IMP
Process View
negative regulation of insulin receptor signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of insulin receptor signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| LOC100363783 | rCG53773-like | 0.192 | ||
| Zyx | zyxin | 0.078 | ||
| Cmklr1 | chemokine-like receptor 1 | 0.077 | ||
| Syngr2 | synaptogyrin 2 | 0.075 | ||
| Stat6 | signal transducer and activator of transcription 6 | 0.075 | ||
| Plxnb2 | plexin B2 | 0.074 | ||
| Slc4a2 | solute carrier family 4 (anion exchanger), member 2 | 0.065 | ||
| Map3k11 | mitogen-activated protein kinase kinase kinase 11 | 0.064 | ||
| Hist1h1a | histone cluster 1, H1a | 0.058 | ||
| Rnf10 | ring finger protein 10 | 0.056 | ||
| Usf2 | upstream transcription factor 2, c-fos interacting | 0.053 | ||
| Cyfip2 | cytoplasmic FMR1 interacting protein 2 | 0.050 | ||
| Snrk | SNF related kinase | 0.049 | ||
| Nfia | nuclear factor I/A | 0.047 | ||
| Alb | albumin | 0.044 | ||
| Lzts2 | leucine zipper, putative tumor suppressor 2 | 0.042 | ||
| Fth1 | ferritin, heavy polypeptide 1 | 0.037 | ||
| Slc2a3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.037 | ||
| Epn1 | Epsin 1 | 0.036 | ||
| Gna12 | guanine nucleotide binding protein (G protein) alpha 12 | 0.035 | ||
| Gria2 | glutamate receptor, ionotropic, AMPA 2 | 0.035 | ||
| Pik3r1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.034 | ||
| Eef2 | eukaryotic translation elongation factor 2 | 0.034 | ||
| Myo1c | myosin IC | 0.034 | ||
| Cugbp2 | CUG triplet repeat, RNA binding protein 2 | 0.034 | ||
| Csnk1g2 | casein kinase 1, gamma 2 | 0.033 | ||
| Hck | hemopoietic cell kinase | 0.033 | ||
| Unc13d | unc-13 homolog D (C. elegans) | 0.033 | ||
| Itpr1 | inositol 1,4,5-triphosphate receptor, type 1 | 0.032 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.032 | ||
| Metap2 | methionyl aminopeptidase 2 | 0.032 | ||
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.032 | ||
| Vasp | vasodilator-stimulated phosphoprotein | 0.031 | ||
| Fgr | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.030 | ||
| Ryr2 | ryanodine receptor 2, cardiac | 0.030 | ||
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.028 | ||
| Csk | c-src tyrosine kinase | 0.026 | ||
| Smad7 | SMAD family member 7 | 0.026 | ||
| Lyn | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.025 | ||
| Pip4k2a | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.025 | ||
| Pkn2 | protein kinase N2 | 0.024 | ||
| Tnip1 | TNFAIP3 interacting protein 1 | 0.024 | ||
| Myh9 | myosin, heavy chain 9, non-muscle | 0.024 | ||
| Smek2 | SMEK homolog 2, suppressor of mek1 (Dictyostelium) | 0.023 | ||
| Gria3 | glutamate receptor, ionotrophic, AMPA 3 | 0.023 | ||
| Fam134a | family with sequence similarity 134, member A | 0.023 | ||
| Dlgap1 | discs, large (Drosophila) homolog-associated protein 1 | 0.023 | ||
| Sla | src-like adaptor | 0.022 | ||
| Hsp90ab1 | heat shock protein 90 alpha (cytosolic), class B member 1 | 0.022 | ||
| Plcb1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.022 | ||
| Cd37 | CD37 molecule | 0.022 | ||
| Ltbr | lymphotoxin beta receptor (TNFR superfamily, member 3) | 0.021 | ||
| Unc5b | unc-5 homolog B (C. elegans) | 0.020 | ||
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.020 | ||
| Anapc5 | anaphase-promoting complex subunit 5 | 0.020 | ||
| Myo1e | myosin IE | 0.019 | ||
| Git1 | G protein-coupled receptor kinase interacting ArfGAP 1 | 0.019 | ||
| Sirpa | signal-regulatory protein alpha | 0.019 | ||
| Phka1 | phosphorylase kinase, alpha 1 | 0.019 | ||
| Ambp | alpha-1-microglobulin/bikunin precursor | 0.019 | ||
| Serbp1 | Serpine1 mRNA binding protein 1 | 0.018 | ||
| Socs2 | suppressor of cytokine signaling 2 | 0.018 | ||
| Adrbk1 | adrenergic, beta, receptor kinase 1 | 0.018 | ||
| Slfn2 | schlafen 2 | 0.017 | ||
| Clcn4-2 | chloride channel 4-2 | 0.017 | ||
| Ppp1r15a | protein phosphatase 1, regulatory (inhibitor) subunit 15A | 0.017 | ||
| Sbno2 | strawberry notch homolog 2 (Drosophila) | 0.017 | ||
| Rpl7a | ribosomal protein L7a | 0.016 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.016 | ||
| Arrdc1 | arrestin domain containing 1 | 0.016 | ||
| Nup88 | nucleoporin 88 | 0.016 | ||
| Apba3 | amyloid beta (A4) precursor protein-binding, family A, member 3 | 0.016 | ||
| Gpc1 | glypican 1 | 0.016 | ||
| Jak3 | Janus kinase 3 | 0.016 | ||
| Kif1b | kinesin family member 1B | 0.016 | ||
| Cx3cl1 | chemokine (C-X3-C motif) ligand 1 | 0.015 | ||
| Gnb2 | guanine nucleotide binding protein (G protein), beta polypeptide 2 | 0.015 | ||
| Foxg1 | forkhead box G1 | 0.015 | ||
| Arhgap4 | Rho GTPase activating protein 4 | 0.015 | ||
| Rps6ka1 | ribosomal protein S6 kinase polypeptide 1 | 0.015 | ||
| Flii | flightless I homolog (Drosophila) | 0.015 | ||
| Lmna | lamin A | 0.015 | ||
| Mxd1 | max dimerization protein 1 | 0.015 | ||
| Pctk1 | PCTAIRE protein kinase 1 | 0.015 | ||
| Ampd1 | adenosine monophosphate deaminase 1 (isoform M) | 0.015 | ||
| Fga | fibrinogen alpha chain | 0.015 | ||
| Mobkl2a | MOB1, Mps One Binder kinase activator-like 2A (yeast) | 0.015 | ||
| Tcfe2a | transcription factor E2a | 0.015 | ||
| Tpt1 | tumor protein, translationally-controlled 1 | 0.015 | ||
| Crk | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.014 | ||
| Map2 | microtubule-associated protein 2 | 0.014 | ||
| Nek9 | NIMA (never in mitosis gene a)- related kinase 9 | 0.014 | ||
| Fnbp1 | formin binding protein 1 | 0.014 | ||
| Sort1 | sortilin 1 | 0.014 | ||
| Cttnbp2 | cortactin binding protein 2 | 0.014 | ||
| LOC100360403 | ATP-binding cassette, sub-family C, member 9-like | 0.014 | ||
| Akap1 | A kinase (PRKA) anchor protein 1 | 0.014 | ||
| Actb | actin, beta | 0.014 | ||
| Rasgrp1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 0.014 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.013 | ||
| Acvr1 | activin A receptor, type I | 0.013 | ||
| Gpam | glycerol-3-phosphate acyltransferase, mitochondrial | 0.013 | ||
| Rbm38 | RNA binding motif protein 38 | 0.013 | ||
| Rara | retinoic acid receptor, alpha | 0.013 | ||
| Itgb5 | integrin, beta 5 | 0.013 | ||
| Herc4 | hect domain and RLD 4 | 0.013 | ||
| Cast | calpastatin | 0.012 | ||
| Abcb4 | ATP-binding cassette, subfamily B (MDR/TAP), member 4 | 0.012 | ||
| Fgg | fibrinogen gamma chain | 0.012 | ||
| Rarb | retinoic acid receptor, beta | 0.012 | ||
| Itgb4 | integrin, beta 4 | 0.012 | ||
| Fzr1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.012 | ||
| Orai1 | ORAI calcium release-activated calcium modulator 1 | 0.012 | ||
| Serpina1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.012 | ||
| Clcn2 | chloride channel 2 | 0.012 | ||
| Stk10 | serine/threonine kinase 10 | 0.012 | ||
| Vps37c | vacuolar protein sorting 37 homolog C (S. cerevisiae) | 0.012 | ||
| Thop1 | thimet oligopeptidase 1 | 0.012 | ||
| Med25 | mediator complex subunit 25 | 0.012 | ||
| Prrx1 | paired related homeobox 1 | 0.012 | ||
| Cd83 | CD83 molecule | 0.012 | ||
| Ptk2b | PTK2B protein tyrosine kinase 2 beta | 0.012 | ||
| Ldlr | low density lipoprotein receptor | 0.012 | ||
| Ckm | creatine kinase, muscle | 0.012 | ||
| Ptger4 | prostaglandin E receptor 4 (subtype EP4) | 0.011 | ||
| Kcng1 | potassium voltage-gated channel, subfamily G, member 1 | 0.011 | ||
| Map2k7 | mitogen activated protein kinase kinase 7 | 0.011 | ||
| Nrgn | neurogranin | 0.011 | ||
| Plec | plectin | 0.011 | ||
| Diaph1 | diaphanous homolog 1 (Drosophila) | 0.011 | ||
| Ntrk1 | neurotrophic tyrosine kinase, receptor, type 1 | 0.011 | ||
| Gtdc1 | glycosyltransferase-like domain containing 1 | 0.011 | ||
| Bcl3 | B-cell CLL/lymphoma 3 | 0.011 | ||
| Meis2 | Meis homeobox 2 | 0.011 | ||
| Fbxw4 | F-box and WD repeat domain containing 4 | 0.011 | ||
| Orm1 | orosomucoid 1 | 0.011 | ||
| Ubtf | upstream binding transcription factor, RNA polymerase I | 0.011 | ||
| Rala | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.011 | ||
| Camk2d | calcium/calmodulin-dependent protein kinase II delta | 0.011 | ||
| Cep57 | centrosomal protein 57 | 0.011 | ||
| Sfrs12 | splicing factor, arginine/serine-rich 12 | 0.011 | ||
| Bcl2l1 | Bcl2-like 1 | 0.011 | ||
| Tln1 | talin 1 | 0.011 | ||
| Arnt | aryl hydrocarbon receptor nuclear translocator | 0.011 | ||
| Sec24a | SEC24 family, member A (S. cerevisiae) | 0.010 | ||
| Cdkn2aip | CDKN2A interacting protein | 0.010 | ||
| Acaca | acetyl-coenzyme A carboxylase alpha | 0.010 | ||
| Nfkbie | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.010 | ||
| Znf654 | zinc finger protein 654 | 0.010 | ||
| Ppard | peroxisome proliferator-activated receptor delta | 0.010 | ||
| Ager | advanced glycosylation end product-specific receptor | 0.010 | ||
| Irf1 | interferon regulatory factor 1 | 0.010 | ||
| Plcl1 | phospholipase C-like 1 | 0.010 | ||
| Mapkapk2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.010 |