IMP
Process View
tetrahydrofolate metabolic process
The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "tetrahydrofolate metabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Dhfr | dihydrofolate reductase | 0.312 | ||
| Ung | uracil-DNA glycosylase | 0.155 | ||
| Top2a | topoisomerase (DNA) II alpha | 0.138 | ||
| Ccnb1 | cyclin B1 | 0.134 | ||
| Kmo | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 0.127 | ||
| Rbp2 | retinol binding protein 2, cellular | 0.123 | ||
| Hn1l | hematological and neurological expressed 1-like | 0.118 | ||
| Cenpi | centromere protein I | 0.111 | ||
| Rad51c | Rad51 homolog c (S. cerevisiae) | 0.089 | ||
| Mcm5 | minichromosome maintenance complex component 5 | 0.081 | ||
| Acsm3 | acyl-CoA synthetase medium-chain family member 3 | 0.076 | ||
| Shmt1 | serine hydroxymethyltransferase 1 (soluble) | 0.073 | ||
| Ccne1 | cyclin E1 | 0.068 | ||
| Pola1 | polymerase (DNA directed), alpha 1 | 0.066 | ||
| Mad2l1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.065 | ||
| Pctp | phosphatidylcholine transfer protein | 0.060 | ||
| Casp7 | caspase 7 | 0.059 | ||
| Fert2 | fer (fms/fps related) protein kinase, testis specific 2 | 0.058 | ||
| Tk1 | thymidine kinase 1, soluble | 0.053 | ||
| Ns5atp9 | NS5A (hepatitis C virus) transactivated protein 9 | 0.052 | ||
| Rpa2 | replication protein A2 | 0.050 | ||
| Nolc1 | nucleolar and coiled-body phosphoprotein 1 | 0.049 | ||
| Mcm2 | minichromosome maintenance complex component 2 | 0.045 | ||
| Bmp7 | bone morphogenetic protein 7 | 0.044 | ||
| Mtr | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.043 | ||
| Tyms | thymidylate synthetase | 0.042 | ||
| Timeless | timeless homolog (Drosophila) | 0.042 | ||
| Chek1 | CHK1 checkpoint homolog (S. pombe) | 0.042 | ||
| Aldob | aldolase B, fructose-bisphosphate | 0.041 | ||
| Mcm4 | minichromosome maintenance complex component 4 | 0.041 | ||
| Josd2 | Josephin domain containing 2 | 0.040 | ||
| RGD1562114 | RGD1562114 | 0.039 | ||
| Asf1b | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | 0.037 | ||
| Ahcy | adenosylhomocysteinase | 0.035 | ||
| Hfe | hemochromatosis | 0.035 | ||
| Aldh18a1 | aldehyde dehydrogenase 18 family, member A1 | 0.033 | ||
| Creb1 | cAMP responsive element binding protein 1 | 0.033 | ||
| Hmmr | hyaluronan mediated motility receptor (RHAMM) | 0.032 | ||
| Hnf1a | HNF1 homeobox A | 0.030 | ||
| Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | 0.030 | ||
| Sf3b3 | splicing factor 3b, subunit 3 | 0.029 | ||
| Slc19a1 | solute carrier family 19 (folate transporter), member 1 | 0.028 | ||
| Cyp2d2 | cytochrome P450, family 2, subfamily d, polypeptide 2 | 0.027 | ||
| Atic | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | 0.027 | ||
| Nup62 | nucleoporin 62 | 0.027 | ||
| Gc | group specific component | 0.027 | ||
| Cct7 | chaperonin containing Tcp1, subunit 7 (eta) | 0.027 | ||
| Gcgr | glucagon receptor | 0.026 | ||
| Brca1 | breast cancer 1 | 0.026 | ||
| Vps45 | vacuolar protein sorting 45 homolog (S. cerevisiae) | 0.026 | ||
| Nhlrc2 | NHL repeat containing 2 | 0.026 | ||
| Slco2a1 | solute carrier organic anion transporter family, member 2a1 | 0.026 | ||
| Acacb | acetyl-Coenzyme A carboxylase beta | 0.026 | ||
| LOC689399 | hypothetical protein LOC689399 | 0.025 | ||
| RGD1304693 | similar to CG14803-PA | 0.025 | ||
| Hat1 | histone acetyltransferase 1 | 0.025 | ||
| Ces1c | carboxylesterase 1C | 0.025 | ||
| Cpsf3 | cleavage and polyadenylation specificity factor 3 | 0.024 | ||
| Asns | asparagine synthetase | 0.023 | ||
| Polr1b | polymerase (RNA) I polypeptide B | 0.023 | ||
| Lmnb1 | lamin B1 | 0.023 | ||
| Apoc4 | apolipoprotein C-IV | 0.023 | ||
| Shmt2 | serine hydroxymethyltransferase 2 (mitochondrial) | 0.023 | ||
| Prim2 | primase, DNA, polypeptide 2 | 0.022 | ||
| Fen1 | flap structure-specific endonuclease 1 | 0.022 | ||
| Rest | RE1-silencing transcription factor | 0.021 | ||
| Nup155 | nucleoporin 155 | 0.021 | ||
| Eif2b2 | eukaryotic translation initiation factor 2B, subunit 2 beta | 0.021 | ||
| RGD1309437 | similar to RIKEN cDNA 2610528E23 | 0.020 | ||
| Thoc6 | THO complex 6 homolog (Drosophila) | 0.020 | ||
| Hnf4a | hepatocyte nuclear factor 4, alpha | 0.019 | ||
| Atp6ap1 | ATPase, H+ transporting, lysosomal accessory protein 1 | 0.019 | ||
| Fas | Fas (TNF receptor superfamily, member 6) | 0.019 | ||
| Gnmt | glycine N-methyltransferase | 0.019 | ||
| RGD1564865 | similar to 20-alpha-hydroxysteroid dehydrogenase | 0.018 | ||
| Pold3 | polymerase (DNA-directed), delta 3, accessory subunit | 0.018 | ||
| Haus4 | HAUS augmin-like complex, subunit 4 | 0.018 | ||
| Agps | alkylglycerone phosphate synthase | 0.018 | ||
| Gins1 | GINS complex subunit 1 (Psf1 homolog) | 0.018 | ||
| Brca2 | breast cancer 2 | 0.017 | ||
| Prim1 | DNA primase, p49 subunit | 0.017 | ||
| Olr59 | olfactory receptor 59 | 0.017 | ||
| Smcr7l | Smith-Magenis syndrome chromosome region, candidate 7-like (human) | 0.017 | ||
| Nlrp6 | NLR family, pyrin domain containing 6 | 0.016 | ||
| Phgdh | phosphoglycerate dehydrogenase | 0.016 | ||
| Irf2 | interferon regulatory factor 2 | 0.016 | ||
| Ceacam10 | carcinoembryonic antigen-related cell adhesion molecule 10 | 0.016 | ||
| Lnpep | leucyl/cystinyl aminopeptidase | 0.016 | ||
| Gulo | gulonolactone (L-) oxidase | 0.016 | ||
| Ppp1r3b | protein phosphatase 1, regulatory (inhibitor) subunit 3B | 0.015 | ||
| Aspg | asparaginase homolog (S. cerevisiae) | 0.015 | ||
| Ezh2 | enhancer of zeste homolog 2 (Drosophila) | 0.015 | ||
| Gspt1 | G1 to S phase transition 1 | 0.015 | ||
| Atxn3 | ataxin 3 | 0.015 | ||
| Mcm3 | minichromosome maintenance complex component 3 | 0.015 | ||
| Aimp2 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 | 0.015 | ||
| Fbp1 | fructose-1,6-bisphosphatase 1 | 0.015 | ||
| Dio1 | deiodinase, iodothyronine, type I | 0.015 | ||
| Msh2 | mutS homolog 2 (E. coli) | 0.015 | ||
| Sema3a | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.015 | ||
| Mlh1 | mutL homolog 1 (E. coli) | 0.015 | ||
| Senp3 | Sumo1/sentrin/SMT3 specific peptidase 3 | 0.014 | ||
| Pank3 | pantothenate kinase 3 | 0.014 | ||
| Rab27a | RAB27A, member RAS oncogene family | 0.014 | ||
| Enah | enabled homolog (Drosophila) | 0.014 | ||
| Hyal2 | hyaluronoglucosaminidase 2 | 0.014 | ||
| Mcm6 | minichromosome maintenance complex component 6 | 0.014 | ||
| Dnmt1 | DNA (cytosine-5-)-methyltransferase 1 | 0.014 | ||
| Cad | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | 0.013 | ||
| Prkaa1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | 0.013 | ||
| Nid67 | putative small membrane protein NID67 | 0.013 | ||
| Asgr1 | asialoglycoprotein receptor 1 | 0.013 | ||
| Cyp7b1 | cytochrome P450, family 7, subfamily b, polypeptide 1 | 0.013 | ||
| Pold2 | polymerase (DNA directed), delta 2, regulatory subunit | 0.013 | ||
| Afp | alpha-fetoprotein | 0.013 | ||
| Wee1 | wee 1 homolog (S. pombe) | 0.013 | ||
| Dvl2 | dishevelled 2 | 0.013 | ||
| Upb1 | ureidopropionase, beta | 0.013 | ||
| Sass6 | spindle assembly 6 homolog (C. elegans) | 0.012 | ||
| Mat1a | methionine adenosyltransferase I, alpha | 0.012 | ||
| Kif11 | kinesin family member 11 | 0.012 | ||
| Nsun4 | NOL1/NOP2/Sun domain family, member 4 | 0.012 | ||
| Cbx2 | chromobox homolog 2 (Pc class homolog, Drosophila) | 0.012 | ||
| Car5a | carbonic anhydrase 5a, mitochondrial | 0.012 | ||
| Nutf2 | nuclear transport factor 2 | 0.012 | ||
| Kif4 | kinesin family member 4 | 0.012 | ||
| RGD1311564 | LOC360590 | 0.012 | ||
| Soat1 | sterol O-acyltransferase 1 | 0.012 | ||
| Prpf3 | PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) | 0.012 | ||
| Skiv2l | superkiller viralicidic activity 2-like (S. cerevisiae ) | 0.012 | ||
| Tmem185b | transmembrane protein 185B | 0.012 | ||
| Slc2a2 | solute carrier family 2 (facilitated glucose transporter), member 2 | 0.012 | ||
| Cars | cysteinyl-tRNA synthetase | 0.011 | ||
| Paics | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 0.011 | ||
| Masp1 | mannan-binding lectin serine peptidase 1 | 0.011 | ||
| Mre11a | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 0.011 | ||
| Timp1 | TIMP metallopeptidase inhibitor 1 | 0.011 | ||
| Bop1 | block of proliferation 1 | 0.011 | ||
| Cirh1a | cirrhosis, autosomal recessive 1A (cirhin) | 0.011 | ||
| Abcc3 | ATP-binding cassette, subfamily C (CFTR/MRP), member 3 | 0.011 | ||
| Aurkb | aurora kinase B | 0.011 | ||
| Igfl3 | IGF-like family member 3 | 0.011 | ||
| COX2 | COXII | 0.011 | ||
| Nudt1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 0.011 | ||
| Pla2g1b | phospholipase A2, group IB, pancreas | 0.011 | ||
| Nup43 | nucleoporin 43 | 0.011 | ||
| Parp1 | poly (ADP-ribose) polymerase 1 | 0.011 | ||
| Pck1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.011 | ||
| Pcbd1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 0.011 | ||
| Gtf2a1 | general transcription factor IIA, 1 | 0.011 | ||
| Abp10 | annexin V-binding protein ABP-10 | 0.011 | ||
| Extl2 | exostoses (multiple)-like 2 | 0.010 | ||
| Pmf1 | polyamine-modulated factor 1 | 0.010 | ||
| Cyp4a2 | cytochrome P450, family 4, subfamily a, polypeptide 2 | 0.010 | ||
| Kitlg | KIT ligand | 0.010 | ||
| Tbl3 | transducin (beta)-like 3 | 0.010 | ||
| Casp6 | caspase 6 | 0.010 | ||
| Mgst2 | microsomal glutathione S-transferase 2 | 0.010 | ||
| Prkca | protein kinase C, alpha | 0.010 | ||
| Qpct | glutaminyl-peptide cyclotransferase | 0.010 |