IMP: Integrative Multi-species Prediction

Rattus norvegicus

33 genes annotated in rat

response to lead ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.

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Known genes in the process in ratInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to lead ion"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "response to lead ion" (in gray)

Name	Description	Probability	Func Analog Organism
Cyp2c13	cytochrome P450, family 2, subfamily c, polypeptide 13	0.417
LOC100134871	beta globin minor gene	0.376
Gstp1	glutathione S-transferase pi 1	0.374
Serpina1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.366
Ephx1	epoxide hydrolase 1, microsomal	0.277
Hbb	hemoglobin, beta	0.264
Gstm1	glutathione S-transferase mu 1	0.254
Orm1	orosomucoid 1	0.240
Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	0.218	Rat
LOC100363106	LRRG00130-like	0.174
LOC100364265	ribosomal protein L19-like	0.136
LOC100359522	LRRGT00191-like	0.136
Cyp2d2	cytochrome P450, family 2, subfamily d, polypeptide 2	0.120
Apoa2	apolipoprotein A-II	0.105
Mettl7b	methyltransferase like 7B	0.101
Ahsg	alpha-2-HS-glycoprotein	0.092
Hmbs	hydroxymethylbilane synthase	0.090
Fga	fibrinogen alpha chain	0.090
C9	complement component 9	0.085
LOC689064	beta-globin	0.079
Qdpr	quinoid dihydropteridine reductase	0.079
Gstm2	glutathione S-transferase mu 2	0.077	Rat
Hpx	hemopexin	0.075
Gsta3	glutathione S-transferase A3	0.074
Cyp4a10	cytochrome P450, family 4, subfamily a, polypeptide 10	0.074
A1i3	alpha-1-inhibitor III	0.073
Pitx3	paired-like homeodomain 3	0.071
Gc	group specific component	0.061
Hrh4	histamine receptor H4	0.060
C3	complement component 3	0.060
Pim1	pim-1 oncogene	0.059
Ppard	peroxisome proliferator-activated receptor delta	0.058
Apoe	apolipoprotein E	0.058
Tpt1	tumor protein, translationally-controlled 1	0.057
Apoa5	apolipoprotein A-V	0.056
Agxt2	alanine-glyoxylate aminotransferase 2	0.054
Spink3	serine peptidase inhibitor, Kazal type 3	0.050
Trhr	thyrotropin releasing hormone receptor	0.050
Alb	albumin	0.048
Apcs	amyloid P component, serum	0.047
Il8rb	interleukin 8 receptor, beta	0.046
Azgp1	alpha-2-glycoprotein 1, zinc-binding	0.045
Csf3	colony stimulating factor 3 (granulocyte)	0.044
LOC287167	globin, alpha	0.042
F9	coagulation factor IX	0.042
Aldh2	aldehyde dehydrogenase 2 family (mitochondrial)	0.040
Cyb5r3	cytochrome b5 reductase 3	0.040
Cyp2c22	cytochrome P450, family 2, subfamily c, polypeptide 22	0.039
Bcl2	B-cell CLL/lymphoma 2	0.039	Rat
Tubb5	tubulin, beta 5	0.037
Mpst	mercaptopyruvate sulfurtransferase	0.037
Slc22a7	solute carrier family 22 (organic anion transporter), member 7	0.036
Spp2	secreted phosphoprotein 2	0.035
Ttr	transthyretin	0.035
Mcm6	minichromosome maintenance complex component 6	0.035
S100b	S100 calcium binding protein B	0.034
Tst	thiosulfate sulfurtransferase	0.034
Hba-a2	hemoglobin alpha, adult chain 2	0.033
Mgst1	microsomal glutathione S-transferase 1	0.033
Prdx1	peroxiredoxin 1	0.033
Cdc42bpb	CDC42 binding protein kinase beta (DMPK-like)	0.032
Igfals	insulin-like growth factor binding protein, acid labile subunit	0.032
Cdk4	cyclin-dependent kinase 4	0.031
Cyb5a	cytochrome b5 type A (microsomal)	0.031
Olr226	olfactory receptor 226	0.031
Aqp9	aquaporin 9	0.031
Csn1s2a	casein alpha s2-like A	0.030
Fn1	fibronectin 1	0.030
Gucy2f	guanylate cyclase 2F	0.030
Hbb-b1	hemoglobin, beta adult major chain	0.029
Slc25a11	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	0.029
Ctsb	cathepsin B	0.028
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.028
Serpind1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.028
Ctdsp1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	0.028
Abcc6	ATP-binding cassette, subfamily C (CFTR/MRP), member 6	0.027
Apex1	APEX nuclease (multifunctional DNA repair enzyme) 1	0.027
Apoh	apolipoprotein H (beta-2-glycoprotein I)	0.027
RGD1562618	similar to RIKEN cDNA 6030419C18 gene	0.027
Pecr	peroxisomal trans-2-enoyl-CoA reductase	0.027
Cyp4f1	cytochrome P450, family 4, subfamily f, polypeptide 1	0.027
Sqstm1	sequestosome 1	0.027
Anxa5	annexin A5	0.027
RGD1306474	similar to RIKEN cDNA 9530003J23	0.026
Slc22a1	solute carrier family 22 (organic cation transporter), member 1	0.026
Gckr	glucokinase (hexokinase 4) regulator	0.026
Itih3	inter-alpha trypsin inhibitor, heavy chain 3	0.026
Ambp	alpha-1-microglobulin/bikunin precursor	0.026
Foxe1	forkhead box E1 (thyroid transcription factor 2)	0.025
Rdh7	retinol dehydrogenase 7	0.025
Mosc2	MOCO sulphurase C-terminal domain containing 2	0.025
Hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2	0.024
Fasn	fatty acid synthase	0.024
Slc13a2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.024
Apoa1	apolipoprotein A-I	0.024
Nlrp6	NLR family, pyrin domain containing 6	0.024
Hsd17b1	hydroxysteroid (17-beta) dehydrogenase 1	0.024
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.023
Atp4b	ATPase, H+/K+ exchanging, beta polypeptide	0.023
Fetub	fetuin B	0.023
Cdkn1a	cyclin-dependent kinase inhibitor 1A	0.023
Afm	afamin	0.023
Me1	malic enzyme 1, NADP(+)-dependent, cytosolic	0.022
Chrna2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	0.022
Gfap	glial fibrillary acidic protein	0.022
LOC299282	Serine protease inhibitor	0.022	Rat
Cyb5r1	cytochrome b5 reductase 1	0.022
A2m	alpha-2-macroglobulin	0.021
Trap1	TNF receptor-associated protein 1	0.021
Sod3	superoxide dismutase 3, extracellular	0.021
Cyp3a2	cytochrome P450, family 3, subfamily a, polypeptide 2	0.021
RT1-M5	RT1 class Ib, locus M5	0.021
Acsm2	acyl-CoA synthetase medium-chain family member 2	0.021
Atp4a	ATPase, H+/K+ exchanging, alpha polypeptide	0.021
Olr857	olfactory receptor 857	0.021
Ctsj	cathepsin J	0.021
Trhr2	thyrotropin releasing hormone receptor 2	0.021
Sag	S-antigen; retina and pineal gland (arrestin)	0.021
Cyp2c23	cytochrome P450, family 2, subfamily c, polypeptide 23	0.021
Aldob	aldolase B, fructose-bisphosphate	0.020
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.020	Rat
Pzp	pregnancy-zone protein	0.020
Gcsh	glycine cleavage system protein H (aminomethyl carrier)	0.020
Aph1a	anterior pharynx defective 1 homolog A (C. elegans)	0.020
Gstm7	glutathione S-transferase, mu 7	0.020	Rat
Npvf	neuropeptide VF precursor	0.020
Aqp8	aquaporin 8	0.020
Sephs2	selenophosphate synthetase 2	0.020
Ucp2	uncoupling protein 2 (mitochondrial, proton carrier)	0.020
Cyp2a1	cytochrome P450, family 2, subfamily a, polypeptide 1	0.020
Cyp2c7	cytochrome P450, family 2, subfamily c, polypeptide 7	0.020
Selenbp1	selenium binding protein 1	0.019
Gstm5	glutathione S-transferase, mu 5	0.019	Rat
Col10a1	collagen, type X, alpha 1	0.019
Dao	D-amino-acid oxidase	0.019
Tgfb1	transforming growth factor, beta 1	0.019
Hsd17b6	hydroxysteroid (17-beta) dehydrogenase 6	0.019
Gna11	guanine nucleotide binding protein, alpha 11	0.019
Gnat3	guanine nucleotide binding protein, alpha transducing 3	0.019
Pemt	phosphatidylethanolamine N-methyltransferase	0.018
RGD620382	Nucleoside 2-deoxyribosyltransferase domain containing protein RGD620382	0.018
LOC100361261	rCG23560-like	0.018
Fgb	fibrinogen beta chain	0.018
Bpnt1	3'(2'), 5'-bisphosphate nucleotidase 1	0.018
Cryge	crystallin, gamma E	0.018
Rara	retinoic acid receptor, alpha	0.018
Mbl1	mannose-binding lectin (protein A) 1	0.018
Miox	myo-inositol oxygenase	0.018
Aqp3	aquaporin 3	0.018
Selp	selectin P	0.017
Slc7a1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	0.017
Itih4	inter alpha-trypsin inhibitor, heavy chain 4	0.017
Proc	protein C	0.017
Ddt	D-dopachrome tautomerase	0.017
Dhrs7	dehydrogenase/reductase (SDR family) member 7	0.017
Slc48a1	solute carrier family 48 (heme transporter), member 1	0.017
Sncb	synuclein, beta	0.017
Alox15	arachidonate 15-lipoxygenase	0.017
Apba1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.017
Crybb3	crystallin, beta B3	0.017
Foxd3	forkhead box D3	0.016
Fxyd4	FXYD domain-containing ion transport regulator 4	0.016
Igfbp1	insulin-like growth factor binding protein 1	0.016
Akr1c18	aldo-keto reductase family 1, member C18	0.016
Sccpdh	saccharopine dehydrogenase (putative)	0.016
Hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	0.016
Ahcy	adenosylhomocysteinase	0.016
Taldo1	transaldolase 1	0.016
Si	sucrase-isomaltase (alpha-glucosidase)	0.016
Clu	clusterin	0.016
Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	0.016
Tnp1	transition protein 1	0.016
Gal	galanin prepropeptide	0.016
Aldoc	aldolase C, fructose-bisphosphate	0.016
Cps1	carbamoyl-phosphate synthetase 1	0.015
Gnmt	glycine N-methyltransferase	0.015
Akr7a2	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	0.015
Ces1c	carboxylesterase 1C	0.015
LOC494499	LOC494499 protein	0.015
Nmu	neuromedin U	0.015
Exosc4	exosome component 4	0.015
Il12b	interleukin 12B	0.015
Prdx6	peroxiredoxin 6	0.015
Coro1b	coronin, actin-binding protein, 1B	0.015
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.015
Gamt	guanidinoacetate N-methyltransferase	0.015
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.015
Prdm2	PR domain containing 2, with ZNF domain	0.015
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.015
Galr3	galanin receptor 3	0.015
Prss35	protease, serine, 35	0.015
Cpb1	carboxypeptidase B1 (tissue)	0.015
Adra1a	adrenergic, alpha-1A-, receptor	0.015
Cbs	cystathionine beta synthase	0.014
Ybx1	Y box binding protein 1	0.014
C8b	complement component 8, beta polypeptide	0.014
Slc38a3	solute carrier family 38, member 3	0.014
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.014
Epn1	Epsin 1	0.014
Aldh1l1	aldehyde dehydrogenase 1 family, member L1	0.014
Kng1	kininogen 1	0.014
Avpr2	arginine vasopressin receptor 2	0.014
Ppara	peroxisome proliferator activated receptor alpha	0.014
Mcm4	minichromosome maintenance complex component 4	0.014
Rup2	urinary protein 2	0.014
Col4a1	collagen, type IV, alpha 1	0.014
Gipc3	GIPC PDZ domain containing family, member 3	0.014
Afp	alpha-fetoprotein	0.014
F12	coagulation factor XII (Hageman factor)	0.014
Col3a1	collagen, type III, alpha 1	0.014
Nme3	non-metastatic cells 3, protein expressed in	0.014
Scn5a	sodium channel, voltage-gated, type V, alpha subunit	0.014
Vdr	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.014
Tnp2	transition protein 2	0.014
Ppox	protoporphyrinogen oxidase	0.013
Kcnh5	potassium voltage-gated channel, subfamily H (eag-related), member 5	0.013
Slco1a4	solute carrier organic anion transporter family, member 1a4	0.013
Crygd	crystallin, gamma D	0.013
Slc10a1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.013
Agxt	alanine-glyoxylate aminotransferase	0.013
Lphn3	latrophilin 3	0.013
Cyp3a23/3a1	cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1	0.013
Tkt	transketolase	0.013
Ugt2b1	UDP glucuronosyltransferase 2 family, polypeptide B1	0.013
Serpinc1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.013
Cyp4a2	cytochrome P450, family 4, subfamily a, polypeptide 2	0.013
Gstt3	glutathione S-transferase, theta 3	0.013
Idh1	isocitrate dehydrogenase 1 (NADP+), soluble	0.013
Foxd1	forkhead box D1	0.013
Nipsnap1	nipsnap homolog 1 (C. elegans)	0.013
Avp	arginine vasopressin	0.013
Slc26a1	solute carrier family 26 (sulfate transporter), member 1	0.013
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.013
Hagh	hydroxyacyl glutathione hydrolase	0.013
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.013
Ugt1a6	UDP glucuronosyltransferase 1 family, polypeptide A6	0.013
Hp	haptoglobin	0.013
Chrna6	cholinergic receptor, nicotinic, alpha 6	0.013
Slc23a3	solute carrier family 23 (nucleobase transporters), member 3	0.013
LOC293989	cytochrome P450-like	0.013
Spg21	spastic paraplegia 21 homolog (human)	0.013
Scarb1	scavenger receptor class B, member 1	0.013
Nos3	nitric oxide synthase 3, endothelial cell	0.012
Akr7a3	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)	0.012
Cyp3a18	cytochrome P450, family 3, subfamily a, polypeptide 18	0.012
Nrarp	Notch-regulated ankyrin repeat protein	0.012
Ptafr	platelet-activating factor receptor	0.012
Fgg	fibrinogen gamma chain	0.012
Gjb2	gap junction protein, beta 2	0.012
Abcb11	ATP-binding cassette, subfamily B (MDR/TAP), member 11	0.012
Fgd6	FYVE, RhoGEF and PH domain containing 6	0.012
Serpina11	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	0.012	Rat
Mylk2	myosin light chain kinase 2	0.012
Slc25a10	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	0.012
Gpr12	G protein-coupled receptor 12	0.012
Tdo2	tryptophan 2,3-dioxygenase	0.012
Th	tyrosine hydroxylase	0.012
F2	coagulation factor II (thrombin)	0.012
Ralgds	ral guanine nucleotide dissociation stimulator	0.012
Cst8	cystatin 8 (cystatin-related epididymal specific)	0.012
Plg	plasminogen	0.012
Slc6a13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.012	Rat
Pah	phenylalanine hydroxylase	0.012
Tp53	tumor protein p53	0.012
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.012
Zic1	Zic family member 1 (odd-paired homolog, Drosophila)	0.012
Chrnb4	cholinergic receptor, nicotinic, beta 4	0.012
Arl9	ADP-ribosylation factor-like 9	0.012
Gpx1	glutathione peroxidase 1	0.012
P4hb	prolyl 4-hydroxylase, beta polypeptide	0.011
Hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.011
Cpb2	carboxypeptidase B2 (plasma)	0.011
Cyp2f4	cytochrome P450, family 2, subfamily f, polypeptide 4	0.011
Phkg1	phosphorylase kinase, gamma 1	0.011
Crisp1	cysteine-rich secretory protein 1	0.011
Klkb1	kallikrein B, plasma 1	0.011
Aldh7a1	aldehyde dehydrogenase 7 family, member A1	0.011
Cdc25b	cell division cycle 25 homolog B (S. pombe)	0.011
Slc22a2	solute carrier family 22 (organic cation transporter), member 2	0.011
RGD1565859	RGD1565859	0.011
Gulo	gulonolactone (L-) oxidase	0.011
Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	0.011
Barhl2	BarH-like homeobox 2	0.011
Pgf	placental growth factor	0.011
Glud1	glutamate dehydrogenase 1	0.011
Zp3	zona pellucida glycoprotein 3 (sperm receptor)	0.011
Chrng	cholinergic receptor, nicotinic, gamma	0.011
Cntn2	contactin 2 (axonal)	0.011
Atp6v0e2	ATPase, H+ transporting V0 subunit e2	0.011
Cd81	Cd81 molecule	0.011
Etnk2	ethanolamine kinase 2	0.011
Timp2	TIMP metallopeptidase inhibitor 2	0.011
Olr1361	olfactory receptor 1361	0.011
Gh1	growth hormone 1	0.011
Pop7	processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)	0.011
Git1	G protein-coupled receptor kinase interacting ArfGAP 1	0.011
Hamp	hepcidin antimicrobial peptide	0.011
Cyp2b3	cytochrome P450, family 2, subfamily b, polypeptide 3	0.011
Abp1	amiloride binding protein 1 (amine oxidase, copper-containing)	0.011
Acsl1	acyl-CoA synthetase long-chain family member 1	0.011
Rps29	ribosomal protein S29	0.011
Hbg1	hemoglobin, gamma A	0.011
Plp1	proteolipid protein 1	0.011
Gast	gastrin	0.011
Setd6	SET domain containing 6	0.011
Dpp6	dipeptidylpeptidase 6	0.011
Kcna6	potassium voltage gated channel, shaker related subfamily, member 6	0.011
Cyp2b15	cytochrome P450, family 2, subfamily b, polypeptide 15	0.011
Khk	ketohexokinase	0.011
RGD1560925	similar to 2610034M16Rik protein	0.011
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.011	Rat
P2ry4	pyrimidinergic receptor P2Y, G-protein coupled, 4	0.011
Olr1500	olfactory receptor 1500	0.011
Clcn2	chloride channel 2	0.011
Pmfbp1	polyamine modulated factor 1 binding protein 1	0.011
Apob	apolipoprotein B	0.011
Sult1b1	sulfotransferase family, cytosolic, 1B, member 1	0.011
Il1rn	interleukin 1 receptor antagonist	0.011
Gpc1	glypican 1	0.011
Tubg1	tubulin, gamma 1	0.010
Il5	interleukin 5	0.010
Lpar1	lysophosphatidic acid receptor 1	0.010
Cpe	carboxypeptidase E	0.010
Alad	aminolevulinate, delta-, dehydratase	0.010
Ces2c	carboxylesterase 2C	0.010
Tmem82	transmembrane protein 82	0.010
Rfc3	replication factor C (activator 1) 3	0.010
Cckar	cholecystokinin A receptor	0.010
Kcnh6	potassium voltage-gated channel, subfamily H (eag-related), member 6	0.010
Dpys	dihydropyrimidinase	0.010
Grik3	glutamate receptor, ionotropic, kainate 3	0.010
Pnliprp2	pancreatic lipase-related protein 2	0.010
Apoc4	apolipoprotein C-IV	0.010
Sec14l2	SEC14-like 2 (S. cerevisiae)	0.010
Cysltr2	cysteinyl leukotriene receptor 2	0.010
Crygc	crystallin, gamma C	0.010
Cdk5	cyclin-dependent kinase 5	0.010
Dpm2	dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit	0.010
Tsx	testis specific X-linked gene	0.010
March8	membrane-associated ring finger (C3HC4) 8	0.010
Slc25a16	solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16	0.010
Omp	olfactory marker protein	0.010
Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	0.010