IMP: Integrative Multi-species Prediction

Rattus norvegicus

2 genes annotated in rat

Multi-species View

positive regulation of phosphatidylinositol 3 kinase activity

GO:0043552

Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of phosphatidylinositol 3 kinase activity"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of phosphatidylinositol 3 kinase activity" (in gray)

Name	Description	Probability	Func Analog Organism
Sirpa	signal-regulatory protein alpha	0.261
Klk1c10l2	kallikrein 1-related peptidase c10-like 2	0.129
Tpo	thyroid peroxidase	0.104
Prkcd	protein kinase C, delta	0.088
Fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.086	Human Rat
Dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.083
Ptprc	protein tyrosine phosphatase, receptor type, C	0.081
Klk8	kallikrein related-peptidase 8	0.077
Il2rg	interleukin 2 receptor, gamma	0.074
Nos3	nitric oxide synthase 3, endothelial cell	0.073
Plcg2	phospholipase C, gamma 2	0.073
RT1-DOa	RT1 class II, locus DOa	0.068
Arf6	ADP-ribosylation factor 6	0.068
Ptger4	prostaglandin E receptor 4 (subtype EP4)	0.066
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.064
Inpp5d	inositol polyphosphate-5-phosphatase D	0.064
Pik3r1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.063
Bhlha15	basic helix-loop-helix family, member a15	0.062
Mobkl2a	MOB1, Mps One Binder kinase activator-like 2A (yeast)	0.061
Cd37	CD37 molecule	0.060
Adra2b	adrenergic, alpha-2B-, receptor	0.058
Cbl	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.057
Fgfr1	Fibroblast growth factor receptor 1	0.054
Pdgfd	platelet-derived growth factor, D polypeptide	0.052
Fam26f	family with sequence similarity 26, member F	0.048
Tpm3	tropomyosin 3, gamma	0.047
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.046
Hprt1	hypoxanthine phosphoribosyltransferase 1	0.043
Vav1	vav 1 guanine nucleotide exchange factor	0.043
Stat6	signal transducer and activator of transcription 6	0.043
Hoxc4	homeo box C4	0.043
Il2rb	interleukin 2 receptor, beta	0.042
Myo1g	myosin IG	0.039
Bak1	BCL2-antagonist/killer 1	0.039
Klk1b21	kallikrein 1-related peptidase b21	0.038	Mouse
LOC100361261	rCG23560-like	0.037
Prrx1	paired related homeobox 1	0.037
Mpp3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.036
Eif4h	eukaryotic translation initiation factor 4H	0.036
Ets1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.035
Pdgfb	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.034	Human
Gzmf	granzyme F	0.032
Pik3cd	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.031
Spink1	serine peptidase inhibitor, Kazal type 1	0.031
LOC171161	common salivary protein 1	0.030
LOC363326	hypothetical LOC363326	0.030
Rab3il1	RAB3A interacting protein (rabin3)-like 1	0.030
Arpc2	actin related protein 2/3 complex, subunit 2	0.029
Batf	basic leucine zipper transcription factor, ATF-like	0.028
Plek	pleckstrin	0.028
Runx1	runt-related transcription factor 1	0.028
Gata3	GATA binding protein 3	0.028
Btnl7	butyrophilin-like 7	0.027
Lbp	lipopolysaccharide binding protein	0.026
LOC100364854	similar to RIKEN cDNA A430107P09 gene-like	0.026
Ttyh3	tweety homolog 3 (Drosophila)	0.025
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.025
Sox17	SRY (sex determining region Y)-box 17	0.025
Bst1	bone marrow stromal cell antigen 1	0.025
Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.025	Mouse Rat
Rhoh	ras homolog gene family, member H	0.025
Klrc2	killer cell lectin-like receptor subfamily C, member 2	0.024
Acacb	acetyl-Coenzyme A carboxylase beta	0.024
Msn	moesin	0.024
Cyct	cytochrome c, testis	0.024
Ptprs	protein tyrosine phosphatase, receptor type, S	0.024
Gnb2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.024
Cd38	CD38 molecule	0.023
Parp14	poly (ADP-ribose) polymerase family, member 14	0.023
Map4k1	mitogen activated protein kinase kinase kinase kinase 1	0.023
Gzmm	granzyme M (lymphocyte met-ase 1)	0.023
Alox5ap	arachidonate 5-lipoxygenase activating protein	0.022
Utrn	utrophin	0.022
Fnbp1	formin binding protein 1	0.022
Emcn	endomucin	0.022
Arhgap27	Rho GTPase activating protein 27	0.021
Slc5a1	solute carrier family 5 (sodium/glucose cotransporter), member 1	0.021
Rab10	RAB10, member RAS oncogene family	0.021
Jak2	Janus kinase 2	0.021
Fabp1	fatty acid binding protein 1, liver	0.021
Irf5	interferon regulatory factor 5	0.021
Spic	Spi-C transcription factor (Spi-1/PU.1 related)	0.021
Padi4	peptidyl arginine deiminase, type IV	0.021
Hspa1l	heat shock protein 1-like	0.021
Atp1a4	ATPase, Na+/K+ transporting, alpha 4 polypeptide	0.021
Cd14	CD14 molecule	0.020
Trh	thyrotropin releasing hormone	0.020
Myo1f	myosin IF	0.020
Testin	testin gene	0.020
Acp5	acid phosphatase 5, tartrate resistant	0.020
Cd4	Cd4 molecule	0.020
Cybb	cytochrome b-245, beta polypeptide	0.020
Cabp1	calcium binding protein 1	0.020
RT1-Ha	RT1 class II, locus Ha	0.020
Hcls1	hematopoietic cell specific Lyn substrate 1	0.019
Cd2	Cd2 molecule	0.019
Ptpn18	protein tyrosine phosphatase, non-receptor type 18	0.019
Ucp2	uncoupling protein 2 (mitochondrial, proton carrier)	0.019
Andpro	androgen regulated protein	0.019
Cd8a	CD8a molecule	0.019
Kcne1	potassium voltage-gated channel, Isk-related family, member 1	0.019
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.019
Fmnl1	formin-like 1	0.019
Ugt1a7c	UDP glucuronosyltransferase 1 family, polypeptide A7C	0.018
Acvrl1	activin A receptor type II-like 1	0.018
Ehf	ets homologous factor	0.018
Arrb2	arrestin, beta 2	0.018
Ggt5	gamma-glutamyltransferase 5	0.018
Matk	megakaryocyte-associated tyrosine kinase	0.018
LOC259244	alpha-2u globulin PGCL3	0.018
Nphs1	nephrosis 1 homolog (human)	0.018
Klk1c10	T-kininogenase	0.018	Mouse
LOC100363671	hypothetical protein LOC100363671	0.018
Tgfbr2	transforming growth factor, beta receptor II	0.018
Cd3d	CD3 molecule, delta	0.018
Fkbp1a	FK506 binding protein 1a	0.018
Ncf4	neutrophil cytosolic factor 4	0.018
Zp3	zona pellucida glycoprotein 3 (sperm receptor)	0.018
RGD1564878	similar to natural killer cell protease 7	0.018
Ugt2b5	UDP glucuronosyltransferase 2 family, polypeptide B5	0.017
Cd5	Cd5 molecule	0.017
Myh9	myosin, heavy chain 9, non-muscle	0.017
Pecam1	platelet/endothelial cell adhesion molecule 1	0.017
Cycs	cytochrome c, somatic	0.017
Htr2b	5-hydroxytryptamine (serotonin) receptor 2B	0.017
Cyfip1	cytoplasmic FMR1 interacting protein 1	0.017
Pdha2	pyruvate dehydrogenase (lipoamide) alpha 2	0.017
Stat4	signal transducer and activator of transcription 4	0.017
Atp2a3	ATPase, Ca++ transporting, ubiquitous	0.017
Epas1	endothelial PAS domain protein 1	0.017
Megf10	multiple EGF-like domains 10	0.017
Neurog1	neurogenin 1	0.017
Aqp5	aquaporin 5	0.016
Ube2a	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.016
Ly86	lymphocyte antigen 86	0.016
B4galnt1	beta-1,4-N-acetyl-galactosaminyl transferase 1	0.016
Grb2	growth factor receptor bound protein 2	0.016
Alx1	ALX homeobox 1	0.016
Hes3	hairy and enhancer of split 3 (Drosophila)	0.016
Smad7	SMAD family member 7	0.016
Mapk3	mitogen activated protein kinase 3	0.016
Prss2	protease, serine, 2	0.016
Rab38	RAB38, member RAS oncogene family	0.016
Hlf	hepatic leukemia factor	0.016
Tuba1a	tubulin, alpha 1A	0.016
Amh	anti-Mullerian hormone	0.016
Ptgir	prostaglandin I2 (prostacyclin) receptor (IP)	0.016
Pou6f1	POU class 6 homeobox 1	0.016
Atp1b3	ATPase, Na+/K+ transporting, beta 3 polypeptide	0.016
LOC100361349	hypothetical protein LOC100361349	0.016
Ntf4	neurotrophin 4	0.015
Fgd2	FYVE, RhoGEF and PH domain containing 2	0.015
Mip	major intrinsic protein of lens fiber	0.015
Npr1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.015
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.015
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.015
LOC100360587	hypothetical protein LOC100360587	0.015
Klk1	kallikrein 1	0.015	Mouse
Grem1	gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)	0.015
Znf76	zinc finger protein 76 (expressed in testis)	0.015
Add3	adducin 3 (gamma)	0.015
Plaur	plasminogen activator, urokinase receptor	0.015
Gpr116	G protein-coupled receptor 116	0.015
Mprip	myosin phosphatase Rho interacting protein	0.015
Tnp1	transition protein 1	0.015
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.015
Myh13	myosin, heavy chain 13, skeletal muscle	0.015
Fgfr2	fibroblast growth factor receptor 2	0.015
Il1r1	interleukin 1 receptor, type I	0.015
LOC259246	alpha-2u globulin PGCL1	0.015
Ptpn1	protein tyrosine phosphatase, non-receptor type 1	0.014
Prkch	protein kinase C, eta	0.014
Lep	leptin	0.014
Tlr2	toll-like receptor 2	0.014
Pear1	platelet endothelial aggregation receptor 1	0.014
Gcg	glucagon	0.014
Smad1	SMAD family member 1	0.014
Kif1c	kinesin family member 1C	0.014
Acox2	acyl-Coenzyme A oxidase 2, branched chain	0.014
Csn1s2a	casein alpha s2-like A	0.014
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.014
Acaa1b	acetyl-Coenzyme A acyltransferase 1B	0.014
Dnase2a	deoxyribonuclease II alpha	0.014
RGD1559588	similar to cell surface receptor FDFACT	0.014
Grpca	glutamine/glutamic acid-rich protein A	0.014
Gkn1	gastrokine 1	0.014
Foxs1	forkhead box S1	0.014
Pfdn5	prefoldin subunit 5	0.014
Tph1	tryptophan hydroxylase 1	0.014
Slit3	slit homolog 3 (Drosophila)	0.014
Art2	ADP-ribosyltransferase 2	0.014
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.014
Il18r1	interleukin 18 receptor 1	0.014
Jtb	jumping translocation breakpoint	0.014
Slc22a12	solute carrier family 22 (organic anion/urate transporter), member 12	0.014
Agtr1a	angiotensin II receptor, type 1a	0.014
Tnfaip8l2	tumor necrosis factor, alpha-induced protein 8-like 2	0.014
Nlrp6	NLR family, pyrin domain containing 6	0.014
Prpg1	proline-rich proteoglycan 1	0.013
Lama2	laminin, alpha 2	0.013
Nfia	nuclear factor I/A	0.013
Fut4	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	0.013
Hmha1	histocompatibility (minor) HA-1	0.013
Cd80	Cd80 molecule	0.013
Icam1	intercellular adhesion molecule 1	0.013
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.013
Mical1	microtubule associated monoxygenase, calponin and LIM domain containing 1	0.013
Igh-6	immunoglobulin heavy chain 6	0.013
Clec4a1	C-type lectin domain family 4, member a1	0.013
Itgb5	integrin, beta 5	0.013
Myh11	myosin, heavy chain 11, smooth muscle	0.013
Mcpt3	mast cell peptidase 3	0.013
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.013
Lef1	lymphoid enhancer binding factor 1	0.013
Svs6	seminal vesicle secretory protein 6	0.013
LOC689770	similar to osteoclast inhibitory lectin	0.013
Ramp3	receptor (G protein-coupled) activity modifying protein 3	0.013
Creb1	cAMP responsive element binding protein 1	0.013
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.013
Tek	TEK tyrosine kinase, endothelial	0.013	Human
Nptxr	neuronal pentraxin receptor	0.013
Cd40	CD40 molecule, TNF receptor superfamily member 5	0.013
Phemx	pan hematopoietic expression	0.013
Plxnd1	plexin D1	0.013
Lrp5	low density lipoprotein receptor-related protein 5	0.013
Krt7	keratin 7	0.013
Tff2	trefoil factor 2	0.013
Obp3	alpha-2u globulin PGCL4	0.013
Brca1	breast cancer 1	0.013
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.013
Bcl2	B-cell CLL/lymphoma 2	0.012
Cap1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.012
Kcnj1	potassium inwardly-rectifying channel, subfamily J, member 1	0.012
Cdh4	cadherin 4	0.012
Vwf	von Willebrand factor	0.012
Kcnf1	potassium voltage-gated channel, subfamily F, member 1	0.012
Cxcl13	chemokine (C-X-C motif) ligand 13	0.012
Map3k1	mitogen activated protein kinase kinase kinase 1	0.012
Cldn8	claudin 8	0.012
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.012
Sycp1	synaptonemal complex protein 1	0.012
Cd47	Cd47 molecule	0.012
Scarb1	scavenger receptor class B, member 1	0.012
Otp	orthopedia homeobox	0.012
Rhoa	ras homolog gene family, member A	0.012
Lmod1	leiomodin 1 (smooth muscle)	0.012
RT1-Bb	RT1 class II, locus Bb	0.012
Hrh1	histamine receptor H 1	0.012
Casp1	caspase 1	0.012
Sbp	spermine binding protein	0.012
Rbp2	retinol binding protein 2, cellular	0.012
Cdh5	cadherin 5	0.012
Cdc7	cell division cycle 7 homolog (S. cerevisiae)	0.012
Ptpre	protein tyrosine phosphatase, receptor type, E	0.012
Snai2	snail homolog 2 (Drosophila)	0.012
Ager	advanced glycosylation end product-specific receptor	0.012
Unc5a	unc-5 homolog A (C. elegans)	0.012
Plekho1	pleckstrin homology domain containing, family O member 1	0.012
Msmb	microseminoprotein, beta	0.012
Grm3	glutamate receptor, metabotropic 3	0.012
LOC308990	hypothetical protein LOC308990	0.012
LOC690507	similar to Vomeromodulin	0.012
B3gnt7	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	0.012
Mycs	myc-like oncogene, s-myc protein	0.012
Plau	plasminogen activator, urokinase	0.012
RT1-EC2	RT1 class Ib, locus EC2	0.012
Arhgap25	Rho GTPase activating protein 25	0.012
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.012
Prdm8	PR domain containing 8	0.012
Ltb	lymphotoxin beta (TNF superfamily, member 3)	0.012
Cst5	cystatin D	0.012
Mup5	major urinary protein 5	0.012
Rin2	Ras and Rab interactor 2	0.011
Rya3	antimicrobial peptide RYA3	0.011
Klk1b3	kallikrein 1-related peptidase b3	0.011	Mouse
Dcaf17	DDB1 and CUL4 associated factor 17	0.011
Skap2	src kinase associated phosphoprotein 2	0.011
Man2b1	mannosidase, alpha, class 2B, member 1	0.011
Dmrta1	DMRT-like family A1	0.011
Traf3ip3	TRAF3 interacting protein 3	0.011
Sla	src-like adaptor	0.011
Amelx	amelogenin X chromosome	0.011
Hspg2	heparan sulfate proteoglycan 2	0.011
Lcn5	lipocalin 5	0.011
Maf	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	0.011
F13a1	coagulation factor XIII, A1 polypeptide	0.011
Ttl	tubulin tyrosine ligase	0.011
Calml3	calmodulin-like 3	0.011
LOC679931	hypothetical protein LOC679931	0.011
Cask	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.011
Gimap1	GTPase, IMAP family member 1	0.011
Itpr3	inositol 1,4,5-triphosphate receptor, type 3	0.011
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.011
Cd69	Cd69 molecule	0.011
Bmp5	bone morphogenetic protein 5	0.011
Elf1	E74-like factor 1	0.011
Rgs1	regulator of G-protein signaling 1	0.011
Kl	Klotho	0.011
Arhgap9	Rho GTPase activating protein 9	0.011
RGD1311493	similar to CG13379-PA	0.011
Gimap4	GTPase, IMAP family member 4	0.011
Cyth3	cytohesin 3	0.011
Gja1	gap junction protein, alpha 1	0.011
Cyp3a2	cytochrome P450, family 3, subfamily a, polypeptide 2	0.011
Tlr7	toll-like receptor 7	0.011
Itpr2	inositol 1,4,5-triphosphate receptor, type 2	0.011
Col4a3	collagen, type IV, alpha 3	0.011
Arhgdib	Rho, GDP dissociation inhibitor (GDI) beta	0.011
Pawr	PRKC, apoptosis, WT1, regulator	0.011
Pou2f2	POU class 2 homeobox 2	0.011
Ppp1r3b	protein phosphatase 1, regulatory (inhibitor) subunit 3B	0.011
Lnpep	leucyl/cystinyl aminopeptidase	0.011
Cspg4	chondroitin sulfate proteoglycan 4	0.011
Micalcl	MICAL C-terminal like	0.011
Arl5c	ADP-ribosylation factor-like 5C	0.011
Tbc1d10c	TBC1 domain family, member 10C	0.011
Znf521	zinc finger protein 521	0.011
Basp1	brain abundant, membrane attached signal protein 1	0.011
Ube2b	ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)	0.011
Zfp362	zinc finger protein 362	0.011
Dock8	dedicator of cytokinesis 8	0.011
Hist1h2ba	histone cluster 1, H2ba	0.010
Slpi	secretory leukocyte peptidase inhibitor	0.010
Ifnk	interferon kappa	0.010
Sema6b	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	0.010
Fabp12	fatty acid binding protein 12	0.010
Olr1307	olfactory receptor 1307	0.010
Slit1	slit homolog 1 (Drosophila)	0.010
Hpcal4	hippocalcin-like 4	0.010
Prkcb	protein kinase C, beta	0.010
Serpinb6b	serine (or cysteine) peptidase inhibitor, clade B, member 6b	0.010
Dapk1	death associated protein kinase 1	0.010
Chrnb2	cholinergic receptor, nicotinic, beta 2 (neuronal)	0.010
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.010
Prb1	proline-rich protein BstNI subfamily 1	0.010
Lrp1	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	0.010
Bin2	bridging integrator 2	0.010
Tulp2	tubby-like protein 2	0.010
Gpr34	G protein-coupled receptor 34	0.010
Ephb6	Eph receptor B6	0.010
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.010
Amy2	amylase 2, pancreatic	0.010
Gimap5	GTPase, IMAP family member 5	0.010
Wt1	Wilms tumor 1	0.010
Fbxo39	F-box protein 39	0.010
Ocln	occludin	0.010
Soat1	sterol O-acyltransferase 1	0.010
Ctsr	cathepsin R	0.010
Strn4	striatin, calmodulin binding protein 4	0.010
S100a8	S100 calcium binding protein A8	0.010
Sycn	syncollin	0.010
Cox7a2l	cytochrome c oxidase subunit VIIa polypeptide 2 like	0.010
Slc18a3	solute carrier family 18 (vesicular acetylcholine), member 3	0.010