IMP
Process View
lens fiber cell differentiation
The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "lens fiber cell differentiation"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Anxa1 | annexin A1 | 0.426 | ||
| Anxa5 | annexin A5 | 0.182 | ||
| Ubtf | upstream binding transcription factor, RNA polymerase I | 0.165 | ||
| Timp1 | TIMP metallopeptidase inhibitor 1 | 0.107 | ||
| Anxa2 | annexin A2 | 0.106 | ||
| Sparc | secreted protein, acidic, cysteine-rich (osteonectin) | 0.098 | ||
| Crygc | crystallin, gamma C | 0.091 | Rat | |
| Wdfy1 | WD repeat and FYVE domain containing 1 | 0.082 | ||
| Igf2 | insulin-like growth factor 2 | 0.063 | ||
| Zfp91 | zinc finger protein 91 | 0.062 | ||
| Itgb1 | integrin, beta 1 | 0.059 | ||
| Lep | leptin | 0.050 | ||
| Acr | acrosin | 0.048 | ||
| Lim2 | lens intrinsic membrane protein 2 | 0.046 | ||
| Ush1c | Usher syndrome 1C homolog (human) | 0.046 | ||
| Pfkfb3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.043 | ||
| Cald1 | caldesmon 1 | 0.041 | ||
| Espn | espin | 0.040 | ||
| Snrk | SNF related kinase | 0.039 | ||
| Crybb1 | crystallin, beta B1 | 0.037 | ||
| Grn | granulin | 0.036 | ||
| Dab2 | disabled homolog 2 (Drosophila) | 0.036 | ||
| Tas2r123 | taste receptor, type 2, member 123 | 0.035 | ||
| Mep1a | meprin 1 alpha | 0.035 | ||
| Vipr1 | vasoactive intestinal peptide receptor 1 | 0.034 | ||
| Tnp2 | transition protein 2 | 0.034 | ||
| Myh9 | myosin, heavy chain 9, non-muscle | 0.033 | ||
| Aebp1 | AE binding protein 1 | 0.033 | ||
| Foxe3 | forkhead box E3 | 0.031 | ||
| Arid4a | AT rich interactive domain 4A (Rbp1 like) | 0.031 | ||
| Sgp158 | proline-rich glycoprotein (sgp158) | 0.030 | ||
| Rab14 | RAB14, member RAS oncogene family | 0.028 | ||
| Cryba1 | crystallin, beta A1 | 0.028 | Rat | |
| C1r | complement component 1, r subcomponent | 0.028 | ||
| Slc1a6 | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 | 0.028 | ||
| Capn2 | calpain 2 | 0.027 | ||
| Cyp21a1 | cytochrome P450, family 21, subfamily a, polypeptide 1 | 0.026 | ||
| Ncam1 | neural cell adhesion molecule 1 | 0.026 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.026 | ||
| Prrxl1 | paired related homeobox protein-like 1 | 0.025 | ||
| Chd4 | chromodomain helicase DNA binding protein 4 | 0.025 | ||
| Crygs | crystallin, gamma S | 0.025 | Rat | |
| Smad7 | SMAD family member 7 | 0.025 | ||
| Tln1 | talin 1 | 0.024 | ||
| Grifin | galectin-related inter-fiber protein | 0.024 | ||
| Lin28 | lin-28 homolog (C. elegans) | 0.024 | ||
| Abp10 | annexin V-binding protein ABP-10 | 0.024 | ||
| LOC100362601 | PBPC1BS-like | 0.023 | ||
| LOC100360165 | rCG29588-like | 0.023 | ||
| Opn4 | opsin 4 | 0.023 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.022 | ||
| Tyr | tyrosinase | 0.022 | ||
| Fabp12 | fatty acid binding protein 12 | 0.022 | ||
| Msh5 | mutS homolog 5 (E. coli) | 0.022 | ||
| Dbc1 | deleted in bladder cancer 1 (human) | 0.022 | ||
| Cldn19 | claudin 19 | 0.021 | ||
| Gngt1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.021 | ||
| Serpinh1 | serine (or cysteine) peptidase inhibitor, clade H, member 1 | 0.021 | ||
| Cpg1 | candidate plasticity gene 1 | 0.021 | ||
| Lyn | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.021 | ||
| Bmp15 | bone morphogenetic protein 15 | 0.021 | ||
| Pdpn | podoplanin | 0.020 | ||
| Megf6 | multiple EGF-like-domains 6 | 0.020 | ||
| Gja3 | gap junction protein, alpha 3 | 0.020 | ||
| RGD1306750 | LOC362451 | 0.020 | ||
| Tbxa2r | thromboxane A2 receptor | 0.020 | ||
| Lhx9 | LIM homeobox 9 | 0.020 | ||
| Rin1 | Ras and Rab interactor 1 | 0.019 | ||
| Crybb3 | crystallin, beta B3 | 0.019 | ||
| Sf1 | splicing factor 1 | 0.019 | ||
| Tas2r114 | taste receptor, type 2, member 114 | 0.019 | ||
| Klk1b3 | kallikrein 1-related peptidase b3 | 0.019 | ||
| Ptprm | protein tyrosine phosphatase, receptor type, M | 0.019 | ||
| Crygn | crystallin, gamma N | 0.019 | Rat | |
| Hdlbp | high density lipoprotein binding protein | 0.019 | ||
| Fxyd5 | FXYD domain-containing ion transport regulator 5 | 0.019 | ||
| Gse1 | genetic suppressor element 1 | 0.019 | ||
| Baz2b | bromodomain adjacent to zinc finger domain, 2B | 0.019 | ||
| Cdx2 | caudal type homeo box 2 | 0.019 | ||
| Hes3 | hairy and enhancer of split 3 (Drosophila) | 0.019 | ||
| Ephb3 | Eph receptor B3 | 0.019 | ||
| Ptprs | protein tyrosine phosphatase, receptor type, S | 0.018 | ||
| Atp7b | ATPase, Cu++ transporting, beta polypeptide | 0.018 | ||
| Ubr4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.018 | ||
| RGD1562234 | similar to S100 calcium-binding protein, ventral prostate | 0.018 | ||
| RGD1564599 | RGD1564599 | 0.018 | ||
| Olr825 | olfactory receptor 825 | 0.018 | ||
| Grm5 | glutamate receptor, metabotropic 5 | 0.018 | ||
| Ece1 | endothelin converting enzyme 1 | 0.018 | ||
| Amh | anti-Mullerian hormone | 0.018 | ||
| Myh13 | myosin, heavy chain 13, skeletal muscle | 0.017 | ||
| Nrg1 | neuregulin 1 | 0.017 | ||
| Mcam | melanoma cell adhesion molecule | 0.017 | ||
| Homer3 | homer homolog 3 (Drosophila) | 0.017 | ||
| Shank1 | SH3 and multiple ankyrin repeat domains 1 | 0.016 | ||
| Cd3d | CD3 molecule, delta | 0.016 | ||
| Grik3 | glutamate receptor, ionotropic, kainate 3 | 0.016 | ||
| Gabrr3 | gamma-aminobutyric acid (GABA) receptor, rho 3 | 0.016 | ||
| Mip | major intrinsic protein of lens fiber | 0.016 | ||
| Kcna5 | potassium voltage-gated channel, shaker-related subfamily, member 5 | 0.016 | ||
| Matk | megakaryocyte-associated tyrosine kinase | 0.016 | ||
| Lrit1 | leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 | 0.016 | ||
| Il9 | interleukin 9 | 0.016 | ||
| Hbegf | heparin-binding EGF-like growth factor | 0.016 | ||
| Slc17a7 | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 | 0.016 | ||
| Wbp4 | WW domain binding protein 4 (formin binding protein 21) | 0.016 | ||
| Svs6 | seminal vesicle secretory protein 6 | 0.016 | ||
| Robo1 | roundabout homolog 1 (Drosophila) | 0.015 | ||
| Enpp6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | 0.015 | ||
| Col5a2 | collagen, type V, alpha 2 | 0.015 | ||
| S100a11 | S100 calcium binding protein A11 (calizzarin) | 0.015 | ||
| Slc22a9 | solute carrier family 22 (organic anion transporter), member 9 | 0.015 | ||
| Fn1 | fibronectin 1 | 0.015 | Zebrafish | |
| Pcdh21 | protocadherin 21 | 0.015 | ||
| Prss8 | protease, serine, 8 | 0.015 | ||
| Zfp362 | zinc finger protein 362 | 0.015 | ||
| Lif | leukemia inhibitory factor | 0.015 | ||
| Hspa1a | heat shock 70kD protein 1A | 0.015 | ||
| Crygd | crystallin, gamma D | 0.015 | ||
| Btc | betacellulin | 0.015 | ||
| Vpreb3 | pre-B lymphocyte 3 | 0.015 | ||
| Rest | RE1-silencing transcription factor | 0.015 | ||
| Itgad | integrin, alpha D | 0.014 | ||
| Mpp4 | membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) | 0.014 | ||
| Lgals3 | lectin, galactoside-binding, soluble, 3 | 0.014 | ||
| Klf2 | Kruppel-like factor 2 (lung) | 0.014 | ||
| Clcn5 | chloride channel 5 | 0.014 | ||
| Omg | oligodendrocyte-myelin glycoprotein | 0.014 | ||
| Gna15 | guanine nucleotide binding protein, alpha 15 | 0.014 | ||
| Arhgef7 | Rho guanine nucleotide exchange factor (GEF7) | 0.014 | ||
| Gcn1l1 | GCN1 general control of amino-acid synthesis 1-like 1 (yeast) | 0.014 | ||
| Aqp5 | aquaporin 5 | 0.014 | ||
| Sirpa | signal-regulatory protein alpha | 0.014 | ||
| Srrm2 | serine/arginine repetitive matrix 2 | 0.014 | ||
| Crkrs | Cdc2-related kinase, arginine/serine-rich | 0.014 | ||
| Sdc3 | syndecan 3 | 0.014 | ||
| Ctu2 | cytosolic thiouridylase subunit 2 homolog (S. pombe) | 0.014 | ||
| Gabrr1 | gamma-aminobutyric acid (GABA) receptor, rho 1 | 0.014 | ||
| Crhbp | corticotropin releasing hormone binding protein | 0.014 | ||
| Igf2r | insulin-like growth factor 2 receptor | 0.014 | ||
| Mcpt9 | mast cell protease 9 | 0.014 | ||
| Dnajb14 | DnaJ (Hsp40) homolog, subfamily B, member 14 | 0.014 | ||
| Necab2 | N-terminal EF-hand calcium binding protein 2 | 0.014 | ||
| Bmpr2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.013 | ||
| Adrb1 | adrenergic, beta-1-, receptor | 0.013 | ||
| Arhgap23 | Rho GTPase activating protein 23 | 0.013 | ||
| Tmed5 | transmembrane emp24 protein transport domain containing 5 | 0.013 | ||
| Vars | valyl-tRNA synthetase | 0.013 | ||
| Krtap1-5 | keratin associated protein 1-5 | 0.013 | ||
| Igsf9 | immunoglobulin superfamily, member 9 | 0.013 | ||
| Fgfr1 | Fibroblast growth factor receptor 1 | 0.013 | ||
| Chrna6 | cholinergic receptor, nicotinic, alpha 6 | 0.013 | ||
| Prr5l | proline rich 5 like | 0.013 | ||
| Rnf165 | ring finger protein 165 | 0.013 | ||
| Slc4a4 | solute carrier family 4, sodium bicarbonate cotransporter, member 4 | 0.013 | ||
| Pex1 | peroxisomal biogenesis factor 1 | 0.013 | ||
| Mpeg1 | macrophage expressed 1 | 0.013 | ||
| Jund | jun D proto-oncogene | 0.013 | ||
| Slc6a11 | solute carrier family 6 (neurotransmitter transporter, GABA), member 11 | 0.013 | ||
| UST4r | integral membrane transport protein UST4r | 0.013 | ||
| A2m | alpha-2-macroglobulin | 0.013 | ||
| Nek9 | NIMA (never in mitosis gene a)- related kinase 9 | 0.013 | ||
| Acap1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 | 0.013 | ||
| Setbp1 | SET binding protein 1 | 0.013 | ||
| Ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 0.012 | ||
| Mpp2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.012 | ||
| Ril | reversion induced LIM gene | 0.012 | ||
| RGD1566368 | similar to Solute carrier family 6 (neurotransmitter transporter), member 20 | 0.012 | ||
| Fgb | fibrinogen beta chain | 0.012 | ||
| Mgat3 | mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase | 0.012 | ||
| Aanat | arylalkylamine N-acetyltransferase | 0.012 | ||
| Irx4 | iroquois homeobox 4 | 0.012 | ||
| Slc24a4 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 | 0.012 | ||
| Epb4.1l2 | erythrocyte membrane protein band 4.1-like 2 | 0.012 | ||
| Slit3 | slit homolog 3 (Drosophila) | 0.012 | ||
| Hmox1 | heme oxygenase (decycling) 1 | 0.012 | ||
| Pax6 | paired box 6 | 0.012 | ||
| Madd | MAP-kinase activating death domain | 0.012 | ||
| Aplnr | apelin receptor | 0.012 | ||
| Kif26b | kinesin family member 26B | 0.012 | ||
| Sag | S-antigen; retina and pineal gland (arrestin) | 0.012 | ||
| Lrp1 | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 0.012 | ||
| Pde4d | phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) | 0.012 | ||
| B4galnt4 | beta-1,4-N-acetyl-galactosaminyl transferase 4 | 0.012 | ||
| Tuba1c | tubulin, alpha 1C | 0.012 | ||
| Hoxd3 | homeo box D3 | 0.012 | ||
| Adam17 | ADAM metallopeptidase domain 17 | 0.012 | ||
| Ppp1r12a | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 0.012 | ||
| RGD1561440 | similar to nemo like kinase | 0.012 | ||
| Clic5 | chloride intracellular channel 5 | 0.012 | ||
| Rcvrn | recoverin | 0.012 | ||
| Abca4 | ATP-binding cassette, subfamily A (ABC1), member 4 | 0.012 | ||
| LOC100359739 | F-box and leucine-rich repeat protein 13-like | 0.012 | ||
| Pate4 | prostate and testis expressed 4 | 0.012 | ||
| Lenep | lens epithelial protein | 0.012 | ||
| Pcsk4 | proprotein convertase subtilisin/kexin type 4 | 0.012 | ||
| Mkl1 | megakaryoblastic leukemia (translocation) 1 | 0.012 | ||
| Ngfr | nerve growth factor receptor (TNFR superfamily, member 16) | 0.012 | ||
| Gdf15 | growth differentiation factor 15 | 0.012 | ||
| Mtor | mechanistic target of rapamycin (serine/threonine kinase) | 0.012 | ||
| Msmb | microseminoprotein, beta | 0.012 | ||
| Fosl2 | fos-like antigen 2 | 0.012 | ||
| Slc23a1 | solute carrier family 23 (nucleobase transporters), member 1 | 0.012 | ||
| Mark2 | MAP/microtubule affinity-regulating kinase 2 | 0.012 | ||
| Cox6a2 | cytochrome c oxidase, subunit VIa, polypeptide 2 | 0.012 | ||
| Cldn2 | claudin 2 | 0.012 | ||
| Cerk | ceramide kinase | 0.011 | ||
| Srd5a2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | 0.011 | ||
| Neto2 | neuropilin (NRP) and tolloid (TLL)-like 2 | 0.011 | ||
| Guca1a | guanylate cyclase activator 1a (retina) | 0.011 | ||
| Sct | secretin | 0.011 | ||
| Epn1 | Epsin 1 | 0.011 | ||
| Dnah2 | dynein, axonemal, heavy chain 2 | 0.011 | ||
| Sin3a | SIN3 homolog A, transcription regulator (yeast) | 0.011 | ||
| Zfp382 | zinc finger protein 382 | 0.011 | ||
| Lalba | lactalbumin, alpha | 0.011 | ||
| Ikbkap | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein | 0.011 | ||
| Mertk | c-mer proto-oncogene tyrosine kinase | 0.011 | ||
| Bdnf | brain-derived neurotrophic factor | 0.011 | ||
| Stac3 | SH3 and cysteine rich domain 3 | 0.011 | ||
| Sorbs1 | sorbin and SH3 domain containing 1 | 0.011 | ||
| Klc3 | kinesin light chain 3 | 0.011 | ||
| Nkx3-1 | NK3 homeobox 1 | 0.011 | ||
| Mthfd2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.011 | ||
| Gpr125 | G protein-coupled receptor 125 | 0.011 | ||
| Onecut1 | one cut homeobox 1 | 0.011 | ||
| Rfx1 | regulatory factor X, 1 (influences HLA class II expression) | 0.011 | ||
| Igfbpl1 | insulin-like growth factor binding protein-like 1 | 0.011 | ||
| Myst3 | MYST histone acetyltransferase (monocytic leukemia) 3 | 0.011 | ||
| Ttll9 | tubulin tyrosine ligase-like family, member 9 | 0.011 | ||
| Lpar3 | lysophosphatidic acid receptor 3 | 0.011 | ||
| Obp1f | odorant binding protein I f | 0.011 | ||
| Bcl2l10 | BCL2-like 10 (apoptosis facilitator) | 0.011 | ||
| Arpc1b | actin related protein 2/3 complex, subunit 1B | 0.011 | ||
| Fibcd1 | fibrinogen C domain containing 1 | 0.011 | ||
| Ss18l1 | synovial sarcoma translocation gene on chromosome 18-like 1 | 0.011 | ||
| Btg4 | B-cell translocation gene 4 | 0.011 | ||
| RGD1563458 | similar to D0H6S2654E protein | 0.011 | ||
| Krtap13-2 | keratin associated protein 13-2 | 0.011 | ||
| Grxcr1 | glutaredoxin, cysteine rich 1 | 0.011 | ||
| LOC681740 | similar to jumonji protein | 0.011 | ||
| Synpo | synaptopodin | 0.011 | ||
| Gcm1 | glial cells missing homolog 1 (Drosophila) | 0.011 | ||
| LOC100359454 | hypothetical protein LOC100359454 | 0.011 | ||
| Dffb | DNA fragmentation factor, beta polypeptide (caspase-activated DNase) | 0.011 | ||
| Smad6 | SMAD family member 6 | 0.011 | ||
| Tcfe2a | transcription factor E2a | 0.011 | ||
| Susd3 | sushi domain containing 3 | 0.011 | ||
| RGD1565997 | similar to 4931417G12Rik protein | 0.011 | ||
| Pcdha13 | protocadherin alpha 13 | 0.011 | ||
| Btnl7 | butyrophilin-like 7 | 0.010 | ||
| Cpne4 | copine IV | 0.010 | ||
| Crybb2 | crystallin, beta B2 | 0.010 | ||
| Npr3 | natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) | 0.010 | ||
| Actl7b | actin-like 7b | 0.010 | ||
| Fkbp5 | FK506 binding protein 5 | 0.010 | ||
| Bcl2l2 | Bcl2-like 2 | 0.010 | ||
| LOC361646 | similar to K04F10.2 | 0.010 | ||
| RGD1563556 | similar to mKIAA1377 protein | 0.010 | ||
| Psen1 | presenilin 1 | 0.010 | ||
| Slc6a9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 0.010 | ||
| Znf667 | zinc finger protein 667 | 0.010 | ||
| Cetn1 | centrin, EF-hand protein, 1 | 0.010 | ||
| Brd2 | bromodomain containing 2 | 0.010 | ||
| Fbxo17 | F-box protein 17 | 0.010 | ||
| Pdzd2 | PDZ domain containing 2 | 0.010 | ||
| Sptan1 | spectrin, alpha, non-erythrocytic 1 | 0.010 | ||
| Ctsql2 | cathepsin Q-like 2 | 0.010 | ||
| Cbl | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.010 | ||
| LOC687035 | similar to Tripartite motif protein 56 | 0.010 | ||
| Ddx31 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 | 0.010 | ||
| Mecp2 | methyl CpG binding protein 2 | 0.010 | ||
| Trpv4 | transient receptor potential cation channel, subfamily V, member 4 | 0.010 | ||
| Pqcp | polyglutamine-containing protein | 0.010 | ||
| Lrfn2 | leucine rich repeat and fibronectin type III domain containing 2 | 0.010 | ||
| Usf2 | upstream transcription factor 2, c-fos interacting | 0.010 | ||
| Padi1 | peptidyl arginine deiminase, type I | 0.010 | ||
| Ptgir | prostaglandin I2 (prostacyclin) receptor (IP) | 0.010 |