SOCS box-containing 12	0.014
Crygd	crystallin, gamma D	0.014
Mypn	myopalladin	0.014	Human
Kcnn2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	0.014
Hspb8	heat shock protein B8	0.014
Adprhl1	ADP-ribosylhydrolase like 1	0.014
Ltbp4	latent transforming growth factor beta binding protein 4	0.014
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.013
Prkcdbp	protein kinase C, delta binding protein	0.013
Baiap2l1	BAI1-associated protein 2-like 1	0.013
Nr2f6	nuclear receptor subfamily 2, group F, member 6	0.013
Ptpn3	protein tyrosine phosphatase, non-receptor type 3	0.013
A1i3	alpha-1-inhibitor III	0.013
Pcdh1	protocadherin 1	0.013
Uqcrh	ubiquinol-cytochrome c reductase hinge protein	0.013
Chrnd	cholinergic receptor, nicotinic, delta	0.013
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.013
Fam129b	family with sequence similarity 129, member B	0.013
Dhdpsl	dihydrodipicolinate synthase-like, mitochondrial	0.013
Usp13	ubiquitin specific protease 13 (isopeptidase T-3)	0.013
Spink8	serine peptidase inhibitor, Kazal type 8	0.013
Hrc	histidine rich calcium binding protein	0.013
Tmem115	transmembrane protein 115	0.013
Gabarapl1	GABA(A) receptor-associated protein like 1	0.013
Srf	serum response factor (c-fos serum response element-binding transcription factor)	0.013
LOC686781	similar to NFkB interacting protein 1	0.013
Grb14	growth factor receptor bound protein 14	0.013
Aco1	aconitase 1, soluble	0.013
Pwwp2b	PWWP domain containing 2B	0.013
Cnnm4	cyclin M4	0.013
Myl4	myosin, light chain 4	0.013
Arpc4	actin related protein 2/3 complex, subunit 4	0.013
Fgfr4	fibroblast growth factor receptor 4	0.013
Gngt1	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1	0.013
Ndufb9	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9	0.013
Ogfr	opioid growth factor receptor	0.013
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.012
Mybpc2	myosin binding protein C, fast-type	0.012
Kif13a	kinesin family member 13A	0.012
Tagln	transgelin	0.012
Cyp24a1	cytochrome P450, family 24, subfamily a, polypeptide 1	0.012
Kbtbd5	kelch repeat and BTB (POZ) domain containing 5	0.012
Arfgap1	ADP-ribosylation factor GTPase activating protein 1	0.012
Freq	frequenin homolog (Drosophila)	0.012
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.012
Smyd1	SET and MYND domain containing 1	0.012
Csnk1g2	casein kinase 1, gamma 2	0.012
Phka1	phosphorylase kinase, alpha 1	0.012
Tmem116	transmembrane protein 116	0.012
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.012
Nppa	natriuretic peptide precursor A	0.012
Ucn2	urocortin 2	0.012
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.012
Emp3	epithelial membrane protein 3	0.012
Lrrc10	leucine-rich repeat-containing 10	0.012
Trpv4	transient receptor potential cation channel, subfamily V, member 4	0.011
Ctnna1	catenin (cadherin associated protein), alpha 1	0.011
Bcar1	breast cancer anti-estrogen resistance 1	0.011
Pdcd6ip	programmed cell death 6 interacting protein	0.011
Stau1	staufen RNA binding protein homolog 1 (Drosophila)	0.011
Hk2	hexokinase 2	0.011
Mos	Moloney sarcoma oncogene	0.011
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.011	Human
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.011
Prkca	protein kinase C, alpha	0.011
Fhl2	four and a half LIM domains 2	0.011
Plb1	phospholipase B1	0.011
Disp1	dispatched homolog 1 (Drosophila)	0.011
Cbx8	chromobox homolog 8 (Pc class homolog, Drosophila)	0.011
Pdlim5	PDZ and LIM domain 5	0.011
Cd99	CD99 antigen	0.011
Olr1606	olfactory receptor 1606	0.011
Ankrd9	ankyrin repeat domain 9	0.011
Tgm2	transglutaminase 2, C polypeptide	0.011
Eef1a1	eukaryotic translation elongation factor 1 alpha 1	0.011
Ddah1	dimethylarginine dimethylaminohydrolase 1	0.011
Ulk1	Unc-51 like kinase 1 (C. elegans)	0.011
Gpr155	G protein-coupled receptor 155	0.011
Aph1a	anterior pharynx defective 1 homolog A (C. elegans)	0.011
Sdc1	syndecan 1	0.011
Ltbr	lymphotoxin beta receptor (TNFR superfamily, member 3)	0.011
Ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.011
Ganab	glucosidase, alpha; neutral AB	0.011
Gucy2g	guanylate cyclase 2G	0.011
S100vp	S100 calcium-binding protein, ventral prostate	0.010
Naga	N-acetyl galactosaminidase, alpha	0.010
Vps37b	vacuolar protein sorting 37 homolog B (S. cerevisiae)	0.010
Agrn	agrin	0.010
Zgpat	zinc finger, CCCH-type with G patch domain	0.010
Myo1e	myosin IE	0.010
Actr1b	ARP1 actin-related protein 1 homolog B (yeast)	0.010
Npr3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	0.010
Naprt1	nicotinate phosphoribosyltransferase domain containing 1	0.010
Inadl2	InaD-like 2 (Drosophila)	0.010
Vipr1	vasoactive intestinal peptide receptor 1	0.010
LOC298139	similar to RIKEN cDNA 2310003M01	0.010
Vasp	vasodilator-stimulated phosphoprotein	0.010
Ncor2	nuclear receptor co-repressor 2	0.010
Fbln5	fibulin 5	0.010
Pam	peptidylglycine alpha-amidating monooxygenase	0.010
Mta1	metastasis associated 1	0.010