IMP
Process View
natural killer cell mediated cytotoxicity directed against tumor cell target
The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "natural killer cell mediated cytotoxicity directed against tumor cell target"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Klra5 | killer cell lectin-like receptor, subfamily A, member 5 | 0.935 | Rat | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.895 | ||
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.791 | ||
| Nkg7 | natural killer cell group 7 sequence | 0.649 | ||
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.472 | ||
| Gzmk | granzyme K | 0.464 | ||
| Igsf6 | immunoglobulin superfamily, member 6 | 0.413 | ||
| Slamf9 | SLAM family member 9 | 0.316 | ||
| Il7r | interleukin 7 receptor | 0.270 | ||
| Tlr7 | toll-like receptor 7 | 0.217 | ||
| Rgs1 | regulator of G-protein signaling 1 | 0.173 | ||
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.154 | Rat | |
| Xcl1 | chemokine (C motif) ligand 1 | 0.137 | ||
| Cyp2c12 | cytochrome P450, family 2, subfamily c, polypeptide 12 | 0.131 | ||
| St8sia4 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | 0.130 | ||
| Clec4f | C-type lectin domain family 4, member f | 0.122 | ||
| Serpine1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.113 | ||
| Klra22 | killer cell lectin-like receptor subfamily A, member 22 | 0.108 | Rat | |
| Tnfrsf12a | tumor necrosis factor receptor superfamily, member 12a | 0.101 | ||
| Gzmm | granzyme M (lymphocyte met-ase 1) | 0.099 | ||
| Il1rl1 | interleukin 1 receptor-like 1 | 0.096 | ||
| Cd8a | CD8a molecule | 0.094 | ||
| Olr1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.093 | Rat | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.089 | ||
| Clec12a | C-type lectin domain family 12, member A | 0.085 | ||
| Klra17 | killer cell lectin-like receptor, subfamily A, member 17 | 0.080 | ||
| Klrc2 | killer cell lectin-like receptor subfamily C, member 2 | 0.075 | Rat | |
| Gzmb | granzyme B | 0.075 | ||
| Pcsk1 | proprotein convertase subtilisin/kexin type 1 | 0.075 | ||
| Zap70 | zeta-chain (TCR) associated protein kinase | 0.070 | ||
| Prf1 | perforin 1 (pore forming protein) | 0.070 | ||
| Slc9a4 | solute carrier family 9 (sodium/hydrogen exchanger), member 4 | 0.070 | ||
| Ccl5 | chemokine (C-C motif) ligand 5 | 0.064 | ||
| Il18r1 | interleukin 18 receptor 1 | 0.064 | ||
| Clec9a | C-type lectin domain family 9, member a | 0.061 | Rat | |
| Hcls1 | hematopoietic cell specific Lyn substrate 1 | 0.060 | ||
| Cd2 | Cd2 molecule | 0.059 | ||
| Cyp2c13 | cytochrome P450, family 2, subfamily c, polypeptide 13 | 0.058 | ||
| Mcpt8 | mast cell protease 8 | 0.056 | ||
| Vom1r93 | vomeronasal 1 receptor 93 | 0.055 | ||
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.053 | ||
| Myc | myelocytomatosis oncogene | 0.051 | ||
| Atf3 | activating transcription factor 3 | 0.050 | ||
| Litaf | lipopolysaccharide-induced TNF factor | 0.049 | ||
| Txnrd1 | thioredoxin reductase 1 | 0.046 | ||
| Zcwpw1 | zinc finger, CW-type with PWWP domain 1 | 0.045 | ||
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.045 | ||
| Ctsj | cathepsin J | 0.045 | ||
| Spn | sialophorin | 0.045 | ||
| Samsn1 | SAM domain, SH3 domain and nuclear localization signals, 1 | 0.043 | ||
| Sit1 | signaling threshold regulating transmembrane adaptor 1 | 0.043 | ||
| Cd72 | Cd72 molecule | 0.043 | ||
| Clec7a | C-type lectin domain family 7, member a | 0.042 | Rat | |
| Klrb1a | killer cell lectin-like receptor subfamily B, member 1A | 0.041 | ||
| Sell | selectin L | 0.041 | ||
| Serpinb3a | serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A | 0.039 | ||
| Ccl19 | chemokine (C-C motif) ligand 19 | 0.038 | ||
| Il1b | interleukin 1 beta | 0.038 | ||
| Vcsa2 | variable coding sequence A2 | 0.035 | ||
| Tmem182 | transmembrane protein 182 | 0.035 | ||
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.034 | ||
| Lrrc8c | leucine rich repeat containing 8 family, member C | 0.032 | ||
| Pla1a | phospholipase A1 member A | 0.031 | ||
| Fam65b | family with sequence similarity 65, member B | 0.031 | ||
| Scin | scinderin | 0.030 | ||
| LOC300024 | similar to Ly6-B antigen gene | 0.030 | ||
| Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.029 | ||
| Tnni3k | TNNI3 interacting kinase | 0.029 | ||
| P2ry14 | purinergic receptor P2Y, G-protein coupled, 14 | 0.029 | ||
| Cyp7b1 | cytochrome P450, family 7, subfamily b, polypeptide 1 | 0.028 | ||
| Sept6 | septin 6 | 0.027 | ||
| Oasl | 2'-5'-oligoadenylate synthetase-like | 0.027 | ||
| Plaur | plasminogen activator, urokinase receptor | 0.026 | ||
| Oas1b | 2-5 oligoadenylate synthetase 1B | 0.026 | ||
| Trpv1 | transient receptor potential cation channel, subfamily V, member 1 | 0.025 | ||
| Mmp12 | matrix metallopeptidase 12 | 0.025 | ||
| Slc22a25 | solute carrier family 22, member 25 | 0.025 | ||
| Ubd | ubiquitin D | 0.024 | ||
| Prm2 | protamine 2 | 0.024 | ||
| Mcpt4 | mast cell protease 4 | 0.024 | ||
| Ms4a7 | membrane-spanning 4-domains, subfamily A, member 7 | 0.024 | ||
| Gimap6 | GTPase, IMAP family member 6 | 0.024 | ||
| Cd244 | Cd244 molecule, natural killer cell receptor 2B4 | 0.023 | ||
| Il6 | interleukin 6 | 0.023 | ||
| Cxcl1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.023 | ||
| Cd69 | Cd69 molecule | 0.022 | Rat | |
| Prl2a1 | Prolactin family 2, subfamily a, member 1 | 0.022 | ||
| Gen1 | Gen homolog 1, endonuclease (Drosophila) | 0.022 | ||
| Igfl3 | IGF-like family member 3 | 0.022 | ||
| C7 | complement component 7 | 0.022 | ||
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.021 | ||
| Phemx | pan hematopoietic expression | 0.021 | ||
| Rnd1 | Rho family GTPase 1 | 0.020 | ||
| Maff | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | 0.020 | ||
| Spic | Spi-C transcription factor (Spi-1/PU.1 related) | 0.020 | ||
| Vom1r102 | vomeronasal 1 receptor 102 | 0.020 | ||
| Gfra3 | GDNF family receptor alpha 3 | 0.020 | ||
| S100vp | S100 calcium-binding protein, ventral prostate | 0.020 | ||
| Krtap13-2 | keratin associated protein 13-2 | 0.020 | ||
| Cd22 | CD22 molecule | 0.020 | ||
| Fcgr1a | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 0.020 | ||
| LOC494538 | ABP beta | 0.020 | ||
| Cpa3 | carboxypeptidase A3, mast cell | 0.020 | ||
| MGC105649 | hypothetical LOC302884 | 0.020 | ||
| Fcgr3a | Fc fragment of IgG, low affinity IIIa, receptor | 0.020 | ||
| Cd247 | Cd247 molecule | 0.020 | ||
| Atp6v1g3 | ATPase, H+ transporting, lysosomal V1 subunit G3 | 0.019 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A | 0.019 | ||
| Pou1f1 | POU class 1 homeobox 1 | 0.019 | ||
| Ifng | interferon gamma | 0.019 | ||
| Bcl2a1d | B-cell leukemia/lymphoma 2 related protein A1d | 0.019 | ||
| Pik3cd | phosphoinositide-3-kinase, catalytic, delta polypeptide | 0.018 | ||
| Ccl9 | chemokine (C-C motif) ligand 9 | 0.018 | ||
| Pate4 | prostate and testis expressed 4 | 0.018 | ||
| Ctla2a | cytotoxic T lymphocyte-associated protein 2 alpha | 0.018 | ||
| Ldb3 | LIM domain binding 3 | 0.017 | ||
| Lilrb4 | leukocyte immunoglobulin-like receptor, subfamily B, member 4 | 0.017 | ||
| Art2 | ADP-ribosyltransferase 2 | 0.017 | ||
| Clec1a | C-type lectin domain family 1, member a | 0.017 | Rat | |
| Gem | GTP binding protein (gene overexpressed in skeletal muscle) | 0.017 | ||
| Fcrla | Fc receptor-like A | 0.017 | ||
| Mrc1 | mannose receptor, C type 1 | 0.017 | ||
| Unc5cl | unc-5 homolog C (C. elegans)-like | 0.017 | ||
| Inpp4b | inositol polyphosphate-4-phosphatase, type II | 0.017 | ||
| Klrc1 | killer cell lectin-like receptor subfamily C, member 1 | 0.017 | Rat | |
| Timp1 | TIMP metallopeptidase inhibitor 1 | 0.016 | ||
| Dclre1c | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) | 0.016 | ||
| Gzma | granzyme A | 0.016 | ||
| Gpr114 | G protein-coupled receptor 114 | 0.016 | ||
| Slc13a1 | solute carrier family 13 (sodium/sulfate symporters), member 1 | 0.016 | ||
| Sh2d2a | SH2 domain protein 2A | 0.016 | ||
| Phyhip | phytanoyl-CoA 2-hydroxylase interacting protein | 0.016 | ||
| Sycp1 | synaptonemal complex protein 1 | 0.016 | ||
| Myo1f | myosin IF | 0.015 | ||
| Cxcl11 | chemokine (C-X-C motif) ligand 11 | 0.015 | ||
| Gpr64 | G protein-coupled receptor 64 | 0.015 | ||
| Prl2b1 | Prolactin family 2, subfamily b, member 1 | 0.015 | ||
| Klhl6 | kelch-like 6 (Drosophila) | 0.015 | ||
| Psbpc2 | prostatic steroid-binding protein C2 | 0.015 | ||
| Cd3g | CD3 molecule, gamma | 0.015 | ||
| Dpp4 | dipeptidylpeptidase 4 | 0.014 | ||
| Stab2 | stabilin 2 | 0.014 | ||
| Csn3 | casein kappa | 0.014 | ||
| Plod2 | procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.014 | ||
| Acmsd | aminocarboxymuconate semialdehyde decarboxylase | 0.014 | ||
| Itgal | integrin, alpha L | 0.014 | ||
| Cst7 | cystatin F (leukocystatin) | 0.014 | ||
| Card6 | caspase recruitment domain family, member 6 | 0.014 | ||
| Slpi | secretory leukocyte peptidase inhibitor | 0.014 | ||
| Mca32 | mast cell antigen 32 | 0.014 | ||
| C6 | complement component 6 | 0.013 | ||
| Hbegf | heparin-binding EGF-like growth factor | 0.013 | ||
| Olr1226 | olfactory receptor 1226 | 0.013 | ||
| Mbnl3 | muscleblind-like 3 (Drosophila) | 0.013 | ||
| Prdm1 | PR domain containing 1, with ZNF domain | 0.013 | ||
| Tnfrsf14 | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) | 0.013 | ||
| Slfn3 | schlafen 3 | 0.013 | ||
| Gimap4 | GTPase, IMAP family member 4 | 0.013 | ||
| Ifrd1 | interferon-related developmental regulator 1 | 0.013 | ||
| Cyp3a2 | cytochrome P450, family 3, subfamily a, polypeptide 2 | 0.013 | ||
| Spef2 | sperm flagellar 2 | 0.013 | ||
| Lilrb3 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 | 0.013 | ||
| Naglt1 | Na+ dependent glucose transporter 1 | 0.013 | ||
| Gucy2g | guanylate cyclase 2G | 0.012 | ||
| Nox4 | NADPH oxidase 4 | 0.012 | ||
| Kcnv1 | potassium channel, subfamily V, member 1 | 0.012 | ||
| Skap1 | src kinase associated phosphoprotein 1 | 0.012 | ||
| Mcpt3 | mast cell peptidase 3 | 0.012 | ||
| LOC100361765 | homeobox B2 | 0.012 | ||
| Tnf | tumor necrosis factor (TNF superfamily, member 2) | 0.012 | ||
| Hmox1 | heme oxygenase (decycling) 1 | 0.011 | ||
| Itgb2 | integrin, beta 2 | 0.011 | ||
| LOC100362325 | rCG28200-like | 0.011 | ||
| Stap1 | signal transducing adaptor family member 1 | 0.011 | ||
| LOC687399 | hypothetical protein LOC687399 | 0.011 | ||
| Cd7 | Cd7 molecule | 0.011 | ||
| Il10ra | interleukin 10 receptor, alpha | 0.011 | ||
| RGD1307325 | similar to RIKEN cDNA 4933411K20 | 0.011 | ||
| RT1-Ha | RT1 class II, locus Ha | 0.011 | ||
| Cd200r2 | Cd200 receptor 2 | 0.011 | ||
| Ccl21 | chemokine (C-C motif) ligand 21 | 0.011 | ||
| LOC100361053 | mCG1039741-like | 0.011 | ||
| Ambn | ameloblastin | 0.011 | ||
| Chrm5 | cholinergic receptor, muscarinic 5 | 0.011 | ||
| Uba7 | ubiquitin-like modifier activating enzyme 7 | 0.011 | ||
| Pak1ip1 | PAK1 interacting protein 1 | 0.010 | ||
| RGD1561226 | similar to DNA segment, Chr 5, ERATO Doi 577, expressed | 0.010 | ||
| Alx3 | aristaless-like homeobox 3 | 0.010 | ||
| Plin5 | perilipin 5 | 0.010 | ||
| Uqcr11 | ubiquinol-cytochrome c reductase, complex III subunit XI | 0.010 | ||
| Olr1283 | olfactory receptor 1283 | 0.010 | ||
| Clec2g | C-type lectin domain family 2, member g | 0.010 | ||
| Prl8a9 | prolactin family 8, subfamily a, member 9 | 0.010 | ||
| Dppa3 | developmental pluripotency-associated 3 | 0.010 | ||
| Reg3g | regenerating islet-derived 3 gamma | 0.010 | ||
| Sval2 | seminal vesicle antigen-like 2 | 0.010 |