IMP: Integrative Multi-species Prediction

Rattus norvegicus

7 genes annotated in rat

Multi-species View

negative regulation of smooth muscle contraction

GO:0045986

Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of smooth muscle contraction"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of smooth muscle contraction" (in gray)

Name	Description	Probability	Func Analog Organism
Gucy1b3	guanylate cyclase 1, soluble, beta 3	0.194
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.111
Syt8	synaptotagmin VIII	0.110
Nfasc	neurofascin	0.075
Cx3cr1	chemokine (C-X3-C motif) receptor 1	0.075
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.058
Csrnp2	cysteine-serine-rich nuclear protein 2	0.056
Hcrt	hypocretin	0.044
Sox17	SRY (sex determining region Y)-box 17	0.044
Adora1	adenosine A1 receptor	0.044
Gpr6	G protein-coupled receptor 6	0.043
Avpr1b	arginine vasopressin receptor 1B	0.040
Hrh3	histamine receptor H3	0.038
Fgf14	fibroblast growth factor 14	0.036
Prp15	proline-rich protein 15	0.036
Gabra3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.035
Ncan	neurocan	0.033
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.033
Atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.033
Gad2	glutamate decarboxylase 2	0.032
Ucn	urocortin	0.032
Tubb3	tubulin, beta 3	0.031
Tpsb2	tryptase beta 2	0.031
Ar	androgen receptor	0.031
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	0.030
Aqp2	aquaporin 2 (collecting duct)	0.030
Pdyn	prodynorphin	0.030
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.029
Gabrr3	gamma-aminobutyric acid (GABA) receptor, rho 3	0.029
Kcnn3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	0.028
Cckar	cholecystokinin A receptor	0.027
Mchr1	melanin-concentrating hormone receptor 1	0.026
Mmp13	matrix metallopeptidase 13	0.026
Cxcr5	chemokine (C-X-C motif) receptor 5	0.025
Iapp	islet amyloid polypeptide	0.025
Grm6	glutamate receptor, metabotropic 6	0.025
Oprk1	opioid receptor, kappa 1	0.025
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.024
Grik3	glutamate receptor, ionotropic, kainate 3	0.024
Pcsk1	proprotein convertase subtilisin/kexin type 1	0.023
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1	0.023
Rgs9	regulator of G-protein signaling 9	0.023
Insrr	insulin receptor-related receptor	0.022
Agtr1a	angiotensin II receptor, type 1a	0.021
Gpr1	G protein-coupled receptor 1	0.021
Cd40lg	CD40 ligand	0.021
Csf1	colony stimulating factor 1 (macrophage)	0.020
Adra1a	adrenergic, alpha-1A-, receptor	0.020
Olr416	olfactory receptor 416	0.020
Cckbr	cholecystokinin B receptor	0.020
Crhbp	corticotropin releasing hormone binding protein	0.019
LOC60591	calcium-activated potassium channel beta subunit	0.019
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.019
Tacr1	tachykinin receptor 1	0.019
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.019
Mag	myelin-associated glycoprotein	0.019
Strn	striatin, calmodulin binding protein	0.019
Cpa3	carboxypeptidase A3, mast cell	0.018
Acrv1	acrosomal vesicle protein 1	0.018
Nkx6-1	NK6 homeobox 1	0.017
Cmtm2a	CKLF-like MARVEL transmembrane domain containing 2A	0.017
Cox8a	cytochrome c oxidase subunit VIIIa	0.016
P2rx3	purinergic receptor P2X, ligand-gated ion channel, 3	0.016
Chrna1	cholinergic receptor, nicotinic, alpha 1 (muscle)	0.016
Grik1	glutamate receptor, ionotropic, kainate 1	0.016
Slc6a7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.016
Vcsa1	variable coding sequence A1	0.016
Prm2	protamine 2	0.016
Kcnab2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	0.016
Bcan	brevican	0.015
Lims1	LIM and senescent cell antigen-like domains 1	0.015
Gpr176	G protein-coupled receptor 176	0.015
Sprr1al	small proline-rich protein 1A-like	0.015
Grin2b	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.015
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.015
Hsd3b5	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	0.015
Fgf7	fibroblast growth factor 7	0.015
Pth	parathyroid hormone	0.014
Chrna7	cholinergic receptor, nicotinic, alpha 7	0.014
Grp	gastrin releasing peptide	0.014
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.014
Neurod2	neurogenic differentiation 2	0.014
Adam3a	ADAM metallopeptidase domain 3A (cyritestin 1)	0.014
Slc6a17	solute carrier family 6 (neurotransmitter transporter), member 17	0.014
Adora2a	adenosine A2a receptor	0.013	Rat
Igsf1	immunoglobulin superfamily, member 1	0.013
Rab15	RAB15, member RAS oncogene family	0.013
Uhmk1	U2AF homology motif (UHM) kinase 1	0.013
Testin	testin gene	0.013
Sfrp4	secreted frizzled-related protein 4	0.013
Hsd17b1	hydroxysteroid (17-beta) dehydrogenase 1	0.012
RGD1564327	similar to integrin alpha 8	0.012
Cyp4a8	cytochrome P450, family 4, subfamily a, polypeptide 8	0.012
Dcc	deleted in colorectal carcinoma	0.012
Prkci	protein kinase C, iota	0.012
Avpr2	arginine vasopressin receptor 2	0.012
Olr1654	olfactory receptor 1654	0.012
Chrne	cholinergic receptor, nicotinic, epsilon	0.012
Kcnq2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.012
Chrnb2	cholinergic receptor, nicotinic, beta 2 (neuronal)	0.012
Ptprz1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.012
Avp	arginine vasopressin	0.012
Mc5r	melanocortin 5 receptor	0.012
Clstn3	calsyntenin 3	0.012
Grin3a	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	0.012
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.012
Aspg	asparaginase homolog (S. cerevisiae)	0.011
Scn10a	sodium channel, voltage-gated, type X, alpha subunit	0.011
Smgb	neonatal submandibular gland protein B	0.011
Hnmt	histamine N-methyltransferase	0.011
Kcna5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.011
Bhlha15	basic helix-loop-helix family, member a15	0.011
Npy5r	neuropeptide Y receptor Y5	0.011
F2rl1	coagulation factor II (thrombin) receptor-like 1	0.011
Sycp3	synaptonemal complex protein 3	0.011
Kitlg	KIT ligand	0.011
Apba1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.010
Nov	nephroblastoma overexpressed gene	0.010
Trh	thyrotropin releasing hormone	0.010
Pon1	paraoxonase 1	0.010
Dlg4	discs, large homolog 4 (Drosophila)	0.010
Fgfr2	fibroblast growth factor receptor 2	0.010