IMP: Integrative Multi-species Prediction

Rattus norvegicus

1 genes annotated in rat

Multi-species View

activation of mapkkk activity

GO:0000185

Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).

Loading network...

In addition to gene-name show these genes:

Known genes in the process in ratInclude functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "activation of mapkkk activity"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "activation of mapkkk activity" (in gray)

Name	Description	Probability	Func Analog Organism
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.161
Prkacb	protein kinase, cAMP dependent, catalytic, beta	0.148
Taok1	TAO kinase 1	0.111
Rnf4	ring finger protein 4	0.107
Adam10	ADAM metallopeptidase domain 10	0.095
Mapk9	mitogen-activated protein kinase 9	0.067
Homer1	homer homolog 1 (Drosophila)	0.056
Nek9	NIMA (never in mitosis gene a)- related kinase 9	0.056
Gria1	glutamate receptor, ionotropic, AMPA 1	0.056
Kcnk1	potassium channel, subfamily K, member 1	0.054
Cap1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.053
Atf2	activating transcription factor 2	0.052
Dctn4	dynactin 4	0.046
Slc30a1	solute carrier family 30 (zinc transporter), member 1	0.043
Grip1	glutamate receptor interacting protein 1	0.042
Gad2	glutamate decarboxylase 2	0.039
Csnk1g3	casein kinase 1, gamma 3	0.039
Arih1	ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)	0.037
Golph3	golgi phosphoprotein 3 (coat-protein)	0.037
Nsf	N-ethylmaleimide-sensitive factor	0.036
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.036
Tcf12	transcription factor 12	0.036
Cntn3	contactin 3 (plasmacytoma associated)	0.035
Pou3f3	POU class 3 homeobox 3	0.031
Arhgef1	Rho guanine nucleotide exchange factor (GEF) 1	0.031
Mobp	myelin-associated oligodendrocyte basic protein	0.030
Bsn	bassoon	0.029
Grm7	glutamate receptor, metabotropic 7	0.028
Pou3f2	POU class 3 homeobox 2	0.028
Ier2	immediate early response 2	0.028
Ppp1r15a	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.027
Cplx2	complexin 2	0.025
Mll4	myeloid/lymphoid or mixed-lineage leukemia 4	0.025
Opcml	opioid binding protein/cell adhesion molecule-like	0.025
Tle4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0.024
Gria2	glutamate receptor, ionotropic, AMPA 2	0.023
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.023
Spire1	spire homolog 1 (Drosophila)	0.023
Snrk	SNF related kinase	0.023
Cnksr2	connector enhancer of kinase suppressor of Ras 2	0.022
Cntn4	contactin 4	0.022
Camk1g	calcium/calmodulin-dependent protein kinase IG	0.021
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.021
Dlg1	discs, large homolog 1 (Drosophila)	0.021
Gria4	glutamate receptor, ionotrophic, AMPA 4	0.020
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.020
Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2	0.020
Grm2	glutamate receptor, metabotropic 2	0.020	Rat
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.019
Ryr2	ryanodine receptor 2, cardiac	0.018
Epn1	Epsin 1	0.018
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.018
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.018
Slc26a1	solute carrier family 26 (sulfate transporter), member 1	0.018
Gpr85	G protein-coupled receptor 85	0.018
Gabra2	gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2	0.018
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.018
Epha5	EphA5	0.018
Ppp1r13b	protein phosphatase 1, regulatory (inhibitor) subunit 13B	0.017
Lin7b	lin-7 homolog b (C. elegans)	0.017
Myt1l	myelin transcription factor 1-like	0.017
Ireb2	iron responsive element binding protein 2	0.017
Errfi1	ERBB receptor feedback inhibitor 1	0.017
Kcnd2	potassium voltage-gated channel, Shal-related subfamily, member 2	0.017
Slc6a1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.017
Exoc5	exocyst complex component 5	0.016
Dnm1l	dynamin 1-like	0.016
Dlgap3	discs, large (Drosophila) homolog-associated protein 3	0.016
RGD1309414	similar to KIAA0913 protein	0.016
Csdc2	cold shock domain containing C2, RNA binding	0.016
Lyst	lysosomal trafficking regulator	0.016
Rftn2	raftlin family member 2	0.016
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.016
Adar	adenosine deaminase, RNA-specific	0.016
Mgat5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	0.016
Cryba4	crystallin, beta A4	0.016
Kcnb2	potassium voltage gated channel, Shab-related subfamily, member 2	0.016
Gabrg1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	0.016
Fgf14	fibroblast growth factor 14	0.016
Kcnc1	potassium voltage gated channel, Shaw-related subfamily, member 1	0.016
Dnah1	dynein, axonemal, heavy chain 1	0.016
Accn2	amiloride-sensitive cation channel 2, neuronal	0.015
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, beta 3	0.015
Cugbp2	CUG triplet repeat, RNA binding protein 2	0.015
Tnr	tenascin R	0.015
Fgfr1	Fibroblast growth factor receptor 1	0.015
Cdc42bpb	CDC42 binding protein kinase beta (DMPK-like)	0.014
Lrrc56	leucine rich repeat containing 56	0.014
Kcnt1	potassium channel, subfamily T, member 1	0.014
Nmbr	neuromedin B receptor	0.014
Slc1a1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	0.014
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, beta 2	0.014
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.014
Apc	adenomatous polyposis coli	0.014
Gabra4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	0.014
Lig3	ligase III, DNA, ATP-dependent	0.014
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.013
Senp2	Sumo1/sentrin/SMT3 specific peptidase 2	0.013
Pnoc	prepronociceptin	0.013
Cast	calpastatin	0.013
Mtmr7	myotubularin related protein 7	0.013
Ptch1	patched homolog 1 (Drosophila)	0.013
Agap2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.013
Gna12	guanine nucleotide binding protein (G protein) alpha 12	0.013
Cdk11b	cyclin-dependent kinase 11B	0.013
Hpcal4	hippocalcin-like 4	0.013
Slc12a5	solute carrier family 12 (potassium-chloride transporter), member 5	0.013
Camk2n2	calcium/calmodulin-dependent protein kinase II inhibitor 2	0.013
Slc4a4	solute carrier family 4, sodium bicarbonate cotransporter, member 4	0.013
C1qtnf4	C1q and tumor necrosis factor related protein 4	0.013
Adprhl2	ADP-ribosylhydrolase like 2	0.013
Tgoln1	trans-golgi network protein	0.013
Rundc3b	RUN domain containing 3B	0.013
Nalcn	sodium leak channel, non-selective	0.013
Syt5	synaptotagmin V	0.012
Dlg3	discs, large homolog 3 (Drosophila)	0.012
Rgs9	regulator of G-protein signaling 9	0.012
Tub	tubby homolog (mouse)	0.012
Trpc4	transient receptor potential cation channel, subfamily C, member 4	0.012
Cacng3	calcium channel, voltage-dependent, gamma subunit 3	0.012
Syt4	synaptotagmin IV	0.012
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.012
Gabrb1	gamma-aminobutyric acid (GABA) A receptor, beta 1	0.012
Pcdhb12	protocadherin beta 12	0.012
Slc25a27	solute carrier family 25, member 27	0.012
Enpp6	ectonucleotide pyrophosphatase/phosphodiesterase 6	0.012
Folh1	folate hydrolase 1	0.012
Calb2	calbindin 2	0.012
Ptgds	prostaglandin D2 synthase (brain)	0.012
Fbxo16	F-box protein 16	0.012
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	0.012
Hes3	hairy and enhancer of split 3 (Drosophila)	0.012
Btnl7	butyrophilin-like 7	0.012
Nrcam	neuronal cell adhesion molecule	0.012
Dmwd	dystrophia myotonica, WD repeat containing	0.012
Vip	vasoactive intestinal peptide	0.012
Dnajc5	DnaJ (Hsp40) homolog, subfamily C, member 5	0.012
Ear11	eosinophil-associated, ribonuclease A family, member 11	0.012
Oprl1	opiate receptor-like 1	0.011
Gsk3a	glycogen synthase kinase 3 alpha	0.011
Pde1b	phosphodiesterase 1B, calmodulin-dependent	0.011
Ephb1	Eph receptor B1	0.011
Scn3a	sodium channel, voltage-gated, type III, alpha	0.011
Prp2l1	proline rich protein 2-like 1	0.011
Cnga4	cyclic nucleotide gated channel alpha 4	0.011
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.011
Foxi2	forkhead box I2	0.011
Kcnh4	potassium voltage-gated channel, subfamily H (eag-related), member 4	0.011
Klk1c10l2	kallikrein 1-related peptidase c10-like 2	0.011
Sstr2	somatostatin receptor 2	0.011
Pcnxl3	pecanex-like 3 (Drosophila)	0.011
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.011
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.011
Syt2	synaptotagmin II	0.011
Cnga2	cyclic nucleotide gated channel alpha 2	0.011
Ctnnd2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	0.011
Cdcp1	CUB domain containing protein 1	0.011
Crybb2	crystallin, beta B2	0.011
Dio2	deiodinase, iodothyronine, type II	0.011
Hpcal1	hippocalcin-like 1	0.011
Myo1b	myosin Ib	0.011
Pak3	p21 protein (Cdc42/Rac)-activated kinase 3	0.011	Yeast
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.011
Mapk1	mitogen activated protein kinase 1	0.011
Rab3c	RAB3C, member RAS oncogene family	0.010
Scg3	secretogranin III	0.010
Sfrp4	secreted frizzled-related protein 4	0.010
Mog	myelin oligodendrocyte glycoprotein	0.010
Bcl2l1	Bcl2-like 1	0.010
Pick1	protein interacting with PRKCA 1	0.010
Nrg2	neuregulin 2	0.010
Map3k3	mitogen activated protein kinase kinase kinase 3	0.010
B3galt5	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	0.010
Grp	gastrin releasing peptide	0.010
Mbd6	methyl-CpG binding domain protein 6	0.010
Atp2b3	ATPase, Ca++ transporting, plasma membrane 3	0.010
Dusp26	dual specificity phosphatase 26 (putative)	0.010
Gnai1	guanine nucleotide binding protein (G protein), alpha inhibiting 1	0.010
Dlg2	discs, large homolog 2 (Drosophila)	0.010