IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 genes annotated in rat

retinitis pigmentosa

DOID:10584

A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "retinitis pigmentosa" (in gray)

Name	Description	Probability	Func Analog Organism
Slc24a1	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	0.966
Grk1	G protein-coupled receptor kinase 1	0.685
Gngt1	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1	0.662
Prph2	peripherin 2	0.616
Sag	S-antigen; retina and pineal gland (arrestin)	0.616	Human
Tulp1	tubby like protein 1	0.560	Human
Mpp4	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	0.463
Crx	cone-rod homeobox	0.382	Human
Aipl1	aryl hydrocarbon receptor-interacting protein-like 1	0.380
Cacna1f	calcium channel, voltage-dependent, L type, alpha 1F subunit	0.377
Pcp2	Purkinje cell protein 2	0.285
Nrl	neural retina leucine zipper	0.265	Human
Rax	retina and anterior neural fold homeobox	0.230
Lrit1	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	0.230
Rho	rhodopsin	0.226	Human
Pdc	phosducin	0.223
Opn4	opsin 4	0.221
Pde6b	phosphodiesterase 6B, cGMP-specific, rod, beta	0.208	Human
Tspan1	tetraspanin 1	0.205
Impg2	interphotoreceptor matrix proteoglycan 2	0.202	Human
Slco4a1	solute carrier organic anion transporter family, member 4a1	0.198
Six6	SIX homeobox 6	0.190
Opn1mw	opsin 1 (cone pigments), medium-wave-sensitive	0.176
Guca1b	guanylate cyclase activator 1B	0.174	Human
Impg1	interphotoreceptor matrix proteoglycan 1	0.173
LOC100362817	rCG33447-like	0.152
Lad1	ladinin 1	0.148
Irf3	interferon regulatory factor 3	0.145
Rpgrip1	retinitis pigmentosa GTPase regulator interacting protein 1	0.131
Lin28	lin-28 homolog (C. elegans)	0.125
Slc5a7	solute carrier family 5 (choline transporter), member 7	0.122
Ndufs1	NADH dehydrogenase (ubiquinone) Fe-S protein 1	0.118
Cnga1	cyclic nucleotide gated channel alpha 1	0.115	Human
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive	0.113
Ush1c	Usher syndrome 1C homolog (human)	0.112
Pax4	paired box 4	0.104
Rtbdn	retbindin	0.100
Cldn19	claudin 19	0.099
RGD1560925	similar to 2610034M16Rik protein	0.091
Pla2g5	phospholipase A2, group V	0.086
Mip	major intrinsic protein of lens fiber	0.084
Irx4	iroquois homeobox 4	0.083
Pla2g1b	phospholipase A2, group IB, pancreas	0.079
Myo16	myosin XVI	0.068
Syt7	synaptotagmin VII	0.066
Slc26a4	solute carrier family 26, member 4	0.066
Crygs	crystallin, gamma S	0.060
Fundc1	FUN14 domain containing 1	0.059
Timm17a	translocase of inner mitochondrial membrane 17 homolog A (yeast)	0.057
Crygb	crystallin, gamma B	0.057
Pcdh21	protocadherin 21	0.055
Mak	male germ cell-associated kinase	0.053	Human
Crybb1	crystallin, beta B1	0.053
Tnp2	transition protein 2	0.053
LOC302999	similar to tripartite motif protein 32	0.050
Miox	myo-inositol oxygenase	0.050
Pde6h	phosphodiesterase 6H, cGMP-specific, cone, gamma	0.049
Asmt	acetylserotonin O-methyltransferase	0.048
Sdha	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.048
Rcvrn	recoverin	0.048
LOC683313	similar to keratin complex 2, basic, gene 6a	0.047
Otx2	orthodenticle homeobox 2	0.046
LOC688297	similar to Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase gamma-subunit (GMP-PDE gamma)	0.046
Fbxo3	F-box protein 3	0.046
Vax2	ventral anterior homeobox 2	0.042
Kcnh6	potassium voltage-gated channel, subfamily H (eag-related), member 6	0.041
Cryba2	crystallin, beta A2	0.041
Cngb1	cyclic nucleotide gated channel beta 1	0.039	Human
Cep57	centrosomal protein 57	0.038
Efha2	EF hand domain family, member A2	0.038
Osbp2	oxysterol binding protein 2	0.038
Dhh	desert hedgehog homolog (Drosophila)	0.037
Cnnm1	cyclin M1	0.037
Tyrp1	tyrosinase-related protein 1	0.037
Fbxo17	F-box protein 17	0.036
Ss18l1	synovial sarcoma translocation gene on chromosome 18-like 1	0.036
Gucy2f	guanylate cyclase 2F	0.035
Gipr	gastric inhibitory polypeptide receptor	0.035
Trpm1	transient receptor potential cation channel, subfamily M, member 1	0.035
Med15	mediator complex subunit 15	0.034
Ucn2	urocortin 2	0.034
Kcne2	potassium voltage-gated channel, Isk-related family, member 2	0.034
Morn1	MORN repeat containing 1	0.034
Irx1	iroquois homeobox 1	0.033
Myh6	myosin, heavy chain 6, cardiac muscle, alpha	0.032
Gabrr3	gamma-aminobutyric acid (GABA) receptor, rho 3	0.032
Sntg2	syntrophin, gamma 2	0.031
Ndufs2	NADH dehydrogenase (ubiquinone) Fe-S protein 2	0.031
Susd3	sushi domain containing 3	0.030
Guca1a	guanylate cyclase activator 1a (retina)	0.030
Gpr4	G protein-coupled receptor 4	0.030
Crygn	crystallin, gamma N	0.029
Dld	dihydrolipoamide dehydrogenase	0.029
Ptges	prostaglandin E synthase	0.029
Nrn1l	neuritin 1-like	0.029
Sctr	secretin receptor	0.029
Acot12	acyl-CoA thioesterase 12	0.028
Uqcrfs1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.028
Slc24a4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	0.028
Rdh12	retinol dehydrogenase 12 (all-trans/9-cis/11-cis)	0.027	Human
Abca4	ATP-binding cassette, subfamily A (ABC1), member 4	0.027	Human
Sost	sclerosteosis	0.027
RGD1308759	similar to KIAA0892 protein	0.027
Prol1	proline rich, lacrimal 1	0.027
Akap4	A kinase (PRKA) anchor protein 4	0.026
A4galt	alpha 1,4-galactosyltransferase	0.026
Pde6a	phosphodiesterase 6A, cGMP-specific, rod, alpha	0.026	Human
Drd4	dopamine receptor D4	0.025
Prdm1	PR domain containing 1, with ZNF domain	0.024
Fbxo36	F-box protein 36	0.024
Ndufv1	NADH dehydrogenase (ubiquinone) flavoprotein 1	0.023
Prdx3	peroxiredoxin 3	0.023
Lrrc15	leucine rich repeat containing 15	0.023
Rev3l	REV3-like, catalytic subunit of DNA polymerase zeta (yeast)	0.023
Tsks	testis-specific serine kinase substrate	0.023
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.022
Sp3	Sp3 transcription factor	0.022
Znf483	zinc finger protein 483	0.022
Lhx9	LIM homeobox 9	0.021
Sap25	sin3A-binding protein, SAP25	0.021
Btbd1	BTB (POZ) domain containing 1	0.021
Slc22a8	solute carrier family 22 (organic anion transporter), member 8	0.021
Klc3	kinesin light chain 3	0.021
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.021
Pomc	proopiomelanocortin	0.021
Tbata	thymus, brain and testes associated	0.020
Pcmtd2	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	0.020
Hbe2	hemoglobin, epsilon 2	0.020
Grin2b	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.020
Hcn1	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	0.020
Pvrl4	poliovirus receptor-related 4	0.020
Nphs1	nephrosis 1 homolog (human)	0.019
P2rx2	purinergic receptor P2X, ligand-gated ion channel, 2	0.019
Pgc	progastricsin (pepsinogen C)	0.019
Snip	SNAP25-interacting protein	0.019
Slc25a3	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3	0.019
Slco1c1	solute carrier organic anion transporter family, member 1c1	0.019
Pigl	phosphatidylinositol glycan anchor biosynthesis, class L	0.018
LOC363060	similar to RIKEN cDNA 1600029D21	0.018
Chrna3	cholinergic receptor, nicotinic, alpha 3	0.018
Aco2	aconitase 2, mitochondrial	0.018
Pitx3	paired-like homeodomain 3	0.018
LOC100359595	hypothetical protein LOC100359595	0.018
Suclg1	succinate-CoA ligase, alpha subunit	0.018
Cym	chymosin	0.018
Cysltr2	cysteinyl leukotriene receptor 2	0.017
Fabp12	fatty acid binding protein 12	0.017
Rcbtb1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	0.017
Dhx8	DEAH (Asp-Glu-Ala-His) box polypeptide 8	0.017
Atp5a1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.017
LOC361188	similar to WD repeat domain 17	0.017
Uqcrc2	ubiquinol cytochrome c reductase core protein 2	0.017
Plcd3	phospholipase C, delta 3	0.017
Tmem138	transmembrane protein 138	0.017
Bmp15	bone morphogenetic protein 15	0.017
Tbc1d2	TBC1 domain family, member 2	0.016
Psd	pleckstrin and Sec7 domain containing	0.016
Hcn3	hyperpolarization-activated cyclic nucleotide-gated potassium channel 3	0.016
Kcnb2	potassium voltage gated channel, Shab-related subfamily, member 2	0.016
Slc6a11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.016
Runx3	runt-related transcription factor 3	0.016
Zbtb48	zinc finger and BTB domain containing 48	0.016
Pde8b	phosphodiesterase 8B	0.016
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.016
Accn4	amiloride-sensitive cation channel 4, pituitary	0.015
Cartpt	CART prepropeptide	0.015
Nol9	nucleolar protein 9	0.015
Npvf	neuropeptide VF precursor	0.015
LOC305076	similar to hypothetical protein MGC29875; novel putative protein similar to YIL091C yeast hypothetical 84 kD protein from SGA1-KTR7	0.015
Mbd6	methyl-CpG binding domain protein 6	0.015
Cabp4	calcium binding protein 4	0.015
Ocm	oncomodulin	0.015
Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	0.015
C1ql1	complement component 1, q subcomponent-like 1	0.015
Tufm	Tu translation elongation factor, mitochondrial	0.015
Znf536	zinc finger protein 536	0.015
Nxnl1	nucleoredoxin-like 1	0.015
Kcnv2	potassium channel, subfamily V, member 2	0.015
Sert1	Sertoli cell protein 1	0.015
Msh5	mutS homolog 5 (E. coli)	0.015
Shh	sonic hedgehog	0.014
Grpcb	glutamine/glutamic acid-rich protein A	0.014
Defb4	defensin beta 4	0.014
LOC100359739	F-box and leucine-rich repeat protein 13-like	0.014
Fancc	Fanconi anemia, complementation group C	0.014
Fbxo10	F-box protein 10	0.014
Mpp2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	0.014
Cplx3	complexin 3	0.014
Hoxa4	homeo box A4	0.013
Pon1	paraoxonase 1	0.013
Optc	opticin	0.013
Arr3	arrestin 3, retinal (X-arrestin)	0.013
Znf689	zinc finger protein 689	0.013
Iapp	islet amyloid polypeptide	0.013
Tpcn2	two pore segment channel 2	0.013
Fam83h	family with sequence similarity 83, member H	0.013
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.013
Fh1	fumarate hydratase 1	0.013
Tcfap2b	transcription factor AP-2 beta	0.013
Edn2	endothelin 2	0.013
Rpusd2	RNA pseudouridylate synthase domain containing 2	0.013
Col5a3	collagen, type V, alpha 3	0.013
Top3b	topoisomerase (DNA) III beta	0.013
Rhbdl3	rhomboid, veinlet-like 3 (Drosophila)	0.013
Fcer1a	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	0.013
Sebox	SEBOX homeobox	0.012
Prl4a1	prolactin family 4, subfamily a, member 1	0.012
Sec1	secretory blood group 1	0.012
Lrrc50	leucine rich repeat containing 50	0.012
Tmem116	transmembrane protein 116	0.012
LOC100365683	nuclear receptor subfamily 2, group E, member 3-like	0.012
LOC361646	similar to K04F10.2	0.012
S100vp	S100 calcium-binding protein, ventral prostate	0.012
Sco1	SCO cytochrome oxidase deficient homolog 1 (yeast)	0.012
Alox15	arachidonate 15-lipoxygenase	0.012
Cirh1a	cirrhosis, autosomal recessive 1A (cirhin)	0.012
Gabrr2	gamma-aminobutyric acid (GABA) receptor, rho 2	0.012
RGD1304963	similar to hypothetical protein MGC38716	0.012
Lamp3	lysosomal-associated membrane protein 3	0.012
LOC691572	hypothetical protein LOC691572	0.012
Hcrt	hypocretin	0.012
Ivl	involucrin	0.012
Oasl	2'-5'-oligoadenylate synthetase-like	0.011
Inpp4b	inositol polyphosphate-4-phosphatase, type II	0.011
Bsnd	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	0.011
Zfp37	zinc finger protein 37	0.011
Fxyd4	FXYD domain-containing ion transport regulator 4	0.011
Fgfbp1	fibroblast growth factor binding protein 1	0.011
Recql4	RecQ protein-like 4	0.011
Ghdc	GH3 domain containing	0.011
Myt1	myelin transcription factor 1	0.011
Gnat1	guanine nucleotide binding protein (G protein), alpha transducing 1	0.011
Sftpa1	surfactant protein A1	0.011
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.011
Rlbp1	retinaldehyde binding protein 1	0.011
Gp2	glycoprotein 2 (zymogen granule membrane)	0.011
Ctnnal1	catenin (cadherin associated protein), alpha-like 1	0.011
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.011
Gucy2g	guanylate cyclase 2G	0.011
Ear11	eosinophil-associated, ribonuclease A family, member 11	0.011
Clk2	CDC-like kinase 2	0.011
Gpr135	G protein-coupled receptor 135	0.011
Rnft2	ring finger protein, transmembrane 2	0.011
Ehbp1	EH domain binding protein 1	0.010
Cabp1	calcium binding protein 1	0.010
Cyp46a1	cytochrome P450, family 46, subfamily a, polypeptide 1	0.010
Rad21	RAD21 homolog (S. pombe)	0.010
Cdcp1	CUB domain containing protein 1	0.010
Krt15	keratin 15	0.010
Espn	espin	0.010
Tmem8a	transmembrane protein 8A	0.010
Vegp1	von Ebners gland protein 1	0.010
Clcnkb	chloride channel Kb	0.010