IMP: Integrative Multi-species Prediction

Rattus norvegicus

4 genes annotated in rat

negative regulation of luteinizing hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of luteinizing hormone secretion"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of luteinizing hormone secretion" (in gray)

Name	Description	Probability	Func Analog Organism
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.192
Slc14a2	solute carrier family 14 (urea transporter), member 2	0.147
Kcnq3	potassium voltage-gated channel, KQT-like subfamily, member 3	0.130
RGD1310262	hypothetical LOC304650	0.106
Dspp	dentin sialophosphoprotein	0.104
Slc22a7	solute carrier family 22 (organic anion transporter), member 7	0.102
Avp	arginine vasopressin	0.086
Hand1	heart and neural crest derivatives expressed 1	0.082
Prss21	protease, serine, 21	0.081
Hsd3b5	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	0.066
Grin2c	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.065
Hcrt	hypocretin	0.060
Gja6	gap junction protein, alpha 6	0.059
P2rx2	purinergic receptor P2X, ligand-gated ion channel, 2	0.058
Notch3	Notch homolog 3 (Drosophila)	0.054
Mrgprf	MAS-related GPR, member F	0.054
Psp	parotid secretory protein	0.053
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.053
St18	suppression of tumorigenicity 18	0.053
Faslg	Fas ligand (TNF superfamily, member 6)	0.052
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.051
Hrh3	histamine receptor H3	0.050
Nxph4	neurexophilin 4	0.044
Myl7	myosin, light chain 7, regulatory	0.044
Scn10a	sodium channel, voltage-gated, type X, alpha subunit	0.044
Hhip	Hedgehog-interacting protein	0.044
Npffr2	neuropeptide FF receptor 2	0.043
Ghrl	ghrelin/obestatin prepropeptide	0.041
Csf1	colony stimulating factor 1 (macrophage)	0.041
Gpr6	G protein-coupled receptor 6	0.040
Chrna7	cholinergic receptor, nicotinic, alpha 7	0.039
Cyp21a1	cytochrome P450, family 21, subfamily a, polypeptide 1	0.039
Slc22a25	solute carrier family 22, member 25	0.039
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.039
Pcp2	Purkinje cell protein 2	0.039
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.038
Slco2b1	solute carrier organic anion transporter family, member 2b1	0.038
Slc18a1	solute carrier family 18 (vesicular monoamine), member 1	0.037
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.037
Syt8	synaptotagmin VIII	0.037
N5	DNA binding protein N5	0.037
Chrm2	cholinergic receptor, muscarinic 2	0.036
Shank1	SH3 and multiple ankyrin repeat domains 1	0.036
Necab2	N-terminal EF-hand calcium binding protein 2	0.036
Cgm4	carcinoembryonic antigen gene family 4	0.035
Afap1	actin filament associated protein 1	0.034
Gzmk	granzyme K	0.034
Acrv1	acrosomal vesicle protein 1	0.033
Shh	sonic hedgehog	0.033
Prl6a1	prolactin family 6, subfamily a, member 1	0.032
Mag	myelin-associated glycoprotein	0.032
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.032
Mep1a	meprin 1 alpha	0.032
Ivl	involucrin	0.031
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, gamma 3	0.031
Atp2a3	ATPase, Ca++ transporting, ubiquitous	0.031
Prl3d4	prolactin family 3, subfamily d, member 4	0.031
Robo1	roundabout homolog 1 (Drosophila)	0.031
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.030
Mamdc4	MAM domain containing 4	0.030
Fxyd4	FXYD domain-containing ion transport regulator 4	0.030
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.029
Elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	0.029
Adam3a	ADAM metallopeptidase domain 3A (cyritestin 1)	0.029
Vipr2	vasoactive intestinal peptide receptor 2	0.028	Rat
Aqp2	aquaporin 2 (collecting duct)	0.027
Il13	interleukin 13	0.027
Fgf16	fibroblast growth factor 16	0.027
RGD1306474	similar to RIKEN cDNA 9530003J23	0.027
Tbx2	T-box 2	0.027
Uncx	UNC homeobox	0.026
Pmch	pro-melanin-concentrating hormone	0.026
Cx3cr1	chemokine (C-X3-C motif) receptor 1	0.026
Casp2	caspase 2	0.026
Nfasc	neurofascin	0.026
Cort	cortistatin	0.026
Igf2	insulin-like growth factor 2	0.025
Bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.025
Trpm1	transient receptor potential cation channel, subfamily M, member 1	0.025
Isl1	ISL LIM homeobox 1	0.025
Mcpt2	mast cell protease 2	0.025
Adam1a	a disintegrin and metallopeptidase domain 1a	0.025
Il9r	interleukin 9 receptor	0.025
Lep	leptin	0.025
Fev	FEV (ETS oncogene family)	0.024
Gsg1l	GSG1-like	0.024
Cyp4f4	cytochrome P450, family 4, subfamily f, polypeptide 4	0.024
Gjb4	gap junction protein, beta 4	0.024
Aspg	asparaginase homolog (S. cerevisiae)	0.023
Cnga4	cyclic nucleotide gated channel alpha 4	0.023
Syt7	synaptotagmin VII	0.023
Dll3	delta-like 3 (Drosophila)	0.023
Dcc	deleted in colorectal carcinoma	0.023
Dock8	dedicator of cytokinesis 8	0.023
Prkg2	protein kinase, cGMP-dependent, type II	0.023
Htr3a	5-hydroxytryptamine (serotonin) receptor 3a	0.023
Nrl	neural retina leucine zipper	0.023
Ednra	endothelin receptor type A	0.023
Gpr1	G protein-coupled receptor 1	0.022
Grm6	glutamate receptor, metabotropic 6	0.022
Cyp2b3	cytochrome P450, family 2, subfamily b, polypeptide 3	0.022
Zic1	Zic family member 1 (odd-paired homolog, Drosophila)	0.021
Olr1867	olfactory receptor 1867	0.021
Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.021
Adam10	ADAM metallopeptidase domain 10	0.021
Glp1r	glucagon-like peptide 1 receptor	0.021	Rat
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.021
Drd3	dopamine receptor D3	0.020
Nrxn3	neurexin 3	0.020
Svs4	seminal vesicle secretory protein 4	0.020
Hrh2	histamine receptor H 2	0.020
Insr	insulin receptor	0.020
Mmp2	matrix metallopeptidase 2	0.020
Mchr1	melanin-concentrating hormone receptor 1	0.020
Ncr1	natural cytotoxicity triggering receptor 1	0.020
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.020
Uhmk1	U2AF homology motif (UHM) kinase 1	0.020
Gfi1b	growth factor independent 1B transcription repressor	0.020
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.019
Bcan	brevican	0.019
Sfrp4	secreted frizzled-related protein 4	0.019
Kcnn3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	0.019
Mmp13	matrix metallopeptidase 13	0.019
Lhb	luteinizing hormone beta	0.019
Cmklr1	chemokine-like receptor 1	0.019
Gad2	glutamate decarboxylase 2	0.019
Slc7a12	solute carrier family 7 (cationic amino acid transporter, y+ system), member 12	0.018
Tacr1	tachykinin receptor 1	0.018
Csrnp2	cysteine-serine-rich nuclear protein 2	0.018
Sag	S-antigen; retina and pineal gland (arrestin)	0.018
Nrarp	Notch-regulated ankyrin repeat protein	0.018
Olr1493	olfactory receptor gene Olr1493	0.018
Testin	testin gene	0.018
Rup2	urinary protein 2	0.018
Adora2a	adenosine A2a receptor	0.018
Smgb	neonatal submandibular gland protein B	0.018
Prrt4	proline-rich transmembrane protein 4	0.018
Bcl2	B-cell CLL/lymphoma 2	0.018
Hcn4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	0.018
Slc18a3	solute carrier family 18 (vesicular acetylcholine), member 3	0.017
Ncan	neurocan	0.017
Htr4	5-hydroxytryptamine (serotonin) receptor 4	0.017
Apba1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.017
Avpr1b	arginine vasopressin receptor 1B	0.017
Sst	somatostatin	0.017
Scnn1b	sodium channel, nonvoltage-gated 1, beta	0.017
Cd40lg	CD40 ligand	0.017
Oprk1	opioid receptor, kappa 1	0.017
Pax6	paired box 6	0.017
Ucn	urocortin	0.017	Rat
Ceacam3	carcinoembryonic antigen-related cell adhesion molecule 3	0.017
Myh3	myosin, heavy chain 3, skeletal muscle, embryonic	0.017
Foxa1	forkhead box A1	0.017
Fbxo10	F-box protein 10	0.017
Arhgap4	Rho GTPase activating protein 4	0.017
Ceacam9	carcinoembryonic antigen-related cell adhesion molecule 9	0.016
Plin	perilipin	0.016
Gcnt3	glucosaminyl (N-acetyl) transferase 3, mucin type	0.016
Fam38b	family with sequence similarity 38, member B	0.016
Olr1496	olfactory receptor 1496	0.016
Dio1	deiodinase, iodothyronine, type I	0.016
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.016
Gck	glucokinase	0.016
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.016
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.016
Synpo	synaptopodin	0.016
Serpind1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.016
Slc16a8	solute carrier family 16, member 8 (monocarboxylic acid transporter 3)	0.016
Foxa3	forkhead box A3	0.016
Phox2a	paired-like homeobox 2a	0.016
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.016
Cxcr3	chemokine (C-X-C motif) receptor 3	0.016
Cntfr	ciliary neurotrophic factor receptor	0.016
Kcnb2	potassium voltage gated channel, Shab-related subfamily, member 2	0.016
Pomc	proopiomelanocortin	0.016
Pzp	pregnancy-zone protein	0.016
Vip	vasoactive intestinal peptide	0.015
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.015
Btc	betacellulin	0.015
Kcnh6	potassium voltage-gated channel, subfamily H (eag-related), member 6	0.015
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.015
Slc30a2	solute carrier family 30 (zinc transporter), member 2	0.015
Car5a	carbonic anhydrase 5a, mitochondrial	0.015
Hcrtr1	hypocretin (orexin) receptor 1	0.015
Cyp2c23	cytochrome P450, family 2, subfamily c, polypeptide 23	0.015
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1	0.015
Grip2	glutamate receptor interacting protein 2	0.015
Pde1c	phosphodiesterase 1C	0.015
Krt31	keratin 31	0.015
Umod	uromodulin	0.014
Prlh	prolactin releasing hormone	0.014
Adora1	adenosine A1 receptor	0.014
Dnase1l3	deoxyribonuclease 1-like 3	0.014
Pdyn	prodynorphin	0.014
Atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.014
Tnni3	troponin I type 3 (cardiac)	0.014
Csn1s1	casein alpha s1	0.014
Prl7a3	prolactin family 7, subfamily a, member 3	0.014
Prm3	protamine 3	0.014
Cd86	CD86 molecule	0.014
Pnma1	paraneoplastic antigen MA1	0.014
Pip	prolactin induced protein	0.014
Gip	gastric inhibitory polypeptide	0.014
Apoa4	apolipoprotein A-IV	0.014
Asgr1	asialoglycoprotein receptor 1	0.014
RGD1308759	similar to KIAA0892 protein	0.014
Rho	rhodopsin	0.014
Notch4	Notch homolog 4 (Drosophila)	0.014
Kcnh8	potassium voltage-gated channel, subfamily H (eag-related), member 8	0.014
Chrnb3	cholinergic receptor, nicotinic, beta 3	0.013
Afm	afamin	0.013
Insrr	insulin receptor-related receptor	0.013
Th	tyrosine hydroxylase	0.013
Cyss	cystatin S	0.013
Nfya	nuclear transcription factor-Y alpha	0.013
Il10ra	interleukin 10 receptor, alpha	0.013
Teddm1	transmembrane epididymal protein 1	0.013
B4galnt4	beta-1,4-N-acetyl-galactosaminyl transferase 4	0.013
Lbxcor1	LBXCOR1 homolog (mouse)	0.013
RGD1564664	similar to LOC387763 protein	0.013
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.013
Gucy2d	guanylate cyclase 2d	0.013
Gfra1	GDNF family receptor alpha 1	0.013
Rgs9	regulator of G-protein signaling 9	0.013
Gapdhs	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.013
Scn11a	sodium channel, voltage-gated, type XI, alpha	0.013
Mbl1	mannose-binding lectin (protein A) 1	0.013
LOC286987	hemiferrin, transferrin-like protein	0.013
Csn2	casein beta	0.013
Ghr	growth hormone receptor	0.013
Tas2r126	taste receptor, type 2, member 126	0.013
Ttll9	tubulin tyrosine ligase-like family, member 9	0.013
Clps	colipase, pancreatic	0.013
Krt5	keratin 5	0.012
Cyp4a8	cytochrome P450, family 4, subfamily a, polypeptide 8	0.012
Prl2a1	Prolactin family 2, subfamily a, member 1	0.012
C1qtnf6	C1q and tumor necrosis factor related protein 6	0.012
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.012
Kif6	kinesin family member 6	0.012
LOC56764	dnaj-like protein	0.012
LOC100362814	hypothetical protein LOC100362814	0.012
Crisp2	cysteine-rich secretory protein 2	0.012
Hbz	hemoglobin, zeta	0.012
P2rx3	purinergic receptor P2X, ligand-gated ion channel, 3	0.012
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.012
Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11	0.012
Cnnm1	cyclin M1	0.012
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.012
Galr3	galanin receptor 3	0.012
RGD1560871	similar to plexin 1	0.012
Gabre	gamma-aminobutyric acid (GABA) A receptor, epsilon	0.012
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.012
Pnoc	prepronociceptin	0.012
Krt1	keratin 1	0.012
Calcr	calcitonin receptor	0.012	Rat
Fut2	fucosyltransferase 2 (secretor status included)	0.012
Fgf15	fibroblast growth factor 15	0.011
RGD1309873	similar to hypothetical protein BC010003	0.011
Mybph	myosin binding protein H	0.011
Slc28a3	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3	0.011
Psg19	pregnancy specific glycoprotein 19	0.011
Vom2r18	vomeronasal 2 receptor, 18	0.011
Vom1r97	vomeronasal 1 receptor 97	0.011
Cartpt	CART prepropeptide	0.011
Fgf10	fibroblast growth factor 10	0.011
Sdc3	syndecan 3	0.011
G6pc	glucose-6-phosphatase, catalytic subunit	0.011
Cxcr5	chemokine (C-X-C motif) receptor 5	0.011
Ghsr	growth hormone secretagogue receptor	0.011
Cd4	Cd4 molecule	0.011
Prlhr	prolactin releasing hormone receptor	0.011
Slc6a11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.011
Hcn3	hyperpolarization-activated cyclic nucleotide-gated potassium channel 3	0.011
Oprm1	opioid receptor, mu 1	0.011
Rhobtb2	Rho-related BTB domain containing 2	0.011
Tff1	trefoil factor 1	0.011
Tgfbr3	transforming growth factor, beta receptor III	0.011
Ecel1	endothelin converting enzyme-like 1	0.011
Tnni1	troponin I type 1 (skeletal, slow)	0.011
Olr1641	olfactory receptor 1641	0.011
Accn2	amiloride-sensitive cation channel 2, neuronal	0.011
Adam6	a disintegrin and metallopeptidase domain 6	0.011
Atxn1	ataxin 1	0.011
Cfp	complement factor properdin	0.011
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.011
Slco6b1	solute carrier organic anion transporter family, member 6b1	0.011
Oprl1	opiate receptor-like 1	0.011
RT1-A3	RT1 class I, locus A3	0.011
Retnla	resistin like alpha	0.011
Fgf11	fibroblast growth factor 11	0.011
Prokr1	prokineticin receptor 1	0.011
Foxj1	forkhead box J1	0.011
Cyp27b1	cytochrome P450, family 27, subfamily b, polypeptide 1	0.011
LOC100360165	rCG29588-like	0.011
Olr226	olfactory receptor 226	0.011
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.011
Ctsj	cathepsin J	0.011
Rock1	Rho-associated coiled-coil containing protein kinase 1	0.011
Crhr2	corticotropin releasing hormone receptor 2	0.011
Hes3	hairy and enhancer of split 3 (Drosophila)	0.011
Prf1	perforin 1 (pore forming protein)	0.011
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.011
Svs3a	seminal vesicle secretory protein 3A	0.010
RGD1566083	similar to hypothetical protein MGC24047	0.010
Chrna2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	0.010
Vegp2	von Ebners gland protein 2	0.010
Slc7a3	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	0.010
Slc8a3	solute carrier family 8 (sodium/calcium exchanger), member 3	0.010
Crhbp	corticotropin releasing hormone binding protein	0.010
Krt86	keratin 86	0.010
Olr416	olfactory receptor 416	0.010
Clock	clock homolog (mouse)	0.010
Cntn6	contactin 6	0.010
Cyp2a3	cytochrome P450, family 2, subfamily a, polypeptide 3	0.010
Ar	androgen receptor	0.010
Pde3a	phosphodiesterase 3A, cGMP inhibited	0.010
Cel	carboxyl ester lipase	0.010
Ptprz1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.010