IMP
Process View
tricarboxylic acid cycle
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
Loading network...
In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "tricarboxylic acid cycle"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Atp5a1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | 0.922 | ||
| Sdhd | succinate dehydrogenase complex, subunit D, integral membrane protein | 0.846 | ||
| Ndufs2 | NADH dehydrogenase (ubiquinone) Fe-S protein 2 | 0.792 | ||
| Slc25a3 | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 | 0.677 | ||
| Sdha | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 0.396 | ||
| Idh3g | isocitrate dehydrogenase 3 (NAD), gamma | 0.344 | ||
| Uqcrfs1 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | 0.279 | ||
| Fh1 | fumarate hydratase 1 | 0.220 | ||
| Aco2 | aconitase 2, mitochondrial | 0.136 | ||
| Atp5c1 | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 | 0.127 | ||
| Ndufv1 | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.114 | ||
| Acat1 | acetyl-coenzyme A acetyltransferase 1 | 0.079 | ||
| Idh3B | isocitrate dehydrogenase 3 (NAD+) beta | 0.064 | ||
| Sdhc | succinate dehydrogenase complex, subunit C, integral membrane protein | 0.042 | ||
| Mdh2 | malate dehydrogenase 2, NAD (mitochondrial) | 0.040 | ||
| Hadhb | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 0.039 | ||
| Ndufs1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1 | 0.037 | ||
| Atp5b | ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide | 0.037 | ||
| Etfdh | electron-transferring-flavoprotein dehydrogenase | 0.027 | ||
| Gfm1 | G elongation factor, mitochondrial 1 | 0.026 | ||
| Slc25a11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 | 0.025 | ||
| Pdhb | pyruvate dehydrogenase (lipoamide) beta | 0.021 | ||
| Gna12 | guanine nucleotide binding protein (G protein) alpha 12 | 0.019 | ||
| Prdx3 | peroxiredoxin 3 | 0.017 | ||
| Tufm | Tu translation elongation factor, mitochondrial | 0.016 | ||
| Ghitm | growth hormone inducible transmembrane protein | 0.015 | ||
| Timm17a | translocase of inner mitochondrial membrane 17 homolog A (yeast) | 0.015 | ||
| Aldh6a1 | aldehyde dehydrogenase 6 family, member A1 | 0.014 | ||
| Nnt | nicotinamide nucleotide transhydrogenase | 0.013 | ||
| Mdh1 | malate dehydrogenase 1, NAD (soluble) | 0.012 | ||
| Pfkm | phosphofructokinase, muscle | 0.012 | ||
| Uqcrc2 | ubiquinol cytochrome c reductase core protein 2 | 0.012 | ||
| LOC683519 | similar to ribosomal protein, mitochondrial, S22 | 0.012 | ||
| Rab1b | RAB1B, member RAS oncogene family | 0.012 | ||
| Slc25a12 | solute carrier family 25 (mitochondrial carrier, Aralar), member 12 | 0.011 | ||
| Uqcrc1 | ubiquinol-cytochrome c reductase core protein I | 0.011 | ||
| Got1 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 0.010 | ||
| Acadl | acyl-Coenzyme A dehydrogenase, long-chain | 0.010 |