IMP: Integrative Multi-species Prediction

Rattus norvegicus

1 genes annotated in rat

negative regulation of natural killer cell mediated immune response to tumor cell

Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of natural killer cell mediated immune response to tumor cell"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of natural killer cell mediated immune response to tumor cell" (in gray)

Name	Description	Probability	Func Analog Organism
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.972
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.928	Rat
Mmp12	matrix metallopeptidase 12	0.844
Ccr2	chemokine (C-C motif) receptor 2	0.715
Gzmk	granzyme K	0.514
Igsf6	immunoglobulin superfamily, member 6	0.511
Nkg7	natural killer cell group 7 sequence	0.417
Cyp2c13	cytochrome P450, family 2, subfamily c, polypeptide 13	0.392
Klrc2	killer cell lectin-like receptor subfamily C, member 2	0.390	Rat
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.308	Rat
Il7r	interleukin 7 receptor	0.258
Klra17	killer cell lectin-like receptor, subfamily A, member 17	0.224
Tlr7	toll-like receptor 7	0.217
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.209
Ccr5	chemokine (C-C motif) receptor 5	0.158
Mcpt8	mast cell protease 8	0.143
Sell	selectin L	0.138
Klra22	killer cell lectin-like receptor subfamily A, member 22	0.130	Rat
LOC300024	similar to Ly6-B antigen gene	0.116
Gzmm	granzyme M (lymphocyte met-ase 1)	0.113
Xcl1	chemokine (C motif) ligand 1	0.112
Slamf9	SLAM family member 9	0.098
Lilrb4	leukocyte immunoglobulin-like receptor, subfamily B, member 4	0.090
Cd8a	CD8a molecule	0.078
Tnni3k	TNNI3 interacting kinase	0.077
Samsn1	SAM domain, SH3 domain and nuclear localization signals, 1	0.077
Pcsk1	proprotein convertase subtilisin/kexin type 1	0.074
Cd2	Cd2 molecule	0.073
Rgs1	regulator of G-protein signaling 1	0.070
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.068
Ctsj	cathepsin J	0.067
Havcr1	hepatitis A virus cellular receptor 1	0.062
Vom1r93	vomeronasal 1 receptor 93	0.061
Gzmb	granzyme B	0.053
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.051
Il1rl1	interleukin 1 receptor-like 1	0.049
Sit1	signaling threshold regulating transmembrane adaptor 1	0.047
Gucy2g	guanylate cyclase 2G	0.046
Klrb1a	killer cell lectin-like receptor subfamily B, member 1A	0.045
Il1b	interleukin 1 beta	0.045
Zap70	zeta-chain (TCR) associated protein kinase	0.043
Vom1r102	vomeronasal 1 receptor 102	0.042
Il1rn	interleukin 1 receptor antagonist	0.042
Cd72	Cd72 molecule	0.040
Prf1	perforin 1 (pore forming protein)	0.038
Mos	Moloney sarcoma oncogene	0.037
Cyp2c12	cytochrome P450, family 2, subfamily c, polypeptide 12	0.036
Slc9a4	solute carrier family 9 (sodium/hydrogen exchanger), member 4	0.034
Ifng	interferon gamma	0.034
Cd69	Cd69 molecule	0.034	Rat
Zcwpw1	zinc finger, CW-type with PWWP domain 1	0.034
Ccl2	chemokine (C-C motif) ligand 2	0.033
Ccl9	chemokine (C-C motif) ligand 9	0.032
Fam65b	family with sequence similarity 65, member B	0.031
Scn10a	sodium channel, voltage-gated, type X, alpha subunit	0.030
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.030	Rat
Mcpt4	mast cell protease 4	0.029
Ambn	ameloblastin	0.028
Cd3g	CD3 molecule, gamma	0.028
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.028
Scin	scinderin	0.027
Reg3g	regenerating islet-derived 3 gamma	0.027
Pou1f1	POU class 1 homeobox 1	0.027
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.027
LOC687399	hypothetical protein LOC687399	0.027
Stab2	stabilin 2	0.025
Ubd	ubiquitin D	0.025
Slc22a25	solute carrier family 22, member 25	0.025
Dok2	docking protein 2	0.025
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.023
Clec7a	C-type lectin domain family 7, member a	0.023	Rat
Slc13a1	solute carrier family 13 (sodium/sulfate symporters), member 1	0.023
Pate4	prostate and testis expressed 4	0.023
Prl2b1	Prolactin family 2, subfamily b, member 1	0.023
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.022
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.022	Rat
P2ry14	purinergic receptor P2Y, G-protein coupled, 14	0.022
Slfn3	schlafen 3	0.022
Spic	Spi-C transcription factor (Spi-1/PU.1 related)	0.021
Unc5cl	unc-5 homolog C (C. elegans)-like	0.021
Atp6v1g3	ATPase, H+ transporting, lysosomal V1 subunit G3	0.020
Serpine1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.019
Gpr64	G protein-coupled receptor 64	0.019
Cxcl11	chemokine (C-X-C motif) ligand 11	0.019
Cyp7b1	cytochrome P450, family 7, subfamily b, polypeptide 1	0.019
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.019
Il18r1	interleukin 18 receptor 1	0.019
S100vp	S100 calcium-binding protein, ventral prostate	0.019
Skap1	src kinase associated phosphoprotein 1	0.018
Myct1	myc target 1	0.018
Inpp4b	inositol polyphosphate-4-phosphatase, type II	0.018
Ccl4	chemokine (C-C motif) ligand 4	0.018
Fev	FEV (ETS oncogene family)	0.018
Fam38b	family with sequence similarity 38, member B	0.018
LOC100362325	rCG28200-like	0.018
Tfec	transcription factor EC	0.017
RGD1562844	similar to serine (or cysteine) proteinase inhibitor, clade B, member 9	0.017
Clec9a	C-type lectin domain family 9, member a	0.017	Rat
Prl2a1	Prolactin family 2, subfamily a, member 1	0.017
Tmem182	transmembrane protein 182	0.017
Vcsa2	variable coding sequence A2	0.017
Nox4	NADPH oxidase 4	0.017
Mageb16	melanoma antigen family B, 16	0.016
Cyp3a2	cytochrome P450, family 3, subfamily a, polypeptide 2	0.016
RGD1311300	similar to T cell receptor V delta 6	0.016
Sh2d1a	SH2 domain protein 1A	0.016
Lrrc8c	leucine rich repeat containing 8 family, member C	0.016
Oprm1	opioid receptor, mu 1	0.015
Ugt2a1	UDP glucuronosyltransferase 2 family, polypeptide A1	0.015
Gfra3	GDNF family receptor alpha 3	0.015
Stfa2l3	stefin A2-like 3	0.015
Mcpt3	mast cell peptidase 3	0.015
LOC100361053	mCG1039741-like	0.015
Reg3b	regenerating islet-derived 3 beta	0.015
C7	complement component 7	0.015
LOC100361765	homeobox B2	0.015
Gzma	granzyme A	0.014
Cd86	CD86 molecule	0.014
Cela1	chymotrypsin-like elastase family, member 1	0.014
Spn	sialophorin	0.014
Serpinb3a	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A	0.014
Oas1b	2-5 oligoadenylate synthetase 1B	0.014
RT1-A3	RT1 class I, locus A3	0.014
Chrm5	cholinergic receptor, muscarinic 5	0.014
Sept6	septin 6	0.014
Ccl5	chemokine (C-C motif) ligand 5	0.014
Testin	testin gene	0.014
Kynu	kynureninase (L-kynurenine hydrolase)	0.013
Dclre1c	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)	0.013
Olr59	olfactory receptor 59	0.013
Alx3	aristaless-like homeobox 3	0.013
Stx11	syntaxin 11	0.013
Ccl19	chemokine (C-C motif) ligand 19	0.013
RGD1304644	similar to RIKEN cDNA 2310046K01	0.013
Spink1	serine peptidase inhibitor, Kazal type 1	0.012
Gen1	Gen homolog 1, endonuclease (Drosophila)	0.012
Pnliprp1	pancreatic lipase-related protein 1	0.012
Cxcl1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.012
Serpinb7	serpin peptidase inhibitor, clade B (ovalbumin), member 7	0.012
Slpi	secretory leukocyte peptidase inhibitor	0.012
RGD1566368	similar to Solute carrier family 6 (neurotransmitter transporter), member 20	0.012
Gimap6	GTPase, IMAP family member 6	0.012
Slc12a1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	0.012
Rt1.aa	MHC class I RT1.Aa alpha-chain	0.012
Spef2	sperm flagellar 2	0.012
Sh2d2a	SH2 domain protein 2A	0.011
Cd200r2	Cd200 receptor 2	0.011
Plin5	perilipin 5	0.011
Cd22	CD22 molecule	0.011
Lepr	leptin receptor	0.011
Cxcl10	chemokine (C-X-C motif) ligand 10	0.011
Hcls1	hematopoietic cell specific Lyn substrate 1	0.011
Snrpe	small nuclear ribonucleoprotein polypeptide E	0.011
Odf4	outer dense fiber of sperm tails 4	0.011
Igfl3	IGF-like family member 3	0.011
Il2	interleukin 2	0.011
Duoxa1	dual oxidase maturation factor 1	0.011
Hnmt	histamine N-methyltransferase	0.011
Tas2r105	taste receptor, type 2, member 105	0.011
Serpinb2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.011
Csn3	casein kappa	0.011
Fyb	FYN binding protein (FYB-120/130)	0.011
Tmem154	transmembrane protein 154	0.011
Ccl3	chemokine (C-C motif) ligand 3	0.011
Ms4a7	membrane-spanning 4-domains, subfamily A, member 7	0.011
RGD1560925	similar to 2610034M16Rik protein	0.010
C6	complement component 6	0.010
Card6	caspase recruitment domain family, member 6	0.010
Gcgr	glucagon receptor	0.010
Olr1283	olfactory receptor 1283	0.010
Tnf	tumor necrosis factor (TNF superfamily, member 2)	0.010
Ly49si1	immunoreceptor Ly49si1	0.010	Rat
Sgms2	sphingomyelin synthase 2	0.010
Pde4d	phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)	0.010
Cma1	chymase 1, mast cell	0.010